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A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis
Open accessAbstract
New neurons arise from quiescent adult neural progenitors throughout life in specific regions of the mammalian brain. Little is known about the embryonic origin and establishment of adult neural progenitors. Here, we show that Hopx+ precursors in the mouse dentate neuroepithelium at embryonic day 11.5 give rise to proliferative Hopx+ neural progenitors in the primitive dentate region, and they, in turn, generate granule neurons, but not other neurons, throughout development and then transition into Hopx+ quiescent radial glial-like neural progenitors during an early postnatal period. RNA-seq and ATAC-seq analyses of Hopx+ embryonic, early postnatal, and adult dentate neural progenitors further reveal common molecular and epigenetic signatures and developmental dynamics. Together, our findings support a "continuous" model wherein a common neural progenitor population exclusively contributes to dentate neurogenesis throughout development and adulthood. Adult dentate neurogenesis may therefore represent a lifelong extension of development that maintains heightened plasticity in the mammalian hippocampus.
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“Some have demonstrated that neural stem cells in the adult hippocampal subgranular zone (SGZ) niche are remnants of dentate neuroepithelium92 and this same population of progenitors exclusively contributes to hippocampal neurogenesis throughout development and into adulthood, shifting out of quiescence at different time points93.”
From Dysregulation of adult hippocampal neuroplasticity in major depression: Pathogenesis and therapeutic implications (2022) · cites this paper as [93]
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Metadata
- Authors
- Berg, D. A., Su, Y., Jimenez-Cyrus, D., Patel, A., Huang, N., Morizet, D., Lee, S., Shah, R., Ringeling, F. R., Jain, R., Epstein, J. A., Wu, Q.-F., Canzar, S., Ming, G.-L., Song, H., & Bond, A. M.
- Affiliations
- University of Pennsylvania (US)
- Johns Hopkins University (US)
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Ming, Guo-Li
- Song, Hongjun
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 177
- Issue
- 3
- Pages
- 654-668.e15
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC6496946
- OpenAlex
- W2925077238
- Cited by
- 267
- References
- 62
- Citations by year
- 2026: 23 · 2025: 38 · 2024: 39 · 2023: 39 · 2022: 42 · 2021: 36 · 2020: 33 · 2019: 17
- FWCI
- 12.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
- Funders
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Vetenskapsrådet
- Burroughs Wellcome Fund
- EMBO
- National Institutes of Health (R37NS047344, R35HL140018, DP2HL147123, P01NS097206, R01MH105128, R35NS097370)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- adult neurogenesis, HOPX, dentate gyrus, granule neurons, hippocampus, epigenetic signatures, developmental dynamics, neural stem cells
- MeSH terms
- Animals, Cell Differentiation, Embryo, Mammalian, Female, Hippocampus, Male, Mice, Inbred C57BL, Mice, Transgenic, Homeodomain Proteins, Gene Expression Regulation, Developmental, Dentate Gyrus, Mice, Embryonic Stem Cells, Neurogenesis, Neural Stem Cells
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