Cited by 459Immune Cell Function and InteractionCancer Immunotherapy and BiomarkersImmune cells in cancer

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A pan-cancer single-cell panorama of human natural killer cells

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Tang, Fei, Li, Jinhu, Qi, Lu, Liu, Dongfang, Bo, Yufei, Qin, Shishang, Miao, Yuhui, Yu, Kezhuo, Hou, Wenhong, Li, Jianan, Peng, Jirun, Tian, Zhigang, Zhu, Linnan, Peng, Hui, Wang, Dongfang, Zhang, Zemin·2023·Cell

DOI 10.1016/j.cell.2023.07.034

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Abstract

dendritic cells, appear to mediate the regulation of NK cell anti-tumor immunity. Our study provides insights into NK-cell-based cancer immunity and highlights potential clinical utilities of NK cell subsets as therapeutic targets.

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Background
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Background
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“Additionally, TaNKs and iCAF were significantly correlated with resistance to immunotherapy [46, 134].”
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“…cell (EC) (VWF) [35], lymphatic endothelial cell (LEC) (TFF3) [35]; immune cells: T cell (CD3D) [19, 35], B cell (CD79A) [19, 35], NK cell (KLRB1) [51], monocyte (CD14) [35, 52], mast cell (TPSB2) [35]; cells in cell cycle (cycling) (TOP2A) [53] and red blood cell (RBC) (HBA2) [54] (Fig.”
Background
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NK cells with adhesion defects and reduced cytotoxic functions are associated with a poor prognosis in multiple myeloma
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Machine Learning Integration with Single-Cell Transcriptome Sequencing Datasets Reveals the Impact of Tumor-Associated Neutrophils on the Immune Microenvironment and Immunotherapy Outcomes in Gastric Cancer
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Influential
The role of long non‐coding RNA Maternally Expressed Gene 3 in cancer‐associated fibroblasts at single cell pan‐cancer level
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Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factorPreprint
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BackgroundInfluential
Robust differentiation of NK cells from MSLN.CAR-IL-15–engineered human iPSCs with enhanced antitumor efficacy against solid tumors
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Single-cell RNA sequencing reveals different cellular states in malignant cells and the tumor microenvironment in primary and metastatic ER-positive breast cancer
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Redefining the tumor microenvironment with emerging therapeutic strategies
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Modulation of natural killer cell exhaustion in the lungs: the key components from lung microenvironment and lung tumor microenvironment
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“Further transcriptomic feature analysis in this study has shown that a subset of tumor-associated NK cells is enriched in tumors and displays exhaustion features and impaired antitumor functions in multiple cancers, including lung cancer (58).”
Background
RAC1high NK cell-based immunotherapy in hepatocellular carcinoma via STAT3-NKG2D axis
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HPK1 Dysregulation‐Associated NK Cell Dysfunction and Defective Expansion Promotes Metastatic Melanoma Progression
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Large-scale bulk and single-cell RNA sequencing combined with machine learning reveals glioblastoma-associated neutrophil heterogeneity and establishes a VEGFA+ neutrophil prognostic model
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“…subsets were each characterized by established NK cell markers from molecular and SCT studies of tumour-infiltrating NK cells, including those for proliferation ( MKI67 ), NK differentiation ( BATF3 ), IL32 , memory-like NK phenotype ( KLRC2 ), stress ( CREM ) and NK cell dysfunction ( EGR2 ) 74 .”
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Multi-omics approaches for identifying the PANoptosis signature and prognostic model via a multimachine-learning computational framework for intrahepatic cholangiocarcinoma
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“Using a pan-cancer single-cell atlas approach, Tang et al. 16 identified a tumor-enriched dysfunctional CD56 dim CD16 hi NK cell population interacting with LAMP3 + dendritic cells in the tumor microenvironment (TME).”
MethodResultInfluential
A perspective on integrating digital pathology, proteomics, clinical data and AI analytics in cancer research
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“Considering that NK cells in the TME have been reported to exhibit different phenotypes, including dysfunctional states, 18,47 we examined NK cells isolated from orthotopic tumors and performed Smart-seq2 to ensure that the elevated tumor-in ﬁ ltrating NK cells induced by ACAT1 were activated.”
Engineering NK and T cells with metabolite-sensing receptors to target solid tumors
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NKG7 is a Stable Marker of Cytotoxicity Across Immune Contexts and Within the Tumor Microenvironment
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“…analysis of patient samples across 24 cancer types, which demonstrated that NK cell heterogeneity was specific to tumor type and that tumor-infiltrating NK cells had reduced cytotoxic features compared to blood-derived NK cells [148], suggesting that NK cells shift their phenotype upon tumor entry.”

Authors: Tang, F., Li, J., Qi, L., Liu, D., Bo, Y., Qin, S., Miao, Y., Yu, K., Hou, W., Li, J., Peng, J., Tian, Z., Zhu, L., Peng, H., Wang, D., & Zhang, Z.
Affiliations: Peking University (CN)
Capital Medical University (CN)
Shenzhen Bay Laboratory (CN)
University of Science and Technology of China (CN)
Corresponding author: Zhu, Linnan
Peng, Hui
Wang, Dongfang
Zhang, Zemin
ORCID: Tang, Fei
Qi, Lu
Liu, Dongfang
Qin, Shishang
Miao, Yuhui
Yu, Kezhuo
Li, Jianan
Tian, Zhigang
Zhu, Linnan
Peng, Hui
Wang, Dongfang
Zhang, Zemin
Venue: Cell
Publisher: Elsevier BV
Published: 2023-09
Volume: 186
Issue: 19
Pages: 4235-4251.e20
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2023.07.034
OpenAlex: W4386034505
Cited by: 450
References: 91
Citations by year: 2026: 136 · 2025: 181 · 2024: 120 · 2023: 11
FWCI: 50.09
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Cell (publishedVersion, cc-by)
PubMed (publishedVersion)
Greater South Information System
Funders: National Natural Science Foundation of China (31991171, 592259205, 62203019, 81988101, 91959000, 92159305)
Peking University
Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park (Z221100007022002)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: natural killer cells, pan-cancer, single-cell transcriptomics, NK cell subsets, cancer immunotherapy, dendritic cells, antitumor immunity
MeSH terms: Single-Cell Gene Expression Analysis, Dendritic Cells, Humans, Immunity, Innate, Immunotherapy, Killer Cells, Natural, Neoplasms, Myeloid Cells, Tumor Microenvironment

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A pan-cancer single-cell panorama of human natural killer cells

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