Cited by 7Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorGastrointestinal motility and disorders

Immediate glucose signaling transmitted via the vagus nerve in gut–brain neural communication

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Yamada, Serika, Natsubori, Akiyo, Harada, Kazuki, Tsuboi, Takashi, Monai, Hiromu·2025·iScience

Published version of a preprint

Abstract

Sucrose consumption is influenced by certain gut–brain signaling mechanisms. One possible pathway could be the interaction between the vagus nerve and the central nervous system, mediated by neuropod cells forming synaptic connections with vagus nerves, which immediately activate the central dopaminergic pathways. In this study, we demonstrated that intestinal glucose administration activates the frontal cortex via the vagus nerve and central dopamine signaling. The immediate activation of both the vagus nerve and the frontal cortex was mediated by the sodium–glucose cotransporter 1 (SGLT1). Furthermore, Ca 2+ signal activation in both astrocytes and neurons in the frontal cortex was mediated by D2 and D1 receptors, respectively. Finally, we showed that psychological stress, which causes a sucrose preference reduction, significantly diminished the activation levels of both the vagus nerve and the frontal cortex. These findings highlight the role of a comprehensive gut–brain network via vagus nerves in modulating sucrose preference.

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Crossref · 10.1016/j.isci.2025.112439

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Authors
Yamada, S., Natsubori, A., Harada, K., Tsuboi, T., & Monai, H.
Affiliations
  • Ochanomizu University (JP)
  • Tokyo Metropolitan Institute of Medical Science (JP)
  • The University of Tokyo (JP)
Corresponding author
Monai, Hiromu
Venue
iScience
Publisher
Elsevier BV
Published
2025-05
Volume
28
Issue
5
Pages
112439
ISSN
2589-0042 (ISSN-L)
OpenAlex
W4410091755
Cited by
7
References
80
Citations by year
2026: 7
FWCI
3.28
Type
journal article
Language
en
Open access
Locations
  • iScience (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Research Foundation for Opto-Science and Technology
  • RIKEN
  • Keio University
  • Japan Science and Technology Corporation
  • Japan Association for Chemical Innovation
  • Japan Science and Technology Agency (JPMJFR204G)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
gut-brain axis, vagus nerve, glucose signaling, sucrose preference, SGLT1, dopamine signaling, frontal cortex, astrocytes, dopamine D1 receptor, dopamine D2 receptor, calcium signaling, psychological stress

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