The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
R Loops: From Physiological to Pathological Roles
Open accessAbstract
DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent non-scheduled co-transcriptional structures with a negative impact on transcription, replication and DNA repair. Accumulating evidence suggests that they constitute a source of replication stress, DNA breaks and genome instability. Reciprocally, DNA breaks facilitate DNA-RNA hybrid formation by releasing the double helix torsional conformation. Cells avoid DNA-RNA accumulation by either preventing or removing hybrids directly or by DNA repair-coupled mechanisms. Given the R-loop impact on chromatin and genome organization and its potential relation with genetic diseases, we review R-loop homeostasis as well as their physiological and pathological roles.
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Cites
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679
An Oncogene-Induced DNA Damage Model for Cancer Development
Halazonetis, T. D., Gorgoulis, V. G., & Bartek, J. (2008) · Science · doi:10.1126/science.1140735 · Cited by 1,851
R Loops: From Transcription Byproducts to Threats to Genome Stability
Aguilera, A., & García-Muse, T. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.009 · Cited by 1,026
Self-citationR-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters
Ginno, P. A., Lott, P. L., Christensen, H. C., Korf, I., & Chédin, F. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.01.017 · Cited by 910
Skourti-Stathaki, K., Proudfoot, N. J., & Gromak, N. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.026 · Cited by 819
Inactivation of the SR Protein Splicing Factor ASF/SF2 Results in Genomic Instability
Li, X., & Manley, J. L. (2005) · Cell · doi:10.1016/j.cell.2005.06.008 · Cited by 769
Huertas, P., & Aguilera, A. (2003) · Molecular Cell · doi:10.1016/j.molcel.2003.08.010 · Cited by 746
Self-citationR-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
Yu, K., Chedin, F., Hsieh, C.-L., Wilson, T. E., & Lieber, M. R. (2003) · Nature Immunology · doi:10.1038/ni919 · Cited by 746
R-Loops as Cellular Regulators and Genomic Threats
Crossley, M. P., Bocek, M., & Cimprich, K. A. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.01.024 · Cited by 746
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Bossaert, M., Pipier, A., Riou, J.-F., Noirot, C., Nguyên, L.-T., Serre, R.-F., Bouchez, O., Defrancq, E., Calsou, P., Britton, S., et al. (2021) · eLife · doi:10.7554/elife.65184 · Cited by 97
“We also demonstrate that impairing RNA-Pol II progression by inhibiting the transcriptional elongation-promoting BRD4 protein increases the number of DSBs induced by PDS. Interestingly, the inhibition of BRD4 and TOP1 activities as well as the reduction of RNA-Pol elongation has been shown to promote R-loops (Shivji e…”
BackgroundDNA damage and transcription stress
Milano, L., Gautam, A., & Caldecott, K. W. (2024) · Molecular Cell · doi:10.1016/j.molcel.2023.11.014 · Cited by 88
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes
Giordano, A. M. S., Luciani, M., Gatto, F., Abou Alezz, M., Beghè, C., Della Volpe, L., Migliara, A., Valsoni, S., Genua, M., Dzieciatkowska, M., et al. (2022) · Journal of Experimental Medicine · doi:10.1084/jem.20211121 · Cited by 76
Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factor
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Metadata
- Authors
- García-Muse, T., & Aguilera, A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 179
- Issue
- 3
- Pages
- 604-618
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2979531443
- Cited by
- 697
- References
- 127
- FWCI
- 18.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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