Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking
Open accessAbstract
A proper balance between chemical reduction and oxidation (known as redox balance) is essential for normal cellular physiology. Deregulation in the production of oxidative species leads to DNA damage, lipid peroxidation and aberrant post-translational modification of proteins, which in most cases induces injury, cell death and disease. However, physiological concentrations of oxidative species are necessary to support important cell functions, such as chemotaxis, hormone synthesis, immune response, cytoskeletal remodeling, Ca(2+) homeostasis and others. Recent evidence suggests that redox balance regulates actin and microtubule dynamics in both physiological and pathological contexts. Microtubules and actin microfilaments contain certain amino acid residues that are susceptible to oxidation, which reduces the ability of microtubules to polymerize and causes severing of actin microfilaments in neuronal and non-neuronal cells. In contrast, inhibited production of reactive oxygen species (ROS; e.g., due to NOXs) leads to aberrant actin polymerization, decreases neurite outgrowth and affects the normal development and polarization of neurons. In this review, we summarize emerging evidence suggesting that both general and specific enzymatic sources of redox species exert diverse effects on cytoskeletal dynamics. Considering the intimate relationship between cytoskeletal dynamics and trafficking, we also discuss the potential effects of redox balance on intracellular transport via regulation of the components of the microtubule and actin cytoskeleton as well as cytoskeleton-associated proteins, which may directly impact localization of proteins and vesicles across the soma, dendrites and axon of neurons.
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High blue light can cause ROS to regulate chloroplast light-avoiding movement by regulating the polymerization or depolymerization of actin filaments.
“High blue light can cause ROS (produced by high-energy concentrations to induce NADPH oxidase) to regulate chloroplast light-avoiding movement by regulating the polymerization or depolymerization of actin filaments”
From The action of enhancing weak light capture via phototropic growth and chloroplast movement in plants (2022) · cites this paper as Wilson and González-Billault, 2015
The section “Actin Modification and Regulation of F-Actin Dynamics by Oxidative Species” (page not provided) reports that ROS affect actin polymerization and filament dynamics. It discusses immune cells and neurons, not high-blue-light exposure or chloroplast light-avoiding movement; those specific parts of the claim are unsupported by our copy. (LLM, conf=0.88)
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- Authors
- Wilson, C., & González-Billault, C.
- Affiliations
- University of Chile (CL)
- Corresponding author
- González-Billault, Christian
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-09-30
- Volume
- 9
- Pages
- 381-381
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4588006
- OpenAlex
- W1850305390
- Cited by
- 238
- References
- 103
- Citations by year
- 2026: 23 · 2025: 19 · 2024: 12 · 2023: 14 · 2022: 32 · 2021: 32 · 2020: 35 · 2019: 22 · 2018: 16 · 2017: 14 · 2016: 16 · 2015: 2
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Funders
- Comisión Nacional de Investigación Científica y Tecnológica (ACT1114, 21120221)
- Fondo Nacional de Desarrollo Científico y Tecnológico (1140325)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- redox signaling, oxidative stress, redox homeostasis, cytoskeletal dynamics, actin dynamics, microtubule dynamics, reactive oxygen species, neuronal development, neuronal polarity, neurite outgrowth, intracellular trafficking, axonal transport, protein oxidation, nitric oxide synthase
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