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Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner
Open accessAbstract
Immune cells residing in white adipose tissue have been highlighted as important factors contributing to the pathogenesis of metabolic diseases, but the molecular regulators that drive adipose tissue immune cell remodeling during obesity remain largely unknown. Using index and transcriptional single-cell sorting, we comprehensively map all adipose tissue immune populations in both mice and humans during obesity. We describe a novel and conserved Trem2+ lipid-associated macrophage (LAM) subset and identify markers, spatial localization, origin, and functional pathways associated with these cells. Genetic ablation of Trem2 in mice globally inhibits the downstream molecular LAM program, leading to adipocyte hypertrophy as well as systemic hypercholesterolemia, body fat accumulation, and glucose intolerance. These findings identify Trem2 signaling as a major pathway by which macrophages respond to loss of tissue-level lipid homeostasis, highlighting Trem2 as a key sensor of metabolic pathologies across multiple tissues and a potential therapeutic target in metabolic diseases.
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“MASH is associated with the emergence of lipid-associated macrophages (LAM) that highly express Trem2 along with Cd9, Gpnmb, and Spp1 (3–5)”
From Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2 (2024) · cites this paper as [4]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“While the majority of murine studies to date have suggested a role for LAMs/LAM-like KCs in tissue repair, contributing to dead cell and lipid clearance, thus reducing lipotoxic stress, and preventing uncontrolled inflammation (36, 108, 122–126)”
From Targeting macrophages in liver fibrosis (2026) · cites this paper as [126]
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In the citing paper
“TREM2 ligands include a variety of molecules, such as bacterial wall products, Aβ oligomers, lipoproteins, and anionic lipids, such as phospholipids and sphingolipids29,32–35”
From TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity (2025) · cites this paper as [33]
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“Notably, these included the lysosomal enzymes ASAH1, LIPA, CTSA, CTSG, CTSZ, PLA2G15 and PPT1, enzymes part of the Coordinated Lysosomal Expression and Regulation network60, as well as PLA2G7, previously associated with atherosclerotic plaques61 and with the LAM48 and MIMS-foamy microglial states11.”
From Foamy microglia link oxylipins to disease progression in multiple sclerosis (2026) · cites this paper as [48]
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“The foamy, GPNMB+ microglial phenotype in MS lesions bears striking transcriptional similarity to LAMs in obesity, amyloid-responsive microglia in Alzheimer’s disease and foam cells in atherosclerosis18,46,48,50,51.”
From Foamy microglia link oxylipins to disease progression in multiple sclerosis (2026) · cites this paper as [48]
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“The disease-associated phenotype of microglia seems to be shared by aging, as well as neurological and non-neurological diseases with different etiology, e.g. AD and amyotrophic lateral sclerosis (Holtman et al., 2015; Keren-Shaul et al., 2017), atherosclerosis and obesity, characterized by lipid overload (Jaitin et al., 2019; Martinet et al., 2019).”
From Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response (2021) · cites this paper as Jaitin et al., 2019
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“There was considerable overlap between the Micro_D profile and previously reported microglial states, such as the MIMS-foamy state reported in ref. 11, amyloid-associated microglia in Alzheimer’s disease43,46,47 and lipid-associated macrophages (LAMs) in obesity48 (Extended Data Fig. 8).”
From Foamy microglia link oxylipins to disease progression in multiple sclerosis (2026) · cites this paper as [48]
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“In the adipose tissue, TREM2 sustains the presence of a population of lipid-associated macrophages (LAMs) that prevent the dysmetabolism engendered by a high-fat diet (Jaitin et al., 2019).”
From TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy (2020) · cites this paper as Jaitin et al., 2019
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“lipid-associated macrophages have recently been identified in mouse and human adipose tissue, where TREM2 expression was found to regulate lipid homeostasis [57].”
From TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation (2021) · cites this paper as [57]
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“These cells had a similar transcriptional profile to DAM [57]”
From TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation (2021) · cites this paper as [57]
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“although the mouse DAM transcriptome profile may not be fully present in AD brain, as human microglia show a distinct AD-related gene signature (Jaitin et al., 2019; Mathys et al., 2019).”
From Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response (2021) · cites this paper as Jaitin et al., 2019
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“However, in experimental liver fibrosis in murine models, TREM2-deficient macrophages failed to acquire reparative phenotypes, showed impaired efferocytosis, and exacerbated fibrogenesis (36, 122–126).”
From Targeting macrophages in liver fibrosis (2026) · cites this paper as [126]
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“The finding of lipid droplet containing microglia in GRN−/− mice is corroborated by a recent study which showed that cultured progranulin-deficient macrophages exhibited increased foam cell formation, i.e. lipid droplet accumulation, compared to wild type macrophages49.”
From Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain (2020) · cites this paper as [49]
Experimental — accuracy not yet measuredIn the citing paper
“These monocyte-derived/bone marrow-dependent macrophages in NASH livers share striking similarities with macrophages in related extrahepatic compartments such as the bone marrow or adipose tissue,72,73 including a subset of “lipid-associated macrophages” with a unique metabolically activated phenotype.74”
From Understanding the cellular interactome of non-alcoholic fatty liver disease (2022) · cites this paper as [73]
In the citing paper
“Second, monocyte-derived macrophages replace liver resident Kupffer cells that normally clear iron, resulting in iron overload, oxidative stress, and activation of HSCs into myofibroblasts (70, 74-77).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [76]
In the citing paper
“In fatty liver, a novel subset of lipid-associated macrophages (LAMs) display a unique ability to metabolize lipids, but their contribution to fibrosis is unknown (70, 76).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [76]
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Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890
HISAT: a fast spliced aligner with low memory requirements
Kim, D., Langmead, B., & Salzberg, S. L. (2015) · Nature Methods · doi:10.1038/nmeth.3317 · Cited by 24,112
DAVID: Database for Annotation, Visualization, and Integrated Discovery
Dennis, G., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., & Lempicki, R. A. (2003) · Genome Biology · doi:10.1186/gb-2003-4-5-p3 · Cited by 9,327
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493
Self-citationSlingshot: cell lineage and pseudotime inference for single-cell transcriptomics
Street, K., Risso, D., Fletcher, R. B., Das, D., Ngai, J., Yosef, N., Purdom, E., & Dudoit, S. (2018) · BMC Genomics · doi:10.1186/s12864-018-4772-0 · Cited by 3,159
TREM2 Variants in Alzheimer's Disease
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020
Inflammation, metaflammation and immunometabolic disorders
Hotamisligil, G. S. (2017) · Nature · doi:10.1038/nature21363 · Cited by 2,570
Variant of TREM2 Associated with the Risk of Alzheimer's Disease
Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558
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Items 501–600 of 999
Mesenchymal stromal cells as conductors of adipose tissue remodelingPreprint
Cannavino, J., & Gupta, R. K. (2023) · Genes & Development · doi:10.1101/gad.351069.123 · Cited by 25
Iwata, A., Maruyama, J., Natsuki, S., Nishiyama, A., Tamura, T., Tanaka, M., Shichino, S., Seki, T., Komai, T., Okamura, T., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06357-5 · Cited by 25
“Known as scar-associated macrophages (SAMs) 12,13 , these recruited monocyte-derived cells best resemble lipid-associated macrophages (LAMs) that aggregate to surround dead adipocytes in obese adipose tissue 14 , and are therefore named hepatic LAMs (hLAMs) 8 .”
Patra, D., Ramprasad, P., Sharma, S., Dey, U., Kumar, V., Singh, S., Dasgupta, S., Kumar, A. A., Tikoo, K., & Pal, D. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107328 · Cited by 27
TREM2+ macrophages: a key role in disease development
Wang, X., Wang, Y., Yang, L. X., Zhang, Y., & Yang, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1550893 · Cited by 29
Huang, Y., & Fang, W. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01152-9 · Cited by 30
Metabolic factors in the regulation of hypothalamic innate immune responses in obesity
Folick, A., Cheang, R. T., Valdearcos, M., & Koliwad, S. K. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00666-z · Cited by 26
Orliaguet, L., Ejlalmanesh, T., Humbert, A., Ballaire, R., Diedisheim, M., Julla, J., Chokr, D., Cuenco, J., Michieletto, J., Charbit, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32813-z · Cited by 25
Adipose tissue aging: An update on mechanisms and therapeutic strategies
Cai, Z., & He, B. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155328 · Cited by 27
Ochocka, N., Segit, P., Wojnicki, K., Cyranowski, S., Swatler, J., Jacek, K., Grajkowska, W., & Kaminska, B. (2023) · Cell Reports · doi:10.1016/j.celrep.2022.111971 · Cited by 28
A novel strategy to dissect multifaceted macrophage function in human diseases
Karlinsey, K., Qu, L., Matz, A. J., & Zhou, B. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.6mr0522-685r · Cited by 23
Wang, Y., Guan, Y., Feng, D., Maccioni, L., Parra, M. A., Peiffer, B., Mackowiak, B., Kuwabara, T., Mori, K., Mukoyama, M., et al. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01343-1 · Cited by 23
Zhang, Y., Cheng, Z., Hong, L., Liu, J., Ma, X., Wang, W., Pan, R., Lu, W., Luo, Q., Gao, S., et al. (2023) · Molecular Biomedicine · doi:10.1186/s43556-023-00158-8 · Cited by 23
Adipose tissue macrophage heterogeneity in the single-cell genomics era
Kang, H., & Lee, J. (2024) · Molecules and Cells · doi:10.1016/j.mocell.2024.100031 · Cited by 25
Fan, S., Tan, Y., Yuan, X., Liu, C., Wu, X., Dai, T., Ni, S., Wang, J., Weng, Y., & Zhao, H. (2024) · Journal of Tissue Engineering · doi:10.1177/20417314241231452 · Cited by 22
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Randall, T. D., & Meza‐Perez, S. (2024) · Immunological Reviews · doi:10.1111/imr.13344 · Cited by 26
Huang, H., Wu, F., Yu, Y., Xu, B., Chen, D., Huo, Y., & Li, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1436131 · Cited by 29
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Zhu, B., Liu, Y., & Peng, D. (2024) · Biomarker Research · doi:10.1186/s40364-024-00675-w · Cited by 28
Song, Y., Li, N., Jiang, S., Wang, K., Lv, G., Fan, Z., Du, X., Gao, W., Lei, L., Wang, Z., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57574-3 · Cited by 25
Immunometabolic Interactions in Obesity: Implications for Therapeutic Strategies
Fei, Q., Huang, J., He, Y., Zhang, Y., Zhang, X., Wang, J., & Fu, Q. (2025) · Biomedicines · doi:10.3390/biomedicines13061429 · Cited by 28
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Koh, H. E., van Vliet, S., Pietka, T., Meyer, G. A., Razani, B., Laforest, R. A., Gropler, R. J., & Mittendorfer, B. (2021) · Diabetes · doi:10.2337/db21-0160 · Cited by 24
Yu, Z., Shu, W., Hou, X., & Wang, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.702835 · Cited by 23
Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis
Gadipudi, L. L., Ramavath, N. N., Provera, A., Reutelingsperger, C. P. M., Albano, E., Perretti, M., & Sutti, S. (2022) · Clinical Science · doi:10.1042/cs20211122 · Cited by 23
Vasamsetti, S. B., Coppin, E., Zhang, X., Florentin, J., Koul, S. M., Götberg, M., Clugston, A. S., Thoma, F. W., Sembrat, J., Bullock, G. C., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw0638 · Cited by 23
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Gessain, G., Blériot, C., & Ginhoux, F. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.613116 · Cited by 24
Self-citationGene-Expression Profiling to Decipher Breast Cancer Inter- and Intratumor HeterogeneityPreprint
Swarbrick, A., Fernández-Martínez, A., & Perou, C. M. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041320 · Cited by 23
Serum soluble TREM2 is an independent biomarker associated with coronary heart disease
Liu, W., Weng, S., Liu, H., Cao, C., Wang, S., Wu, S., He, J., Yang, Y., Hu, D., Luo, Y., et al. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117499 · Cited by 22
Liang, Y., Hu, Y., Zhang, J., Song, H., Zhang, X., Chen, Y., Peng, Y., Sun, L., Sun, Y., Xue, R., et al. (2024) · Theranostics · doi:10.7150/thno.94121 · Cited by 27
Dahik, V. D., Pukar, K. C., Materne, C., Reydellet, C., Lhomme, M., Cruciani‐Guglielmacci, C., Denom, J., Bun, E., Ponnaiah, M., Deknuydt, F., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adi6682 · Cited by 26
Espinoza, F. I., Tankov, S., Chliate, S., Couto, J. P., Marinari, E., Vermeil, T., Lecoultre, M., Harane, N. E., Dutoit, V., Migliorini, D., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05642-8 · Cited by 25
Yu, W., Haoyu, Y., Ling, Z., Xing, H., Pengfei, X., Anzhu, W., Lili, Z., & Linhua, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1549484 · Cited by 25
ICI-induced cardiovascular toxicity: mechanisms and immune reprogramming therapeutic strategies
Zheng, J., Yi, Y., Tian, T., Luo, S., Liang, X., & Bai, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1550400 · Cited by 24
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Hakeem, A. N., van Berlo, J. H., & Revelo, X. S. (2025) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2025.05.004 · Cited by 24
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David, B. A., Andreata, F., Blériot, C., Ginhoux, F., Kubes, P., & Iannacone, M. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01288-0 · Cited by 25
Self-citationObesity and ethnicity alter gene expression in skin
Walker, J. M., Garcet, S., Alemán, J. O., Mason, C. E., Danko, D., Butler, D., Zuffa, S., Swann, J. R., Krueger, J. G., Breslow, J. L., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-70244-2 · Cited by 25
Ferrière, A., Santa, P., Garreau, A., Bandopadhyay, P., Blanco, P., Ganguly, D., & Sisirak, V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.624256 · Cited by 24
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Park, J., Sohn, J. H., Han, S. M., Park, Y. J., Huh, J. Y., Choe, S. S., & Kim, J. B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.598566 · Cited by 22
Wang, Y. Y., Wang, Y., Qi, X.-Y., Liao, Z., Mai, Y.-N., & Xiao, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.839849 · Cited by 24
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Garcia, J. N., Wanjalla, C. N., Mashayekhi, M., & Hasty, A. H. (2022) · Current Hypertension Reports · doi:10.1007/s11906-022-01222-4 · Cited by 25
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Lee, K., An, S., Kim, M., Kim, S. M., Jeong, W., Ko, H., Yang, Y. M., Noh, M., & Han, Y. (2022) · Immunology and Cell Biology · doi:10.1111/imcb.12616 · Cited by 24
Zhou, Z., Zhang, H., Tao, Y., Jie, H., Zhao, J., Zang, J., Li, H., Wang, Y., Wang, T., Zhao, H., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112424 · Cited by 24
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Emont, M. P., & Rosen, E. D. (2023) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2023.102045 · Cited by 22
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Zhu, J., Fan, J., Xia, Y., Wang, H., Li, Y., Feng, Z., & Fu, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1219487 · Cited by 26
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Ather, J. L., Vliet, K. E. V. D., Mank, M. M., Reed, L. F., Dixon, A. E., & Poynter, M. E. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00316.2020 · Cited by 19
de Biagi, C. A. O., Cury, S. S., Alves, C. P., Rabhi, N., Silva, W. A., Farmer, S. R., Carvalho, R. F., & Júnior, M. L. B. (2021) · Cells · doi:10.3390/cells10113073 · Cited by 25
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Chen, K., Li, Y., Ni, J., Yang, X., Zhou, Y., Pang, Y., Ye, R., Chen, H., Yu, S., Wang, P., et al. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00587-3 · Cited by 22
Jang, J. H., Sung, J. H., & Huh, J. Y. (2025) · Immune Network · doi:10.4110/in.2025.25.e12 · Cited by 25
Kohda, H., Tanaka, M., Shichino, S., Arakawa, S., Komori, T., Ito, A., Wada, E., Ochi, K., Yuan, X., Takeda, T., et al. (2025) · Diabetes · doi:10.2337/db24-0762 · Cited by 22
Ijaz, A., Yarlagadda, B. R. G., & Orecchioni, M. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1589629 · Cited by 26
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Zhao, F., Yue, Z., Zhang, L., Qi, Y., Sun, Y., Wang, S., & Tian, Q. (2025) · Journal of Innate Immunity · doi:10.1159/000546476 · Cited by 23
Hoover, P., Raparia, C., Lieb, D., Tzur, Y., Kang, J. B., Arazi, A., Leavitt, R., Mishra, R., Shah, S. I., Simmons, D. P., et al. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20241873 · Cited by 28
Ahmed, H. A., Aly, H. F., Abou-Elella, F., Salem, S. H., SALAMA, Z. A. E.-R., & Aboul‐Enein, A. M. (2021) · Egyptian Journal of Chemistry · doi:10.21608/ejchem.2021.93875.4422 · Cited by 21
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Bharadwaj, S., Groza, Y., Mierzwicka, J. M., & Malý, P. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112042 · Cited by 23
Musrati, M. A., Stijlemans, B., Azouz, A., Kancheva, D., Mesbahi, S., Hadadi, E., Lebegge, E., Ali, L., De Vlaminck, K., Scheyltjens, I., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.07.007 · Cited by 21
Macrophage heterogeneity and its interactions with stromal cells in tumour microenvironment
Cao, L., Meng, X., Zhang, Z., Liu, Z., & He, Y. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01201-z · Cited by 28
Self-citationIL-6 signaling drives self-renewal and alternative activation of adipose tissue macrophages
Ackermann, J., Arndt, L., Fröba, J. S., Lindhorst, A., Glaß, M., Kirstein, M., Hobusch, C., Wunderlich, F. T., Braune, J., & Gericke, M. T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1201439 · Cited by 22
Chirality Regulates Bone Regeneration through Mechanoresponse and Immunoregulation
Lou, T., Wang, X., Li, J., Wang, W., Han, P., Yu, S., Fan, C., Zhou, C. H., & Ruan, H. (2025) · ACS Nano · doi:10.1021/acsnano.4c13164 · Cited by 20
Koike, H., Sugimura, M., Ouchi, R., Yoshimoto, Y., Manabe, I., & Oishi, Y. (2025) · Aging Cell · doi:10.1111/acel.70042 · Cited by 22
Advances in Adipose Tissue Biology
Corvera, S., Rajan, A., Townsend, K. L., Shamsi, F., Wu, J., Svensson, K. J., Zeltser, L. M., Collins, S., Reis, T., Tseng, Y., et al. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf032 · Cited by 27
Ye, H., Li, P., Zhai, Q., Yang, S., Yang, S., Sun, Y., Wu, S., Huang, R., 陈齐兴, & Fang, X. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111178 · Cited by 20
Macrophage Heterogeneity in NASH: More Than Just Nomenclature
Parthasarathy, G., & Malhi, H. (2021) · Hepatology · doi:10.1002/hep.31790 · Cited by 20
BAF60a Deficiency in Macrophage Promotes Diet-Induced Obesity and Metabolic Inflammation
Kong, Q., Zou, J., Zhang, Z., Pan, R., Zhang, Z. Y., Han, S., Xu, Y., Gao, Y., & Meng, Z. (2022) · Diabetes · doi:10.2337/db22-0114 · Cited by 22
Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils
Li, J., Ruggiero-Ruff, R. E., He, Y., Qiu, X., Lainez, N. M., Villa, P. A., Godzik, A., Coss, D., & Nair, M. G. (2023) · eLife · doi:10.7554/elife.86001 · Cited by 24
Macrophage heterogeneity in atherosclerosis: A matter of context
Wieland, E. B., Kempen, L. J., Donners, M. M. P. C., Biessen, E. A. L., & Goossens, P. (2023) · European Journal of Immunology · doi:10.1002/eji.202350464 · Cited by 26
Chen, G., Hu, X., Huang, Y., Xiang, X., Pan, S., Chen, R., & Xu, X. (2023) · MedComm · doi:10.1002/mco2.444 · Cited by 22
Maresin 1 repletion improves muscle regeneration after volumetric muscle loss
Castor‐Macias, J. A., Larouche, J. A., Wallace, E. C., Spence, B. D., Eames, A., Duran, P., Yang, B. A., Fraczek, P. M., Davis, C. S., Brooks, S. V., et al. (2023) · eLife · doi:10.7554/elife.86437 · Cited by 21
Therapeutic strategies targeting mechanisms of macrophages in diabetic heart disease
Zhang, C., Shi, Y., Liu, C., Sudesh, S. M., Zhao, H., Li, P., Liu, Q., Ma, Y., Shi, A., & Cai, H. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02273-4 · Cited by 24
Innate immunity champions: The diverse functions of macrophages
Biscu, F., Zouzaf, A., Cicia, D., Pridans, C., & Matteoli, G. (2024) · European Journal of Immunology · doi:10.1002/eji.202451139 · Cited by 25
Sato, R., Reuter, T., Hiranuma, R., Shibata, T., Fukui, R., Motoi, Y., Murakami, Y., Tsukamoto, H., Yamazaki, S., Liu, K., et al. (2020) · International Immunology · doi:10.1093/intimm/dxaa055 · Cited by 22
Mohammad-Rezaei, M., Ahmadi, R., Rafiei, A., Khaledifar, A., Fattahi, S., Samiei-Sefat, A., Emami, S., & Bagheri, N. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06441-7 · Cited by 20
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Zhu, X., Xu, Z., Liu, Y., Yang, J. M., Bai, L., Li, X., Sun, Q., Li, H., & Chen, G. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.07.039 · Cited by 19
Lanman, N. A., Meco, E., Fitchev, P., Kolliegbo, A. K., Broman, M. M., Filipovich, Y., Kothandaraman, H., Cresswell, G. M., Talaty, P., Antoniak, M., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1494476 · Cited by 20
Clark, A. T., Russo-Savage, L., Ashton, L. A., Haghshenas, N., Amselle, N. A., & Schulman, I. G. (2025) · Nature Communications · doi:10.1038/s41467-025-56565-8 · Cited by 19
Chen, Y.-F., Lee, C., Li, Y.-S. J., Lin, W.-T., Chen, H.-Y., Chen, Y., Lin, C., Ho, J. H., Lu, L., Chien, S., et al. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01467-4 · Cited by 20
Gonzalez-Hurtado, E., Leveau, C., Li, K., Mishra, M., Qu, R., Goldberg, E. L., Sidorov, S., Damani‐Yokota, P., Yeung, S. T., Khairallah, C. F., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00952-9 · Cited by 22
TREM2 in Neurodegenerative Diseases: Mechanisms and Therapeutic Potential
Li, L., Zheng, X., Ma, H., Zhu, M., Li, X., Sun, X., & Feng, X. (2025) · Cells · doi:10.3390/cells14171387 · Cited by 22
Efimova, I., Steinberg, I., Zvibel, I., Neumann, A., Mantelmacher, F. D., Drucker, D. J., Fishman, S., & Varol, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.643144 · Cited by 20
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Tomas, L., Prica, F., & Schulz, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.718432 · Cited by 22
The versatile role of TREM2 in regulating of microglia fate in the ischemic stroke
Ma, W.-Y., Wang, S., Wu, Q.-L., Zhou, X., Chu, S., & Chen, N. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108733 · Cited by 20
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Ameka, M., Beavers, W. N., Shaver, C. M., Ware, L. B., Kerchberger, V. E., Schoenfelt, K. Q., Sun, L., Koyama, T., Skaar, E. P., Becker, L., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137417 · Cited by 20
New insights into macrophage subsets in atherosclerosis
Wang, Y., Wang, Q. A., & Xu, D. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02224-0 · Cited by 19
Tada, Y., Kasai, K., Makiuchi, N., Igarashi, N., Kani, K., Takano, S., Honda, H., Yanagibashi, T., Watanabe, Y., Usui‐Kawanishi, F., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113251 · Cited by 19
The miR-23-27-24 clusters drive lipid-associated macrophage proliferation in obese adipose tissue
Sprenkle, N. T., Winn, N. C., Bunn, K. E., Zhao, Y., Park, D. J., Giese, B. G., Karijolich, J. J., Ansel, K. M., Serezani, C. H., Hasty, A. H., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112928 · Cited by 19
Wu, Y., Hsu, Y., Huang, Y., Su, Y., Wu, K., Chang, C., Ong, C.-T., Lai, J.-C., Shen, T.-Y., Lee, T.-H., et al. (2023) · Theranostics · doi:10.7150/thno.85084 · Cited by 19
Evans, F., Alí‐Ruiz, D., Rego, N., Negro‐Demontel, M. L., Lago, N., Cawen, F. A., Pannunzio, B., Sanchez-Molina, P., Reyes, L., Paolino, A., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113269 · Cited by 18
Defining and targeting macrophage heterogeneity in the mammary gland and breast cancer
Elfstrum, A. K., Bapat, A. S., & Schwertfeger, K. L. (2024) · Cancer Medicine · doi:10.1002/cam4.7053 · Cited by 22
Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases
He, X.-Y., Tan, S., Shao, Z., & Wang, X. (2021) · Genes & Diseases · doi:10.1016/j.gendis.2021.06.007 · Cited by 20
Function and mechanism of TREM2 in bacterial infection
Wu, Z., Yang, S., Fang, X., Shu, Q., & Chen, Q. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1011895 · Cited by 19
Resolution of inflammation during rheumatoid arthritis
Ye, X., Ren, D., Chen, Q., Shen, J., Wang, B., Wu, S., & Zhang, H. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1556359 · Cited by 23
TREM2 in MASH: integrating lipid metabolism and immune response
Shi, S., Zhou, Y. Y., Zhang, H., & Zhang, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1604837 · Cited by 21
Wang, Z., Zhang, Y., Li, X., Xia, N., Han, S., Pu, L., & Wang, X. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-1088 · Cited by 19
Metadata
- Authors
- Jaitin, D. A., Adlung, L., Thaiss, C. A., Weiner, A., Li, B., Descamps, H., Lundgren, P., Bleriot, C., Liu, Z., Deczkowska, A., Keren-Shaul, H., David, E., Zmora, N., Eldar, S. M., Lubezky, N., Shibolet, O., Hill, D. A., Lazar, M. A., Colonna, M., Ginhoux, F., Shapiro, H., Elinav, E., & Amit, I.
- Affiliations
- Weizmann Institute of Science (IL)
- University of Pennsylvania (US)
- Shanghai Jiao Tong University (CN)
- Tel Aviv University (IL)
- Tel Aviv Sourasky Medical Center (IL)
- Children's Hospital of Philadelphia (US)
- Washington University in St. Louis (US)
- Agency for Science, Technology and Research (SG)
- Corresponding author
- Elinav, Eran
- Amit, Ido
- ORCID
- Jaitin, Diego Adhemar
- Adlung, Lorenz
- Thaiss, Christoph A.
- Weiner, Assaf
- Li, Baoguo
- Descamps, Hélène
- Lundgren, Patrick
- Liu, Zhaoyuan
- Deczkowska, Aleksandra
- David, Eyal
- Zmora, Niv
- Eldar, Shai Meron
- Lubezky, Nir
- Shibolet, Oren
- Hill, David A.
- Lazar, Mitchell A.
- Colonna, Marco
- Ginhoux, Florent
- Shapiro, Hagit
- Elinav, Eran
- Amit, Ido
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 178
- Issue
- 3
- Pages
- 686-698.e14
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC7068689
- OpenAlex
- W2955261360
- Cited by
- 1,377
- References
- 61
- Citations by year
- 2026: 243 · 2025: 244 · 2024: 229 · 2023: 218 · 2022: 170 · 2021: 152 · 2020: 97 · 2019: 20
- FWCI
- 83.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Chan Zuckerberg Initiative
- HHMI
- European Research Council (724471-HemTree2.0)
- Thompson Family Foundation
- MRA (509044)
- Foundation (703/15)
- Ernest and Bonnie Beutler Research Program for Excellence in Genomic Medicine
- Helen and Martin Kimmel
- NeuroMac DFG/Transregional Collaborative Research Center
- International Progressive MS Alliance
- NMSS (PA-1604-08459)
- Adelis Foundation
- Wolfson Foundation
- NIH (DK116668, DK49780)
- CHOP
- The Center for Applied Genomics
- Children's Hospital of Philadelphia
- Human Metabolic Tissue Bank
- Penn Diabetes Research Center (P30 NIH DK19525, P30-DK-019525)
- Edward Mallinckrodt, Jr. Foundation
- Agilent
- Global Probiotics Council
- PennCHOP Microbiome Program
- Penn Institute for Immunology
- Penn Center for Molecular Studies in Digestive and Liver Diseases (P30-DK-050306)
- Penn Skin Biology and Diseases Resource-based Center (P30-AR-069589)
- Gilead Sciences International Research Scholars Program in Liver Disease
- The V.R. Schwartz Research Fellow Chair
- Y. and R. Ungar
- Leona M. and Harry B. Helmsley Charitable Trust
- J.L. and V. Schwartz
- D.L. Schwarz
- Israel Science Foundation
- Helmholtz Foundation
- Bill and Melinda Gates Foundation
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- TREM2, lipid-associated macrophages, white adipose tissue, obesity, adipose tissue macrophages, metabolic homeostasis, adipocyte hypertrophy, hypercholesterolemia, impaired glucose tolerance, single-cell transcriptomics, macrophage origin, metabolic disorders
- MeSH terms
- Animals, Humans, Lipids, Macrophages, Membrane Glycoproteins, Mice, Inbred C57BL, Monocytes, Obesity, Receptors, Immunologic, Signal Transduction, Glucose Intolerance, Mice, Knockout, Intra-Abdominal Fat, Lipid Metabolism, Mice, Adipose Tissue, White, Single-Cell Analysis, Diet, High-Fat
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