Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
Baar, Marjolein P., Brandt, Renata M.C., Putavet, Diana A., Klein, Julian D.D., Derks, Kasper W.J., Bourgeois, Benjamin R.M., Stryeck, Sarah, Rijksen, Yvonne +13 more·2017·Cell
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- Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiotaYingchun Zhao, Xinglong Liu, Yinan Zheng, Wencong Liu, Chuanbo Ding · 2021 · Scientific Reports
- Ultra-high dose-rate proton FLASH improves tumor controlSamriddhi Shukla, Taniya Saha, Nihar Rama, Anusha Acharya, Tien T. Le, Fenghua Bian, Johnny Donovan, Lin Abigail Tan, Ralph E. Vatner, Vladimir V. Kalinichenko et al. · 2023 · Radiotherapy and Oncology
- Cellular senescence and kidney agingNikolai Rex, Anette Melk, Roland Schmitt · 2023 · Clinical Science
- Cellular senescence in the aging brain: A promising target for neurodegenerative diseasesSahu, Manas Ranjan, Rani, Linchi, Subba, Rhea, Mondal, Amal Chandra · 2022 · Mechanisms of Ageing and Development
- The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stressAnerillas, Carlos, Mazan-Mamczarz, Krystyna, Herman, Allison B., Munk, Rachel, Lam, Kwan-Wood Gabriel, Calvo-Rubio, Miguel, Garrido, Amanda, Tsitsipatis, Dimitrios, Martindale, Jennifer L., Altés, Gisela et al. · 2023 · Nature Aging
- Transplanting cells from old but not young donors causes physical dysfunction in older recipientsWang, Binsheng, Liu, Zukai, Chen, Vicky P., Wang, Lichao, Inman, Christina L., Zhou, Yueying, Guo, Chun, Tchkonia, Tamar, Rowe, David W., Kuchel, George A. et al. · 2020 · Aging Cell
- Cellular Senescence in Lung FibrosisFernanda Hernández‐González, Rosa Faner, Mauricio M. Rojas, Alvar G.N. Agustí, Manuel Serrano, Jacobo Sellarés · 2021 · International Journal of Molecular Sciences
- Taxifolin retards the d -galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in miceXinglong Liu, Yingchun Zhao, Hongyan Zhu, Ming‐Fang Wu, Yinan Zheng, Min Yang, Zhiqiang Cheng, Chuanbo Ding, Wencong Liu · 2021 · Food & Function
- Hallmarks of Testicular Aging: The Challenge of Anti-Inflammatory and Antioxidant Therapies Using Natural and/or Pharmacological Compounds to Improve the Physiopathological Status of the Aged Male GonadMaría Eugenia Matzkin, Ricardo Saúl Calandra, Soledad Paola Rossi, Andrzej Bartke, Mónica Beatriz Frungieri · 2021 · Cells
- Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant TherapyMarco Malavolta, Massimo Bracci, Lory Santarelli, Md. Abu Sayeed, Elisa Pierpaoli, Robertina Giacconi, Laura Costarelli, Francesco Piacenza, Andrea Basso, Maurizio Cardelli et al. · 2018 · Mediators of Inflammation
- Senolytic activity of piperlongumine analogues: Synthesis and biological evaluationLiu, Xingui, Wang, Yingying, Zhang, Xuan, Gao, Zhengya, Zhang, Suping, Shi, Peizhong, Zhang, Xin, Song, Lin, Hendrickson, Howard, Zhou, Daohong et al. · 2018 · Bioorganic & Medicinal Chemistry
- Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral DefenseYukang Yuan, Ying Miao, Liping Qian, Yang Zhang, Chao Liu, Jin Liu, Yibo Zuo, Feng Qian, Tingting Guo, Liting Zhang et al. · 2019 · Molecular Cell
- Effects of senolytic drugs on human mesenchymal stromal cellsClara Grezella, Eduardo Fernández‐Rebollo, Julia Franzen, Mónica S. Ventura Ferreira, Fabian Beier, Wolfgang Wagner · 2018 · Stem Cell Research & Therapy
- Targeting senescent cells to attenuate cardiovascular disease progressionPing Song, Qiang Zhao, Ming‐Hui Zou · 2020 · Ageing Research Reviews
- Early SRC activation skews cell fate from apoptosis to senescenceAnerillas, Carlos, Herman, Allison B., Rossi, Martina, Munk, Rachel, Lehrmann, Elin, Martindale, Jennifer L., Cui, Chang-Yi, Abdelmohsen, Kotb, De, Supriyo, Gorospe, Myriam · 2022 · Science Advances
- A functional genetic screen defines the AKT-induced senescence signaling networkChan, Keefe T., Blake, Shaun, Zhu, Haoran, Kang, Jian, Trigos, Anna S., Madhamshettiwar, Piyush B., Diesch, Jeannine, Paavolainen, Lassi, Horvath, Peter, Hannan, Ross D. et al. · 2020 · Cell Death & Differentiation
- Senescent cells as promising targets to tackle age-related diseasesEva Prašnikar, Jure Borišek, Andrej Perdih · 2020 · Ageing Research Reviews
- Aging, Cell Senescence, the Pathogenesis and Targeted Therapies of OsteoarthritisXinxin Zhang, Shi‐Hao He, Xu Liang, Wei Li, Tian-Fang Li, Daifeng Li · 2021 · Frontiers in Pharmacology
- Exploring the Communication of the SASP: Dynamic, Interactive, and Adaptive Effects on the MicroenvironmentJoëlle Giroud, Inès Bouriez, Hugo Paulus, Albin Pourtier, Florence Debacq‐Chainiaux, Olivier Pluquet · 2023 · International Journal of Molecular Sciences
- Cognitive Performance in Breast Cancer Survivors and Markers of Biological AgingJ. Carroll, K. V. Van Dyk, J. Bower, Z. Scuric, L. Petersen, R. Schiestl, Michael R. Irwin, P. Ganz · 2018 · Cancer
- Elimination of senescent osteoclast progenitors has no effect on the age‐associated loss of bone mass in miceKim, Ha‐Neui, Chang, Jianhui, Iyer, Srividhya, Han, Li, Campisi, Judith, Manolagas, Stavros C., Zhou, Daohong, Almeida, Maria · 2019 · Aging Cell
- The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applicationsBasisty, Nathan, Kale, Abhijit, Patel, Sandip, Campisi, Judith, Schilling, Birgit · 2020 · Expert Review of Proteomics
- Embryonic senescent cells re-enter cell cycle and contribute to tissues after birthLi, Yi, Zhao, Huan, Huang, Xiuzhen, Tang, Juan, Zhang, Shaohua, Li, Yan, Liu, Xiuxiu, He, Lingjuan, Ju, Zhengyu, Lui, Kathy O. et al. · 2018 · Cell Research
- Cellular senescence in age-related disordersJapneet Kaur, Joshua N. Farr · 2020 · Translational research
- Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in miceScarlett Acklin, Manchao Zhang, Wuying Du, Xin Zhao, Matthew D. Plotkin, Jianhui Chang, Judith Campisi, Daohong Zhou, Fen Xia · 2020 · Scientific Reports
- Elimination of senescent cells by treatment with Navitoclax/ABT263 reverses whole brain irradiation-induced blood-brain barrier disruption in the mouse brainRafał Gulej, Ádám Nyúl‐Tóth, Chetan Ahire, Jordan DelFavero, Priya Balasubramanian, Tamás Kiss, Stefano Tarantini, Zoltán Benyó, Pál Pacher, Boglárka Csík et al. · 2023 · GeroScience
- The senescence journey in cancer immunoeditingAlessandra Zingoni, Fabrizio Antonangeli, Silvano Sozzani, Angela Santoni, Marco Cippitelli, Alessandra Soriani · 2024 · Molecular Cancer
- Characterization of cellular senescence in doxorubicin-induced aging miceSun, Tianyue, Zhang, Lanxin, Feng, Jiali, Bao, Lingyuan, Wang, Jiqun, Song, Zhouzhi, Mao, Zhifan, Li, Jian, Hu, Zelan · 2022 · Experimental Gerontology
- Cellular Senescence: Mechanisms, Morphology, and Mouse ModelsJessica A. Beck, Izumi Horikawa, Curtis C. Harris · 2020 · Veterinary Pathology
- Senescence and Apoptosis During in vitro Embryo Development in a Bovine ModelPriscila Ramos‐Ibeas, Isabel Gimeno, Karina Cañón-Beltrán, Alfonso Gutiérrez‐Adán, Dimitrios V. Rizos, Enrique Gómez · 2020 · Frontiers in Cell and Developmental Biology
- Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in miceEdward Fielder, Tengfei Wan, Ghazaleh Alimohammadiha, Abbas Ishaq, Evon Low, B. Melanie Weigand, George Kelly, Craig Parker, Brigid Griffin, Diana Jurk et al. · 2022 · eLife
- Cellular senescenceMarta Varela-Eirín, Marco Demaria · 2022 · Current Biology
- Cellular senescence in brain aging and cognitive declineAreez Shafqat, Saifullah Khan, Mohamed H. Omer, Mahnoor Niaz, Ibrahem Albalkhi, Khaled Manae AlKattan, Ahmed Yaqinuddin, Tamar Tchkonia, James L. Kirkland, Shahrukh Khurshid Hashmi · 2023 · Frontiers in Aging Neuroscience
- Therapeutic Potential of Senolytics in Cardiovascular DiseaseDookun, Emily, Passos, João F., Arthur, Helen M., Richardson, Gavin D. · 2022 · Cardiovascular Drugs and Therapy
- Endothelial Senescence: A New Age in Pulmonary HypertensionMiranda K. Culley, Stephen Y. Chan · 2022 · Circulation Research
- The impact of senescence on muscle wasting in chronic kidney diseaseYing Huang, Bin Wang, Faten Hassounah, Stephen Russ Price, Janet D. Klein, Tamer Mohamed, Yanhua Wang, Jeanie Park, Hui Cai, Xuemei Zhang et al. · 2022 · Journal of Cachexia Sarcopenia and Muscle
- Cellular senescence: a view throughout organismal lifeCayetano von Kobbe · 2018 · Cellular and Molecular Life Sciences
- Hydrogen sulfide ameliorates aging-associated changes in the kidneyHak Joo Lee, Denis Féliers, Jeffrey L. Barnes, Sae Byeol Oh, Goutam Ghosh Choudhury, Vivian Diaz, Verónica Galván, Randy Strong, James F. Nelson, Adam B. Salmon et al. · 2018 · GeroScience
- Molecular Aspects of Senescence and Organismal Ageing—DNA Damage Response, Telomeres, Inflammation and ChromatinSławińska, Natalia, Krupa, Renata · 2021 · International Journal of Molecular Sciences
- Advancements in therapeutic drugs targeting of senescenceZhu, Mingsheng, Meng, Ping, Ling, Xian, Zhou, Lili · 2020 · Therapeutic Advances in Chronic Disease
- Abnormalities in Skeletal Muscle Myogenesis, Growth, and Regeneration in Myotonic DystrophyLaurène M. André, C. Rosanne M. Ausems, Derick G. Wansink, Bé Wieringa · 2018 · Frontiers in Neurology
- “Bone-SASP” in Skeletal AgingChing‐Lien Fang, Bin Liu, Mei Wan · 2023 · Calcified Tissue International
- Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14ARF, and TAU3 transcript expression and contribute to cognitive declineJed J. Lye, Eva Latorre, Benjamin P. Lee, Stefania Bandinelli, Janet E. Holley, Nicholas J. Gutowski, Luigi Ferrucci, Lorna W. Harries · 2019 · GeroScience
- A drug library screen identifies Carbenoxolone as novel FOXO inhibitor that overcomes FOXO3-mediated chemoprotection in high-stage neuroblastomaStefan Salcher, Gilles A. Spoden, Judith Hagenbuchner, Sebastian Führer, Teresa Kaserer, Martin Tollinger, Petra Huber‐Cantonati, Thomas Gruber, Daniela Schuster, Ronald Gust et al. · 2019 · Oncogene
- Cell Senescence: A Nonnegligible Cell State under Survival Stress in Pathology of Intervertebral Disc DegenerationYuang Zhang, Biao Yang, Jingkai Wang, Feng Cheng, Kesi Shi, Liwei Ying, Chenggui Wang, Kaishun Xia, Xianpeng Huang, Zhe Gong et al. · 2020 · Oxidative Medicine and Cellular Longevity
- Therapeutic targeting of senescent cells in the CNSMarkus Rießland, Methodios Ximerakis, Andrew A. Jarjour, Bin Zhang, Miranda E. Orr · 2024 · Nature Reviews Drug Discovery
- Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brainKiss, Tamas, Nyúl-Tóth, Ádám, DelFavero, Jordan, Balasubramanian, Priya, Tarantini, Stefano, Faakye, Janet, Gulej, Rafal, Ahire, Chetan, Ungvari, Anna, Yabluchanskiy, Andriy et al. · 2022 · GeroScience
- Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functionsShengjie Fan, Yingxuan Yan, Ying Xia, Zhenyu Zhou, Lingling Luo, Mengnan Zhu, Yongli Han, Deqiang Yao, Lijun Zhang, Minglv Fang et al. · 2023 · Nature Communications
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- Epigenetic regulation in cell senescenceCheng, Li-Qin, Zhang, Zhu-Qin, Chen, Hou-Zao, Liu, De-Pei · 2017 · Journal of Molecular Medicine
- The emerging role of cellular senescence in renal diseasesBingru Zhou, Ying Wan, Rong Chen, Chunmei Zhang, Xuesen Li, Fanyin Meng, Shannon S. Glaser, Nan Wu, Tianhao Zhou, Siwen Li et al. · 2020 · Journal of Cellular and Molecular Medicine
- SenotherapyJonathan R. Baker, Louise Donnelly, Peter John Barnes · 2020 · CHEST Journal
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- Local delivery of a senolytic drug in ischemia and reperfusion-injured heart attenuates cardiac remodeling and restores impaired cardiac functionJu‐Ro Lee, Bong‐Woo Park, Jae-Hyun Park, Songhyun Lim, Sung Pil Kwon, Ji‐Won Hwang, Hyeok Kim, Hun‐Jun Park, Byung‐Soo Kim · 2021 · Acta Biomaterialia
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- Structured Long-Chain Omega-3 Fatty Acids for Improvement of Cognitive Function during AgingIgnasi Mora, Lluı́s Arola, Antoni Caimari, Xavier Escoté, Francesc Puiggròs · 2022 · International Journal of Molecular Sciences
- High‐fat diet‐induced obesity augments the deleterious effects of estrogen deficiency on bone: Evidence from ovariectomized miceDalia Ali, Florence Figeac, Atenisa Caci, Nicholas Ditzel, Clarissa Schmal, Greet Kerckhofs, Jesper Foged Havelund, Nils Joakim Færgeman, Alexander Rauch, Michaela Tencerová et al. · 2022 · Aging Cell
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- Epigenetic Basis of Cellular Senescence and Its Implications in AgingTimothy Nacarelli, Pingyu Liu, Rugang Zhang · 2017 · Genes
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