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100 years of the Warburg effect: A cancer metabolism endeavor
Open accessAbstract
If you are a scientist and you only know one thing about tumor metabolism, it's likely the Warburg effect. But who was Otto Warburg, and how did his discoveries regarding the metabolism of tumors shape our current thinking about the metabolic needs of cancer cells?
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“Accumulating evidence has demonstrated a close association between glycolytic activity and tumor cell proliferation, survival, and disease progression across multiple cancer types (27).”
From Bioinformatics-based identification of glycolysis-related signatures associated with drug resistance and prognosis in lung adenocarcinoma (2026) · cites this paper as [27]
Citations
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Metadata
- Authors
- Fendt, S.-M.
- Affiliations
- VIB-KU Leuven Center for Cancer Biology (BE)
- Corresponding author
- Fendt, Sarah-Maria
- ORCID
- Fendt, Sarah-Maria
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2024-07
- Volume
- 187
- Issue
- 15
- Pages
- 3824-3828
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W4400978492
- Cited by
- 223
- References
- 53
- Citations by year
- 2026: 116 · 2025: 98 · 2024: 9
- FWCI
- 44.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 389 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Funders
- Stichting Tegen Kanker
- World Cancer Research Fund International (IIG_FULL_2023_001)
- Fonds Baillet Latour
- Fonds Wetenschappelijk Onderzoek
- Gilead Sciences
- Wereld Kanker Onderzoek Fonds
- Australian Research Council
- KU Leuven
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- Warburg effect, Otto Warburg, cancer metabolism, glycolysis, history of cancer research, metabolic reprogramming
- MeSH terms
- Warburg Effect, Oncologic, Animals, Glycolysis, Humans, Neoplasms, History, 20th Century, History, 21st Century
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