Cited by 277Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital heart defects research

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A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis

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Berg, Daniel A., Su, Yijing, Jimenez-Cyrus, Dennisse, Patel, Aneek, Huang, Nancy, Morizet, David, Lee, Stephanie, Shah, Reeti, Ringeling, Francisca Rojas, Jain, Rajan, Epstein, Jonathan A., Wu, Qing-Feng, Canzar, Stefan, Ming, Guo-Li, Song, Hongjun, Bond, Allison M.·2019·Cell

DOI 10.1016/j.cell.2019.02.010PMC PMC6496946

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Abstract

New neurons arise from quiescent adult neural progenitors throughout life in specific regions of the mammalian brain. Little is known about the embryonic origin and establishment of adult neural progenitors. Here, we show that Hopx+ precursors in the mouse dentate neuroepithelium at embryonic day 11.5 give rise to proliferative Hopx+ neural progenitors in the primitive dentate region, and they, in turn, generate granule neurons, but not other neurons, throughout development and then transition into Hopx+ quiescent radial glial-like neural progenitors during an early postnatal period. RNA-seq and ATAC-seq analyses of Hopx+ embryonic, early postnatal, and adult dentate neural progenitors further reveal common molecular and epigenetic signatures and developmental dynamics. Together, our findings support a "continuous" model wherein a common neural progenitor population exclusively contributes to dentate neurogenesis throughout development and adulthood. Adult dentate neurogenesis may therefore represent a lifelong extension of development that maintains heightened plasticity in the mammalian hippocampus.

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Authors: Berg, D. A., Su, Y., Jimenez-Cyrus, D., Patel, A., Huang, N., Morizet, D., Lee, S., Shah, R., Ringeling, F. R., Jain, R., Epstein, J. A., Wu, Q.-F., Canzar, S., Ming, G.-L., Song, H., & Bond, A. M.
Affiliations: University of Pennsylvania (US)
Johns Hopkins University (US)
Ludwig-Maximilians-Universität München (DE)
Corresponding author: Ming, Guo-Li
Song, Hongjun
ORCID: Berg, Daniel A.
Su, Yijing
Patel, Aneek
Jain, Rajan
Epstein, Jonathan A.
Canzar, Stefan
Ming, Guo-Li
Song, Hongjun
Venue: Cell
Publisher: Elsevier BV
Published: 2019-04
Volume: 177
Issue: 3
Pages: 654-668.e15
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2019.02.010
PMC: PMC6496946
OpenAlex: W2925077238
Cited by: 267
References: 62
Citations by year: 2026: 23 · 2025: 38 · 2024: 39 · 2023: 39 · 2022: 42 · 2021: 36 · 2020: 33 · 2019: 17
FWCI: 12.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 383 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
Funders: Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
Vetenskapsrådet
Burroughs Wellcome Fund
EMBO
National Institutes of Health (R37NS047344, R35HL140018, DP2HL147123, P01NS097206, R01MH105128, R35NS097370)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords: adult neurogenesis, HOPX, dentate gyrus, granule neurons, hippocampus, epigenetic signatures, developmental dynamics, neural stem cells
MeSH terms: Animals, Cell Differentiation, Embryo, Mammalian, Female, Hippocampus, Male, Mice, Inbred C57BL, Mice, Transgenic, Homeodomain Proteins, Gene Expression Regulation, Developmental, Dentate Gyrus, Mice, Embryonic Stem Cells, Neurogenesis, Neural Stem Cells

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A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis

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