Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
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Abstract
Eluding detection: Influenza viruses evade immunity initiated by previous infection, which explains recurrent influenza pandemics. Unlike the error-prone RNA-dependent RNA polymerase of influenza, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and related viruses contain polymerases with proofreading activity. However, proofreading cannot correct deletions, which during a long-term persistent infection could result in the generation of viruses showing alteration of entire stretches of amino acids and the structures they form. McCarthy et al. identified an evolutionary signature defined by prevalent and recurrent deletions in the spike protein of SARS-CoV-2 at four antigenic sites. Deletion variants show human-to-human transmission of viruses with altered antigenicity. Science , this issue p. 1139
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The recent emergence of B.1.1.7, B.1.351 and P.1 marks the beginning of SARS-CoV-2 antigenic drift.
“The recent emergence of B.1.1.7,B.1.351and P.1 marks the beginning of SARS-CoV-2 antigenic drift.”
From Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7 (2021) · cites this paper as [45]
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- Authors
- McCarthy, K. R., Rennick, L. J., Nambulli, S., Robinson-McCarthy, L. R., Bain, W. G., Haidar, G., & Duprex, W. P.
- Affiliations
- Boston Children's Hospital (US)
- University of Pittsburgh (US)
- Department of Genetics, Harvard Medical School, Boston, MA, USA.
- Corresponding author
- McCarthy, Kevin R.
- Duprex, W. Paul
- ORCID
- Venue
- Science
- Published
- 2021-03-12
- Volume
- 371
- Issue
- 6534
- Pages
- 1139-1142
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7971772
- OpenAlex
- W3127143267
- Cited by
- 535
- References
- 33
- Citations by year
- 2026: 12 · 2025: 24 · 2024: 42 · 2023: 66 · 2022: 173 · 2021: 216 · 2020: 1 · 2012: 1
- FWCI
- 39.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Science (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Science
- Funders
- U.S. Department of Veterans Affairs (IK2 BX004886)
- Richard King Mellon Foundation
- Hillman Foundation
- UPMC Immune Transplant and Therapy Center
- The Center for Vaccine Research
- The University of Pittsburgh
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- SARS-CoV-2, spike protein, recurrent deletions, antibody escape, neutralizing antibodies, antigenic evolution, adaptive evolution, immune evasion, viral evolution, zoonotic spillover
- MeSH terms
- COVID-19, SARS-CoV-2, Amino Acid Sequence, Antibodies, Viral, Antigens, Viral, Humans, Protein Conformation, Sequence Deletion, Evolution, Molecular, Amino Acid Substitution, Genetic Drift, Immune Evasion, Antibodies, Neutralizing, Spike Glycoprotein, Coronavirus
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