The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging
Open accessAbstract
Summary Mammalian tissues engage in specialized physiology that is regulated through reversible modification of protein cysteine residues by reactive oxygen species (ROS). ROS regulate a myriad of biological processes, but the protein targets of ROS modification that drive tissue-specific physiology in vivo are largely unknown. Here we develop Oximouse, a comprehensive and quantitative mapping of the mouse cysteine redox proteome in vivo. We use Oximouse to establish several paradigms of physiological redox signaling. We define and validate cysteine redox networks within each tissue that are tissue-selective and underlie tissue-specific biology. We describe a common mechanism for encoding cysteine redox sensitivity by electrostatic gating. Moreover, we comprehensively identify redox-modified disease networks that remodel in aged mice, establishing a systemic molecular basis for the longstanding proposed links between redox dysregulation and tissue aging. We provide the Oximouse compendium as a framework for understanding mechanisms of redox regulation in physiology and aging.
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Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
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Metadata
- Authors
- Xiao, H., Jedrychowski, M. P., Schweppe, D. K., Huttlin, E. L., Yu, Q., Heppner, D. E., Li, J., Long, J., Mills, E. L., Szpyt, J., He, Z., Du, G., Garrity, R., Reddy, A., Vaites, L. P., Paulo, J. A., Zhang, T., Gray, N. S., Gygi, S. P., & Chouchani, E. T.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 180
- Issue
- 5
- Pages
- 968-983.e24
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W3007811953
- Cited by
- 409
- References
- 74
- FWCI
- 13.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Xiao, H., Jedrychowski, M. P., Schweppe, D. K., Huttlin, E. L., Yu, Q., Heppner, D. E., Li, J., Long, J., Mills, E. L., Szpyt, J., He, Z., Du, G., Garrity, R., Reddy, A., Vaites, L. P., Paulo, J. A., Zhang, T., Gray, N. S., Gygi, S. P., & Chouchani, E. T. (2020). A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. https://doi.org/10.1016/j.cell.2020.02.012
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