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The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities

Open access
Jia, Na, Wang, Jinfeng, Shi, Wenqiang, Du, Lifeng, Sun, Yi, Zhan, Wei, Jiang, Jia-Fu, Wang, Qian, Zhang, Bing, Ji, Peifeng, Bell-Sakyi, Lesley, Cui, Xiao-Ming, Yuan, Ting-Ting, Jiang, Bao-Gui, Yang, Wei-Fei, Lam, Tommy Tsan-Yuk, Chang, Qiao-Cheng, Ding, Shu-Jun, Wang, Xian-Jun, Zhu, Jin-Guo, Ruan, Xiang-Dong, Zhao, Lin, Wei, Jia-Te, Ye, Run-Ze, Que, Teng Cheng, Du, Chun-Hong, Zhou, Yu-Hao, Cheng, Jing Xia, Dai, Pei-Fang, Guo, Wen-Bin, Han, Xiao-Hu, Huang, En-Jiong, Li, Lian-Feng, Wei, Wei, Gao, Yu-Chi, Liu, Jing-Ze, Shao, Hong-Ze, Wang, Xin, Wang, Chong-Cai, Yang, Tian-Ci, Huo, Qiu-Bo, Li, Wei, Chen, Hai-Ying, Chen, Shen-En, Zhou, Ling-Guo, Ni, Xue-Bing, Tian, Jun-Hua, Sheng, Yue, Liu, Tao, Pan, Yu-Sheng, Xia, Luo-Yuan, Li, Jie, Zhao, Fangqing, Cao, Wu-Chun·2020·Cell

Abstract

Among arthropod vectors, ticks transmit the most diverse human and animal pathogens, leading to an increasing number of new challenges worldwide. Here we sequenced and assembled high-quality genomes of six ixodid tick species and further resequenced 678 tick specimens to understand three key aspects of ticks: genetic diversity, population structure, and pathogen distribution. We explored the genetic basis common to ticks, including heme and hemoglobin digestion, iron metabolism, and reactive oxygen species, and unveiled for the first time that genetic structure and pathogen composition in different tick species are mainly shaped by ecological and geographic factors. We further identified species-specific determinants associated with different host ranges, life cycles, and distributions. The findings of this study are an invaluable resource for research and control of ticks and tick-borne diseases.

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Metadata

Authors
Jia, N., Wang, J., Shi, W., Du, L., Sun, Y., Zhan, W., Jiang, J.-F., Wang, Q., Zhang, B., Ji, P., Bell-Sakyi, L., Cui, X.-M., Yuan, T.-T., Jiang, B.-G., Yang, W.-F., Lam, T. T.-Y., Chang, Q.-C., Ding, S.-J., Wang, X.-J., Zhu, J.-G., Ruan, X.-D., Zhao, L., Wei, J.-T., Ye, R.-Z., Que, T. C., Du, C.-H., Zhou, Y.-H., Cheng, J. X., Dai, P.-F., Guo, W.-B., Han, X.-H., Huang, E.-J., Li, L.-F., Wei, W., Gao, Y.-C., Liu, J.-Z., Shao, H.-Z., Wang, X., Wang, C.-C., Yang, T.-C., Huo, Q.-B., Li, W., Chen, H.-Y., Chen, S.-E., Zhou, L.-G., Ni, X.-B., Tian, J.-H., Sheng, Y., Liu, T., Pan, Y.-S., Xia, L.-Y., Li, J., Zhao, F., & Cao, W.-C.
Venue
Cell
Publisher
Elsevier BV
Published
2020-09
Volume
182
Issue
5
Pages
1328-1340.e13
ISSN
0092-8674 (ISSN-L)
OpenAlex
W3064831296
Cited by
317
References
13
FWCI
29.53
Type
journal article
Language
en
Open access
bronze

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Jia, N., Wang, J., Shi, W., Du, L., Sun, Y., Zhan, W., Jiang, J.-F., Wang, Q., Zhang, B., Ji, P., Bell-Sakyi, L., Cui, X.-M., Yuan, T.-T., Jiang, B.-G., Yang, W.-F., Lam, T. T.-Y., Chang, Q.-C., Ding, S.-J., Wang, X.-J., . . . Cao, W.-C. (2020). Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities. Cell. https://doi.org/10.1016/j.cell.2020.07.023

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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