Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
Baar, Marjolein P., Brandt, Renata M.C., Putavet, Diana A., Klein, Julian D.D., Derks, Kasper W.J., Bourgeois, Benjamin R.M., Stryeck, Sarah, Rijksen, Yvonne +13 more·2017·Cell
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- Targeted Therapeutics Delivery by Exploiting Biophysical Properties of Senescent CellsJessalyn Low, Brian Chan, Andy Kah Ping Tay · 2021 · Advanced Functional Materials
- The development of an anti-cancer peptide M1-21 targeting transcription factor FOXM1Haojie Cheng, Jie Yuan, Chaozhu Pei, Min Ouyang, Huitong Bu, Yan Chen, Xiaoqin Huang, Zhenwang Zhang, Yu Li, Yongjun Tan · 2023 · Cell & Bioscience
- Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practicePeng Chen, Yulai Wang, Benhong Zhou · 2024 · Mechanisms of Ageing and Development
- Small extracellular vesicles secreted by urine-derived stem cells enhanced wound healing in aged mice by ameliorating cellular senescenceYongjin Sun, Juntao Zhang, Bi Chen, Yunlong Yang, Haiyan Li, Xin Niu, Qing Li, Weidong Wu, Zongping Xie, Yunfeng Chen et al. · 2020 · Journal of Material Science and Technology
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- Development of a novel senolytic by precise disruption of FOXO4-p53 complexUtkarsh Tripathi, Selim Chaib, Erin O. Wissler Gerdes, Kelly A. Hogan, Yi Zhun Zhu · 2021 · EBioMedicine
- Shaving black fur uncovers hidden issues in p16-3MR miceNozomi Hori, Shimpei Kawamoto, Ken Uemura, Yumiko Okumura, Kentaro Tanaka, Jeong Hoon Park, Naoko Ohtani, Daisuke Motooka, Eiji Hara · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- KYA1797K, a Novel Small Molecule Destabilizing β-Catenin, Is Superior to ICG-001 in Protecting against Kidney AgingMingsheng Zhu, Xian Ling, Shan Yu Zhou, Ping Meng, Qiyan Chen, Shuangqin Chen, Kunyu Shen, Chao Xie, Yaozhong Kong, Maosheng Wang et al. · 2022 · Kidney Diseases
- Body Composition and Senescence: Impact of Polyphenols on Aging-Associated EventsTanila Wood dos Santos, Quélita Cristina Pereira, Isabela Monique Fortunato, Fabrício de Sousa Oliveira, Marisa Claudia Alvarez, Marcelo Lima Ribeiro · 2024 · Nutrients
- The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunitiesZehua Wang, Chen Chen, Jiaoyu Ai, Yaping Gao, Lei Wang, Shurui Xia, Yongxu Jia, Yanru Qin · 2025 · MedComm
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- Current strategies for senescence treatment: Focused on theranostic performance of nanomaterialsYiyang Cong, Xiaoyang Li, Hao Hong · 2025 · Journal of Controlled Release
- Cellular senescence in age-related musculoskeletal diseasesJinming Xiong, Qiaoyue Guo, Xianghang Luo · 2025 · Frontiers of Medicine
- The Destructive Cycle in Bronchopulmonary Dysplasia: The Rationale for Systems Pharmacology TherapeuticsMing Foey Teng, Tzong-Jin Wu, Kirkwood A. Pritchard, Billy W. Day, Stephen Naylor, Ru‐Jeng Teng · 2025 · Antioxidants
- Unveiling the link: aging and its impact on ocular diseasesKe Wang, Yifang Xie, Yumeng Lin, Renhe Zhu, Tenghui Gao, Zhongyu Han, Zhengyu Yang, Xuan Jiang, Haoran Chen, Zhengfang Wu et al. · 2025 · Experimental Eye Research
- Abrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-related dysfunctionsTakumi Mikawa, Masahiro Kameda, Sumiko Ikari, Eri Shibata, Shuyu Liu, Sawa Miyagawa, Koh Ono, Tomiko Ito, Akihiko Yoshizawa, Masataka Sugimoto et al. · 2025 · Signal Transduction and Targeted Therapy
- In vitro and in vivo toxicity assessment of the senotherapeutic Peptide 14Alessandra Arcoverde Cavalcanti Zonari, Lear E. Brace, Thuany Alencar‐Silva, William Farias Porto, Daniel A. Foyt, Mylieneth Guiang, Edgar Andrés Ochoa Cruz, Octávio Luiz Franco, Carolina R. Oliveira, Mariana Boroni et al. · 2022 · Toxicology Reports
- FoxO3 Regulates the Progress and Development of Aging and Aging-Related DiseasesZaoshang Chang, Zhiming He, Jingbo Xia · 2022 · Current Molecular Medicine
- Cellular Senescence and Senolytic Agents: Recent Updates on Their Role and ApplicationsLokesh Chandrakar, Ramesh Ambatwar, Gopal Lal Khatik · 2023 · Current Topics in Medicinal Chemistry
- TRIM21-dependent ultrasmall chiral gold nanoparticles for preventing microglia senescence against Alzheimer’s diseaseMeiru Lu, Changlong Hao, Liguang Xu, Yu Feng, Jiwei Jiang, Yanli Wang, Jun Xu, Hua Kuang, Chuanlai Xu, Maozhong Sun · 2024 · Science China Chemistry
- Endothelium and aging: mechanisms for formation of senescence associated phenotype of endothelial cellsTatyana Ivanovna Vlasova, Н. Н. Петрищев, Timur Dmitrievich Vlasov · 2023 · Regional blood circulation and microcirculation
- Beyond Making Ends Meet: DNA-PK, Metabolism, and AgingXiao Tian, Andrei Seluanov, Vera A. Gorbunova · 2017 · Cell Metabolism
- Effects of low-to-moderate ethanol consumption on colonic growth and gene expression in young adult and middle-aged male ratsNicole Wells, Jacqueline A. Quigley, Jeremy Pascua, Natalie J. Pinkowski, Lama Almaiman, Susan M. Brasser, Mee Young Hong · 2020 · PLoS ONE
- Single-cell RNA sequencing to detect age-associated genes that identify senescent cells in the liver of aged miceYuta Doshida, Shinichi Hashimoto, Sadahiro Iwabuchi, Yuka Takino, Toshiyuki Ishiwata, Toshiro Aigaki, Akihito Ishigami · 2023 · Scientific Reports
- Dopaminergic mediation in the brain aging and neurodegenerative diseases: a role of senescent cellsPavel V. Nekrasov, Vasily Vorobyov · 2018 · Neural Regeneration Research
- Pharmacological inhibition of guanosine triphosphate cyclohydrolase1 elevates tyrosine phosphorylation of caveolin1 and cellular senescenceSoniya Charles, V. Samuel Raj, Mohankumar Ramasamy, Kaliappan Ilango, Jesu Arockiaraj, Murugesan Sakthivadivel, Kanchana Mala · 2019 · European Journal of Pharmacology
- Anti-cancer effect of marchantin C via inducing lung cancer cellular senescence associated with less secretory phenotypeXiulei Zhang, Xiaotian Ji, Bin Sun, Lilin Qian, Xue-Lei Hu, Hong‐Xiang Lou, Huiqing Yuan · 2019 · Biochimica et Biophysica Acta (BBA) - General Subjects
- Molecular Mechanisms of Senescence and Implications for the Treatment of Myeloid MalignanciesPhilipp Ernst, Florian Heinrich Heidel · 2021 · Cancers
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- The Glutaminase-1 Inhibitor [11C-carbony]BPTES: Synthesis and Positron Emission Tomography Study in MiceYiding Zhang, Katsushi Kumata, Lin Xie, Yusuke Kurihara, Masanao Ogawa, Tomomi Kokufuta, Nobuki Nengaki, Ming‐Rong Zhang · 2023 · Pharmaceuticals
- Revolutionizing Senescence Detection: Advancements from Traditional Methods to Cutting-Edge TechniquesRuopeng Xiao, Sinan Hu, Xiaohui Du, Yiwen Wang, Ke Fang, Yibin Zhu, Nanbin Lou, Chunhui Yuan, Jing Yang · 2024 · Aging and Disease
- Potential of natural senolytic compounds in eliminating senescent cells and alleviating age-related skin deterioration: a narrative reviewGabriel Athayde Ramirez, Tânia Araújo Viel · 2024 · Aging advances.
- A Binary siRNA‐Loaded Tetrahedral DNA Nanobox for Synergetic Anti‐Aging TherapyZiqi Yue, Yichen Yang, Lulingxiao Nie, Yuezhang Sun, Qi Wang, Yunfeng Lin, Yang Gao, Xiaoxiao Cai · 2024 · Small
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- Cationic microbubbles loading shFOXO4/SDF1 rejuvenate the aged heart and alleviate myocardial ischemia-reperfusion injury in the elderlyXingpei Jiang, Limeng Chao, Kexun Liu, Yuanzhong Zhao, Jie Wu, Chang Liu, Wei Chen, Dongyang Zhang, Hai Tian · 2025 · Free Radical Biology and Medicine
- Aging‐Regulating Microspheres for Enhancing Mitochondrial Biogenesis in Early Senescence and Clearing Late Senescent CellsHonglin Xiang, Caiping Yan, Yefei Lei, Neng Lai, Pengrui Zhang, Ke Jiang, Weikang Zhao, Hanfeng Yang, Wenguo Cui, Yuling Li · 2025 · Advanced Functional Materials
- Forkhead box O proteins in chondrocyte aging and diseasesYuchen He, Weihong Zhu, Peter Geoffrey Alexander, Sophie E. Hines, Olivia Bartholomew, Chunfeng Zhao, Qian Liu, Hang Lin · 2025 · Journal of Orthopaedic Translation
- Targeting cellular senescence in diabetic kidney disease: potential of regenerative, cell-based therapies and other senotherapeutic approachesHelly A. Patel, Jiaxuan Wang, Caroline J. Zinn, Maya Learmonth, Xiaohui Bian, Diana Jurk, Lilach O. Lerman, Joy Wolfram, LaTonya J. Hickson · 2026 · Kidney International
- Insights into the therapeutic strategies for aging and aging-associated diseasesRuifang Dong, Qiming Wu, Juntao Kan, Caili Fu, Vincenzo Sorrentino, Ashley Chow, Yanan Lei, Di Wu, Zhenzhen Xu, Jun Du et al. · 2026 · Signal Transduction and Targeted Therapy
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- Recent Advancement in Elimination Strategies and Potential Rejuvenation Targets of SenescenceSanjay Kumar Kureel, Brandon Blair, Michael P. Sheetz · 2023 · Advanced Biology
- Decreased hepatic thyroid hormone signaling in systemic and liver-specific but not brain-specific accelerated aging due to DNA repair deficiency in miceSander Barnhoorn, Marcel E. Meima, Robin Patrick Peeters, Veerle Darras, Selmar Leeuwenburgh, Jan H.J. Hoeijmakers, Wilbert P. Vermeij, W. Edward Visser · 2023 · European Thyroid Journal
- 2′-O-ribose methylation levels of ribosomal RNA distinguish different types of growth arrest in human dermal fibroblastsGuohuan Yang, Maximilian Schmid-Siegel, Clemens Heissenberger, Isabelle C. Kos‐Braun, Martina Prechtl, Gabriel Meca-Laguna, Marta Rocha, Anja Wagner-Schrittwieser, Vera Pils, Barbara Meixner et al. · 2024 · Journal of Cell Science
- Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin agingKento Takaya, Kazuo Kishi · 2024 · Biogerontology
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- Identification of a Proteomic Signature of Senescence in Primary Human Mammary Epithelial CellsDelfarah, Alireza, Hartel, Nicolas G., Zheng, DongQing, Yang, Jesse, Graham, Nicholas A. · 2021 · Journal of Proteome Research
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- Senotherapeutic Drugs: A New Avenue for Skincare?Ben P. Lee, Lorna W. Harries · 2021 · Plastic & Reconstructive Surgery
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- The chemotherapeutic drug doxorubicin does not exacerbate p16Ink4a-positive senescent cell accumulation and cardiometabolic disease development in young adult female LDLR-deficient miceAndrea C. Postmus, Janine K. Kruit, Roos E. Eilers, Rick Havinga, Mirjam H. Koster, Yoshikazu Johmura, Makoto Nakanishi, Bart van de Sluis, Johan W. Jonker · 2023 · Toxicology and Applied Pharmacology
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- Senescent Cells Drive Frailty through Systemic SignalsJohannes Lehmann, Marjolein P. Baar, Peter L.J. de Keizer · 2018 · Trends in Molecular Medicine
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