Cited by 204Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and ObesityNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record.

A Neural Circuit for Gut-Induced Reward

Open access

Han, Wenfei, Tellez, Luis A., Perkins, Matthew H., Perez, Isaac O., Qu, Taoran, Ferreira, Jozelia, Ferreira, Tatiana L., Quinn, Danielle, Liu, Zhong-Wu, Gao, Xiao-Bing, Kaelberer, Melanie M., Bohórquez, Diego V., Shammah-Lagnado, Sara J., de Lartigue, Guillaume, de Araujo, Ivan E.·2018·Cell

DOI 10.1016/j.cell.2018.10.018

Open this paper in CoChat — free account Open PDF

Integrity signals

Registry

Crossref · 10.1016/j.cell.2018.10.018

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 101–200 of 204

Early Life Social Stress Causes Sex- and Region-Dependent Dopaminergic Changes that Are Prevented by Minocycline
Catale, C., Iacono, L. L., Martini, A., Heil, C., Guatteo, E., Mercuri, N. B., Viscomi, M. T., Palacios, D., & Carola, V. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02830-6 · Cited by 19
A Gut Feeling: The Importance of the Intestinal Microbiota in Psychiatric Disorders
Ochoa‐Repáraz, J., Ramelow, C. C., & Kasper, L. H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.510113 · Cited by 21
A triple-node heart-brain neuroimmune loop underlying myocardial infarction
Yadav, S., Ninh, V. K., Lovelace, J. W., Ma, J., Pham, A., Salamon, R. J., Ji, E., Na, Y., Fu, Z., Ugochukwu, S. I., et al. (2026) · Cell · doi:10.1016/j.cell.2025.12.058 · Cited by 25
Transcutaneous electrical acupuncture stimulation (TEAS) for gastrointestinal dysfunction in adults undergoing abdominal surgery: study protocol for a prospective randomized controlled trial
Bai, Y., Gao, C., Li, W., Du, Y., & An, L. (2020) · Trials · doi:10.1186/s13063-020-04470-4 · Cited by 19
Vagus nerve stimulation promotes cortical reorganization and reduces task-dependent calorie intake in male and female rats
Tseng, C.-T., Brougher, J., Gaulding, S. J., Hassan, B. S., & Thorn, C. A. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147099 · Cited by 18
Brainstem neuropeptidergic neurons link a neurohumoral axis to satiation
Chowdhury, S., Kamatkar, N. G., Wang, W. X., Akerele, C., Huang, J., Wu, J., Nwankpa, A., Kane, C. M., Bhave, V. M., Huang, H., et al. (2025) · Cell · doi:10.1016/j.cell.2025.01.018 · Cited by 18
Brain-Body Control of Glucose Homeostasis—Insights From Model Organisms
MacDonald, A. J., Yang, Y. H. C., Cruz, A. M., Beall, C., & Ellacott, K. L. J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.662769 · Cited by 16
The bidirectional relationship of depression and disturbances in B cell homeostasis: Double trouble
Wu, S., Yin, Y., & Du, L. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.110993 · Cited by 17
Monitoring In Vivo Neural Activity to Understand Gut–Brain Signaling
Alhadeff, A. L. (2021) · Endocrinology · doi:10.1210/endocr/bqab029 · Cited by 18
D1 and D2 neurons in the nucleus accumbens enable positive and negative control over sugar intake in mice
Sandoval-Rodríguez, R., Parra-Reyes, J. A., Han, W., Rueda‐Orozco, P. E., Pérez-Martínez, I. O., de Araújo, I. E., & Téllez, L. A. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112190 · Cited by 15
Self-citation
Influence of visual food cues on autonomic activity and craving
Rebollo, I., Schmidt, M., Longren, L. L., & Park, S. Q. (2021) · Biological Psychology · doi:10.1016/j.biopsycho.2021.108197 · Cited by 15
Vagus nerve spiking activity associated with locomotion and cortical arousal states in a freely moving rat
Shikano, Y., Nishimura, Y., Okonogi, T., Ikegaya, Y., & Sasaki, T. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14275 · Cited by 14
“Further studies with more data sample collections from a variety of behavioral environments and physiological techniques to manipulate temporal dynamics of VN (e.g., Han et al., 2018) are required to reveal the functional roles of the VN in various behavioral patterns.”
Influential
GABAergic interneurons’ feedback inhibition of dorsal raphe-projecting pyramidal neurons of the medial prefrontal cortex suppresses feeding of adolescent female mice undergoing activity-based anorexia
Du, M., Santiago, A. N., Akiz, C., & Aoki, C. J. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02507-9 · Cited by 12
Neurons Co-Expressing GLP-1, CCK, and PYY Receptors Particularly in Right Nodose Ganglion and Innervating Entire GI Tract in Mice
Lansbury, E., Vana, V., Lund, M. L., Ludwig, M. Q., Mamedova, E., Gautron, L., Arnold, M., Egerod, K. L., Kuhre, R. E., Holst, J. J., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052053 · Cited by 14
“Specifically, they showed that the gut hormone CCK’s control of food intake is primarily mediated through the right NG [6].”
Influential
Anterograde Neuronal Circuit Tracers Derived from Herpes Simplex Virus 1: Development, Application, and Perspectives
Li, D., Yang, H., Xiong, F., Xu, X., Zeng, W., Zhao, F., & Luo, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165937 · Cited by 13
Vagal interoception of microbial metabolites from the small intestinal lumenPreprint
Jameson, K. G., Kazmi, S. A., Son, C., Mazdeyasnan, D., Leshan, E., Vuong, H. E., Paramo, J., Lopez-Romero, A., Yang, L., Schweizer, F. E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.18.572257 · Cited by 13
“…tracing studies have uncovered polysynaptic connections from gut-innervating vagal afferent neurons to higher order brain regions such as substantia nigra and hippocampus, 84 suggesting the potential for microbial metabolites to impact complex behavioral responses beyond those involved in feeding.”
Background
PVH-Peri5 Pathway for Stress-Coping Oromotor and Anxious Behaviors in Mice
Xiao, F., Hu, A., Meng, B., Zhang, Y., Han, W., & Su, J. (2022) · Journal of Dental Research · doi:10.1177/00220345221130305 · Cited by 13
“The ABC/DAB procedure was used as described previously (Han et al. 2018).”
MethodSelf-citation
Analgesic Effects of Vagus Nerve Stimulation on Visceral Hypersensitivity: A Direct Comparison Between Invasive and Noninvasive Methods in Rats
Guo, Y., & Gharibani, P. M. (2023) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2023.04.001 · Cited by 13
Negative Emotions Recruit the Parabrachial Nucleus Efferent to the VTA to Disengage Instrumental Food Seeking
Tsou, J., Lee, S. M., Chiang, C.-Y., Yang, Y.-J., Guo, F.-Y., Ni, S.-Y., & Yau, H. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.2114-22.2023 · Cited by 12
Alleviating hypertension by selectively targeting angiotensin receptor expressing vagal sensory neurons
Baumer-Harrison, C., Elsaafien, K., Johnson, D. N., et al. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1154-23.2023 · Cited by 12
Self-citation
Profiling the mid-adult cecal microbiota associated with host healthy by using herbal formula Kang Shuai Lao Pian treated mid-adult mice
Gong, S., Ting-Ting, Y. E., Wang, M., Hong, Z., Liu, L., Chen, H., & Qian, J. (2020) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(20)30010-8 · Cited by 12
Right vagus nerve stimulation improves motor behavior by exerting neuroprotective effects in Parkinson’s disease rats
Wang, C., Su, T., Xiao, L., Wang, Y., Huo, X., Li, W., Ding, J., & Sun, T. S. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-5366 · Cited by 12
Impact of the gut microbiome on nicotine’s motivational effects and glial cells in the ventral tegmental area in male mice
Lakosa, A., Rahimian, A., Tomasi, F., Marti, F., Reynolds, L. M., Tochon, L., David, V., Danckaert, A., Canonne, C., Tahraoui, S., et al. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01563-x · Cited by 10
“Gut microbiota modulation of astrocytes within the pVTA Several mechanisms may connect the gut microbiota to VTA DA neurons including bacterial production of short chain fatty acids [70–72], gut peptides [15, 57] or the vagus nerve [12, 73].”
Ticking and talking in the brainstem satiety centre: Circadian timekeeping and interactions in the diet-sensitive clock of the dorsal vagal complex
Chrobok, Ł., Ahern, J., & Piggins, H. D. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.931167 · Cited by 9
“Recently, it has been demonstrated that by receiving these gut-brain information from so called neuropod cells the NTS forms an integral part of the gut-induced reward pathway (Han et al., 2018; Kaelberer et al., 2018; Bai et al., 2019; Chen et al., 2020).”
A gut-brain-gut interoceptive circuit loop gates sugar ingestion in DrosophilaPreprint
Cui, X., Meiselman, M. R., Thornton, S., & Yapici, N. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.02.610892 · Cited by 10
From Mammals to Insects: Exploring the Genetic and Neural Basis of Eating Behavior
Mahishi, D., Agrawal, N., Jiang, W., & Yapici, N. (2024) · Annual Review of Genetics · doi:10.1146/annurev-genet-111523-102202 · Cited by 13
Novel neural pathways targeted by GLP-1R agonists and bariatric surgery
Hankir, M. K., & Lutz, T. A. (2024) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-024-03047-3 · Cited by 13
“Further, the appetite-suppressing effects of CCK are blocked with ablation of right vagal afferents, neurons in the lPBN and substantia nigra, and antagonism of D1R/D2Rs in the dorsal striatum [106], suggesting overlapping central mechanisms of CCK with RYGB.”
Repeated vagus nerve stimulation produces anxiolytic effects via upregulation of AMPAR function in centrolateral amygdala of male rats
Zhang, S.-Q., Xia, Z., Deng, Q., Yang, P., Long, L., Wang, F., & Chen, J. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100453 · Cited by 10
The Role and Mechanisms of Probiotic Supplementation on Depressive Symptoms: A Narrative Review
Dacaya, P., Sarapis, K., & Moschonis, G. (2025) · Current Nutrition Reports · doi:10.1007/s13668-025-00644-1 · Cited by 13
“Microbial metabolites have shown to activate the vagus nerve by stimulating sensory neurons of the enteric nervous sys-tem [58, 59].”
Properties and functions of transcriptionally distinct enteric neurons
Shi, D., Reddy, P., Marrin, M. E., Walker, C. J., Siu, C., Muller, P. A., Yap, E.-L., & Sharma, N. (2025) · Cell · doi:10.1016/j.cell.2025.10.041 · Cited by 13
Midbrain and Lateral Nucleus Accumbens Dopamine Depletion Affects Free-choice High-fat high-sugar Diet Preference in Male Rats
Joshi, A., Faivre, F., la Fleur, S. E., & Barrot, M. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.05.022 · Cited by 10
Non-invasive vagus nerve stimulation normalizes food liking and improves liking ratings in depressionPreprint
Koepp, V., Klaus, J., Ferstl, M., et al. (2021) · doi:10.31234/osf.io/3j5xy · Cited by 8
Immediate glucose signaling transmitted via the vagus nerve in gut–brain neural communication
Yamada, S., Natsubori, A., Harada, K., Tsuboi, T., & Monai, H. (2025) · iScience · doi:10.1016/j.isci.2025.112439 · Cited by 7
Cholinergic Neurotransmission Controls Orexigenic Endocannabinoid Signaling in the Gut in Diet-Induced Obesity
Wood, C. P., Alvarez, C., & DiPatrizio, N. V. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.0813-23.2024 · Cited by 8
Vagus Nerve Stimulation (VNS) Modulates Synaptic Plasticity in the Infralimbic Cortex via Trk-B Receptor Activation to Reduce Drug-Seeking in Male Rats
Driskill, C. M., Childs, J. E., Phensy, A. J., Rodriguez, S. R., O'Brien, J. T., Lindquist, K. L., Naderi, A. O., Bordieanu, B., McGinty, J. F., & Kroener, S. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.0107-24.2024 · Cited by 9
Post-oral fat-induced satiation is mediated by endogenous CCK and GLP-1 in a fat self-administration mouse model
Vana, V., Lærke, M. K., Kleberg, K., Mroz, P. A., Lindberg, B. L., Ekberg, J. H., Rehfeld, J. F., Schwartz, T. W., & Hansen, H. S. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113315 · Cited by 7
Neuroimaging and modulation in obesity and diabetes research: 10th anniversary meeting
Laughlin, M. R., Cooke, B., Boutelle, K. N., Savage, C. R., Kravitz, A. V., Small, D. M., Arvanitakis, Z., Martin, A. D., & Stoeckel, L. E. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-01025-8 · Cited by 7
“NTS neurons, in turn, project to the parabrachial nucleus, substantia nigra, and finally the dorsal striatum where they regulate dopamine release, reward and reinforcement [75].”
Feeding signals inhibit fluid‐satiation signals in the mouse lateral parabrachial nucleus to increase intake of highly palatable, caloric solutions
Aitken, C. M., Jaramillo, J. C. M., Davis, W., Brennan‐Xie, L., McDougall, S. J., Lawrence, A. J., & Ryan, P. J. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15991 · Cited by 5
“The cl LPBN may be part of an alternate food satiation pathway (Garfield et al., 2015; Shah et al., 2014 ), which likely corresponds to a re-ward-related subdivision of the LPBN (Han et al., 2018 ).”
The microbial metabolite p -Cresol induces autistic-like behaviors in mice by remodeling the gut microbiotaPreprint
Bermudez-Martin, P., Becker, J. A. J., Caramello, N., Fernandez, S. P., Campos, R. C., Canaguier, J., Barbosa, S., Martinez-Gili, L., Myridakis, A., Dumas, M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.18.101147 · Cited by 10
'Liking' as a First Draft of the Affective FuturePreprint
Dayan, P. (2021) · doi:10.31234/osf.io/g7zfq · Cited by 4
Gaps in our understanding of how vagal afferents to the small intestinal mucosa detect luminal stimuli
Fox, E. A., & Serlin, H. K. (2024) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00252.2023 · Cited by 5
Taste Processing: Insights from Animal Models
Molero‐Chamizo, A., & Urbina, G. N. R. (2020) · Molecules · doi:10.3390/molecules25143112 · Cited by 5
“For example, the sweet taste of saccharin or glucose, which provides high calories and therefore energy [23,24], induces dopamine release in the reward system of the brain [25,26].”
Apple versus chocolate: Evidence for discrimination of distension-related and calorie-related satiety signals in post-prandial fullness and hunger, and in the quality and location of other body sensations
Mantzavinou, A., & Rogers, P. J. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.114051 · Cited by 5
“, [33,34,46,47]), whereas it appears that neither gastric nor intestinal distension per se is intrinsically rewarding, but instead potentially aversive (e.”
Background
Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting
Sun, J., Ince, M. N., Abraham, C., Barrett, T. A., Brenner, L. A., Cong, Y., Dashti, R., Dudeja, P. K., Elliott, D. E., Griffith, T. S., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2267180 · Cited by 6
Biased histamine signaling selectively gates fat preference
Zheng, Y., Liao, J., Fang, Z., Tang, X., Zhou, Z., Zhao, X., Li, M., Liu, M., Xu, S., Chen, J., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.10.035 · Cited by 4
Diet-dependent modulation of energy balance by CB1 signaling in peripheral sensory neurons
Linden, B., Herz, H., Jarrah, M., Tasabehji, D., Saleh, S., Fraer, A., Clark, P., Ye, Y., Chu, Y., Al-Khalil, Z., et al. (2025) · iScience · doi:10.1016/j.isci.2025.113124 · Cited by 4
“…several studies have shown that vagal afferent fibers are essential for regulating other meal termination and reward-related feeding behaviors, 40–42 our findings suggest that spinal sensory pathways mediate the selective effects of peripheral CB1 signaling on food intake, possibly by…”
Neuron-Microglia Interaction is Involved in Anti-inflammatory Response by Vagus Nerve Stimulation in the Prefrontal Cortex of Rats Injected with Polyinosinic:Polycytidylic Acid
Kim, K.-J., Hwang, J., Lee, K., Kim, J., Han, Y., & Namgung, U. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04054-2 · Cited by 7
“It was reported that selective stimulation of gut-innervating vagal sensory neurons induces the activation of reward circuitry between the parabrachial nucleus and septum in the rat brain [16].”
Central leptin signaling transmits positive valence
Alhadeff, A. L., Conway, S. M., Ong, Z. Y., Wald, H. S., Roitman, M. F., & Grill, H. J. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146441 · Cited by 3
The sweet taste receptor, glucose transporters, and the ATP-sensitive K+ (KATP) channel: sugar sensing for the regulation of energy homeostasis
Yoshida, R., Yasumatsu, K., & Ninomiya, Y. (2021) · Current Opinion in Physiology · doi:10.1016/j.cophys.2021.01.009 · Cited by 4
Gut–brain interactions
Kano, M., & Fukudo, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00036-x · Cited by 6
Differential control of intestine function by genetically defined enteric neuronsPreprint
Shi, D., Reddy, P., Walker, C., Marrin, M. E., Siu, C., & Sharma, N. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.02.592229 · Cited by 4
Auricular vagus nerve stimulation drives analgesia via an auricle–brain axis in a mouse model of neuropathic pain
Peng, X., Liu, Y., Liu, Y., Mao, Y., Xia, Q., Liu, A., Dai, Q., Tai, Y., Luo, B., Wang, H., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72214-0 · Cited by 5
“Moreover, existing neuroa-natomical models of vagal afferent pathways largely focus on ﬁ bers originating from internal organs 44,45 or rely on genetic labeling of taVNS-a responsive NTS neurons 11 , rather than tracing projections directly from the auricle.”
Potential Transmission of Alpha-Synuclein from the Gastrointestinal Tract to the Substantia Nigra along the Vagal Afferent Pathway
Han, F., Liu, M., Jiao, Q., Du, X., Yan, C., Chen, X., & Jiang, H. F. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01509-x · Cited by 3
“Studies by De Araujo et al. also confirmed that, after transmitting GI signals to the medulla via the vagus nerve, signals are further relayed to the SN, affecting DA release from the SN to the striatum [11].”
Protective effect of HCN2-induced SON sensitization on chronic visceral hypersensitivity in neonatal-CRD rat model
Miao, B., Mao, G., Wu, J., Zhao, B., Shi, H., & Fei, S. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147538 · Cited by 3
Optical Intracranial Self-Stimulation (oICSS): A New Behavioral Model for Studying Drug Reward and Aversion in Rodents
Song, R., Soler‐Cedeño, O., & Xi, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063455 · Cited by 4
Vagus nerve stimulation accelerates motor learning through cholinergic modulationPreprint
Bowles, S. G., Hickman, J. L., Peng, X., Williamson, W. R., Huang, R., Washington, K. A., Donegan, D., & Welle, C. G. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.28.466306 · Cited by 3
Brainstem Dbh + Neurons Control Chronic Allergen-Induced Airway HyperreactivityPreprint
Su, Y., Xu, J., Zhu, Z., Chin, J., Xu, L., Yu, H. V., Nudell, V., Dash, B., Moya, E. A., Li, Y., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.04.527145 · Cited by 3
Non-invasive Vagal Nerve Stimulation Decreases the Need for Rescue Medication for Nausea Exacerbation in Patients with Chronic Nausea and Vomiting
Barahona, G. A., Villatoro, L. G., Sidhu, S. S., et al. (2025) · Digestive Diseases and Sciences · doi:10.1007/s10620-025-09457-2 · Cited by 2
Exploring the Gut-Brain Connection: Are Probiotics the Next Frontier in Alzheimer’s Disease Treatment?
Medeiros, E. B., Lídio, A. V., Zabot, G. C., Fenilli, G. P., Silveira, G. D. B., Keller, G. S., Carrion, F. R. A., Felice, F. G. D., Kluwe‐Schiavon, B., Walss‐Bass, C., et al. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-10927-w · Cited by 3
“Thus, neuroimmune dysfunction and vagus nerve communication provide the neuronal mechanisms by which the gut directly contributes to persistent neuroinflammation and the progression of neurofibrillary and amyloid pathol - ogy in AD [ 71 , 72 ].”
Elucidating gut microbiota–hippocampus interactions in emerging psychosis: A new perspective for the development of early interventions for memory impairments
Iseli, G. C., Ulrich, S., & Schmidt, A. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1098019 · Cited by 2
“A groundbreaking study has further shown that optogenetic stimulation of gut vagal afferents mediated motivation for reward and striatal dopamine activity in mice (68), establishing a neural circuit for gut-induced reward.”
Neural regulation of feeding behaviors
Zhan, C. (2020) · Scientia Sinica Vitae · doi:10.1360/ssv-2020-0294 · Cited by 2
Role of the gut-brain axis in HIV and drug abuse-mediated neuroinflammation
Ray, S., Sil, S., Kannan, M., Periyasamy, P., & Buch, S. J. (2023) · Advances in Drug and Alcohol Research · doi:10.3389/adar.2023.11092 · Cited by 3
Mapping the Central and Peripheral Projections of Lung Innervating Sensory NeuronsPreprint
Su, Y., Barr, J., Jaquish, A., Xu, J., Verheyden, J. M., & Sun, X. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.05.442702 · Cited by 3
Enteroendocrine cell lineages that differentially control feeding and gut motilityPreprint
Hayashi, M., Kaye, J. A., Douglas, E., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.18.484842 · Cited by 2
A vagal influence on schizophrenia? A nationwide retrospective cohort of vagotomized individualsPreprint
Richter, C., Skibicka, K. P., Meyer, U., Rohrmann, S., & Krieger, J.-P. (2024) · medRxiv · doi:10.1101/2024.01.30.24301418 · Cited by 2
“The authors have no conflicts to declare.”
Exploration-Exploitation Trade-Off is Regulated by Metabolic State and Taste Value In DrosophilaPreprint
Whitehead, S. C., Sahai, S. Y., Stonemetz, J. M., & Yapici, N. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.2139/ssrn.4846519 · Cited by 3
Beyond hedonic eating
Small, D. M. (2025) · Science · doi:10.1126/science.adw3646 · Cited by 2
NodoMap: a spatio-cellular map of the mouse nodose gangliaPreprint
Cheng, S., Dowsett, G. K. C., Rainbow, K., Norton, M., Roberts, A. G., Phuah, P., Bewick, G. A., Lam, B., Yeo, G. S. H., & Murphy, K. G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.11.653249 · Cited by 2
Dopamine Magnitude and Timing in Food Reward
Leslie, E. H., Kelly, A. L., & DiFeliceantonio, A. G. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780190671051.003.0016 · Cited by 2
Associative learning: A mechanism for conditioned taste aversion
Carter, M. E. (2025) · Current Biology · doi:10.1016/j.cub.2024.12.046 · Cited by 1
Gut-brain axis modulation in remote rehabilitation of Parkinson’s disease: reconstructing the fecal metabolome and nigral network connectivity
Jin, Y., Wang, H., & Song, J. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1644490 · Cited by 3
Control of feeding behavior by modified retrograde AAV to the gastrointestinal tract nerve afferents
Marongiu, R., Wang, J., Unda, S. R., Barbera, J., Velazquez, L., Li, R., Jiménez-González, M., Tower, W., de Silva, N., Retik, R., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-31377-4 · Cited by 1
“Recent studies have used the Cre-lox system combined with viral vectors, including rgAAV2, to manipulate the activity of vagal afferent neurons innervating the gastro-intestinal tract 5,6,20,21 .”
Enteroendocrine Cells Sense Sucrose and Alter Enteric Neuron Excitability via Insulin Signaling
Snyder, J. R., Ahmed, M., Bhave, S. M., Hotta, R., Koppes, R. A., Goldstein, A. M., & Koppes, A. N. (2024) · Advanced Biology · doi:10.1002/adbi.202300566 · Cited by 1
Sex-specific effects of appetite suppressants on stereotypy in rats
Lopez, A., Gil-Lievana, E., & Gutiérrez, R. (2025) · PLoS ONE · doi:10.1371/journal.pone.0325067 · Cited by 1
A cortical basis for perception of internal gut sensationsPreprint
Rafael-Izhaki, O., Shtiglitz, S., Miller, J., Prilutski, Y., Talpir, I., Lavi, A., & Livneh, Y. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.11.705298 · Cited by 2
Second Brain in your Gut
Thaman, R. G. (2019) · AMEI's Current Trends in Diagnosis & Treatment · doi:10.5005/ctdt-3-2-vi
Endocannabinoids Promote Ethanol Drinking Via Cb 1 Receptor-Mediated Increase in Ghrelin Acylation and Signaling in the StomachPreprint
Godlewski, G., Çınar, R., Coffey, N. J., Liu, J., Jourdan, T., Mukhopadhyay, B., Chedester, L., Liu, Z., Osei‐Hyiaman, D., Iyer, M. R., et al. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3316795
Self-citation
Gut microbiota and brain function and pathophysiology
Duttaroy, A. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822405-2.00014-1
Feedback inhibition by GABAergic interneurons that are driven by dorsal raphe-projecting pyramidal neurons of the medial prefrontal cortex suppress feeding of adolescent female mice undergoing activity-based anorexiaPreprint
Du, M., Santiago, A. N., Akiz, C., & Aoki, C. J. (2021) · Research Square · doi:10.21203/rs.3.rs-947130/v1
“…used), viruses containing exogenous genes were transcranially injected through Nanoject II Auto-Nanoliter Injector (#3-000-204, Drummond) at different sites: DR was injected with a retrogradely transported AAV carrying a Cre-EBFP construct (AAVrg-EBFP-Cre) (Han et al., 2018; Tervo et al., 2016).”
Method
A dual mechanism fully blocks ethanol relapse: Role of vagal innervation
Quintanilla, M. E., Ezquer, F. E., Morales, P., Santapau, D., Ezquer, M., Herrera‐Marschitz, M., & Israel, Y. (2022) · Addiction Biology · doi:10.1111/adb.13140 · Cited by 1
“likely mediates the reinforcing effect of vagal self-stimulation since, via the tenth cranial nerve, the vagal nerve innervates tyrosinehydroxylase positive neurons in the ventral tegmental area and nucleus accumbens.(9,18) Vagal activity potentiates or contributes to the reinforcing effects of ethanol, as shown by st…”
Background
Reward-Punishment Processing and Learning
Kim, H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00150-x
Prokinetic meranzin hydrate from Chaihu-Shugan-San improves depression-like behaviors and hypomotility in rats via ghrelin and neurocircuitryPreprint
Zhang, T., Li, J., Chen, K., Liu, X., Lin, M., Han, L., Liu, J., Zheng, W., Chen, Y., Zhou, J., et al. (2020) · doi:10.21203/rs.3.rs-23794/v1
Dietary interventions for the real world? Addressing hedonic appetite and impulsive eating behaviours in the digital age
Moore, H. (2022) · Queensland University of Technology · doi:10.5204/thesis.eprints.235040
Reduced postabsorptive interoception of nutrients in obesity: cause or consequence?
Berthoud, H. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.07.015
Chronic vagotomy induces nTS glial activation, reduced glutamatergic signaling, and blunted cardiorespiratory responses
Hofmann, G. (2023) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/98757
The impact of stress, alcohol, and malnutrition on gut and brain monoaminergic profiles
Bauer, E. E. (2022) · doi:10.31274/td-20240329-759
Encoding the Glucose Identity by Discrete Hypothalamic NeuronsPreprint
Kim, J., Kim, S., Jung, W., Kim, Y., Park, H.-Y., Yoo, D. Y., Hwang, I. K., Froemke, R. C., Lee, S., Schwartz, G. J., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4795155
Disordered Eating and the Brain
Westwater, M. L., Ziauddeen, H., & Fletcher, P. C. (2024) · doi:10.1093/oso/9780190671051.003.0060
Beyond Brain Boundaries: The Emerging Significance of Vagal Body-to-brain Communication in Schizophrenia
Krieger, J.-P., & Meyer, U. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/9781837672059-00057
Vagal afferent activation induces a NREM-sleep-like state with brain-body cooling, but locus coeruleus activationPreprint
Cherrad, N., Foustoukos, G., Fernandez, L. M. J., Osorio-Forero, A., Emmenegger, Y., Franken, P., & Lüthi, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.14.643122
Cholecystokinin and the gut-brain axis
Browning, K. N., & Page, A. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-23720-1.00005-8 · Cited by 1
Cholecystokinin, nutrient preference, and taste aversion
Lewis, J. E., Gribble, F. M., & Reimann, F. M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-23720-1.00009-5
Neurobiology of Ingestive Behavior
Howe, W. M., & DiFeliceantonio, A. G. (2025) · Oxford University Press eBooks · doi:10.1093/9780197675212.003.0003
Additional file 2 of The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota
Bermudez-Martin, P., Becker, J. A. J., Caramello, N., Fernández, S. P., Campos, R. C., Canaguier, J., Barbosa, S., Martínez-Gili, L., Myridakis, A., Dumas, M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14936553
Additional file 1 of Transcutaneous electrical acupuncture stimulation (TEAS) for gastrointestinal dysfunction in adults undergoing abdominal surgery: study protocol for a prospective randomized controlled trial
Bai, Y., Gao, C., Li, W.-J., Du, Y., & An, L. (2020) · Figshare · doi:10.6084/m9.figshare.12618453
A Non-spinal Neural Circuit for Transmitting Information of Bladder Conditions
Zhu, Z., Liu, Z., Wang, Z., Cui, G., Shi, M.-Y., Lin, K., Qiu, Y., Si, T., Chen, P., Liu, Q., et al. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01570-6
“These labeled brain regions are involved in the processing of visceral sensory information, which induces emotional alterations [50, 58, 59].”
Self-citation
Thalamic gating of nutrient-specific food consumption
Liu, X., & Fu, Y. (2026) · Neuron · doi:10.1016/j.neuron.2025.12.046
Impact d'une alimentation périnatale déséquilibrée sur le développement des circuits de la récompense chez le rat
Paradis, J. (2019) · theses.fr (ABES) · doi:10.70675/8f905b58z2fabz41bdz908dz6d84b37d8f67
Le choix de la cocaïne, une question de délai
Canchy, L. (2020) · theses.fr (ABES) · doi:10.70675/343233aaz22bez4109za45bz4a1f2c63ee4f
Peripheral and intestinal microbiota alterations in Autism Spectrum Disorders : The specific role of p-Cresol
Bermudez-Martin, P. (2020) · theses.fr (ABES) · doi:10.70675/d0d223ffzbc0ez44d9z8475z153f265e94f5

Authors: Han, W., Tellez, L. A., Perkins, M. H., Perez, I. O., Qu, T., Ferreira, J., Ferreira, T. L., Quinn, D., Liu, Z.-W., Gao, X.-B., Kaelberer, M. M., Bohórquez, D. V., Shammah-Lagnado, S. J., de Lartigue, G., & de Araujo, I. E.
ORCID: Han, Wenfei
Perkins, Matthew H.
Ferreira, Tatiana L.
Gao, Xiao-Bing
Kaelberer, Melanie M.
Bohórquez, Diego V.
Venue: Cell
Publisher: Elsevier BV
Published: 2018-10
Volume: 175
Issue: 3
Pages: 887-888
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2018.10.018
OpenAlex: W4233569565
Cited by: 204
References: 0
Citations by year: 2026: 9 · 2025: 25 · 2024: 34 · 2023: 21 · 2022: 29 · 2021: 33 · 2020: 29 · 2019: 22 · 2018: 2
FWCI: 9.80
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 382 d)
Locations: Cell (publishedVersion)
Funders: National Institute on Deafness and Other Communication Disorders (R01DC014859)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: gut-brain axis, vagal afferent neurons, lateral parabrachial nucleus, striatal dopamine release, dopaminergic neurons, rabies virus tracing

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Neural Circuit for Gut-Induced Reward

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks