Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
Baar, Marjolein P., Brandt, Renata M.C., Putavet, Diana A., Klein, Julian D.D., Derks, Kasper W.J., Bourgeois, Benjamin R.M., Stryeck, Sarah, Rijksen, Yvonne +13 more·2017·Cell
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- Cellular senescence: the sought or the unwanted?Sun, Yu, Coppé, Jean-Philippe, Lam, Eric W.-F. · 2018 · Trends in Molecular Medicine
- Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brainKiss, Tamas, Nyúl-Tóth, Ádám, Balasubramanian, Priya, Tarantini, Stefano, Ahire, Chetan, DelFavero, Jordan, Yabluchanskiy, Andriy, Csipo, Tamas, Farkas, Eszter, Wiley, Graham et al. · 2020 · GeroScience
- Cellular senescence: Molecular mechanisms and pathogenicityWenqiang Wei, Shaoping Ji · 2018 · Journal of Cellular Physiology
- FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretomeFuming Li, Peiwei Huangyang, Michelle Burrows, Kathy Guo, Romain Riscal, Jason T. Godfrey, Kyoung Eun Lee, Nan Lin, Pearl Lee, Ian A. Blair et al. · 2020 · Nature Cell Biology
- Senotherapeutics: emerging strategy for healthy aging and age-related diseaseEok-Cheon Kim, Jae‐Ryong Kim · 2019 · BMB Reports
- Immunosenescence, aging and successful agingYunan Wang, Dong Chen, Yudian Han, Zhifeng Gu, Chi Chin Sun · 2022 · Frontiers in Immunology
- A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cellsWakita, Masahiro, Takahashi, Akiko, Sano, Osamu, Loo, Tze Mun, Imai, Yoshinori, Narukawa, Megumi, Iwata, Hidehisa, Matsudaira, Tatsuyuki, Kawamoto, Shimpei, Ohtani, Naoko et al. · 2020 · Nature Communications
- Reshaping the Tumor Stroma for Treatment of Pancreatic CancerClaire Vennin, Kendelle Joan Murphy, Jennifer P. Morton, Thomas R. Cox, Marina Pajic, Paul Timpson · 2017 · Gastroenterology
- Senolytics and senostatics as adjuvant tumour therapySusan C Short, Edward Fielder, Satomi Miwa, Thomas von Zglinicki · 2019 · EBioMedicine
- Single-cell analyses of aging, inflammation and senescenceBora Uyar, Daniel H. Palmer, Axel Kowald, Hugo Murua Escobar, Israel Barrantes, Steffen Möller, Altuna Akalin, Georg Fuellen · 2020 · Ageing Research Reviews
- Cellular Senescence and Inflammaging in Age-Related DiseasesOlivieri, Fabiola, Prattichizzo, Francesco, Grillari, Johannes, Balistreri, Carmela R. · 2018 · Mediators of Inflammation
- Strategies targeting cellular senescenceOvadya, Yossi, Krizhanovsky, Valery · 2018 · Journal of Clinical Investigation
- Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In VivoOmori, Satotaka, Wang, Teh-Wei, Johmura, Yoshikazu, Kanai, Tomomi, Nakano, Yasuhiro, Kido, Taketomo, Susaki, Etsuo A., Nakajima, Takuya, Shichino, Shigeyuki, Ueha, Satoshi et al. · 2020 · Cell Metabolism
- Vascular senescence in cardiovascular and metabolic diseasesKatsuumi, Goro, Shimizu, Ippei, Yoshida, Yohko, Minamino, Tohru · 2018 · Frontiers in Cardiovascular Medicine
- Cellular Senescence in Postmitotic Cells: Beyond Growth ArrestSapieha, Przemyslaw, Mallette, Frédérick A. · 2018 · Trends in Cell Biology
- Senescent cells: a therapeutic target for cardiovascular diseaseChilds, Bennett G., Li, Hu, van Deursen, Jan M. · 2018 · Journal of Clinical Investigation
- Proteostasis in cardiac health and diseaseHenning, Robert H., Brundel, Bianca J. J. M. · 2017 · Nature Reviews Cardiology
- Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathwayDan Nong He, Hongguang Wu, Jinnan Xiang, Xinsen Ruan, Peike Peng, Yuanyuan Ruan, Ye‐Guang Chen, Yibin Wang, Qiang Yu, Hongbing Zhang et al. · 2020 · Nature Communications
- Roles of extracellular vesicles in the aging microenvironment and age‐related diseasesYujia Yin, Huihui Chen, Yizhi Wang, Ludi Zhang, Xipeng Wang · 2021 · Journal of Extracellular Vesicles
- Senescent Cells: Emerging Targets for Human Aging and Age-Related DiseasesSong, Shuling, Lam, Eric W.-F., Tchkonia, Tamara, Kirkland, James L., Sun, Yu · 2020 · Trends in Biochemical Sciences
- Reducing Senescent Cell Burden in Aging and DiseasePignolo, Robert J., Passos, João F., Khosla, Sundeep, Tchkonia, Tamara, Kirkland, James L. · 2020 · Trends in Molecular Medicine
- The role of telomeres in the mechanisms and evolution of life-history trade-offs and ageingAndrew J. Young · 2018 · Philosophical Transactions of the Royal Society B Biological Sciences
- Sentinel
<i>p16</i>
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cells in the basement membrane form a reparative niche in the lungReyes, Nabora S., Krasilnikov, Maria, Allen, Nancy C., Lee, Jin Young, Hyams, Ben, Zhou, Minqi, Ravishankar, Supriya, Cassandras, Monica, Wang, Chaoqun, Khan, Imran et al. · 2022 · Science
- Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?Ademowo, O. S., Dias, H. K. I., Burton, D. G. A., Griffiths, H. R. · 2017 · Biogerontology
- Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosisStojanović, Stevan D, Fiedler, Jan, Bauersachs, Johann, Thum, Thomas, Sedding, Daniel G · 2020 · European Heart Journal
- Re-evaluating the role of FOXOs in cancerMarten Hornsveld, Tobias B. Dansen, Patrick W.B. Derksen, Boudewijn M.T. Burgering · 2017 · Seminars in Cancer Biology
- Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cellsOgrodnik, Mikolaj, Salmonowicz, Hanna, Gladyshev, Vadim N. · 2019 · Aging Cell
- An OFF–ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in VivoBeatriz Lozano‐Torres, Irene Galiana, Miguel Rovira, Eva María Nieto Garrido, Selim Chaib, Andrea Bernardos, Daniel Muñoz‐Espín, Manuel Serrano, Ramón Martínez‐Máñez, Félix Sancenón · 2017 · Journal of the American Chemical Society
- Senescence as a therapeutic target in cancer and age-related diseasesDomhnall McHugh, Imanol Durán, Jesús Gil · 2024 · Nature Reviews Drug Discovery
- Introduction to FOXO BiologyWolfgang Link · 2018 · Methods in molecular biology
- Regulation of Survival Networks in Senescent Cells: From Mechanisms to InterventionsSoto-Gamez, Abel, Quax, Wim J., Demaria, Marco · 2019 · Journal of Molecular Biology
- Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibitionCrespo-Garcia, Sergio, Tsuruda, Pamela R., Dejda, Agnieszka, Ryan, Rathi D., Fournier, Frederik, Chaney, Shawnta Y., Pilon, Frederique, Dogan, Taner, Cagnone, Gael, Patel, Priyanka et al. · 2021 · Cell Metabolism
- Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseasesQing Zeng, Yongzhen Gong, Neng Zhu, Yaning Shi, Chanjuan Zhang, Qin Li · 2024 · Ageing Research Reviews
- Anti-senescence compounds: A potential nutraceutical approach to healthy agingGurău, Felicia, Baldoni, Simone, Prattichizzo, Francesco, Espinosa, Emma, Amenta, Francesco, Procopio, Antonio Domenico, Albertini, Maria Cristina, Bonafè, Massimiliano, Olivieri, Fabiola · 2018 · Ageing Research Reviews
- On the evolution of cellular senescenceAxel Kowald, João F. Passos, Thomas B. L. Kirkwood · 2020 · Aging Cell
- FOXO transcription factors as therapeutic targets in human diseasesAlba Orea‐Soufi, Jihye Paik, José Bragança, Timothy A. Donlon, Bradley J. Willcox, Wolfgang Link · 2022 · Trends in Pharmacological Sciences
- Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseasesTsukasa Kadota, Yu Fujita, Yusuke Yoshioka, Jun Araya, Kazuyoshi Kuwano, Takahiro Ochiya · 2017 · Molecular Aspects of Medicine
- Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic DrugsNatálie Kudlová, Juan Bautista De Sanctis, Marián Hajdúch · 2022 · International Journal of Molecular Sciences
- Cellular senescence in the aging and diseased kidneyValentijn, F. A., Falke, L. L., Nguyen, T. Q., Goldschmeding, Roel · 2018 · Journal of Cell Communication and Signaling
- The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapyBasu, Alakananda · 2022 · Pharmacology & Therapeutics
- Improving the Supply and Quality of Deceased-Donor Organs for TransplantationTullius, Stefan G., Rabb, Hamid · 2018 · New England Journal of Medicine
- Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implicationsJinwei Xie, Yan Wang, Lingyun Lu, Lu Liu, Xijie Yu, Fuxing Pei · 2021 · Ageing Research Reviews
- Mitochondria, telomeres and cell senescence: Implications for lung ageing and diseaseJodie Birch, Peter John Barnes, João F. Passos · 2017 · Pharmacology & Therapeutics
- Galactose‐modified duocarmycin prodrugs as senolyticsGuerrero, Ana, Guiho, Romain, Herranz, Nicolás, Uren, Anthony, Withers, Dominic J., Martínez‐Barbera, Juan Pedro, Tietze, Lutz F., Gil, Jesús · 2020 · Aging Cell
- The emerging role of alternative splicing in senescence and agingMathieu Deschênes, Benoı̂t Chabot · 2017 · Aging Cell
- Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescenceNatalie A. Gude, Kathleen M. Broughton, Fareheh Firouzi, Mark Alan Sussman · 2018 · Nature Reviews Cardiology
- Cellular senescence in cardiac diseasesIppei Shimizu, Tohru Minamino · 2019 · Journal of Cardiology
- Senescent cell turnover slows with age providing an explanation for the Gompertz lawKarin, Omer, Agrawal, Amit, Porat, Ziv, Krizhanovsky, Valery, Alon, Uri · 2019 · Nature Communications
- Regulation of senescence traits by MAPKsCarlos Anerillas, Kotb Abdelmohsen, Myriam Gorospe · 2020 · GeroScience
- Overcoming the senescence‐associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancerCecilia R. Chambers, Shona Ritchie, Brooke Pereira, Paul Timpson · 2021 · Molecular Oncology
- Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic DevelopmentLi Hu, Huiqin Li, Meiting Zi, Wen Li, Jing Liu, Yang Yang, Daohong Zhou, Qing‐Peng Kong, Yunxia Zhang, Yonghan He · 2022 · Frontiers in Cell and Developmental Biology
- Cellular Senescence: From Mechanisms to Current Biomarkers and SenotherapiesVasco Lucas, Cláudia Cavadas, Célia Alexandra Aveleira · 2023 · Pharmacological Reviews
- The curcumin analog EF24 is a novel senolytic agentLi, Wen, He, Yonghan, Zhang, Rongping, Zheng, Guangrong, Zhou, Daohong · 2019 · Aging
- Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to agingMuñoz, Denise P., Yannone, Steven M., Daemen, Anneleen, Sun, Yu, Vakar-Lopez, Funda, Kawahara, Misako, Freund, Adam M., Rodier, Francis, Wu, Jennifer D., Desprez, Pierre-Yves et al. · 2019 · JCI Insight
- Turning back time with emerging rejuvenation strategiesSalah Mahmoudi, Lucy Xu, Anne Brunet · 2018 · Nature Cell Biology
- Faces of cellular senescence in skin agingChin Yee Ho, Oliver Dreesen · 2021 · Mechanisms of Ageing and Development
- Interfering peptides targeting protein–protein interactions: the next generation of drugs?Heriberto Bruzzoni‐Giovanelli, Valérie Alezra, Nicolas Wolff, Chang‐Zhi Dong, Pierre Tufféry, Angelita Rebollo · 2017 · Drug Discovery Today
- Reflections on telomere dynamics and ageing-related diseases in humansAbraham Aviv, Jerry W. Shay · 2018 · Philosophical Transactions of the Royal Society B Biological Sciences
- Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced DiseasesGuangqi Guan, Yaoxing Chen, Yulan Dong · 2025 · Antioxidants
- Cellular senescence in the aging retina and developments of senotherapies for age-related macular degenerationLee, Keng Siang, Lin, Shuxiao, Copland, David A., Dick, Andrew D., Liu, Jian · 2021 · Journal of Neuroinflammation
- Cellular senescence impairs the reversibility of pulmonary arterial hypertensionvan der Feen, Diederik E., Bossers, Guido P. L., Hagdorn, Quint A. J., Moonen, Jan-Renier, Kurakula, Kondababu, Szulcek, Robert, Chappell, James, Vallania, Francesco, Donato, Michele, Kok, Klaas et al. · 2020 · Science Translational Medicine
- Cellular senescence in musculoskeletal homeostasis, diseases, and regenerationMei Wan, Elise F. Gray-Gaillard, Jennifer H. Elisseeff · 2021 · Bone Research
- Immunosenescence: signaling pathways, diseases and therapeutic targetsYichu Fu, Binhan Wang, Aqu Alu, Weiqi Hong, Lei Hong, Xuemei He, Shi H, Ping Cheng, Xiangliang Yang · 2025 · Signal Transduction and Targeted Therapy
- The role of cellular senescence in skin aging and age-related skin pathologiesToby Chin, Xin Er Lee, Pei Yi Ng, Yaelim Lee, Oliver Dreesen · 2023 · Frontiers in Physiology
- Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and ProgressionBorn, Emmanuelle, Lipskaia, Larissa, Breau, Marielle, Houssaini, Amal, Beaulieu, Delphine, Marcos, Elisabeth, Pierre, Remi, Do Cruzeiro, Marcio, Lefevre, Marine, Derumeaux, Genevieve et al. · 2023 · Circulation
- Shear stress–induced cellular senescence blunts liver regeneration through Notch–sirtuin 1–P21/P16 axisJuanli Duan, Bai Ruan, Ping Song, Zhi‐Qiang Fang, Zhen‐Sheng Yue, Jingjing Liu, Guo‐Rui Dou, Hua Han, Lin Wang · 2021 · Hepatology
- SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent CellsWiley, Christopher D., Liu, Su, Limbad, Chandani, Zawadzka, Anna M., Beck, Jennifer, Demaria, Marco, Artwood, Robert, Alimirah, Fatouma, Lopez-Dominguez, Jose-Alberto, Kuehnemann, Chisaka et al. · 2019 · Cell Reports
- Experimental Models of Sarcopenia: Bridging Molecular Mechanism and Therapeutic StrategySakulrat Mankhong, Sujin Kim, Sohee Moon, Hyo‐Bum Kwak, Dong‐Ho Park, Ju‐Hee Kang · 2020 · Cells
- When dormancy fuels tumour relapseKarla Santos-de-Frutos, Nabil Djouder · 2021 · Communications Biology
- Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane markerPoblocka, Marta, Bassey, Akang Leonard, Smith, Victoria M., Falcicchio, Marta, Manso, Ana Sousa, Althubiti, Mohammad, Sheng, XiaoBo, Kyle, Andrew, Barber, Ruth, Frigerio, Mark et al. · 2021 · Scientific Reports
- The chemistry of senescenceLozano-Torres, Beatriz, Estepa-Fernández, Alejandra, Rovira, Miguel, Orzáez, Mar, Serrano, Manuel, Martínez-Máñez, Ramón, Sancenón, Félix · 2019 · Nature Reviews Chemistry
- Role of the inflammation-autophagy-senescence integrative network in osteoarthritisVinatier, Claire, Domínguez, Eduardo, Guicheux, Jerome, Caramés, Beatriz · 2018 · Frontiers in Physiology
- Ionizing Radiation-Induced Cellular Senescence in Normal, Non-transformed Cells and the Involved DNA Damage Response: A Mini ReviewMengqian Li, Liting You, Jianxin Xue, You Lü · 2018 · Frontiers in Pharmacology
- The costs and benefits of senotherapeutics for human healthRaffaele, Marco, Vinciguerra, Manlio · 2022 · The Lancet Healthy Longevity
- Senescence and the tumor-immune landscape: Implications for cancer immunotherapyLoretah Chibaya, Jarin T. Snyder, Marcus A. Ruscetti · 2022 · Seminars in Cancer Biology
- Mitochondrial peptides modulate mitochondrial function during cellular senescenceSu‐Jeong Kim, Hemal H. Mehta, Junxiang Wan, Chisaka Kuehnemann, Jingcheng Chen, Ji‐Fan Hu, Andrew R. Hoffman, Pinchas Cohen · 2018 · Aging
- Endoplasmic Reticulum (ER) Stress and Its Role in Pancreatic β-Cell Dysfunction and Senescence in Type 2 DiabetesJihye Lee, Jaemin Lee · 2022 · International Journal of Molecular Sciences
- Stress, epigenetics, and aging: Unraveling the intricate crosstalkZeming Wu, Jing Tao Qu, Weiqi Zhang, Guang‐Hui Liu · 2023 · Molecular Cell
- NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.SenNet Consortium, Writing Group, Lee, Patty J., Benz, Christopher C., Blood, Philip, Börner, Katy, Campisi, Judith, Chen, Feng, Daldrup-Link, Heike, De Jager, Phil et al. · 2022 · Nature Aging
- Identifying specific functional roles for senescence across cell types2024
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- Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and DiseaseEleonora Cianflone, Michele Torella, Flavia Biamonte, Antonella De Angelis, Konrad Urbanek, Francesco Saverio Costanzo, Marcello Rota, Georgina M. Ellison, Daniele Torella · 2020 · Cells
- Loss of lamin B1 is a biomarker to quantify cellular senescence in photoaged skinWang, Audrey Shimei, Ong, Peh Fern, Chojnowski, Alexandre, Clavel, Carlos, Dreesen, Oliver · 2017 · Scientific Reports
- FoxO transcription factors in cancer metabolismRaj Kumar Yadav, Anoop Singh Chauhan, Li Zhuang, Boyi Gan · 2018 · Seminars in Cancer Biology
- Sirtuins and FoxOs in osteoporosis and osteoarthritisMaria Almeida, Ryan M. Porter · 2019 · Bone
- Oxidation resistance 1 is a novel senolytic targetZhang, Xin, Zhang, Suping, Liu, Xingui, Wang, Yingying, Chang, Jianhui, Zhang, Xuan, Mackintosh, Samuel G., Tackett, Alan J., He, Yonghan, Lv, Dongwen et al. · 2018 · Aging Cell
- Targeting Senescent Cells for a Healthier Aging: Challenges and OpportunitiesSong, Shuling, Tchkonia, Tamara, Jiang, Jing, Kirkland, James L., Sun, Yu · 2020 · Advanced Science
- Senescent cells: Living or dying is a matter of NK cellsFabrizio Antonangeli, Alessandra Zingoni, Alessandra Soriani, Angela Santoni · 2019 · Journal of Leukocyte Biology
- Epithelial innate immunity mediates tubular cell senescence after kidney injuryHeng Jin, Yan Zhang, Qiong J. Ding, Shanshan Wang, Prerna Rastogi, Dao‐Fu Dai, Dongmei Lu, Madison Purvis, Chao Cao, Angela Yee‐Moon Wang et al. · 2019 · JCI Insight
- Emerging use of senolytics and senomorphics against aging and chronic diseasesJan Martel, David M. Ojcius, Cheng‐Yeu Wu, Hsin‐Hsin Peng, Laurent Voisin, Jean‐Luc Perfettini, Yun‐Fei Ko, John Ding‐E Young · 2020 · Medicinal Research Reviews
- Targeting senescent cells: approaches, opportunities, challengesCayetano von Kobbe · 2019 · Aging
- Cellular Senescence in Diabetes Mellitus: Distinct Senotherapeutic Strategies for Adipose Tissue and Pancreatic β CellsTakaaki Murakami, Nobuya Inagaki, Hiroshi Kondoh · 2022 · Frontiers in Endocrinology
- Immunology of the ageing kidneySato, Yuki, Yanagita, Motoko · 2019 · Nature Reviews Nephrology
- Senotherapeutics: targeting senescence in idiopathic pulmonary fibrosisMerkt, Wolfgang, Bueno, Marta, Mora, Ana L., Lagares, David · 2020 · Seminars in Cell & Developmental Biology
- Mouse Models to Disentangle the Hallmarks of Human AgingFolgueras, Alicia R., Freitas-Rodríguez, Sandra, Velasco, Gloria, López-Otín, Carlos · 2018 · Circulation Research
- Senolytics and Senostatics: A Two-Pronged Approach to Target Cellular Senescence for Delaying Aging and Age-Related Diseases.Chanhee Kang · 2019 · Europe PMC (PubMed Central)
- Molecular Mechanisms Contributing to Mesenchymal Stromal Cell AgingSimona Neri, Rosa Maria Borzı̀ · 2020 · Biomolecules
- Senescence in cancerManuel Colucci, Miles Sarill, Martino Maddalena, Aurora Valdata, Martina Troiani, Martina Massarotti, Marco Bolis, Silvia Bressan, Anna Kohl, Daniele Robesti et al. · 2025 · Cancer Cell
- ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and agingZhao, Jing, Zhang, Lei, Lu, Aiping, Han, Yingchao, Colangelo, Debora, Bukata, Christina, Scibetta, Alex, Yousefzadeh, Matthew J., Li, Xuesen, Gurkar, Aditi U. et al. · 2020 · Aging
- Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell nicheXiaohong Peng, Yi Wu, Uilke Brouwer, Thijmen van Vliet, Boshi Wang, Marco Demaria, Lara Barazzuol, Robert Paul Coppes · 2020 · Cell Death and Disease