Glioma progression is shaped by genetic evolution and microenvironment interactions

Varn, Frederick S.; Johnson, Kevin C.; Martinek, Jan; Huse, Jason T.; Nasrallah, MacLean P.; Wesseling, Pieter; Cooper, Lee A.D.; Malta, Tathiane M.; Wade, Taylor E.; Sabedot, Thais S.; Brat, Daniel; Gould, Peter V.; Wöehrer, Adelheid; Aldape, Kenneth; Ismail, Azzam; Sivajothi, Santhosh K.; Barthel, Floris P.; Kim, Hoon; Kocakavuk, Emre; Ahmed, Nazia; White, Kieron; Datta, Indrani; Moon, Hyo-Eun; Pollock, Steven; Goldfarb, Christine; Lee, Ga-Hyun; Garofano, Luciano; Anderson, Kevin J.; Nehar-Belaid, Djamel; Barnholtz-Sloan, Jill S.; Bakas, Spyridon; Byrne, Annette T.; D’Angelo, Fulvio; Gan, Hui K.; Khasraw, Mustafa; Migliozzi, Simona; Ormond, D. Ryan; Paek, Sun Ha; Van Meir, Erwin G.; Walenkamp, Annemiek M.E.; Watts, Colin; Weiss, Tobias; Weller, Michael; Palucka, Karolina; Stead, Lucy F.; Poisson, Laila M.; Noushmehr, Houtan; Iavarone, Antonio; Verhaak, Roel G.W.; Varn, Frederick S.

doi:10.1016/j.cell.2022.04.038

Cited by 494

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

Glioma progression is shaped by genetic evolution and microenvironment interactions

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Varn, Frederick S., Johnson, Kevin C., Martinek, Jan, Huse, Jason T., Nasrallah, MacLean P., Wesseling, Pieter, Cooper, Lee A.D., Malta, Tathiane M., Wade, Taylor E., Sabedot, Thais S., Brat, Daniel, Gould, Peter V., Wöehrer, Adelheid, Aldape, Kenneth, Ismail, Azzam, Sivajothi, Santhosh K., Barthel, Floris P., Kim, Hoon, Kocakavuk, Emre, Ahmed, Nazia, White, Kieron, Datta, Indrani, Moon, Hyo-Eun, Pollock, Steven, Goldfarb, Christine, Lee, Ga-Hyun, Garofano, Luciano, Anderson, Kevin J., Nehar-Belaid, Djamel, Barnholtz-Sloan, Jill S., Bakas, Spyridon, Byrne, Annette T., D’Angelo, Fulvio, Gan, Hui K., Khasraw, Mustafa, Migliozzi, Simona, Ormond, D. Ryan, Paek, Sun Ha, Van Meir, Erwin G., Walenkamp, Annemiek M.E., Watts, Colin, Weiss, Tobias, Weller, Michael, Palucka, Karolina, Stead, Lucy F., Poisson, Laila M., Noushmehr, Houtan, Iavarone, Antonio, Verhaak, Roel G.W., Varn, Frederick S., Johnson, Kevin C., Martinek, Jan, Huse, Jason T., Nasrallah, MacLean P., Wesseling, Pieter, Cooper, Lee A.D., Malta, Tathiane M., Wade, Taylor E., Sabedot, Thais S., Brat, Daniel, Gould, Peter V., Wöehrer, Adelheid, Aldape, Kenneth, Ismail, Azzam, Sivajothi, Santhosh K., Barthel, Floris P., Kim, Hoon, Kocakavuk, Emre, Ahmed, Nazia, White, Kieron, Datta, Indrani, Moon, Hyo-Eun, Pollock, Steven, Goldfarb, Christine, Lee, Ga-Hyun, Garofano, Luciano, Anderson, Kevin J., Nehar-Belaid, Djamel, Barnholtz-Sloan, Jill S., Bakas, Spyridon, Byrne, Annette T., D’Angelo, Fulvio, Gan, Hui K., Khasraw, Mustafa, Migliozzi, Simona, Ryan Ormond, D., Ha Paek, Sun, Van Meir, Erwin G., Walenkamp, Annemiek M.E., Watts, Colin, Weiss, Tobias, Weller, Michael, Alfaro, Kristin D., Amin, Samirkumar B., Ashley, David M., Bock, Christoph, Brodbelt, Andrew, Bulsara, Ketan R., Castro, Ana Valeria, Connelly, Jennifer M., Costello, Joseph F., de Groot, John F., Finocchiaro, Gaetano, French, Pim J., Golebiewska, Anna, Hau, Ann C., Hong, Chibo, Horbinski, Craig, Kannan, Kasthuri S., Kouwenhoven, Mathilde CM., Lasorella, Anna, LaViolette, Peter S., Ligon, Keith L., Lowman, Allison K., Mehta, Shwetal, Miletic, Hrvoje, Molinaro, Annette M., Ng, Ho Keung, Niclou, Simone P., Niers, Johanna M., Phillips, Joanna J., Rabadan, Raul, Rao, Ganesh, Reifenberger, Guido, Sanai, Nader, Short, Susan C., Sillevis Smitt, Peter, Sloan, Andrew E., Smits, Marion, Snyder, James M., Suzuki, Hiromichi, Tabatabai, Ghazaleh, Tanner, Georgette, Tomaszewski, William H., Wells, Michael, Westerman, Bart A., Wheeler, Helen, Xie, Jichun, Alfred Yung, W.K., Zadeh, Gelareh, Zhao, Junfei, Palucka, Karolina, Stead, Lucy F., Poisson, Laila M., Noushmehr, Houtan, Iavarone, Antonio, Verhaak, Roel GW.·2022·Cell

DOI 10.1016/j.cell.2022.04.038

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Abstract

The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patients with isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant glioma. Tumors recurred in distinct manners that were dependent on IDH mutation status and attributable to changes in histological feature composition, somatic alterations, and microenvironment interactions. Hypermutation and acquired CDKN2A deletions were associated with an increase in proliferating neoplastic cells at recurrence in both glioma subtypes, reflecting active tumor growth. IDH-wild-type tumors were more invasive at recurrence, and their neoplastic cells exhibited increased expression of neuronal signaling programs that reflected a possible role for neuronal interactions in promoting glioma progression. Mesenchymal transition was associated with the presence of a myeloid cell state defined by specific ligand-receptor interactions with neoplastic cells. Collectively, these recurrence-associated phenotypes represent potential targets to alter disease progression.

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Authors: Varn, F. S., Johnson, K. C., Martinek, J., Huse, J. T., Nasrallah, M. P., Wesseling, P., Cooper, L. A. D., Malta, T. M., Wade, T. E., Sabedot, T. S., Brat, D., Gould, P. V., Wöehrer, A., Aldape, K., Ismail, A., Sivajothi, S. K., Barthel, F. P., Kim, H., Kocakavuk, E., Ahmed, N., White, K., Datta, I., Moon, H.-E., Pollock, S., Goldfarb, C., Lee, G.-H., Garofano, L., Anderson, K. J., Nehar-Belaid, D., Barnholtz-Sloan, J. S., Bakas, S., Byrne, A. T., D’Angelo, F., Gan, H. K., Khasraw, M., Migliozzi, S., Ormond, D. R., Paek, S. H., Van Meir, E. G., Walenkamp, A. M. E., Watts, C., Weiss, T., Weller, M., Palucka, K., Stead, L. F., Poisson, L. M., Noushmehr, H., Iavarone, A., Verhaak, R. G. W., Varn, F. S., Johnson, K. C., Martinek, J., Huse, J. T., Nasrallah, M. P., Wesseling, P., Cooper, L. A. D., Malta, T. M., Wade, T. E., Sabedot, T. S., Brat, D., Gould, P. V., Wöehrer, A., Aldape, K., Ismail, A., Sivajothi, S. K., Barthel, F. P., Kim, H., Kocakavuk, E., Ahmed, N., White, K., Datta, I., Moon, H.-E., Pollock, S., Goldfarb, C., Lee, G.-H., Garofano, L., Anderson, K. J., Nehar-Belaid, D., Barnholtz-Sloan, J. S., Bakas, S., Byrne, A. T., D’Angelo, F., Gan, H. K., Khasraw, M., Migliozzi, S., Ryan Ormond, D., Ha Paek, S., Van Meir, E. G., Walenkamp, A. M. E., Watts, C., Weiss, T., Weller, M., Alfaro, K. D., Amin, S. B., Ashley, D. M., Bock, C., Brodbelt, A., Bulsara, K. R., Castro, A. V., Connelly, J. M., Costello, J. F., de Groot, J. F., Finocchiaro, G., French, P. J., Golebiewska, A., Hau, A. C., Hong, C., Horbinski, C., Kannan, K. S., Kouwenhoven, M. C., Lasorella, A., LaViolette, P. S., Ligon, K. L., Lowman, A. K., Mehta, S., Miletic, H., Molinaro, A. M., Ng, H. K., Niclou, S. P., Niers, J. M., Phillips, J. J., Rabadan, R., Rao, G., Reifenberger, G., Sanai, N., Short, S. C., Sillevis Smitt, P., Sloan, A. E., Smits, M., Snyder, J. M., Suzuki, H., Tabatabai, G., Tanner, G., Tomaszewski, W. H., Wells, M., Westerman, B. A., Wheeler, H., Xie, J., Alfred Yung, W. K., Zadeh, G., Zhao, J., Palucka, K., Stead, L. F., Poisson, L. M., Noushmehr, H., Iavarone, A., & Verhaak, R. G.
Venue: Cell
Publisher: Elsevier BV
Published: 2022-06
Volume: 185
Issue: 12
Pages: 2184-2199.e16
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2022.04.038
OpenAlex: W4282932245
Cited by: 494
References: 99
FWCI: 54.67
Type: journal article
Language: en
Open access: hybrid

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This page: CoChat. (2026). Citation check: Glioma progression is shaped by genetic evolution and microenvironment interactions. https://app.cochat.ai/papers/10.1016/j.cell.2022.04.038
The paper: Varn, F. S., Johnson, K. C., Martinek, J., Huse, J. T., Nasrallah, M. P., Wesseling, P., Cooper, L. A. D., Malta, T. M., Wade, T. E., Sabedot, T. S., Brat, D., Gould, P. V., Wöehrer, A., Aldape, K., Ismail, A., Sivajothi, S. K., Barthel, F. P., Kim, H., Kocakavuk, E., . . . Verhaak, R. G. (2022). Glioma progression is shaped by genetic evolution and microenvironment interactions. Cell. https://doi.org/10.1016/j.cell.2022.04.038

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Glioma progression is shaped by genetic evolution and microenvironment interactions

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