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Cited by 319Parkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolismFerroptosis and cancer prognosis

Ferroptosis in Parkinson’s disease: glia–neuron crosstalk

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Wang, Zhang-Li, Yuan, Lin, Li, Wen, Li, Jia-Yi·2022·Trends in Molecular Medicine
DOI 10.1016/j.molmed.2022.02.003
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Abstract

Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron loss and the formation of cytoplasmic protein inclusions. Although the exact pathogenesis of PD is unknown, iron dyshomeostasis has been proposed as a potential contributing factor. Emerging evidence suggests that glial cell activation plays a pivotal role in ferroptosis and subsequent neurodegeneration. We review the association between iron deposition, glial activation, and neuronal death, and discuss whether and how ferroptosis affects α-synuclein aggregation and DA neuron loss. We examine the possible roles of different types of glia in mediating ferroptosis in neurons. Lastly, we review current PD clinical trials targeting iron homeostasis. Although clinical trials are already evaluating ferroptosis modulation in PD, much remains unknown about metal ion metabolism and regulation in PD pathogenesis.

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Cited by

Sorted by citations

Authors
Wang, Z.-L., Yuan, L., Li, W., & Li, J.-Y.
Affiliations
  • China Medical University (CN)
  • Lund University (SE)
Corresponding author
Li, Wen
ORCID
Venue
Trends in Molecular Medicine
Publisher
Elsevier BV
Published
2022-04
Volume
28
Issue
4
Pages
258-269
ISSN
1471-4914 (ISSN-L)
DOI
10.1016/j.molmed.2022.02.003
OpenAlex
W4220809213
Cited by
319
References
8
Citations by year
2026: 65 · 2025: 93 · 2024: 88 · 2023: 57 · 2022: 16
FWCI
9.11
Type
journal article
Language
en
Open access
Licence
Locations
  • Trends in Molecular Medicine (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
Keywords
ferroptosis, Parkinson's disease, iron dyshomeostasis, iron accumulation, glial activation, dopaminergic neuron loss, alpha-synuclein aggregation, neurodegeneration, metal ion metabolism
MeSH terms
Ferroptosis, Humans, Neuroglia, Parkinson Disease, Cell Death, alpha-Synuclein, Dopaminergic Neurons

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