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The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Mitocytosis, a migrasome-mediated mitochondrial quality-control process

Jiao, Haifeng, Jiang, Dong, Hu, Xiaoyu, Du, Wanqing, Ji, Liangliang, Yang, Yuzhuo, Li, Xiaopeng, Sho, Takami, Wang, Xuan, Li, Ying, Wu, Yu-Ting, Wei, Yau-Huei, Hu, Xiaoyu, Yu, Li·2021·Cell
DOI 10.1016/j.cell.2021.04.027
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Abstract

Damaged mitochondria need to be cleared to maintain the quality of the mitochondrial pool. Here, we report mitocytosis, a migrasome-mediated mitochondrial quality-control process. We found that, upon exposure to mild mitochondrial stresses, damaged mitochondria are transported into migrasomes and subsequently disposed of from migrating cells. Mechanistically, mitocytosis requires positioning of damaged mitochondria at the cell periphery, which occurs because damaged mitochondria avoid binding to inward motor proteins. Functionally, mitocytosis plays an important role in maintaining mitochondrial quality. Enhanced mitocytosis protects cells from mitochondrial stressor-induced loss of mitochondrial membrane potential (MMP) and mitochondrial respiration; conversely, blocking mitocytosis causes loss of MMP and mitochondrial respiration under normal conditions. Physiologically, we demonstrate that mitocytosis is required for maintaining MMP and viability in neutrophils in vivo. We propose that mitocytosis is an important mitochondrial quality-control process in migrating cells, which couples mitochondrial homeostasis with cell migration.

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Research works printed but not linked: 19

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Cited by

Metadata

Authors
Jiao, H., Jiang, D., Hu, X., Du, W., Ji, L., Yang, Y., Li, X., Sho, T., Wang, X., Li, Y., Wu, Y.-T., Wei, Y.-H., Hu, X., & Yu, L.
ORCID
Yang, Yuzhuo
Venue
Cell
Publisher
Elsevier BV
Published
2021-05
Volume
184
Issue
11
Pages
2896-2910.e13
ISSN
0092-8674
DOI
10.1016/j.cell.2021.04.027
Cited by
570
References
8
Language
en
Licence
Funders
  • Ministry of Science and Technology of the People's Republic of China
  • National Natural Science Foundation of China
  • Beijing Municipal Science and Technology Commission

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