The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity
Open accessAbstract
Summary Cutaneous TRPV1+ neurons directly sense noxious stimuli, inflammatory cytokines and pathogen-associated molecules and are required for innate immunity against some skin pathogens. Important unanswered questions are whether TRPV1+ neuron activation in isolation is sufficient to initiate innate immune responses and what is the biological function for TRPV1+ neuron-initiated immune responses. We used TRPV1-Ai32 optogenetic mice and cutaneous light stimulation to activate cutaneous neurons in the absence of tissue damage or pathogen-associated products. We found that TRPV1+ neuron activation was sufficient to elicit a local Type-17 immune response that augmented host defense to C. albicans and S. aureus. Moreover, local neuron activation elicited Type-17 responses and augmented host defense at adjacent, unstimulated skin through a nerve reflex arc. These data show the sufficiency of TRPV1+ neuron activation for host defense and demonstrate the existence of functional anticipatory innate immunity at sites adjacent to infection that depends on antidromic neuron activation.
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Cited by
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Metadata
- Authors
- Cohen, J. A., Edwards, T. N., Liu, A. W., Hirai, T., Jones, M. R., Wu, J., Li, Y., Zhang, S., Ho, J., Davis, B. M., Albers, K. M., & Kaplan, D. H.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 178
- Issue
- 4
- Pages
- 919-932.e14
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2963600298
- Cited by
- 371
- References
- 57
- FWCI
- 20.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cohen, J. A., Edwards, T. N., Liu, A. W., Hirai, T., Jones, M. R., Wu, J., Li, Y., Zhang, S., Ho, J., Davis, B. M., Albers, K. M., & Kaplan, D. H. (2019). Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity. Cell. https://doi.org/10.1016/j.cell.2019.06.022
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