The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities
Open accessAbstract
Among arthropod vectors, ticks transmit the most diverse human and animal pathogens, leading to an increasing number of new challenges worldwide. Here we sequenced and assembled high-quality genomes of six ixodid tick species and further resequenced 678 tick specimens to understand three key aspects of ticks: genetic diversity, population structure, and pathogen distribution. We explored the genetic basis common to ticks, including heme and hemoglobin digestion, iron metabolism, and reactive oxygen species, and unveiled for the first time that genetic structure and pathogen composition in different tick species are mainly shaped by ecological and geographic factors. We further identified species-specific determinants associated with different host ranges, life cycles, and distributions. The findings of this study are an invaluable resource for research and control of ticks and tick-borne diseases.
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Fourteen anti-tick vaccine targets are variably conserved in cattle fever ticks
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Metadata
- Authors
- Jia, N., Wang, J., Shi, W., Du, L., Sun, Y., Zhan, W., Jiang, J.-F., Wang, Q., Zhang, B., Ji, P., Bell-Sakyi, L., Cui, X.-M., Yuan, T.-T., Jiang, B.-G., Yang, W.-F., Lam, T. T.-Y., Chang, Q.-C., Ding, S.-J., Wang, X.-J., Zhu, J.-G., Ruan, X.-D., Zhao, L., Wei, J.-T., Ye, R.-Z., Que, T. C., Du, C.-H., Zhou, Y.-H., Cheng, J. X., Dai, P.-F., Guo, W.-B., Han, X.-H., Huang, E.-J., Li, L.-F., Wei, W., Gao, Y.-C., Liu, J.-Z., Shao, H.-Z., Wang, X., Wang, C.-C., Yang, T.-C., Huo, Q.-B., Li, W., Chen, H.-Y., Chen, S.-E., Zhou, L.-G., Ni, X.-B., Tian, J.-H., Sheng, Y., Liu, T., Pan, Y.-S., Xia, L.-Y., Li, J., Zhao, F., & Cao, W.-C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 182
- Issue
- 5
- Pages
- 1328-1340.e13
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W3064831296
- Cited by
- 317
- References
- 13
- FWCI
- 29.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jia, N., Wang, J., Shi, W., Du, L., Sun, Y., Zhan, W., Jiang, J.-F., Wang, Q., Zhang, B., Ji, P., Bell-Sakyi, L., Cui, X.-M., Yuan, T.-T., Jiang, B.-G., Yang, W.-F., Lam, T. T.-Y., Chang, Q.-C., Ding, S.-J., Wang, X.-J., . . . Cao, W.-C. (2020). Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities. Cell. https://doi.org/10.1016/j.cell.2020.07.023
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