A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles

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Items 401–500 of 1,010

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4. Context-dependent tumor-suppressive BMP signaling in diffuse intrinsic pontine glioma regulates stemness through epigenetic regulation of CXXC5
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6. Coding and non-coding transcriptome of mesial temporal lobe epilepsy: critical role of small non-coding RNAs
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   Brian L. Le, Gaia Andreoletti, Tomiko Oskotsky, Albert Vallejo-Gracia, Romel Rosales, Katharine Yu, Idit Kosti, Kristoffer E. Leon, Daniel G. Bunis, Christine Li et al. · 2021 · Scientific Reports
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9. Identification of fibronectin 1 (FN1) and complement component 3 (C3) as immune infiltration-related biomarkers for diabetic nephropathy using integrated bioinformatic analysis
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10. On the correlation between material-induced cell shape and phenotypical response of human mesenchymal stem cells
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12. Enabling Single‐Cell Drug Response Annotations from Bulk RNA‐Seq Using SCAD
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13. MARSY: a multitask deep-learning framework for prediction of drug combination synergy scores
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14. Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics
    Stephan Eckert, Nicola Berner, Karl Kramer, Annika Schneider, Julian Müller, Severin Lechner, Sarah Brajkovic, Amirhossein Sakhteman, Christian Grätz, Jonas Fackler et al. · 2024 · Nature Biotechnology
15. Morphological profiling for drug discovery in the era of deep learning
    Qiaosi Tang, Ranjala Ratnayake, Gustavo de Miranda Seabra, Zhe Jiang, Ruogu Fang, Lina Cui, Yousong Ding, Tamer Kahveci, Jiang Bian, Chenglong Li et al. · 2024 · Briefings in Bioinformatics
16. Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics
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17. Co-expression in Single-Cell Analysis: Saving Grace or Original Sin?
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19. Opportunities and Challenges in Phenotypic Screening for Neurodegenerative Disease Research
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21. Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry
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25. Drug Repurposing: A Network-based Approach to Amyotrophic Lateral Sclerosis
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26. Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome
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27. Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy
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28. Connectivity Analyses of Bioenergetic Changes in Schizophrenia: Identification of Novel Treatments
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29. Common transcriptional signatures of neuropathic pain
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30. Brain Disease Network Analysis to Elucidate the Neurological Manifestations of COVID-19
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31. The Promise of AI for DILI Prediction
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32. A Systems Approach to Brain Tumor Treatment
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34. Benchmarking foundation cell models for post-perturbation RNA-seq prediction
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35. A comprehensive evaluation of connectivity methods for L1000 data
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36. Multi-Transcriptomic Analysis and Experimental Validation Implicate a Central Role of STAT3 in Skin Barrier Dysfunction Induced Aggravation of Rosacea
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37. ESR1 dysfunction triggers neuroinflammation as a critical upstream causative factor of the Alzheimer’s disease process
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38. Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates aging in mice
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39. Identification of inhibitors synergizing gemcitabine sensitivity in the squamous subtype of pancreatic ductal adenocarcinoma (PDAC)
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40. Drug Gene Budger (DGB): an application for ranking drugs to modulate a specific gene based on transcriptomic signatures
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41. Pathophysiology and Future Therapeutic Perspectives for Resolving Fibrosis in Peyronie’s Disease
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42. An Analytical Review of Computational Drug Repurposing
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43. Pimozide suppresses cancer cell migration and tumor metastasis through binding to ARPC2, a subunit of the Arp2/3 complex
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44. AXL knockdown gene signature reveals a drug repurposing opportunity for a class of antipsychotics to reduce growth and metastasis of triple-negative breast cancer
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45. Glucocorticoids rapidly activate cAMP production via G αs to initiate non‐genomic signaling that contributes to one‐third of their canonical genomic effects
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46. Cancer Stem Cell (CSC) Inhibitors in Oncology—A Promise for a Better Therapeutic Outcome: State of the Art and Future Perspectives
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47. Transcriptome-wide association study of treatment-resistant depression and depression subtypes for drug repurposing
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48. Characterization of immune landscape in papillary thyroid cancer reveals distinct tumor immunogenicity and implications for immunotherapy
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49. DNA Damage Repair Status Predicts Opposite Clinical Prognosis Immunotherapy and Non-Immunotherapy in Hepatocellular Carcinoma
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50. HiDRA: Hierarchical Network for Drug Response Prediction with Attention
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51. An update of label-free protein target identification methods for natural active products
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52. Prognostic Ability of Enhancer RNAs in Metastasis of Non-Small Cell Lung Cancer
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53. A machine learning framework develops a DNA replication stress model for predicting clinical outcomes and therapeutic vulnerability in primary prostate cancer
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54. A hybrid deep forest-based method for predicting synergistic drug combinations
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56. Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation
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57. Multidimensional profiling of drug‐treated cells by Imaging Mass Cytometry
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63. scDrug: From single-cell RNA-seq to drug response prediction
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72. Differential Treatments Based on Drug-induced Gene Expression Signatures and Longitudinal Systemic Lupus Erythematosus Stratification
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95. Multiple‐microarray analysis for identification of hub genes involved in tubulointerstial injury in diabetic nephropathy
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100. Molecular characterization of depression trait and state
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