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Antioxidative and prooxidative effects of quercetin on A549 cells
Abstract
Quercetin, a common plant polyphenol, has been reported to show both antioxidant and prooxidant properties. We studied the effects of quercetin on A549 cells in in vitro culture. We found that low concentrations of the flavonoid stimulated cell proliferation and increased total antioxidant capacity (TAC) of the cells; while higher concentrations of the flavonoid decreased cell survival and viability, thiol content, TAC and activities of superoxide dismutase, catalase and glutathione S-transferase. Quercetin decreased production of reactive oxygen species in the cells but produced peroxides in the medium. The cellular effects of quercetin are therefore complex and include both antioxidant effects and induction of oxidative stress due to formation of reactive oxygen species in the extracellular medium.
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“Studies have also suggested that high doses of some antioxidants, such as quercetin and flavonoids, reduce cell survival35,37,38.”
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“In this regard, recent studies employing cell models have highlighted the prooxidative activity of several polyphenols already known as antioxidants such as quercetin, catechins including epicatechin and epigallocatechin-3-gallate (EGCG) and gallic acid.50-55 For example, at high doses, it has been demonstrated that q…”
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Background
Metadata
- Authors
- Robaszkiewicz, A., Balcerczyk, A., & Bartosz, G.
- Affiliations
- University of Łódź (PL)
- Corresponding author
- Robaszkiewicz, Agnieszka
- Venue
- Cell Biology International
- Publisher
- Wiley
- Published
- 2007-10
- Volume
- 31
- Issue
- 10
- Pages
- 1245-1250
- ISSN
- 1065-6995 (ISSN-L)
- 1095-8355
- OpenAlex
- W2086381409
- Cited by
- 279
- References
- 46
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 11 · 2023: 16 · 2022: 31 · 2021: 25 · 2020: 23 · 2019: 9 · 2018: 10 · 2017: 16 · 2016: 15 · 2015: 13 · 2014: 18 · 2013: 18 · 2012: 17
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell Biology International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- quercetin, flavonoids, plant polyphenols, A549 cells, lung epithelial cells, antioxidant capacity, pro-oxidant activity, oxidative stress, reactive oxygen species, superoxide dismutase, catalase, glutathione S-transferase, thiol content, cell proliferation, cell viability, peroxide formation
- MeSH terms
- Antioxidants, Carcinoma, Non-Small-Cell Lung, Catalase, Glutathione Transferase, Humans, Lung Neoplasms, Quercetin, Sulfhydryl Compounds, Superoxide Dismutase, Tumor Cells, Cultured, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Cell Proliferation
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