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SLC7A11 is an unconventional H+ transporter in lysosomes

Zhou, Nan, Chen, Jingzhi, Hu, Meiqin, Wen, Na, Cai, Weijie, Li, Ping, Zhao, Liding, Meng, Yaping, Zhao, Dongdong, Yang, Xiaotong, Liu, Siyu, Huang, Fangqian, Zhao, Cheng, Feng, Xinghua, Jiang, Zikai, Xie, Enjun, Pan, Hongxu, Cen, Zhidong, Chen, Xinhui, Luo, Wei, Tang, Beisha, Min, Junxia, Wang, Fudi, Yang, Junsheng, Xu, Haoxing·2025·Cell
DOI 10.1016/j.cell.2025.04.004
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  • Increased SLC7A11 lysosomal levels upon SNX3-Retromer deficiency may contribute to the lysosomal acidification defects observed upon loss of VPS35 expression.

    “Increased SLC7A11 lysosomal levels upon SNX3-Retromer deficiency may therefore contribute to the lysosomal acidification defects observed upon loss of VPS35 expression [131, 132].”

    From Global identification of neuronal and astrocytic integral membrane proteins that require Retromer for their endosomal recycling (2026) · cites this paper as [132]

    The passage headed “Increasing SLC7A11 expression promotes lysosomal H+ efflux in cells” reports that SLC7A11 overexpression reduced lysosomal acidity, supporting the proposed direction of its effect. Our copy does not establish that SNX3-Retromer deficiency increases lysosomal SLC7A11 or that SLC7A11 contributes to the acidification defect upon VPS35 loss; searches for SNX3 and VPS35 found no such passage. Page numbers were unavailable in the indexed copy. (LLM, conf=0.85)

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Metadata

Authors
Zhou, N., Chen, J., Hu, M., Wen, N., Cai, W., Li, P., Zhao, L., Meng, Y., Zhao, D., Yang, X., Liu, S., Huang, F., Zhao, C., Feng, X., Jiang, Z., Xie, E., Pan, H., Cen, Z., Chen, X., Luo, W., Tang, B., Min, J., Wang, F., Yang, J., & Xu, H.
Venue
Cell
Publisher
Elsevier BV
Published
2025-06
Volume
188
Issue
13
Pages
3441-3458.e25
ISSN
0092-8674
DOI
10.1016/j.cell.2025.04.004
Cited by
105
References
8
Language
en
Licence
Funders
  • National Natural Science Foundation of China (31930057, 32421001, 31970689, 32330047, 92354306)
  • National Key Research and Development Program of China
  • Innovative Research Group Project of the National Natural Science Foundation of China
  • Key Technologies Research and Development Program (2022YFE0210100)

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