Cited by 279Phytochemicals and Antioxidant ActivitiesFlavonoids in Medical ResearchAntioxidant Activity and Oxidative Stress

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Antioxidative and prooxidative effects of quercetin on A549 cells

Robaszkiewicz, Agnieszka, Balcerczyk, Aneta, Bartosz, Grzegorz·2007·Cell Biology International

DOI 10.1016/j.cellbi.2007.04.009

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Abstract

Quercetin, a common plant polyphenol, has been reported to show both antioxidant and prooxidant properties. We studied the effects of quercetin on A549 cells in in vitro culture. We found that low concentrations of the flavonoid stimulated cell proliferation and increased total antioxidant capacity (TAC) of the cells; while higher concentrations of the flavonoid decreased cell survival and viability, thiol content, TAC and activities of superoxide dismutase, catalase and glutathione S-transferase. Quercetin decreased production of reactive oxygen species in the cells but produced peroxides in the medium. The cellular effects of quercetin are therefore complex and include both antioxidant effects and induction of oxidative stress due to formation of reactive oxygen species in the extracellular medium.

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“Previous studies have reported that quercetin possesses antioxidative [8], anticancer [9], antibacterial [10], and antiviral [11] effects.”
Background
Pro-oxidant activity of apocynin radical
Castor, L. R. G., Locatelli, K. A., & Ximenes, V. F. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.010 · Cited by 63
Catechol Type Polyphenol Is a Potential Modifier of Protein Sulfhydryls: Development and Application of a New Probe for Understanding the Dietary Polyphenol Actions
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In vivo EPR measurement of glutathione in tumor-bearing mice using improved disulfide biradical probe
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Production of hydrogen peroxide is responsible for the induction of apoptosis by hydroxytyrosol on HL60 cells
Fabiani, R., Fuccelli, R., Pieravanti, F., Bartolomeo, A. D., & Morozzi, G. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800376 · Cited by 62
Dual Effects ofGinkgo bilobaLeaf Extract on Human Red Blood Cells
He, J., Lin, J., Li, J., Zhang, J., Sun, X., & Zeng, C. (2008) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2008.00354.x · Cited by 62
Multitarget Effects of Quercetin in Leukemia
Maso, V., Calgarotto, A. K., Franchi, G. C., Nowill, A. E., Filho, P. L., Vassallo, J., & Saad, S. T. O. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0383 · Cited by 62
“The antioxidant and anti-inflammatory properties of quercetin have been associated with the amelioration of adverse side effects derived from cancer therapy, which is considered a good strategy to prevention and treatment of cancer (27).”
Background
Antiaging effects of dietary supplements and natural products
Gao, L., Liu, X., Luo, X., Lou, X., Li, P., Li, X., & Liu, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1192714 · Cited by 66
“1–10 μM) and decrease in thiol content, total antioxidant capacity, cell proliferation, and induction of cell apoptosis and necrosis at higher concentrations of the quercetin (>50 mM) (Robaszkiewicz et al., 2007).”
Background
The Bioactive Potential of Red Raspberry ( Rubus idaeus L.) Leaves in Exhibiting Cytotoxic and Cytoprotective Activity on Human Laryngeal Carcinoma and Colon Adenocarcinoma
Durgo, K., Belščak‐Cvitanović, A., Stančić, A., Franekić, J., & Komes, D. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2011.0087 · Cited by 60
“49 In our previous study, 50 we had shown that constitutive levels of GSH are higher in cisplatin-resistant CK2 cells of laryngeal carcinoma than in the parental HEp2 cells, but also that quercetin induces a signiﬁcant increase in the GSH levels of both cell lines, again pointing toward the…”
Overview of biological effects of Quercetin on ovary
Rashidi, Z., Khosravizadeh, Z., Talebi, A., Khodamoradi, K., Ebrahimi, R., & Amidi, F. (2020) · Phytotherapy Research · doi:10.1002/ptr.6750 · Cited by 66
In Vitro Assessment of Antibacterial Activity and Cytocompatibility of Quercetin‐Containing PLGA Nanofibrous Scaffolds for Tissue Engineering
Xing, Z., Meng, W., Yuan, J., Moon, S., Jeong, Y., & Kang, I. (2012) · Journal of Nanomaterials · doi:10.1155/2012/202608 · Cited by 58
Current perspectives in cell-based approaches towards the definition of the antioxidant activity in food
Martinelli, E., Granato, D., Azevedo, L. C., Gonçalves, J. E., Lorenzo, J. M., Munekata, P. E. S., Simal‐Gándara, J., Barba, F. J., Carrillo, C., Rajoka, M. S. R., et al. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.07.024 · Cited by 57
Oral Co-Supplementation of Curcumin, Quercetin, and Vitamin D3 as an Adjuvant Therapy for Mild to Moderate Symptoms of COVID-19—Results From a Pilot Open-Label, Randomized Controlled Trial
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“Extensive in vivo studies have revealed the anti-inflammatory, antiviral, immunoprotective, and antioxidant effects of quercetin (Nair et al., 2002; Robaszkiewicz et al., 2007; Uchide and Toyoda, 2011; Colunga Biancatelli et al., 2020; Salehi et al., 2020).”
Background
A Preliminary Study of the Effect of Quercetin on Cytotoxicity, Apoptosis, and Stress Responses in Glioblastoma Cell Lines
Kusaczuk, M., Krętowski, R., Naumowicz, M., Stypułkowska, A., & Cechowska‐Pasko, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031345 · Cited by 54
“, as an antioxidant scavenging free radicals and preventing apoptosis and as a pro-oxidative agent decreasing levels of glutamate-stimulating hormones (GSH) and facilitating apoptosis) [44].”
Background
Dietary Antioxidant, Quercetin, Protects Sertoli‐Germ Cell Coculture from Atrazine‐Induced Oxidative Damage
Abarikwu, S. O., Pant, A. B., & Farombi, E. O. (2012) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21449 · Cited by 54
“On the other hand, QT can also exhibit prooxidant effects [4].”
Background
Role of flavonoids against adriamycin toxicity
Navarro‐Hortal, M. D., Varela‐López, A., Romero‐Márquez, J. M., Rivas‐García, L., Speranza, L., Battino, M. A., & Quiles, J. L. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111820 · Cited by 52
Morin attenuates dexamethasone-mediated oxidative stress and atrophy in mouse C2C12 skeletal myotubes
Ulla, A., Uchida, T., Miki, Y., Sugiura, K., Higashitani, A., Kobayashi, T., Ohno, A., Nakao, R., Hirasaka, K., Sakakibara, I., et al. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108873 · Cited by 56
A review of propolis antitumour action in vivo and in vitro
Oršolić, N. (2010) · Journal of ApiProduct and ApiMedical Science · doi:10.3896/ibra.4.02.1.01 · Cited by 51
Nrf2 Expression and Apoptosis in Quercetin-treated Malignant Mesothelioma Cells
Lee, Y.-J., Lee, D. M., & Lee, S.-H. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.2268 · Cited by 51
“cells and antagonized the cytotoxic effects of antineoplastic agents in lung cancer A549, colorectal cancer HCT116, and ovarian cancer cells (Li et al., 2014; Robaszkiewicz et al., 2007; Samuel et al, 2012).”
Background
The flavonoid quercetin induces changes in mitochondrial permeability by inhibiting adenine nucleotide translocase
Ortega, R., & Garcı́a, N. (2009) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9198-6 · Cited by 50
“The controversy is based on the characteristics exhibited by flavonoids as antioxidants and pro-oxidants (Cano et al. 2002; Sekher Pannala et al. 2001; Robaszkiewicz et al. 2007).”
Immunomodulation effects of polyphenols from thinned peach treated by different drying methods on RAW264.7 cells through the NF-κB and Nrf2 pathways
Guo, C., Bi, J., Li, X., Lyu, J., Liu, X., Wu, X., & Liu, J. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.127931 · Cited by 48
Time-dependent protective and harmful effects of quercetin on 6-OHDA-induced toxicity in neuronal SH-SY5Y cells
Ossola, B., Kääriäinen, T. M., Raasmaja, A., & Männistö, P. T. (2008) · Toxicology · doi:10.1016/j.tox.2008.04.001 · Cited by 48
Influence of polyphenols on Escherichia coli resistance to oxidative stress
Smirnova, G. V., Samoilova, Z., Muzyka, N. G., & Oktyabrsky, O. N. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.11.017 · Cited by 47
Beneficial effects of quercetin on oxidative stress in liver and kidney induced by titanium dioxide (TiO2) nanoparticles in rats
González-Esquivel, A. E., Charles-Niño, C. L., Pacheco-Moisés, F. P., Ortíz, G. G., Jaramillo‐Juárez, F., & Rincón‐Sánchez, A. R. (2015) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2015.1006491 · Cited by 46
A Review on Antiproliferative and Apoptotic Activities of Natural Honey
Jaganathan, S. K., Balaji, A., Vellayappan, M. V., Asokan, M., Subramanian, A., John, A., Supriyanto, E., Razak, S. I. A., & Marvibaigi, M. (2014) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520614666140722084747 · Cited by 46
PI3K/Akt and ERK1/2 Signalling Are Involved in Quercetin-Mediated Neuroprotection against Copper-Induced Injury
Zubčić, K., Radovanović, V., Vlainić, J., Hof, P. R., Oršolić, N., Šimić, G., & Jembrek, M. J. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9834742 · Cited by 46
“Furthermore, depending on the dose, it may exert antioxidative as well as prooxidative effects [33].”
BackgroundResult
The Stability and Antioxidant Activity of Anthocyanins from Blueberry
He, R., Li, Z. M., & Wang, B. C. (2010) · University of Zagreb University Computing Centre (SRCE) · Cited by 45
Antigenotoxic Effects of (–)-Epigallocatechin-3-Gallate (EGCG), Quercetin, and Rutin on Chromium Trioxide-Induced Micronuclei in the Polychromatic Erythrocytes of Mouse Peripheral Blood
García-Rodríguez, M. D. C., Nicolás-Méndez, T., Montaño-Rodriguez, A., & Altamirano-Lozano, M. (2014) · Journal of Toxicology and Environmental Health, Part A · doi:10.1080/15287394.2013.865006 · Cited by 44
“Studies demonstrated that flavonoids such as quercetin may exert pro-oxidant damage in vivo (Mazumdar et al., 2011) and in vitro (Boots et al., 2007; Resende et al., 2012; Robaszkiewicz et al., 2007).”
Background
The interplay between reactive oxygen species and antioxidants in cancer progression and therapy: a narrative review
Bekhet, O. H., & Eid, M. E. (2021) · Translational Cancer Research · doi:10.21037/tcr-21-629 · Cited by 45
“, quercetin at higher concentrations (>50 μM) can initiate ROS generation especially O2 ; and in another study, it was observed to decrease cell viability, and TAC (77).”
Background
Angiogenic and osteogenic effects of flavonoids in bone regeneration
Shanmugavadivu, A., Balagangadharan, K., & Selvamurugan, N. (2022) · Biotechnology and Bioengineering · doi:10.1002/bit.28162 · Cited by 43
“Quercetin showed a wide range of bioactivities such as antioxidant (Robaszkiewicz et al., 2007), antiviral (Uchide & Toyoda, 2011), anti‐inflammatory (Lesjak et al., 2017), and immunoprotective effects (Nair et al., 2002).”
Background
Flavonoids: Precipitation Kinetics and Interaction with Surfactant Micelles
Löf, D., Schillén, K., & Nilsson, L. (2011) · Journal of Food Science · doi:10.1111/j.1750-3841.2011.02103.x · Cited by 42
Antioxidant activity and anti‐inflammatory effect of fruit extracts from blackcurrant, chokeberry, hawthorn, and rosehip, and their mixture with linseed oil on a model lipid membrane
Strugała, P., Gładkowski, W., Kucharska, A. Z., Sokół‐Łętowska, A., & Gabrielska, J. (2015) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201500001 · Cited by 42
Inhibition of Nrf2 enhances the anticancer effect of 6-O-angeloylenolin in lung adenocarcinoma
Wang, Y., Yu, R., Zhang, J., Zhang, W., Huang, Z., Hu, H., Li, Y.-L., Li, B., & He, Q. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.01.006 · Cited by 40
Treatment of COVID-19 patients with quercetin: a prospective, single center, randomized, controlled trial
Önal, H., Arslan, B., Ergun, N. Ü., Topuz, H. Ş., Semerci, S. Y., KURNAZ, M. E., Yulet Miray, M. O. L. U., Bozkurt, M. A., Suner, N., & Kocataş, A. (2021) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-2104-16 · Cited by 40
“Quercetin, as a widely available plant flavonoid, has antioxidant, anti-inflammatory, antiviral and immunoprotective effects (Nair et al., 2002; Robaszkiewicz et al., 2007; Uchide et al., 2011).”
Background
Cissus quadrangularis Linn exerts dose‐dependent biphasic effects: osteogenic and anti‐proliferative, through modulating ROS , cell cycle and Runx2 gene expression in primary rat osteoblasts
Siddiqui, S., Ahmad, E., Gupta, M., Rawat, V., Shivnath, N., Banerjee, M., Khan, M. S., & Arshad, M. (2015) · Cell Proliferation · doi:10.1111/cpr.12195 · Cited by 40
Role of quercetin on Caco-2 cells against cytotoxic effects of alternariol and alternariol monomethyl ether
Fernández-Blanco, C., Font, G., & Ruiz, M.-J. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.01.011 · Cited by 39
Complementary and Alternative Medicine Use in Radiotherapy: What Are Patients Using?
Gillett, J., Ientile, C. S., Hiscock, J., Plank, A. W., & Martin, J. M. (2012) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2011.0334 · Cited by 39
“It should also be acknowledged that antioxidant compounds, such as quercetin 22 and the lipophilic derivative of vitamin C 23 may act as prooxidants depending on the concentration taken.”
RETRACTED: PEG2000‐DPSE‐coated quercetin nanoparticles remarkably enhanced anticancer effects through induced programed cell death on C6 glioma cells
Wang, G., Wang, J., Luo, J. D., Wang, L., Chen, X.-L., Zhang, L., & Jiang, S. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34607 · Cited by 38
Retracted
Isoliquiritigenin Enhances Radiosensitivity of HepG2 Cells via Disturbance of Redox Status
Sun, C., Zhang, H., Ma, X., Zhou, X. H., Gan, L., Liu, Y.-Y., & Wang, Z. (2012) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-012-9447-x · Cited by 37
Comparison between the effects of quercetin on seizure threshold in acute and chronic seizure models
Nassiri‐Asl, M., Hajiali, F., Taghiloo, M., Abbasi, E., Mohseni, F., & Yousefi, F. (2014) · Toxicology and Industrial Health · doi:10.1177/0748233713518603 · Cited by 37
“Subsequently, it has been suggested that quercetin has complex oxidative and antioxidative effects (Robaszkiewicz et al., 2007).”
Background
Apocynin Ameliorates Cadmium-Induced Hypertension Through Elevation of Endothelium Nitric Oxide Synthase
Nwokocha, C. R., Baker, A., Douglas, D., McCalla, G., Nwokocha, M., & Brown, P. D. (2013) · Cardiovascular Toxicology · doi:10.1007/s12012-013-9216-0 · Cited by 36
“[33] and may underlie some of the recent findings regarding beneficial and/or deleterious effects of this chemical as well as others with pro-oxidant characteristics [34, 35].”
Kaempferol inhibits Entamoeba histolytica growth by altering cytoskeletal functions
Bolaños, V., Díaz-Martínez, A., Soto‐Sánchez, J., Marchat, L. A., Monroy, V. S., & Ramírez‐Moreno, E. (2015) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2015.11.004 · Cited by 38

Authors: Robaszkiewicz, A., Balcerczyk, A., & Bartosz, G.
Affiliations: University of Łódź (PL)
Corresponding author: Robaszkiewicz, Agnieszka
ORCID: Robaszkiewicz, Agnieszka
Balcerczyk, Aneta
Bartosz, Grzegorz
Venue: Cell Biology International
Publisher: Wiley
Published: 2007-10
Volume: 31
Issue: 10
Pages: 1245-1250
ISSN: 1065-6995 (ISSN-L)
1095-8355
DOI: 10.1016/j.cellbi.2007.04.009
OpenAlex: W2086381409
Cited by: 279
References: 46
Citations by year: 2026: 3 · 2025: 4 · 2024: 11 · 2023: 16 · 2022: 31 · 2021: 25 · 2020: 23 · 2019: 9 · 2018: 10 · 2017: 16 · 2016: 15 · 2015: 13 · 2014: 18 · 2013: 18 · 2012: 17
FWCI: 7.64
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1920 d)
Locations: Cell Biology International (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: quercetin, flavonoids, plant polyphenols, A549 cells, lung epithelial cells, antioxidant capacity, pro-oxidant activity, oxidative stress, reactive oxygen species, superoxide dismutase, catalase, glutathione S-transferase, thiol content, cell proliferation, cell viability, peroxide formation
MeSH terms: Antioxidants, Carcinoma, Non-Small-Cell Lung, Catalase, Glutathione Transferase, Humans, Lung Neoplasms, Quercetin, Sulfhydryl Compounds, Superoxide Dismutase, Tumor Cells, Cultured, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Cell Proliferation

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Antioxidative and prooxidative effects of quercetin on A549 cells

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