The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism
Open accessAbstract
SUMMARY Vaccines to generate durable humoral immunity against antigenically evolving pathogens such as influenza virus must elicit antibodies that recognize conserved epitopes. Analysis of single memory B cells from immunized human donors has led us to characterize a previously unrecognized epitope of influenza hemagglutinin (HA) that is immunogenic in humans and conserved among influenza subtypes. Structures show an unrelated antibody from a participant in an experimental infection protocol recognized the epitope as well. IgGs specific for this antigenic determinant do not block viral infection in vitro, but passive administration to mice affords robust, IgG subtype-dependent protection against influenza infection. The epitope, occluded in the pre-fusion form of HA, is at the contact surface between HA head domains; reversible molecular “breathing” of the HA trimer can expose the interface to antibody and B cells. Antigens that present this broadly immunogenic HA epitope may be good candidates for inclusion in “universal” flu vaccines.
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Cited by
Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
McCarthy, K. R., Rennick, L. J., Nambulli, S., Robinson-McCarthy, L. R., Bain, W. G., Haidar, G., & Duprex, W. P. (2021) · Science · doi:10.1126/science.abf6950 · Cited by 535
Self-citationStructural transitions in influenza haemagglutinin at membrane fusion pH
Benton, D. J., Gamblin, S. J., Rosenthal, P. B., & Skehel, J. J. (2020) · Nature · doi:10.1038/s41586-020-2333-6 · Cited by 161
Chen, Z.-S., Huang, H.-C., Wang, X., Schön, K., Jia, Y., Lebens, M., Besavilla, D. F., Murti, J. R., Ji, Y., Sarshad, A. A., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55193-y · Cited by 39
Metadata
- Authors
- Watanabe, A., McCarthy, K. R., Kuraoka, M., Schmidt, A. G., Adachi, Y., Onodera, T., Tonouchi, K., Caradonna, T. M., Bajic, G., Song, S., McGee, C. E., Sempowski, G. D., Feng, F., Urick, P., Kepler, T. B., Takahashi, Y., Harrison, S. C., & Kelsoe, G.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 177
- Issue
- 5
- Pages
- 1124-1135.e16
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2945953636
- Cited by
- 189
- References
- 7
- FWCI
- 16.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Watanabe, A., McCarthy, K. R., Kuraoka, M., Schmidt, A. G., Adachi, Y., Onodera, T., Tonouchi, K., Caradonna, T. M., Bajic, G., Song, S., McGee, C. E., Sempowski, G. D., Feng, F., Urick, P., Kepler, T. B., Takahashi, Y., Harrison, S. C., & Kelsoe, G. (2019). Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism. Cell. https://doi.org/10.1016/j.cell.2019.03.048
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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