The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
A pan-cancer single-cell panorama of human natural killer cells
Open accessAbstract
dendritic cells, appear to mediate the regulation of NK cell anti-tumor immunity. Our study provides insights into NK-cell-based cancer immunity and highlights potential clinical utilities of NK cell subsets as therapeutic targets.
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Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
Zhou, Y., Zhou, B., Pache, L., Chang, M., Khodabakhshi, A. H., Tanaseichuk, O., Benner, C., & Chanda, S. K. (2019) · Nature Communications · doi:10.1038/s41467-019-09234-6 · Cited by 14,611
SCANPY: large-scale single-cell gene expression data analysis
Wolf, F. A., Angerer, P., & Theis, F. J. (2018) · Genome Biology · doi:10.1186/s13059-017-1382-0 · Cited by 8,881
Scenic: single-cell regulatory network inference and clustering.
Aibar, S., González-Blas, C. B., Moerman, T., Huynh-Thu, V. A., Imrichova, H., Hulselmans, G., Rambow, F., Marine, J.-C., Geurts, P., Aerts, J., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4463 · Cited by 6,520 · cited 2×
“We then identified activated regulons for both tumor-infiltrating CD56brightCD16lo and CD56dim CD16hi NK cell subsets using SCENIC.49 Importantly, the tumor-enriched c6-DNAJB1 subset exhibitedmuch higher expression of transcription factors such as KLF6 and EGR3, which are associated with the inhibition of cytotoxicity…”
BackgroundA guide to cancer immunotherapy: from T cell basic science to clinical practice
Waldman, A. D., Fritz, J. M., & Lenardo, M. J. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0306-5 · Cited by 4,154
La Manno, G., Soldatov, R., Zeisel, A., Braun, E., Hochgerner, H., Petukhov, V., Lidschreiber, K., Kastriti, M. E., Lönnerberg, P., Furlan, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0414-6 · Cited by 4,118
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
Stanietsky, N., Simic, H., Arapovic, J., Toporik, A., Levy, O., Novik, A., Levine, Z., Beiman, M., Dassa, L., Achdout, H., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903474106 · Cited by 3,524
Efremova, M., Vento-Tormo, M., Teichmann, S. A., & Vento-Tormo, R. (2020) · Nature Protocols · doi:10.1038/s41596-020-0292-x · Cited by 3,449
Generalizing RNA velocity to transient cell states through dynamical modeling
Bergen, V., Lange, M., Peidli, S., Wolf, F. A., & Theis, F. J. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0591-3 · Cited by 2,951
Scrublet: computational identification of cell doublets in single-cell transcriptomic data
Wolock, S. L., Lopez, R., & Klein, A. M. (2019) · Cell Systems · doi:10.1016/j.cels.2018.11.005 · Cited by 2,758
Scrublet: computational identification of cell doublets in single-cell transcriptomic data
Wolock, S. L., Lopez, R., & Klein, A. M. (2018) · doi:10.1101/357368 · Cited by 2,758
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Marín, D., Li, Y., Başar, R., Rafei, H., Daher, M., Dou, J., Mohanty, V., Dede, M., Nieto, Y. L., Uprety, N., et al. (2024) · Nature Medicine · doi:10.1038/s41591-023-02785-8 · Cited by 567
“This pattern mirrors the stress response observed in T cells in the context of immunotherapy resistance 34 and the poor cytotoxicity seen in tumor-associated NK cells in a recent pan-cancer single-cell atlas of human NK cells 28 .”
BackgroundMethodVivier, É., Rebuffet, L., Narni-Mancinelli, É., Cornen, S., Igarashi, R., & Fantin, V. R. (2024) · Nature · doi:10.1038/s41586-023-06945-1 · Cited by 496
“…cells characterized by reduced cytotoxicity and high expression of stress-associated proteins ( DNAJB1 and HSP gene family), inhibitory MHC-class-I-specific receptors (members of the KIR family) and several transcription factors that control the fitness of NK cells such as NR4A1, EGR3 and KLF6 29 .”
High-dimensional single-cell analysis of human natural killer cell heterogeneity
Rebuffet, L., Melsen, J. E., Escalière, B., Basurto-Lozada, D., Bhandoola, A., Björkström, N. K., Bryceson, Y. T., Castriconi, R., Cichocki, F. M., Colonna, M., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01883-0 · Cited by 325
“We then confirmed the robustness of the classification of human blood NK cells into the NK1, NK2 and NK3 clusters by applying the derived transcriptional signatures to blood NK cells from other available datasets 11 (Extended Data Figs.”
Metabolic reprogramming and therapeutic resistance in primary and metastatic breast cancer
Liu, S., Zhang, X., Wang, W., Li, X., Sun, X., Zhao, Y., Wang, Q., Li, Y., Hu, F., & Ren, H. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02165-x · Cited by 300
Pan-cancer single-cell dissection reveals phenotypically distinct B cell subtypes
Yu, Y., Chen, X., Pan, J., Ning, H., Zhang, Y., Bo, Y., Ren, X., Li, J., Qin, S., Wang, D., et al. (2024) · Cell · doi:10.1016/j.cell.2024.06.038 · Cited by 223
Metadata
- Authors
- Tang, F., Li, J., Qi, L., Liu, D., Bo, Y., Qin, S., Miao, Y., Yu, K., Hou, W., Li, J., Peng, J., Tian, Z., Zhu, L., Peng, H., Wang, D., & Zhang, Z.
- Affiliations
- Peking University (CN)
- Capital Medical University (CN)
- Shenzhen Bay Laboratory (CN)
- University of Science and Technology of China (CN)
- Corresponding author
- Zhu, Linnan
- Peng, Hui
- Wang, Dongfang
- Zhang, Zemin
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2023-09
- Volume
- 186
- Issue
- 19
- Pages
- 4235-4251.e20
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W4386034505
- Cited by
- 450
- References
- 91
- Citations by year
- 2026: 136 · 2025: 181 · 2024: 120 · 2023: 11
- FWCI
- 50.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Greater South Information System
- Funders
- National Natural Science Foundation of China (31991171, 592259205, 62203019, 81988101, 91959000, 92159305)
- Peking University
- Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park (Z221100007022002)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- natural killer cells, pan-cancer, single-cell transcriptomics, NK cell subsets, cancer immunotherapy, dendritic cells, antitumor immunity
- MeSH terms
- Single-Cell Gene Expression Analysis, Dendritic Cells, Humans, Immunity, Innate, Immunotherapy, Killer Cells, Natural, Neoplasms, Myeloid Cells, Tumor Microenvironment
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