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Cited by 136Dermatoglyphics and Human TraitsDevelopmental Biology and Gene RegulationHair Growth and Disorders

The developmental basis of fingerprint pattern formation and variation

Open access
Glover, James D., Sudderick, Zoe R., Shih, Barbara Bo-Ju, Batho-Samblas, Cameron, Charlton, Laura, Krause, Andrew L., Anderson, Calum, Riddell, Jon +13 more·2023·Cell
DOI 10.1016/j.cell.2023.01.015
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Abstract

Fingerprints are complex and individually unique patterns in the skin. Established prenatally, the molecular and cellular mechanisms that guide fingerprint ridge formation and their intricate arrangements are unknown. Here we show that fingerprint ridges are epithelial structures that undergo a truncated hair follicle developmental program and fail to recruit a mesenchymal condensate. Their spatial pattern is established by a Turing reaction-diffusion system, based on signaling between EDAR, WNT, and antagonistic BMP pathways. These signals resolve epithelial growth into bands of focalized proliferation under a precociously differentiated suprabasal layer. Ridge formation occurs as a set of waves spreading from variable initiation sites defined by the local signaling environments and anatomical intricacies of the digit, with the propagation and meeting of these waves determining the type of pattern that forms. Relying on a dynamic patterning system triggered at spatially distinct sites generates the characteristic types and unending variation of human fingerprint patterns.

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  • scRNA-seq enables profiling of gene expression at single-cell resolution and identification of reliable cellular heterogeneity, allowing identification of previously unrecognized heterogeneity, revealing regulatory relationships between genes, and tracking trajectories of distinct cell lineages.

    “It enables both profiling of gene expression measurements at a single-cell resolution and identification of reliable cellular heterogeneity, allowing for the identification of previously unrecognized levels of cellular heterogeneity, revealing regulatory relationships between genes, and tracking the trajectories of distinct cell lineages in the same or different developmental stages [63–66].”

    From Diversity of human skin three-dimensional organotypic cultures (2024) · cites this paper as [63]

    In “Single cell expression profiling delineates shared early but distinct late events,” the paper uses single-nucleus RNA-seq to characterize gene expression and identify distinct cell populations. The methods section also describes pseudotime trajectory analysis. It does not establish that this sequencing analysis revealed regulatory relationships between genes or tracked lineages across different developmental stages; the sequenced skin was from week 14. (LLM, conf=0.85)

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Cited by

Sorted by citations

Authors
Glover, J. D., Sudderick, Z. R., Shih, B. B.-J., Batho-Samblas, C., Charlton, L., Krause, A. L., Anderson, C., Riddell, J., Balic, A., Li, J., Klika, V., Woolley, T. E., Gaffney, E. A., Corsinotti, A., Anderson, R. A., Johnston, L. J., Brown, S. J., Wang, S., Chen, Y., Crichton, M. L., & Headon, D. J.
Affiliations
  • Roslin Institute (GB)
  • Heriot-Watt University (GB)
  • Durham University (GB)
  • Fudan University (CN)
  • Czech Technical University in Prague (CZ)
  • Cardiff University (GB)
  • University of Oxford (GB)
  • MRC Centre for Regenerative Medicine (GB)
  • MRC Centre for Reproductive Health (GB)
  • Institute of Genetics and Cancer (GB)
  • Chinese Academy of Sciences (CN)
Corresponding author
Headon, Denis J.
ORCID
Venue
Cell
Publisher
Elsevier BV
Published
2023-03
Volume
186
Issue
5
Pages
940-956.e20
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2023.01.015
OpenAlex
W4319728712
Cited by
136
References
6
Citations by year
2026: 36 · 2025: 43 · 2024: 42 · 2023: 14 · 2018: 1
FWCI
22.40
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Durham Research Online (Durham University) (publishedVersion, other-oa)
  • ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
  • Durham Research Online (Durham University) (submittedVersion, cc-by)
  • Lancaster EPrints (Lancaster University) (submittedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
Funders
  • Wellcome Trust (220875/Z/20/Z)
  • European Regional Development Fund
  • National Natural Science Foundation of China (32200482, ERDF-Project CZ.02.1.01/0.0/0.0/16-019/0000778)
  • BBSRC (BB/CCG1780/1, BB/N008545/1, BBS/E/D/10002071, BB/T007788/1, BB/T008385/1)
  • Engineering and Physical Sciences Research Council
  • Medical Research Council (MR/N022556/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Dermatoglyphics and Human Traits
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
Keywords
skin epithelium, hair follicle development, mesenchymal condensation, Wnt signaling, BMP signaling, digit development, morphogen gradients
MeSH terms
Humans, Skin, Signal Transduction

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