Cited by 590Circular RNAs in diseasesRNA Research and SplicingCancer-related molecular mechanisms research

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Widespread and Functional RNA Circularization in Localized Prostate Cancer

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Chen, Sujun, Huang, Vincent, Xu, Xin, Livingstone, Julie, Soares, Fraser, Jeon, Jouhyun, Zeng, Yong, Hua, Junjie Tony, Petricca, Jessica, Guo, Haiyang, Wang, Miranda, Yousif, Fouad, Zhang, Yuzhe, Donmez, Nilgun, Ahmed, Musaddeque, Volik, Stas, Lapuk, Anna, Chua, Melvin L.K., Heisler, Lawrence E., Foucal, Adrien, Fox, Natalie S., Fraser, Michael, Bhandari, Vinayak, Shiah, Yu-Jia, Guan, Jiansheng, Li, Jixi, Orain, Michèle, Picard, Valérie, Hovington, Hélène, Bergeron, Alain, Lacombe, Louis, Fradet, Yves, Têtu, Bernard, Liu, Stanley, Feng, Felix, Wu, Xue, Shao, Yang W., Komor, Malgorzata A., Sahinalp, Cenk, Collins, Colin, Hoogstrate, Youri, de Jong, Mark, Fijneman, Remond J.A., Fei, Teng, Jenster, Guido, van der Kwast, Theodorus, Bristow, Robert G., Boutros, Paul C., He, Housheng Hansen·2019·Cell

DOI 10.1016/j.cell.2019.01.025

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Abstract

The cancer transcriptome is remarkably complex, including low-abundance transcripts, many not polyadenylated. To fully characterize the transcriptome of localized prostate cancer, we performed ultra-deep total RNA-seq on 144 tumors with rich clinical annotation. This revealed a linear transcriptomic subtype associated with the aggressive intraductal carcinoma sub-histology and a fusion profile that differentiates localized from metastatic disease. Analysis of back-splicing events showed widespread RNA circularization, with the average tumor expressing 7,232 circular RNAs (circRNAs). The degree of circRNA production was correlated to disease progression in multiple patient cohorts. Loss-of-function screening identified 11.3% of highly abundant circRNAs as essential for cell proliferation; for ∼90% of these, their parental linear transcripts were not essential. Individual circRNAs can have distinct functions, with circCSNK1G3 promoting cell growth by interacting with miR-181. These data advocate for adoption of ultra-deep RNA-seq without poly-A selection to interrogate both linear and circular transcriptomes.

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Crossref · 10.1016/j.cell.2019.01.025

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Additional file 9 of Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1
Lin, J., Wang, X., Zhai, S., Shi, M., Peng, C., Deng, X., Fu, D., Wang, J., & Shen, B. (2022) · Figshare · doi:10.6084/m9.figshare.21019359
Additional file 2 of ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Xin, S., Liu, X., Li, Z., Sun, X., Wang, R., Zhang, Z., Feng, X., Jin, L., Li, W., Tang, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591330
Additional file 3 of Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1
Lin, J., Wang, X., Zhai, S., Shi, M., Peng, C., Deng, X., Fu, D., Wang, J., & Shen, B. (2022) · Figshare · doi:10.6084/m9.figshare.21019335
Additional file 4 of Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway
Xu, Z., Chen, S., Liu, R., Chen, H., Xu, B., Xu, W., & Chen, M. (2022) · Figshare · doi:10.6084/m9.figshare.20329602
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Additional file 3 of Homologous recombination deficiency (HRD) score in aggressive prostatic adenocarcinoma with or without intraductal carcinoma of the prostate (IDC-P)
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Additional file 1 of CircUBA2 promotes the cancer stem cell-like properties of gastric cancer through upregulating STC1 via sponging miR-144-5p
Wang, J.-B., Lin, T.-X., Fan, D.-H., Gao, Y., Chen, Y.-J., Wu, Y.-K., Xu, K.-X., Qiu, Q.-Z., Li, P., Xie, J.-W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26757784
Additional file 11 of CircUBA2 promotes the cancer stem cell-like properties of gastric cancer through upregulating STC1 via sponging miR-144-5p
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Additional file 4 of Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation
Xie, M., Yu, T., Jing, X., Ma, L., Fan, Y., Yang, F., Ma, P., Jiang, H., Wu, X., Shu, Y., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12586286
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Additional file 4 of ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Xin, S., Liu, X., Li, Z., Sun, X., Wang, R., Zhang, Z., Feng, X., Jin, L., Li, W., Tang, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591336
Additional file 2 of METTL3-mediated m6A modification of circGLIS3 promotes prostate cancer progression and represents a potential target for ARSI therapy
Cheng, X., Yang, H., Chen, Y., Zeng, Z., Liu, Y., Zhou, X., Zhang, C., Xie, A., & Wang, G. (2024) · Figshare · doi:10.6084/m9.figshare.26698383
Additional file 9 of ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Xin, S., Liu, X., Li, Z., Sun, X., Wang, R., Zhang, Z., Feng, X., Jin, L., Li, W., Tang, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591351
Additional file 4 of Circular RNA circERBB2 promotes gallbladder cancer progression by regulating PA2G4-dependent rDNA transcription
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Additional file 4 of METTL3-mediated m6A modification of circGLIS3 promotes prostate cancer progression and represents a potential target for ARSI therapy
Cheng, X., Yang, H., Chen, Y., Zeng, Z., Liu, Y., Zhou, X., Zhang, C., Xie, A., & Wang, G. (2024) · Figshare · doi:10.6084/m9.figshare.26777503
Additional file 16 of ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Xin, S., Liu, X., Li, Z., Sun, X., Wang, R., Zhang, Z., Feng, X., Jin, L., Li, W., Tang, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591372
Additional file 1 of The circSPON2/miR-331-3p axis regulates PRMT5, an epigenetic regulator of CAMK2N1 transcription and prostate cancer progression
Yao, B., Zhu, S., Wei, X., Chen, M.-K., Feng, Y., Li, Z., Xu, X., Zhang, Y., Wang, Y., Zhou, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19914948
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Additional file 7 of ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Xin, S., Liu, X., Li, Z., Sun, X., Wang, R., Zhang, Z., Feng, X., Jin, L., Li, W., Tang, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591345
Additional file 18 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636274
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Additional file 10 of CircUBA2 promotes the cancer stem cell-like properties of gastric cancer through upregulating STC1 via sponging miR-144-5p
Wang, J.-B., Lin, T.-X., Fan, D.-H., Gao, Y., Chen, Y.-J., Wu, Y.-K., Xu, K.-X., Qiu, Q.-Z., Li, P., Xie, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26757811
Additional file 14 of CircUBA2 promotes the cancer stem cell-like properties of gastric cancer through upregulating STC1 via sponging miR-144-5p
Wang, J.-B., Lin, T.-X., Fan, D.-H., Gao, Y., Chen, Y.-J., Wu, Y.-K., Xu, K.-X., Qiu, Q.-Z., Li, P., Xie, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26757823
Additional file 2 of The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway
Zhao, J., Jiang, Y., Zhang, H., Zhou, J., Chen, L., Li, H., Xu, J., Zhang, G., & Jing, Z. (2021) · Figshare · doi:10.6084/m9.figshare.14429047
Additional file 17 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636271
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Additional file 5 of Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1
Lin, J., Wang, X., Zhai, S., Shi, M., Peng, C., Deng, X., Fu, D., Wang, J., & Shen, B. (2022) · Figshare · doi:10.6084/m9.figshare.21019341
Additional file 2 of Circular RNA circERBB2 promotes gallbladder cancer progression by regulating PA2G4-dependent rDNA transcription
Huang, X., He, M., Huang, S., Lin, R., Zhan, M., Yang, D., Shen, H., Sunwang, X., Cheng, W., Yu, J., et al. (2019) · Figshare · doi:10.6084/m9.figshare.10730093
Additional file 2 of CD105+CAF-derived exosomes CircAMPK1 promotes pancreatic cancer progression by activating autophagy
He, Z., Li, X., Chen, S., Cai, K., Li, X., & Liu, H. (2024) · Figshare · doi:10.6084/m9.figshare.26500414
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Additional file 15 of Genomic analysis of circular RNAs in heart
Dong, K., He, X., Huabo, S., Fulton, D. J. R., & Zhou, J. (2020) · Figshare · doi:10.6084/m9.figshare.13204493
Additional file 7 of CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing
Shen, P., Yang, T., Chen, Q., Yuan, H., Wu, P., Cai, B., Meng, L., Huang, X., Liu, J., Zhang, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14432018
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Additional file 6 of CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing
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Additional file 4 of Knockout of circRNAs by base editing back-splice sites of circularized exons
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Additional file 16 of CircUBA2 promotes the cancer stem cell-like properties of gastric cancer through upregulating STC1 via sponging miR-144-5p
Wang, J.-B., Lin, T.-X., Fan, D.-H., Gao, Y., Chen, Y.-J., Wu, Y.-K., Xu, K.-X., Qiu, Q.-Z., Li, P., Xie, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26757829
Additional file 1 of Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1
Lin, J., Wang, X., Zhai, S., Shi, M., Peng, C., Deng, X., Fu, D., Wang, J., & Shen, B. (2022) · Figshare · doi:10.6084/m9.figshare.21019323
Additional file 2 of CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1 signaling and acts as a nanotherapeutic target in gastric cancer
Li, Y., Wang, Z., Gao, P., Cao, D., Dong, R., Zhu, M., Fei, Y., Zuo, X., & Cai, J. (2024) · Figshare · doi:10.6084/m9.figshare.26410019
Additional file 1 of The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer
Hansen, E. B., Fredsøe, J., Okholm, T. L. H., Ulhøi, B. P., Klingenberg, S., Jensen, J. B., Kjems, J., Bouchelouche, K., Borre, M., Damgaard, C. K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19069770
Additional file 1 of Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation
Xie, M., Yu, T., Jing, X., Ma, L., Fan, Y., Yang, F., Ma, P., Jiang, H., Wu, X., Shu, Y., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12586274
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Additional file 1 of Knockout of circRNAs by base editing back-splice sites of circularized exons
Gao, X., Ma, X.-K., Li, X., Li, G.-W., Liu, C.-X., Zhang, J., Wang, Y., Wei, J., Chen, J., Chen, L.-L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18132705
Additional file 1 of CircRNAs and their regulatory roles in cancers
Tao, M., Zheng, M., Xu, Y., Ma, S., Zhang, W., & Ju, S. (2021) · Figshare · doi:10.6084/m9.figshare.16456929
Additional file 13 of ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Xin, S., Liu, X., Li, Z., Sun, X., Wang, R., Zhang, Z., Feng, X., Jin, L., Li, W., Tang, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591363
Additional file 1 of Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway
Xu, Z., Chen, S., Liu, R., Chen, H., Xu, B., Xu, W., & Chen, M. (2022) · Figshare · doi:10.6084/m9.figshare.20329593
Self-citation
Additional file 6 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636238
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Additional file 15 of CircUBA2 promotes the cancer stem cell-like properties of gastric cancer through upregulating STC1 via sponging miR-144-5p
Wang, J.-B., Lin, T.-X., Fan, D.-H., Gao, Y., Chen, Y.-J., Wu, Y.-K., Xu, K.-X., Qiu, Q.-Z., Li, P., Xie, J.-W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26757826
Additional file 5 of The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway
Zhao, J., Jiang, Y., Zhang, H., Zhou, J., Chen, L., Li, H., Xu, J., Zhang, G., & Jing, Z. (2021) · Figshare · doi:10.6084/m9.figshare.14429056
Additional file 4 of CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1 signaling and acts as a nanotherapeutic target in gastric cancer
Li, Y., Wang, Z., Gao, P., Cao, D., Dong, R., Zhu, M., Fei, Y., Zuo, X., & Cai, J. (2024) · Figshare · doi:10.6084/m9.figshare.26755921
Additional file 9 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636247
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Additional file 10 of ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Xin, S., Liu, X., Li, Z., Sun, X., Wang, R., Zhang, Z., Feng, X., Jin, L., Li, W., Tang, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591354
Additional file 7 of Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1
Lin, J., Wang, X., Zhai, S., Shi, M., Peng, C., Deng, X., Fu, D., Wang, J., & Shen, B. (2022) · Figshare · doi:10.6084/m9.figshare.21019347
Additional file 1 of Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying functional circRNAs
Zhang, Y., Nguyen, T. M., Zhang, X.-O., Wang, L., Phan, T., Clohessy, J. G., & Pandolfi, P. P. (2021) · Figshare · doi:10.6084/m9.figshare.13626941
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Additional file 2 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24516078
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Additional file 15 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636265
Self-citation
Additional file 5 of METTL3-mediated m6A modification of circGLIS3 promotes prostate cancer progression and represents a potential target for ARSI therapy
Cheng, X., Yang, H., Chen, Y., Zeng, Z., Liu, Y., Zhou, X., Zhang, C., Xie, A., & Wang, G. (2024) · Figshare · doi:10.6084/m9.figshare.26777506
Additional file 16 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636268
Self-citation
Additional file 11 of CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1 signaling and acts as a nanotherapeutic target in gastric cancer
Li, Y., Wang, Z., Gao, P., Cao, D., Dong, R., Zhu, M., Fei, Y., Zuo, X., & Cai, J. (2024) · Figshare · doi:10.6084/m9.figshare.26755945
Additional file 12 of CircUBA2 promotes the cancer stem cell-like properties of gastric cancer through upregulating STC1 via sponging miR-144-5p
Wang, J.-B., Lin, T.-X., Fan, D.-H., Gao, Y., Chen, Y.-J., Wu, Y.-K., Xu, K.-X., Qiu, Q.-Z., Li, P., Xie, J.-W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26757817
Additional file 4 of CircUBA2 promotes the cancer stem cell-like properties of gastric cancer through upregulating STC1 via sponging miR-144-5p
Wang, J.-B., Lin, T.-X., Fan, D.-H., Gao, Y., Chen, Y.-J., Wu, Y.-K., Xu, K.-X., Qiu, Q.-Z., Li, P., Xie, J.-W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26757793
Additional file 3 of ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Xin, S., Liu, X., Li, Z., Sun, X., Wang, R., Zhang, Z., Feng, X., Jin, L., Li, W., Tang, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591333
Additional file 6 of CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1 signaling and acts as a nanotherapeutic target in gastric cancer
Li, Y., Wang, Z., Gao, P., Cao, D., Dong, R., Zhu, M., Fei, Y., Zuo, X., & Cai, J. (2024) · Figshare · doi:10.6084/m9.figshare.26755927
Additional file 14 of ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Xin, S., Liu, X., Li, Z., Sun, X., Wang, R., Zhang, Z., Feng, X., Jin, L., Li, W., Tang, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591366
Additional file 6 of The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway
Zhao, J., Jiang, Y., Zhang, H., Zhou, J., Chen, L., Li, H., Xu, J., Zhang, G., & Jing, Z. (2021) · Figshare · doi:10.6084/m9.figshare.14429059
Additional file 21 of Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1
Lin, J., Wang, X., Zhai, S., Shi, M., Peng, C., Deng, X., Fu, D., Wang, J., & Shen, B. (2022) · Figshare · doi:10.6084/m9.figshare.21019329
Additional file 15 of Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1
Lin, J., Wang, X., Zhai, S., Shi, M., Peng, C., Deng, X., Fu, D., Wang, J., & Shen, B. (2022) · Figshare · doi:10.6084/m9.figshare.21019302
Additional file 12 of Genomic analysis of circular RNAs in heart
Dong, K., He, X., Huabo, S., Fulton, D. J. R., & Zhou, J. (2020) · Figshare · doi:10.6084/m9.figshare.13204484
Additional file 19 of Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1
Lin, J., Wang, X., Zhai, S., Shi, M., Peng, C., Deng, X., Fu, D., Wang, J., & Shen, B. (2022) · Figshare · doi:10.6084/m9.figshare.21019317
Additional file 22 of ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Xin, S., Liu, X., Li, Z., Sun, X., Wang, R., Zhang, Z., Feng, X., Jin, L., Li, W., Tang, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591390
Additional file 11 of Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway
Xu, Z., Chen, S., Liu, R., Chen, H., Xu, B., Xu, W., & Chen, M. (2022) · Figshare · doi:10.6084/m9.figshare.20329590
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Additional file 1 of Genomic analysis of circular RNAs in heart
Dong, K., He, X., Huabo, S., Fulton, D. J. R., & Zhou, J. (2020) · Figshare · doi:10.6084/m9.figshare.13204496
Additional file 12 of ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Xin, S., Liu, X., Li, Z., Sun, X., Wang, R., Zhang, Z., Feng, X., Jin, L., Li, W., Tang, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591360
Additional file 15 of ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Xin, S., Liu, X., Li, Z., Sun, X., Wang, R., Zhang, Z., Feng, X., Jin, L., Li, W., Tang, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591369
Additional file 11 of Genomic analysis of circular RNAs in heart
Dong, K., He, X., Huabo, S., Fulton, D. J. R., & Zhou, J. (2020) · Figshare · doi:10.6084/m9.figshare.13204481
Additional file 3 of CD105+CAF-derived exosomes CircAMPK1 promotes pancreatic cancer progression by activating autophagy
He, Z., Li, X., Chen, S., Cai, K., Li, X., & Liu, H. (2024) · Figshare · doi:10.6084/m9.figshare.26757934
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Additional file 2 of CircUBA2 promotes the cancer stem cell-like properties of gastric cancer through upregulating STC1 via sponging miR-144-5p
Wang, J.-B., Lin, T.-X., Fan, D.-H., Gao, Y., Chen, Y.-J., Wu, Y.-K., Xu, K.-X., Qiu, Q.-Z., Li, P., Xie, J.-W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26757787
Additional file 14 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636262
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Additional file 8 of CircUBA2 promotes the cancer stem cell-like properties of gastric cancer through upregulating STC1 via sponging miR-144-5p
Wang, J.-B., Lin, T.-X., Fan, D.-H., Gao, Y., Chen, Y.-J., Wu, Y.-K., Xu, K.-X., Qiu, Q.-Z., Li, P., Xie, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26757805
Additional file 4 of Homologous recombination deficiency (HRD) score in aggressive prostatic adenocarcinoma with or without intraductal carcinoma of the prostate (IDC-P)
Zhu, S., Zhao, J., Nie, L., Yin, W., Zhang, Y., Zhao, F., Ni, Y., Zhang, X., Wang, Z., Dai, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20353522
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Additional file 1 of Amplification of spatially isolated adenosine pathway by tumor–macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma
Lu, J.-C., Zhang, P.-F., Huang, X.-Y., Guo, X.-J., Gao, C., Zeng, H., Zheng, Y., Wang, S., Cai, J.-B., Sun, Q.-M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17088157
Additional file 8 of The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway
Zhao, J., Jiang, Y., Zhang, H., Zhou, J., Chen, L., Li, H., Xu, J., Zhang, G., & Jing, Z. (2021) · Figshare · doi:10.6084/m9.figshare.14429065
Additional file 19 of ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Xin, S., Liu, X., Li, Z., Sun, X., Wang, R., Zhang, Z., Feng, X., Jin, L., Li, W., Tang, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591381
Additional file 6 of CircUBA2 promotes the cancer stem cell-like properties of gastric cancer through upregulating STC1 via sponging miR-144-5p
Wang, J.-B., Lin, T.-X., Fan, D.-H., Gao, Y., Chen, Y.-J., Wu, Y.-K., Xu, K.-X., Qiu, Q.-Z., Li, P., Xie, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26757799
Additional file 9 of CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1 signaling and acts as a nanotherapeutic target in gastric cancer
Li, Y., Wang, Z., Gao, P., Cao, D., Dong, R., Zhu, M., Fei, Y., Zuo, X., & Cai, J. (2024) · Figshare · doi:10.6084/m9.figshare.26755939
Additional file 3 of CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1 signaling and acts as a nanotherapeutic target in gastric cancer
Li, Y., Wang, Z., Gao, P., Cao, D., Dong, R., Zhu, M., Fei, Y., Zuo, X., & Cai, J. (2024) · Figshare · doi:10.6084/m9.figshare.26755918
Additional file 1 of ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Xin, S., Liu, X., Li, Z., Sun, X., Wang, R., Zhang, Z., Feng, X., Jin, L., Li, W., Tang, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591327
Additional file 1 of CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes
Wu, W., Ji, P., & Zhao, F. (2020) · Figshare · doi:10.6084/m9.figshare.12211826
Additional file 20 of ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Xin, S., Liu, X., Li, Z., Sun, X., Wang, R., Zhang, Z., Feng, X., Jin, L., Li, W., Tang, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591384
Additional file 12 of CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Cui, Y., Wu, X., Jin, J., Man, W., Li, J., Li, X., Li, Y., Yao, H., Zhong, R., Chen, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26636256
Self-citation
Additional file 18 of ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Xin, S., Liu, X., Li, Z., Sun, X., Wang, R., Zhang, Z., Feng, X., Jin, L., Li, W., Tang, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591378
Identification and characterization of circular RNAs involved in cadmium response in Malus hupehensis
Sun, B., Chen, B., Song, J., Zhang, W., & Yang, H. (2026) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2026.106314
Etudes des translocations chromosomiques en utilisant les méthodes d'édition du génome : des mécanismes moléculaires à l’oncogenèse
Babin, L. (2019) · theses.fr (ABES) · doi:10.70675/6096400azb435z40e9zab82zebc5026b539b
Unraveling the Multifaceted Landscape of the Tumor Microenvironment through Mechanistic Insights and Therapeutic Frontiers
Pandit, D., & Sharma, P. (2026) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575442733260324060815
Precision targeting in prostate cancer: Mechanistic drivers and the evolving clinical pipeline
Nathe, P., Singh, Y., Ratre, P., & Kulkarni, S. (2026) · Drug Discovery Today · doi:10.1016/j.drudis.2026.104750
Circ_0001495 promotes bladder cancer progression by regulating miR-1184 via MAPK signaling pathway
Zhang, S., Li, M., Wu, Y., Kang, Y., Yang, T., Han, B., Li, J., & Zhang, A. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12539-7
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CircFut8 Suppresses Bladder Cancer by Modulating SRSF9‐Dependent Pre‐mRNA Splicing
Yang, W., Lv, Y., Wan, L., & Zhuang, C. (2026) · The Journal of Gene Medicine · doi:10.1002/jgm.70108
“Certain circRNAs have participated in innate immunity, neuronal function, cell proliferation, and metastasis [4, 7, 8].”
Non-coding RNAs in tumor-educated platelets: emerging roles in cancer progression, biomarker discovery, and therapeutic targeting
Liu, Y., Zhang, Y., Li, D., Zhao, J., Liu, M., & Wang, Y. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1951597
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Authors: Chen, S., Huang, V., Xu, X., Livingstone, J., Soares, F., Jeon, J., Zeng, Y., Hua, J. T., Petricca, J., Guo, H., Wang, M., Yousif, F., Zhang, Y., Donmez, N., Ahmed, M., Volik, S., Lapuk, A., Chua, M. L. K., Heisler, L. E., Foucal, A., Fox, N. S., Fraser, M., Bhandari, V., Shiah, Y.-J., Guan, J., Li, J., Orain, M., Picard, V., Hovington, H., Bergeron, A., Lacombe, L., Fradet, Y., Têtu, B., Liu, S., Feng, F., Wu, X., Shao, Y. W., Komor, M. A., Sahinalp, C., Collins, C., Hoogstrate, Y., de Jong, M., Fijneman, R. J. A., Fei, T., Jenster, G., van der Kwast, T., Bristow, R. G., Boutros, P. C., & He, H. H.
Affiliations: Ontario Institute for Cancer Research (CA)
University Health Network (CA)
Vancouver Prostate Centre (CA)
Fudan University (CN)
Centre de recherche du CHU de Québec-Université Laval (CA)
Sunnybrook Health Science Centre (CA)
University of California, San Francisco (US)
Nanjing Medical University (CN)
The Netherlands Cancer Institute (NL)
University of British Columbia (CA)
Erasmus MC (NL)
Northeastern University (CN)
Corresponding author: Boutros, Paul C.
He, Housheng Hansen
ORCID: Chen, Sujun
Huang, Vincent
Xu, Xin
Livingstone, Julie
Soares, Fraser
Jeon, Jouhyun
Zeng, Yong
Hua, Junjie Tony
Guo, Haiyang
Zhang, Yuzhe
Ahmed, Musaddeque
Lapuk, Anna
Chua, Melvin L.K.
Heisler, Lawrence E.
Foucal, Adrien
Fox, Natalie S.
Fraser, Michael
Bhandari, Vinayak
Shiah, Yu-Jia
Guan, Jiansheng
Li, Jixi
Orain, Michèle
Picard, Valérie
Hovington, Hélène
Bergeron, Alain
Lacombe, Louis
Fradet, Yves
Têtu, Bernard
Liu, Stanley
Feng, Felix
Wu, Xue
Shao, Yang W.
Komor, Malgorzata A.
Collins, Colin
Hoogstrate, Youri
Fijneman, Remond J.A.
Fei, Teng
Jenster, Guido
Bristow, Robert G.
Boutros, Paul C.
He, Housheng Hansen
Venue: Cell
Publisher: Elsevier BV
Published: 2019-02
Volume: 176
Issue: 4
Pages: 831-843.e22
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2019.01.025
OpenAlex: W2913336364
Cited by: 544
References: 91
Citations by year: 2026: 13 · 2025: 26 · 2024: 107 · 2023: 44 · 2022: 105 · 2021: 110 · 2020: 83 · 2019: 55
FWCI: 31.45
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 371 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Funders: Princess Margaret Cancer Foundation (886012001223)
Canada Foundation for Innovation and Ontario Research Fund (CFI32372)
NSERC (498706)
Canadian Cancer Society (705649, 703800)
Prostate Cancer Canada (RS2014-01, RS2016-1022)
CIHR (146586, 142246, 152863, 152864, 159567)
Ontario Institute for Cancer Research
TFRI
OMIR
Shanghai Committee of Science and Technology (18430711400)
University of Toronto
STARS21
CTMM (03O-402)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: circular RNA, RNA circularization, localized prostate cancer, back-splicing, intraductal carcinoma, metastatic prostate cancer, miR-181, cell proliferation, transcriptomic subtypes
MeSH terms: Genetic Profile, RNA, Circular, Humans, Male, Prostate, Prostatic Neoplasms, RNA, RNA Splicing, Sequence Analysis, RNA, Gene Expression Profiling, RNA, Untranslated, MicroRNAs, HEK293 Cells, Transcriptome

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Widespread and Functional RNA Circularization in Localized Prostate Cancer

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