The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells
Open accessAbstract
Long noncoding RNAs (lncRNAs) evolve more rapidly than mRNAs. Whether conserved lncRNAs undergo conserved processing, localization, and function remains unexplored. We report differing subcellular localization of lncRNAs in human and mouse embryonic stem cells (ESCs). A significantly higher fraction of lncRNAs is localized in the cytoplasm of hESCs than in mESCs. This turns out to be important for hESC pluripotency. FAST is a positionally conserved lncRNA but is not conserved in its processing and localization. In hESCs, cytoplasm-localized hFAST binds to the WD40 domain of the E3 ubiquitin ligase β-TrCP and blocks its interaction with phosphorylated β-catenin to prevent degradation, leading to activated WNT signaling, required for pluripotency. In contrast, mFast is nuclear retained in mESCs, and its processing is suppressed by the splicing factor PPIE, which is highly expressed in mESCs but not hESCs. These findings reveal that lncRNA processing and localization are previously under-appreciated contributors to the rapid evolution of function.
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Metadata
- Authors
- Guo, C.-J., Ma, X.-K., Xing, Y.-H., Zheng, C.-C., Xu, Y.-F., Shan, L., Zhang, J., Wang, S., Wang, Y., Carmichael, G. G., Yang, L., & Chen, L.-L.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 181
- Issue
- 3
- Pages
- 621-636.e22
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W3014773636
- Cited by
- 304
- References
- 82
- FWCI
- 16.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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