Immediate glucose signaling transmitted via the vagus nerve in gut–brain neural communication
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Abstract
Sucrose consumption is influenced by certain gut–brain signaling mechanisms. One possible pathway could be the interaction between the vagus nerve and the central nervous system, mediated by neuropod cells forming synaptic connections with vagus nerves, which immediately activate the central dopaminergic pathways. In this study, we demonstrated that intestinal glucose administration activates the frontal cortex via the vagus nerve and central dopamine signaling. The immediate activation of both the vagus nerve and the frontal cortex was mediated by the sodium–glucose cotransporter 1 (SGLT1). Furthermore, Ca 2+ signal activation in both astrocytes and neurons in the frontal cortex was mediated by D2 and D1 receptors, respectively. Finally, we showed that psychological stress, which causes a sucrose preference reduction, significantly diminished the activation levels of both the vagus nerve and the frontal cortex. These findings highlight the role of a comprehensive gut–brain network via vagus nerves in modulating sucrose preference.
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- Authors
- Yamada, S., Natsubori, A., Harada, K., Tsuboi, T., & Monai, H.
- Affiliations
- Ochanomizu University (JP)
- Tokyo Metropolitan Institute of Medical Science (JP)
- The University of Tokyo (JP)
- Corresponding author
- Monai, Hiromu
- Venue
- iScience
- Publisher
- Elsevier BV
- Published
- 2025-05
- Volume
- 28
- Issue
- 5
- Pages
- 112439
- ISSN
- 2589-0042 (ISSN-L)
- PMC
- PMC12146620
- OpenAlex
- W4410091755
- Cited by
- 7
- References
- 80
- Citations by year
- 2026: 7
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- iScience (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Research Foundation for Opto-Science and Technology
- RIKEN
- Keio University
- Japan Science and Technology Corporation
- Japan Association for Chemical Innovation
- Japan Science and Technology Agency (JPMJFR204G)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut-brain axis, vagus nerve, glucose signaling, sucrose preference, SGLT1, dopamine signaling, frontal cortex, astrocytes, dopamine D1 receptor, dopamine D2 receptor, calcium signaling, psychological stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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