Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

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1. International Journal of Alzheimer's Disease
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2. The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease
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3. Step by step: towards a better understanding of the genetic architecture of Alzheimer’s disease
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4. Amyloid-β impairs mitochondrial dynamics and autophagy in Alzheimer’s disease experimental models
   Macarena de la Cueva, Desireé Antequera, Lara Ordóñez‐Gutiérrez, Francisco G. Wandosell, Antoni Camins, Eva Carro, Fernando Benito Bartolomé · 2022 · Scientific Reports
5. Simultaneous Sensing of H2S and ATP with a Two-Photon Fluorescent Probe in Alzheimer’s Disease: toward Understanding Why H2S Regulates Glutamate-Induced ATP Dysregulation
   Panpan Sun, Haichao Chen, Siyu Lu, Jun Hai, Wenting Guo, Yuhong Jing, Baodui Wang · 2022 · Analytical Chemistry
6. Revisiting the critical roles of reactive astrocytes in neurodegeneration
   Kang Qian, Xiaobing Jiang, Zhiqiang Liu, Juan Zhang, Peng Fei Fu, Ying Su, Nadezda A. Brazhe, Dan Liu, Ling‐Qiang Zhu · 2023 · Molecular Psychiatry
7. Conv-Swinformer: Integration of CNN and shift window attention for Alzheimer's disease classification
   Zhentao Hu, Yan-Yang Li, Zheng Wang, Shuo Zhang, Wei Hou · 2023 · Comput. Biol. Medicine
8. Alzheimer’s disease – the journey of a healthy brain into organ failure
   Todd Eliot Golde · 2022 · Molecular Neurodegeneration
9. The Protective Effects of Osteocyte‐Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging
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10. The Gut Microbiota Modulates Neuroinflammation in Alzheimer's Disease: Elucidating Crucial Factors and Mechanistic Underpinnings
    Jianshe Yang, Junyi Liang, Niyuan Hu, Ningjuan He, Bin Liu, Guoliang Liu, Ying Qin · 2024 · CNS Neuroscience & Therapeutics
11. Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life
    Uhlmann, Ruth E., Rother, Christine, Rasmussen, Jay, Schelle, Juliane, Bergmann, Carina, Ullrich Gavilanes, Emily M., Fritschi, Sarah K., Buehler, Anika, Baumann, Frank, Skodras, Angelos et al. · 2020 · Nature Neuroscience
12. Friend, Foe or Both? Immune Activity in Alzheimer’s Disease
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13. Recent ultrasound advancements for the manipulation of nanobiomaterials and nanoformulations for drug delivery
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14. Modeling Alzheimer’s Disease in Caenorhabditis elegans
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15. Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer’s Disease Management
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16. Detection of multiplex exosomal miRNAs for clinically accurate diagnosis of Alzheimer’s disease using label-free plasmonic biosensor based on DNA-Assembled advanced plasmonic architecture
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17. Statins Use in Alzheimer Disease: Bane or Boon from Frantic Search and Narrative Review
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18. AlzGPS: a genome-wide positioning systems platform to catalyze multi-omics for Alzheimer’s drug discovery
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19. A nanocleaner specifically penetrates the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer's disease
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20. Synaptic dysfunction in early phases of Alzheimer's Disease
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21. Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition
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22. Multipronged diagnostic and therapeutic strategies for Alzheimer's disease
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23. Aβ plaques
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24. Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer’s disease
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25. Iron Dysregulation in Mitochondrial Dysfunction and Alzheimer’s Disease
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26. Proteotoxicity and Neurodegenerative Diseases
    Clara Ruz, José Luis Alcantud, Francisco Vives Montero, Raquel Durán, Sara Bandrés‐Ciga · 2020 · International Journal of Molecular Sciences
27. Identification of immune microenvironment subtypes and signature genes for Alzheimer’s disease diagnosis and risk prediction based on explainable machine learning
    Yongxing Lai, Peiqiang Lin, Fan Lin, Manli Chen, Chunjin Lin, Xing Lin, Lijuan Wu, Mouwei Zheng, Jianhao Chen · 2022 · Frontiers in Immunology
28. Alzheimer’s Disease: A Brief History of Immunotherapies Targeting Amyloid β
    Anne‐Cathrine S. Vogt, Gary T. Jennings, Mona Omar Mohsen, Monique Vogel, Martin F. Bachmann · 2023 · International Journal of Molecular Sciences
29. Current trends in blood biomarker detection and imaging for Alzheimer’s disease
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30. Functions of amyloid precursor protein in metabolic diseases
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31. Oxygen metabolism abnormality and Alzheimer's disease: An update
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32. The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment
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33. Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with Aβ‐PET, neurodegeneration, and cognition
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34. Gut Microbiota: Implications in Alzheimer’s Disease
    Yixi He, Binyin Li, Dingya Sun, Shengdi Chen · 2020 · Journal of Clinical Medicine
35. The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates
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36. Can exercise training teach us how to treat Alzheimer's disease?
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37. A Review on Tramiprosate (Homotaurine) in Alzheimer's Disease and Other Neurocognitive Disorders
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38. β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice
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39. Unraveling the impact of Omega-3 polyunsaturated fatty acids on blood-brain barrier (BBB) integrity and glymphatic function
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40. Plasma p‐tau217 and p‐tau217/Aβ1‐42 are effective biomarkers for identifying CSF‐ and PET imaging‐diagnosed Alzheimer's disease: Insights for research and clinical practice
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41. The Links between Cardiovascular Diseases and Alzheimer's Disease
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42. Sleep, circadian rhythm and gut microbiota: alterations in Alzheimer’s disease and their potential links in the pathogenesis
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43. Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer’s disease brains
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44. TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease
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45. Profiling the molecular signature of satellite glial cells at the single cell level reveals high similarities between rodents and humans
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46. Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming
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47. Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer’s Disease
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48. Transmission of Alzheimer’s disease-associated microbiota dysbiosis and its impact on cognitive function: evidence from mice and patients
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49. Neuropathological Mechanisms Associated with Pesticides in Alzheimer’s Disease
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50. Targeting the Wnt/β-catenin pathway in neurodegenerative diseases: recent approaches and current challenges
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51. Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1–FOXO1/3–PINK1–Parkin-mediated mitophagy
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52. Identification of a Novel Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase: In Vitro and In Silico Studies
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53. Dietary Fiber and Microbiota Metabolite Receptors Enhance Cognition and Alleviate Disease in the 5xFAD Mouse Model of Alzheimer’s Disease
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54. Targeting autophagy in Alzheimer’s disease: Animal models and mechanisms
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55. Nanoparticle-mediated approaches for Alzheimer’s disease pathogenesis, diagnosis, and therapeutics
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56. Brain metabolism in Alzheimer’s disease: biological mechanisms of exercise
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57. When Good Kinases Go Rogue: GSK3, p38 MAPK and CDKs as Therapeutic Targets for Alzheimer’s and Huntington’s Disease
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58. Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease
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60. Integrative metabolomics science in Alzheimer’s disease: Relevance and future perspectives
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62. Genomics and Functional Genomics of Alzheimer's Disease
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63. Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system
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64. Alzheimer’s Disease Diagnosis Using Machine Learning: A Survey
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65. The neuroinflammatory role of microglia in Alzheimer's disease and their associated therapeutic targets
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66. Melatonin: A potential nighttime guardian against Alzheimer’s
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67. Multi-omics analyses identify gut microbiota-fecal metabolites-brain-cognition pathways in the Alzheimer’s disease continuum
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68. Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes
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69. Therapy for Alzheimer’s disease: Missing targets and functional markers?
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70. Phage display derived peptides for Alzheimer's disease therapy and diagnosis
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71. Epigallocatechin-3-gallate Alleviates Cognitive Deficits in APP/PS1 Mice
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72. Brainwide Genetic Sparse Cell Labeling to Illuminate the Morphology of Neurons and Glia with Cre-Dependent MORF Mice
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73. Western Diet Induces Impairment of Liver-Brain Axis Accelerating Neuroinflammation and Amyloid Pathology in Alzheimer's Disease
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74. Regulation of neuronal autophagy and the implications in neurodegenerative diseases
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75. Association of Peripheral Blood Cell Profile With Alzheimer's Disease: A Meta-Analysis
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76. AlCl3 induced learning and memory deficit in zebrafish
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77. Targeting Microglia in Alzheimer’s Disease: Pathogenesis and Potential Therapeutic Strategies
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78. Short-chain fatty acids: Important components of the gut-brain axis against AD
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79. Toll-like receptors in Alzheimer's disease
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80. Actin-mediated Microglial Chemotaxis via G-Protein Coupled Purinergic Receptor in Alzheimer’s Disease
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81. Dysregulated Wnt Signalling in the Alzheimer’s Brain
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82. Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update
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83. Intranasal Transplantation of Human Neural Stem Cells Ameliorates Alzheimer's Disease-Like Pathology in a Mouse Model
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85. Safety and efficacy of lecanemab for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials
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86. The Role of P2X7 Receptor in Alzheimer’s Disease
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87. d-Serine, the Shape-Shifting NMDA Receptor Co-agonist
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88. A Multilevel View of the Development of Alzheimer’s Disease
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89. The Potential Role of Ferroptosis in Alzheimer’s Disease
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90. Dietary Protection against Cognitive Impairment, Neuroinflammation and Oxidative Stress in Alzheimer’s Disease Animal Models of Lipopolysaccharide-Induced Inflammation
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91. B lymphocytes ameliorate Alzheimer’s disease-like neuropathology via interleukin-35
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92. Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies
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93. Microglial Activation and Priming in Alzheimer’s Disease: State of the Art and Future Perspectives
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94. Organismal Protein Homeostasis Mechanisms
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95. Gut Microbiota, Probiotic Interventions, and Cognitive Function in the Elderly: A Review of Current Knowledge
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97. Tear Biomarkers in Alzheimer’s and Parkinson’s Diseases, and Multiple Sclerosis: Implications for Diagnosis (Systematic Review)
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99. RTN4B‐mediated suppression of Sirtuin 2 activity ameliorates β‐amyloid pathology and cognitive impairment in Alzheimer's disease mouse model
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100. Quercetin‐3‐O‐Glucuronide Alleviates Cognitive Deficit and Toxicity in Aβ1‐42‐Induced AD‐Like Mice and SH‐SY5Y Cells
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