Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective

Ratnam, D. Venkat; Ankola, D.D.; Bhardwaj, V.; Sahana, D.K.; Kumar, M.N.V. Ravi

doi:10.1016/j.jconrel.2006.04.015

Cited by 885Antioxidant Activity and Oxidative StressPhytochemicals and Antioxidant ActivitiesDrug Solubulity and Delivery Systems

Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective

Ratnam, D. Venkat, Ankola, D.D., Bhardwaj, V., Sahana, D.K., Kumar, M.N.V. Ravi·2006·Journal of Controlled Release

DOI 10.1016/j.jconrel.2006.04.015

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Abstract

Antioxidants are emerging as prophylactic and therapeutic agents. These are the agents, which scavenge free radicals otherwise reactive oxygen species and prevent the damage caused by them. Free radicals have been associated with pathogenesis of various disorders like cancer, diabetes, cardiovascular diseases, autoimmune diseases, neurodegenerative disorders and are implicated in aging. Several antioxidants like SOD, CAT, epigallocatechin-3-O-gallate, lycopene, ellagic acid, coenzyme Q10, indole-3-carbinol, genistein, quercetin, vitamin C and vitamin E have been found to be pharmacologically active as prophylactic and therapeutic agents for above mentioned diseases. Antioxidants are part of diet but their bioavailability through dietary supplementation depends on several factors. This major drawback of dietary agents may be due to one or many of the several factors like poor solubility, inefficient permeability, instability due to storage of food, first pass effect and GI degradation. Conventional dosage forms may not result in efficient formulation owing to their poor biopharmaceutical properties. Principles of novel drug delivery systems need to be applied to significantly improve the performance of antioxidants. Novel drug delivery systems (NDDS) would also help in delivery of these antioxidants by oral route, as this route is of prime importance when antioxidants are intended for prophylactic purpose. Implication of NDDS for the delivery of antioxidants is largely governed by physicochemical characteristics, biopharmaceutical properties and pharmacokinetic parameters of the antioxidant to be formulated. Recently, chemical modifications, coupling agents, liposomes, microparticles, nanoparticles and gel-based systems have been explored for the delivery of these difficult to deliver molecules. Results from several studies conducted across the globe are positive and provided us with new anticipation for the improvement of human healthcare.

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From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [106]

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139 · see citing works
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513 · see citing works
A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability
Amidon, G. L., Lennernäs, H., Shah, V. P., & Crison, J. R. (1995) · Pharmaceutical Research · doi:10.1023/a:1016212804288 · Cited by 5,430 · see citing works
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282 · see citing works
Oxidative stress: oxidants and antioxidants
Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577 · see citing works
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879 · see citing works
Dietary Intake and Bioavailability of Polyphenols
Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658 · see citing works
Biology of disease: free radicals and tissue injury.
Freeman, B. Α., & Jd, C. (1982) · PubMed · Cited by 3,059 · see citing works
Chitosan Chemistry and Pharmaceutical Perspectives
Kumar, M. N. V. R., Müzzarelli, R. A. A., Muzzarelli, C., Sashiwa, H., & Domb, A. J. (2004) · Chemical Reviews · doi:10.1021/cr030441b · Cited by 2,945 · see citing works
Self-citation
Nanoparticle and targeted systems for cancer therapy
Brannon‐Peppas, L., & Blanchette, J. O. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.02.014 · Cited by 2,335 · see citing works
Potential Synergy of Phytochemicals in Cancer Prevention: Mechanism of Action
Liu, R. H. (2004) · Journal of Nutrition · doi:10.1093/jn/134.12.3479s · Cited by 2,277 · see citing works
Encyclopedia of Pharmaceutical Technology
Swarbrick, J. (2013) · CRC Press eBooks · doi:10.1201/b19309 · Cited by 1,795 · see citing works
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance
Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., Dhariwal, K. R., Park, J. B., Lazarev, A., Graumlich, J. F., King, J., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3704 · Cited by 1,325 · see citing works
Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase.
Abuchowski, A., McCoy, J. R., Palczuk, N. C., Es, T. V., & Davis, F. F. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40292-4 · Cited by 1,276 · see citing works
Nanoparticulate systems for brain delivery of drugs.
Kreuter, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00122-8 · Cited by 1,107 · see citing works
Bioavailability of Pure Isoflavones in Healthy Humans and Analysis of Commercial Soy Isoflavone Supplements
Setchell, K. D. R., Brown, N. M., Desai, P. B., Zimmer-Nechemias, L., Wolfe, B., Brashear, W. T., Kirschner, A. S., Cassidy, A., & Heubi, J. E. (2001) · Journal of Nutrition · doi:10.1093/jn/131.4.1362s · Cited by 974 · see citing works
Nanoparticulate systems for brain delivery of drugs
Kreuter, J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.015 · Cited by 958 · see citing works
A family of mammalian Na+-dependent L-ascorbic acid transporters
Tsukaguchi, H., Tokui, T., Mackenzie, B., Berger, U. V., Chen, X.-Z., Wang, Y., Brubaker, R. F., & Hediger, M. A. (1999) · Nature · doi:10.1038/19986 · Cited by 882 · see citing works
Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier
Gilgun‐Sherki, Y., Melamed, E., & Offen, D. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00019-3 · Cited by 839 · see citing works
Structural dependence of flavonoid interactions with Cu2+ ions: implications for their antioxidant properties
BROWN, E. J., Khodr, H., HIDER, C. R., & Rice-Evans, C. A. (1998) · Biochemical Journal · doi:10.1042/bj3301173 · Cited by 813 · see citing works
LIPID PEROXIDATION, OXYGEN RADICALS, CELL DAMAGE, AND ANTIOXIDANT THERAPY
Halliwell, B. B., & Gutteridge, J. C. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91886-5 · Cited by 796 · see citing works
Dietary Factors That Affect the Bioavailability of Carotenoids
van het Hof, K. H., Weststrate, J. A., West, C. E., & Hautvast, J. G. A. J. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.3.503 · Cited by 776 · see citing works
Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver β‐glucosidase activity
Day, A. J., DuPont, M. S., Ridley, S., Rhodes, M. J. C., Rhodes, M. J. C., Morgan, M. R. A., & Williamson, G. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01101-6 · Cited by 730 · see citing works
Stone agers in the fast lane: chronic degenerative diseases in evolutionary perspective
Eaton, S. B., Konner, M., & Shostak, M. (1988) · The American Journal of Medicine · doi:10.1016/0002-9343(88)90113-1 · Cited by 703 · see citing works
Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics
Hussain, N. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00152-1 · Cited by 681 · see citing works
Uptake of Lycopene and Its Geometrical Isomers Is Greater from Heat-Processed than from Unprocessed Tomato Juice in Humans
Stahl, W., & Sies, H. (1992) · Journal of Nutrition · doi:10.1093/jn/122.11.2161 · Cited by 675 · see citing works
Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment
Kommuru, T. R., Gurley, B. J., Khan, M. A., & Reddy, I. K. (2001) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00614-1 · Cited by 623 · see citing works
Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability
Setchell, K. D. R., Brown, N. M., Zimmer-Nechemias, L., Brashear, W. T., Wolfe, B., Kirschner, A. S., & Heubi, J. E. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.2.447 · Cited by 618 · see citing works
The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man
Hollman, P. C. H., Bijsman, M. N. C. P., van Gameren, Y., Cnossen, E. P. J., de Vries, J. H. M., & Katan, M. (1999) · Free Radical Research · doi:10.1080/10715769900301141 · Cited by 555 · see citing works
Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery
Brannon‐Peppas, L. (1995) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)00324-x · Cited by 528 · see citing works
Absorption, distribution, elimination of tea polyphenols in rats.
Chen, L., Lee, M., Li, H., & Yang, C. S. (1997) · PubMed · Cited by 459 · see citing works
Vitamin C-Induced Decomposition of Lipid Hydroperoxides to Endogenous Genotoxins
Lee, S. H., Oe, T., & Blair, I. A. (2001) · Science · doi:10.1126/science.1059501 · Cited by 416 · see citing works
Targeting antioxidants to mitochondria: A new therapeutic direction
Sheu, S., Nauduri, D., & Anders, M. W. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.10.007 · Cited by 412 · see citing works
Stability, cellular uptake, biotransformation, and efflux of tea polyphenol (-)-epigallocatechin-3-gallate in HT-29 human colon adenocarcinoma cells.
Hong, J., Lu, H., Meng, X., Ryu, J., Hara, Y., & Yang, C. S. (2002) · PubMed · Cited by 400 · see citing works
Bioavailability of all-trans and cis–Isomers of Lycopene
Boileau, T. W.-M., Boileau, A. C., & Erdman, J. W. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222701012 · Cited by 379 · see citing works
Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection
Brown, M. J., Ferruzzi, M. G., Nguyen, M. L., Cooper, D. A., Eldridge, A. L., Schwartz, S. J., & White, W. S. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.396 · Cited by 376 · see citing works
Hydrolysis of dietary flavonoid glycosides by strains of intestinal Bacteroides from humans
Bokkenheuser, V. D., Shackleton, C. H. L., & Winter, J. (1987) · Biochemical Journal · doi:10.1042/bj2480953 · Cited by 340 · see citing works
Plasma metabolites of quercetin and their antioxidant properties
Morand, C., Crespy, V., Manach, C., Besson, C., Demigné, C., & Rémésy, C. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.1.r212 · Cited by 333 · see citing works
Intestinal Uptake and Biliary Excretion of the Isoflavone Genistein in Rats , ,
Sfakianos, J., Coward, L. U., KIRK, M. C., & Barnes, S. (1997) · Journal of Nutrition · doi:10.1093/jn/127.7.1260 · Cited by 328 · see citing works
Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women
Setchell, K. D. R., Faughnan, M. S., Avades, T. Y., Zimmer-Nechemias, L., Brown, N. M., Wolfe, B., Brashear, W. T., Desai, P., Oldfield, M. F., Botting, N. P., et al. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.2.411 · Cited by 320 · see citing works
Epigallocatechin-3-Gallate Is Absorbed but Extensively Glucuronidated Following Oral Administration to Mice
Lambert, J. D., Lee, M., Lu, H., Meng, X., Hong, J. J. J., Seril, D. N., Yang, C. S., & Sturgill, M. G. (2003) · Journal of Nutrition · doi:10.1093/jn/133.12.4172 · Cited by 318 · see citing works
Stability of tea theaflavins and catechins
Su, Y. L., Leung, L. K., Huang, Y., et al. (2003) · Food Chemistry · doi:10.1016/s0308-8146(03)00062-1 · Cited by 313 · see citing works
Nutritional characteristics of wild primate foods: do the diets of our closest living relatives have lessons for us?
Milton, K. (1999) · Nutrition · doi:10.1016/s0899-9007(99)00078-7 · Cited by 313 · see citing works
Nanomedicines for overcoming biological barriers
Alonso, M. J. (2004) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2004.01.007 · Cited by 312 · see citing works
Cis-Lycopene Is More Bioavailable Than Trans-Lycopene In Vitro and In Vivo in Lymph-Cannulated Ferrets
Boileau, A. C., Merchen, N. R., Wasson, K., Atkinson, C., & Erdman, J. W. (1999) · Journal of Nutrition · doi:10.1093/jn/129.6.1176 · Cited by 306 · see citing works
The French paradox: lessons for other countries
Ferrières, J. (2003) · Heart · doi:10.1136/heart.90.1.107 · Cited by 303 · see citing works
Review Paleolithic nutrition revisited: A twelve-year retrospective on its nature and implications
Eaton, S., Eaton, S. B., & Mj, K. (1997) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600389 · Cited by 295 · see citing works
C60 and Water-Soluble Fullerene Derivatives as Antioxidants Against Radical-Initiated Lipid Peroxidation
Wang, I. C., Tai, L. A., Lee, D. D., Kanakamma, P. P., Shen, C. K.-F., Luh, T., Cheng, C., & Hwang, K. C. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm990144s · Cited by 292 · see citing works
Analytical methods for assay of ellagic acid and its solubility studies
Bala, I., Bhardwaj, V., Hariharan, S., & Kumar, M. N. V. R. (2005) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2005.07.006 · Cited by 252 · see citing works
Self-citation
Evolution of dietary antioxidants
Benzie, I. F. F. (2003) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(02)00368-9 · Cited by 247 · see citing works
Lycopene Stability During Food Processing
Nguyen, M. L., & Schwartz, S. J. (1998) · Experimental Biology and Medicine · doi:10.3181/00379727-218-44274 · Cited by 244 · see citing works
Encapsulation of vitamin C in tripolyphosphate cross-linked chitosan microspheres by spray drying
Desai, K. G. H., & Park, H. J. (2005) · Journal of Microencapsulation · doi:10.1080/02652040400026533 · Cited by 239 · see citing works
Daidzein and genistein but not their glucosides are absorbed from the rat stomach
Piskuła, M. K., Yamakoshi, J., & Iwai, Y. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00307-5 · Cited by 237 · see citing works
The Ecology of Eating: Smaller Portion Sizes in France Than in the United States Help Explain the French Paradox
Rozin, P., Kabnick, K., Pete, E., Fischler, C., & Shields, C. (2003) · Psychological Science · doi:10.1111/1467-9280.02452 · Cited by 228 · see citing works
The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides
Arts, I. C. W., Sesink, A. L. A., Faassen-Peters, M., & Hollman, P. C. H. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041123 · Cited by 226 · see citing works
Pharmacokinetics and Tissue Disposition of Indole-3-carbinol and Its Acid Condensation Products after Oral Administration to Mice
Anderton, M. J., Manson, M. M., Verschoyle, R. D., Gescher, A. J., Lamb, J. H., Farmer, P. B., Steward, W. P., & Williams, M. L. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0163 · Cited by 219 · see citing works
Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen
Crespy, V., Morand, C., Manach, C., Besson, C., Demigné, C., & Rémésy, C. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.1.g120 · Cited by 215 · see citing works
Peroral administration of nanoparticles
Kreuter, J. (1991) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(91)90048-h · Cited by 207 · see citing works
Free radical biology – terminology and critical thinking
Azzi, A., Davies, K. J. A., & Kelly, F. J. (2004) · FEBS Letters · doi:10.1016/s0014-5793(03)01526-6 · Cited by 205 · see citing works
Nanoparticle-based dmg delivery systems
Kreuter, J. (1991) · Journal of Controlled Release · doi:10.1016/0168-3659(91)90040-k · Cited by 205 · see citing works
Evaluation of nano- and microparticle uptake by the gastrointestinal tract
Delié, F. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00041-6 · Cited by 202 · see citing works
Quercetin Glucosides Are Completely Hydrolyzed in Ileostomy Patients before Absorption
Walle, T., Otake, Y., Walle, U. K., & Wilson, F. A. (2000) · Journal of Nutrition · doi:10.1093/jn/130.11.2658 · Cited by 201 · see citing works
Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis
Nishikimi, M., & Yagi, K. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.6.1203s · Cited by 195 · see citing works
Study of flavonoids/β-cyclodextrins inclusion complexes by NMR, FT-IR, DSC, X-ray investigation
Ficarra, R., Tommasini, S., Raneri, D., Calabrò, M. L., Bella, M. R. D., Rustichelli, C., Gamberini, M. C., & Ficarra, P. (2002) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(02)00141-3 · Cited by 189 · see citing works
Investigation of intestinal absorption and disposition of green tea catechins by Caco-2 monolayer model
Zhang, L., Zheng, Y., Chow, M. S. S., & Zuo, Z. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.08.020 · Cited by 189 · see citing works
Lectin-bearing Polymerized Liposomes as Potential Oral Vaccine Carriers
Chen, H., Torchilin, V. P., & Langer, R. (1996) · Pharmaceutical Research · doi:10.1023/a:1016030202104 · Cited by 186 · see citing works
Targeting of superoxide dismutase and catalase to vascular endothelium
Muzykantov, V. R. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00215-2 · Cited by 184 · see citing works
Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid—extensive binding to protein and DNA
Whitley, A. C., Stoner, G. D., Darby, M. V., & Walle, T. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00413-1 · Cited by 180 · see citing works
Pharmacokinetic model of ascorbic acid in healthy male volunteers during depletion and repletion
Graumlich, J. F., Ludden, T. M., Conry-Cantilena, C., Cantilena, L. R., Wang, Y., & Levine, M. (1997) · Pharmaceutical Research · doi:10.1023/a:1012186203165 · Cited by 172 · see citing works
Enhanced anticancer efficacy of α-tocopheryl succinate by conjugation with polyethylene glycol
Youk, H., LEE, E., CHOI, M., LEE, Y., Chung, J., KIM, S., Lee, C.-L., & LIM, S. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.05.014 · Cited by 165 · see citing works
Tomatoes, Lycopene, and Prostate Cancer: Progress and Promise
Hadley, C. W., Miller, E. C., Schwartz, S. J., & Clinton, S. K. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222701006 · Cited by 157 · see citing works
Immunotargeting of catalase to the pulmonary endothelium alleviates oxidative stress and reduces acute lung transplantation injury
Kozower, B. D., Christofidou‐Solomidou, M., Sweitzer, T. D., et al. (2003) · Nature Biotechnology · doi:10.1038/nbt806 · Cited by 155 · see citing works
Bioavailability of Quercetin in Pigs Is Influenced by the Dietary Fat Content
Lesser, S., Cermak, R., & Wolffram, S. (2004) · Journal of Nutrition · doi:10.1093/jn/134.6.1508 · Cited by 155 · see citing works
Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress
Muro, S., Cui, X., Gajewski, C., et al. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00099.2003 · Cited by 153 · see citing works
Beneficial and adverse effects of chemopreventive agents
Lee, B. M., & Park, K.-K. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00342-1 · Cited by 141 · see citing works
Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase.
Weydert, C. J. D., Roling, B., Liu, J., Hinkhouse, M. M., Ritchie, J. M., Oberley, L. W., & Cullen, J. J. (2003) · PubMed · Cited by 141 · see citing works
Antioxidant Strategies in Respiratory Medicine
Christofidou‐Solomidou, M., & Muzykantov, V. R. (2006) · Treatments in Respiratory Medicine · doi:10.2165/00151829-200605010-00004 · Cited by 128 · see citing works
The coenzyme Q10 content of the average Danish diet.
Weber, C., Bysted, A., & Hłlmer, G. (1997) · PubMed · Cited by 123 · see citing works
Targeted delivery of human recombinant superoxide dismutase by chemical modification with mono- and polysaccharide derivatives.
Fujita, T., Nishikawa, M., Tamaki, C., Takakura, Y., Hashida, M., & Sezaki, H. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10504-1 · Cited by 119 · see citing works
Evaluation of gliadins nanoparticles as drug delivery systems: a study of three different drugs
Duclairoir, C., Orecchioni, A. M., Depraétère, P., et al. (2003) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00701-9 · Cited by 116 · see citing works
Contribution of Presystemic Hepatic Extraction to the Low Oral Bioavailability of Green Tea Catechins in Rats
Cai, Y., Anavy, N. D., & Chow, H. ‐. S. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.11.1246 · Cited by 115 · see citing works
Polymer nanocarriers protecting active enzyme cargo against proteolysis
Dziubla, T. D., Karim, A., & Muzykantov, V. R. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.10.017 · Cited by 111 · see citing works
Spray dried Eudragit microparticles as encapsulation devices for vitamin C
Esposito, E., Cervellati, F., Menegatti, E., et al. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00176-x · Cited by 106 · see citing works
Sustained release nanoparticulate formulation containing antioxidant-ellagic acid as potential prophylaxis system for oral administration
Bala, I., Bhardwaj, V., Hariharan, S., Kharade, S. V., Roy, N., & Kumar, M. N. V. R. (2006) · Journal of drug targeting · doi:10.1080/10611860600565987 · Cited by 105 · see citing works
Self-citation
Early ADME in Support of Drug Discovery: The Role of Metabolic Stability Studies
Thompson, T. N. (2000) · Current Drug Metabolism · doi:10.2174/1389200003339018 · Cited by 103 · see citing works
Polyethylene glycol-attached antioxidant enzymes decrease pulmonary oxygen toxicity in rats
White, C. W., Jackson, J. H., Abuchowski, A., Kazo, G. M., Mimmack, R. F., Berger, E. M., Freeman, B. Α., McCord, J. M., & Repine, J. E. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.66.2.584 · Cited by 103 · see citing works
Vitamin E: absorption, plasma transport and cell uptake
Hacquebard, M., & Carpentier, Y. (2005) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200503000-00005 · Cited by 102 · see citing works
Gene Therapy for Oxidant Injury-Related Diseases: Adenovirus-Mediated Transfer of Superoxide Dismutase and Catalase cDNAs Protects against Hyperoxia but Not Against Ischemia–Reperfusion Lung Injury
Danel, C. J., ERZURUM, S. C., Prayssac, P., Eissa, N. T., Crystal, R. G., Hervé, P., Baudet, B., Mazmanian, M. G., & Lemarchand, P. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.10-1487 · Cited by 97 · see citing works
Effect of colloidal carriers on ascorbyl palmitate stability
Kristl, J., Volk, B., Gašperlin, M., Šentjurc, M., & Jurkovič, P. (2003) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(03)00104-0 · Cited by 95 · see citing works
Physicochemical characteristics andin vivodeposition of liposome-encapsulated tea catechins by topical and intratumor administrations
Fang, J., Hung, C., Hwang, T., et al. (2005) · Journal of drug targeting · doi:10.1080/10611860400015977 · Cited by 92 · see citing works
PECAM-directed delivery of catalase to endothelium protects against pulmonary vascular oxidative stress
Christofidou‐Solomidou, M., Scherpereel, A., Wiewrodt, R. G., et al. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00021.2003 · Cited by 90 · see citing works
The metabolism and excretion of (+)-[14C]cyanidanol-3 in man following oral administration
Hackett, A. M., Griffiths, L. A., Broillet, A., & Wermeille, M. (1983) · Xenobiotica · doi:10.3109/00498258309052265 · Cited by 86 · see citing works
Estabilidad de los pigmentos carotenoides en los alimentos
Meléndez‐Martínez, A. J., Vicario, I. M., & Heredia, F. J. (2004) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 85 · see citing works
The Coenzyme Q10 Analog Decylubiquinone Inhibits the Redox-activated Mitochondrial Permeability Transition
Armstrong, J. S., Whiteman, M., Rose, P. E., & Jones, D. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307841200 · Cited by 83 · see citing works
Preformulation Study of Epigallocatechin Gallate, a Promising Antioxidant for Topical Skin Cancer Prevention
Proniuk, S., Liederer, B. M., & Blanchard, J. D. (2002) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10009 · Cited by 81 · see citing works
Liposomal antioxidants provide prolonged protection against acute respiratory distress syndrome
Fan, J., Shek, P. N., Suntres, Z. E., Li, Y. H., Oreopoulos, G. D., & Rotstein, O. D. (2000) · Surgery · doi:10.1067/msy.2000.108060 · Cited by 81 · see citing works
Preparation and characterization of novel coenzyme Q10 nanoparticles engineered from microemulsion precursors
Hsu, C.-H., Cui, Z., Mumper, R. J., & Jay, M. (2003) · AAPS PharmSciTech · doi:10.1208/pt040332 · Cited by 80 · see citing works
Isomerization of Lycopene in the Gastric Milieu
Re, R., Fraser, P. D., Long, M. T., et al. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4366 · Cited by 80 · see citing works
Pharmacokinetics of isoflavones, daidzein and genistein, after ingestion of soy beverage compared with soy extract capsules in postmenopausal Thai women
Anupongsanugool, E., Teekachunhatean, S., Rojanasthien, N., et al. (2005) · BMC Clinical Pharmacology · doi:10.1186/1472-6904-5-2 · Cited by 79 · see citing works
Preparation and characterization of coenzyme Q10-loaded PMMA nanoparticles by a new emulsification process based on microfluidization
Kwon, S. S., Nam, Y. S., Lee, J. S., et al. (2002) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/s0927-7757(02)00212-1 · Cited by 79 · see citing works
Protection against dextran sulfate sodium-induced colitis by microspheres of ellagic acid in rats
Ogawa, Y., Kanatsu, K., Iino, T., et al. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01737-x · Cited by 78 · see citing works
Formation and identification of 4'-O-methyl-(-)-epigallocatechin in humans.
Meng, X., Lee, M. J., Li, C., Sheng, S., Zhu, N., Sang, S., Ho, C., & Yang, C. S. (2001) · PubMed · Cited by 78 · see citing works
Design of biodegradable nanoparticles: a novel approach to encapsulating poorly soluble phytochemical ellagic acid
Bala, I., Bhardwaj, V., Hariharan, S., et al. (2005) · Nanotechnology · doi:10.1088/0957-4484/16/12/014 · Cited by 71 · see citing works
Self-citation
Single-Dose Pharmacokinetic Study of Lycopene Delivered in a Well-Defined Food-Based Lycopene Delivery System (Tomato Paste-Oil Mixture) in Healthy Adult Male Subjects
Gustin, D. M., Rodvold, K. A., Sosman, J. A., Diwadkar‐Navsariwala, V., Stacewicz‐Sapuntzakis, M., Viana, M. A. G., Crowell, J. A., Murray, J. L., Tiller, P., & Bowen, P. E. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.850.13.5 · Cited by 71 · see citing works
Redox-Mediated Gene Therapies for Environmental Injury: Approaches and Concepts
Engelhardt, J. F. (1999) · Antioxidants and Redox Signaling · doi:10.1089/ars.1999.1.1-5 · Cited by 69 · see citing works
Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes
Nishikawa, M., Hyoudou, K., Kobayashi, Y., Umeyama, Y., Takakura, Y., & Hashida, M. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.09.017 · Cited by 67 · see citing works
Therapeutic uses of antioxidant liposomes
Stone, W. L., & Smith, M. G. (2004) · Molecular Biotechnology · doi:10.1385/mb:27:3:217 · Cited by 65 · see citing works
Determination of rat oral bioavailability of soy-derived phytoestrogens using an automated on-column extraction procedure and electrospray tandem mass spectrometry
Mallis, L. M., Sarkahian, A., HARRIS, H., et al. (2003) · Journal of Chromatography B · doi:10.1016/j.jchromb.2003.08.003 · Cited by 65 · see citing works
Developments in the rat adjuvant arthritis model and its use in therapeutic evaluation of novel non-invasive treatment by SOD in Transfersomes
Simões, S., Delgado, T. C., Lopes, R. M., Jesús, S. D., Ferreira, A. A., Morais, J., Cruz, M. E. M., Corvo, M. L., & Martins, M. B. F. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.12.008 · Cited by 65 · see citing works
Selected Contribution: Lung hypoxia: antioxidant and antiapoptotic effects of liposomal α-tocopherol
Minko, T., Stefanov, A., & Pozharov, V. P. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00007.2002 · Cited by 63 · see citing works
Biopolymeric colloidal carriers for encapsulation or controlled release applications
Renard, D., Robert, P., Lavenant, L., et al. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00143-6 · Cited by 62 · see citing works
Superoxide dismutase: Rationale for use in reperfusion injury and inflammation
McCord, J. M. (1986) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/s0748-5514(86)80029-0 · Cited by 61 · see citing works
Co-administration of quercetin and catechin in rats alters their absorption but not their metabolism
Silberberg, M., Morand, C., Manach, C., Scalbert, A., & Rémésy, C. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.03.033 · Cited by 59 · see citing works
Disposition of the plant phenol ellagic acid in the mouse following oral administration by gavage
Teel, R. W., & Martin, R. M. (1988) · Xenobiotica · doi:10.3109/00498258809041676 · Cited by 59 · see citing works
Pharmaceutical Aspects of Polymeric Nanoparticles for Oral Drug Delivery
Bhardwaj, V., Hariharan, S., Bala, I., Lamprecht, A., Kumar, N., Panchagnula, R., & Kumar, M. N. V. R. (2005) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2005.033 · Cited by 58 · see citing works
Self-citation
Effect of Storage Temperature and Water Activity on the Content and Profile of Isoflavones, Antioxidant Activity, and in Vitro Protein Digestibility of Soy Protein Isolates and Defatted Soy Flours
Pinto, M. D. S., Lajolo, F. M., & Genovese, M. I. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0502451 · Cited by 57 · see citing works
Nanosphere-mediated delivery of vitamin E increases its efficacy against oxidative stress resulting from exposure to amyloid beta
Shea, T. B., Ortiz, D., Nicolosi, R. J., Kumar, R., & Watterson, A. C. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-7405 · Cited by 55 · see citing works
Long-term delivery of superoxide dismutase and catalase entrapped in poly(lactide-co-glycolide) microspheres: In vitro effects on isolated neonatal porcine pancreatic cell clusters
Giovagnoli, S., Luca, G., Casaburi, I., et al. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.05.021 · Cited by 55 · see citing works
Factors affecting flavonoids absorption
Piskuła, M. K. (2000) · BioFactors · doi:10.1002/biof.5520120128 · Cited by 55 · see citing works
Liposomal antioxidants in combating ischemia-reperfusion injury in rat brain
Sinha, J., Das, N., & Basu, M. K. (2001) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(01)00060-9 · Cited by 54 · see citing works
The Mediterranean diet in Spain.
Moreiras-Varela, O. (1989) · PubMed · Cited by 51 · see citing works
Alcohol‐free red wine prevents arterial thrombosis in dietary‐induced hypercholesterolemic rats: experimental support for the ‘French paradox’
Curtis, A. D., Murzilli, S., Castelnuovo, A. F. D., Rotilio, D., Donati, M. B., de Gaetano, G., & Iacoviello, L. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01126.x · Cited by 48 · see citing works
PHARMACOKINETICS OF SUPEROXIDE DISMUTASE IN RATS AFTER ORAL ADMINISTRATION
Regnault, C., Soursac, M., Roch-Arveiller, M., et al. (1996) · Biopharmaceutics & Drug Disposition · doi:10.1002/(sici)1099-081x(199603)17:2 · Cited by 43 · see citing works
Delivery of antiangiogenic and antioxidant drugs of ophthalmic interest through a nanoporous inorganic filter.
Orosz, K., Gupta, S. S., Hassink, M., et al. (2004) · PubMed · Cited by 42 · see citing works
Enzymatic characterization of lipid-based drug delivery systems
Ljusberg‐Wahren, H., Nielsen, F. S., Brogård, M., et al. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.02.038 · Cited by 41 · see citing works
Effect of β-Cyclodextrin in Improving the Correlation between Lycopene Concentration and ORAC Values
Bangalore, D. V., McGlynn, W. G., & Scott, D. D. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048258m · Cited by 39 · see citing works
Liver targeting of catalase by cationization for prevention of acute liver failure in mice
Ma, S.-F., Nishikawa, M., Katsumi, H., Yamashita, F., & Hashida, M. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.10.016 · Cited by 38 · see citing works
Pharmacokinetics of a Slow-Release Formulation of Soybean Isoflavones in Healthy Postmenopausal Women
Setchell, K. D. R., Brzezinski, A., Brown, N. M., et al. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0488099 · Cited by 34 · see citing works
Does the diet of the Balearic population, a Mediterranean-type diet, ensure compliance with nutritional objectives for the Spanish population?
Tur, J. A., Romaguera, D., & Pons, A. (2005) · Public Health Nutrition · doi:10.1079/phn2004693 · Cited by 33 · see citing works
Photostability of Solid-State Ubidecarenone at Ordinary and Elevated Temperatures under Exaggerated UV Irradiation
Matsuda, Y., & Masahara, R. (1983) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600721023 · Cited by 33 · see citing works
Ellagic acid metabolism and binding to DNA in organ explant cultures of the rat
Teel, R. W., Martin, R. M., & Allahyari, R. (1987) · Cancer Letters · doi:10.1016/0304-3835(87)90092-9 · Cited by 32 · see citing works
Effects of malonate C60 derivatives on activated microglia
Tzeng, S., Lee, J., Kuo, J.-S., Yang, C., Murugan, P., Tai, L. A., & Hwang, K. C. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02592-1 · Cited by 29 · see citing works
Incorporation of α-Tocopherol in Liposomes Promotes the Retention of Liposome-encapsulated Glutathione in the Rat Lung
Suntres, Z. E., & Shek, P. N. (1994) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1994.tb03714.x · Cited by 28 · see citing works
Vitamin C pharmacokinetics of plain and slow release formulations in smokers
Viscovich, M. (2004) · Clinical Nutrition · doi:10.1016/j.clnu.2004.01.007 · Cited by 27 · see citing works
Distribution and metabolism of ellagic acid in the mouse following intraperitoneal administration
Teel, R. W. (1987) · Cancer Letters · doi:10.1016/0304-3835(87)90007-3 · Cited by 26 · see citing works
The effect of liposomes with superoxide dismutase on A2182 cells
Galović, R., Filipović‐Grčić, J., Čepelak, I., Žanić‐Grubišić, T., & Barišić, K. (2005) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.12.002 · Cited by 25 · see citing works
Rational Design and Expression of a Heparin-Targeted Human Superoxide Dismutase
Boissinot, M., Kuhn, L. A., Lee, P. P., et al. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1038 · Cited by 23 · see citing works
Stability of Vitamin C (Ascorbic Acid) in Tablets
Rubin, S. H., DeRitter, E., & Johnson, J. B. (1976) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600650704 · Cited by 21 · see citing works
Fate of superoxide dismutase in mice following oral route of administration.
Giri, S. N., & Misra, H. P. (1984) · PubMed · Cited by 20 · see citing works
Drug targeting to hypoxic tissue using self-inactivating bioreductive delivery systems
Naughton, D. P. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00229-0 · Cited by 20 · see citing works
Controlled Release of Vitamin E from Thermo-Responsive Polymeric Physico-Gel
Ishida, M., Sakai, H., Sugihara, S., et al. (2003) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.51.1348 · Cited by 19 · see citing works
Intestinal absorption of coenzyme Q10 administered in a meal or as capsules to healthy subjects
Weber, C., Bysted, A., & Hølmer, G. (1997) · Nutrition Research · doi:10.1016/s0271-5317(97)00059-6 · Cited by 19 · see citing works
Investigating the Stability of EGCg in Aqueous Media
Zhou, Q., Chiang, H., Porto-Carrero, C., et al. (2003) · Cited by 15 · see citing works
Plasma Pharmacokinetics, Nervous System Biodistribution and Biostability, and Spinal Cord Permeability at the Blood–Brain Barrier of Putrescine-Modified Catalase in the Adult Rat
Reinholz, M. M., Haggard, J. J., Curran, G. L., & Poduslo, J. F. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7117 · Cited by 11 · see citing works
Benzo(alpha)pyrene metabolism and DNA-binding in cultured explants of human bronchus and in monolayer cultures of human bronchial epithelial cells treated with ellagic acid.
Teel, R. W., Gd, S., Babcock, M. S., et al. (1986) · PubMed · Cited by 11 · see citing works
Regular drinking might explain the French paradox
Chawla, R. (2004) · BMJ · doi:10.1136/bmj.329.7478.1308-g · Cited by 9 · see citing works
Chemical and enzymatic stability evaluation of lipoamino acid esters of idebenone
Puleo, A., Niemi, R., Järvinen, T., et al. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2003.12.001 · Cited by 7 · see citing works

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Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275 · see citing works
A review on antioxidants, prooxidants and related controversy: Natural and synthetic compounds, screening and analysis methodologies and future perspectives
Carocho, M., & Ferreira, I. C. F. R. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.09.021 · Cited by 1,661 · see citing works
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Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007176.pub2 · Cited by 924 · see citing works
Oxidative Stress and Anxiety: Relationship and Cellular Pathways
Bouayed, J., Rammal, H., & Soulimani, R. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.2.7944 · Cited by 517 · see citing works
Development of Biodegradable Nanoparticles for Delivery of Quercetin
Kumari, A., Yadav, S. K., Pakade, Y. B., Singh, B., & Yadav, S. C. (2010) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2010.06.002 · Cited by 460 · see citing works
Vitamin C: Update on physiology and pharmacology
Mandl, J., Szarka, A., & Bánhegyi, G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00282.x · Cited by 451 · see citing works
Superoxide dismutase: An updated review on its health benefits and industrial applications
Islam, M. N., Rauf, A., Fahad, F. I., Emran, T. B., Mitra, S., Olatunde, A., Shariati, M. A., Rebezov, M., Rengasamy, K. R. R., & Mubarak, M. S. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1913400 · Cited by 307 · see citing works
Antioxidative and prooxidative effects of quercetin on A549 cells
Robaszkiewicz, A., Balcerczyk, A., & Bartosz, G. (2007) · Cell Biology International · doi:10.1016/j.cellbi.2007.04.009 · Cited by 279 · see citing works
Diet and Skin Aging—From the Perspective of Food Nutrition
Cao, C., Xiao, Z., Wu, Y., & Ge, C. (2020) · Nutrients · doi:10.3390/nu12030870 · Cited by 231 · see citing works
An overview about oxidation in clinical practice of skin aging
Silva, S. A. M. E., Michniak-Kohn, B., & Leonardi, G. R. (2017) · Anais Brasileiros de Dermatologia · doi:10.1590/abd1806-4841.20175481 · Cited by 134 · see citing works
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Ben-Yehuda Greenwald, M., Ben-Sasson, S., Bianco-Peled, H., & Kohen, R. (2016) · Cosmetics · doi:10.3390/cosmetics3010001 · Cited by 49 · see citing works

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Gopia, S., Georgea, R., & .Sriraamb, V. T. (2014) · Asian Journal of Pharmaceutical Technology and Innovation · Cited by 5 · see citing works
Metabolic Fate of Curcumin in the Gastrointestinal Tract in Mice
Li, Z., Sun, Y., Song, M., et al. (2016) · The FASEB Journal · doi:10.1096/fasebj.30.1_supplement.690.9 · Cited by 1 · see citing works
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Kroon, M. A. G. M., Berbee, J. K., Majait, S., et al. (2023) · medRxiv · doi:10.1101/2023.03.23.23287619 · Cited by 2 · see citing works
Analysis of the anticancer activity of curcuminoids, thiotryptophan and 4-phenoxyphenol derivatives
Parsai, S., Keck, R. W., Skrzypczak‐Jankun, E., & Jankun, J. (2013) · Oncology Letters · doi:10.3892/ol.2013.1679 · Cited by 24 · see citing works

Authors: Ratnam, D. V., Ankola, D. D., Bhardwaj, V., Sahana, D. K., & Kumar, M. N. V. R.
Affiliations: National Institute of Pharmaceutical Education and Research (IN)
Corresponding author: Kumar, M.N.V. Ravi
ORCID: Kumar, M.N.V. Ravi
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2006-07
Volume: 113
Issue: 3
Pages: 189-207
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2006.04.015
OpenAlex: W2062502442
Cited by: 885
References: 147
Citations by year: 2026: 13 · 2025: 35 · 2024: 36 · 2023: 54 · 2022: 48 · 2021: 61 · 2020: 41 · 2019: 52 · 2018: 55 · 2017: 42 · 2016: 53 · 2015: 53 · 2014: 55 · 2013: 69 · 2012: 46
FWCI: 3.35
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords: antioxidants, free radicals, reactive oxygen species, disease prevention, drug delivery systems, bioavailability, dietary supplementation, liposomes, nanoparticles, microparticles, oral drug delivery, pharmacokinetics, superoxide dismutase, catalase, epigallocatechin gallate, lycopene, coenzyme Q10, indole-3-carbinol, genistein, quercetin, vitamin C, vitamin E, aging
MeSH terms: Administration, Oral, Animals, Antioxidants, Biological Availability, Cardiovascular Diseases, Chemistry, Pharmaceutical, Drug Carriers, Drug Stability, Free Radicals, Humans, Mitochondria, Permeability, Solubility, Free Radical Scavengers, Drug Delivery Systems, Oxidative Stress, Nanotechnology

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Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective

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