Cited by 517TGF-β signaling in diseasesDevelopmental Biology and Gene RegulationHeterotopic Ossification and Related Conditions

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Signal transduction of bone morphogenetic protein receptors

Nohe, A·2004·Cellular Signalling

DOI 10.1016/j.cellsig.2003.08.011

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Abstract

Bone morphogenetic proteins (BMPs) play a crucial role during all stages of embryonic development. Although only two major signaling pathways have been characterized (the p38 and Smad pathways), the BMP signaling is complex and includes several negative feedback mechanisms. This article reviews the current state of BMP receptor signaling and provides a summary of the crosstalk of the BMP receptor pathway with other major signaling pathways.

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Non-Smad TGF-β signals
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Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
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Bone morphogenetic proteins: a critical review
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Authors: Nohe, A.
Affiliations: Western University (CA)
Corresponding author: Nohe, A
ORCID: Nohe, A
Venue: Cellular Signalling
Publisher: Elsevier BV
Published: 2004-03
Volume: 16
Issue: 3
Pages: 291-299
ISSN: 0898-6568 (ISSN-L)
DOI: 10.1016/j.cellsig.2003.08.011
OpenAlex: W2093271566
Cited by: 514
References: 133
Citations by year: 2026: 3 · 2025: 5 · 2024: 11 · 2023: 7 · 2022: 17 · 2021: 10 · 2020: 12 · 2019: 9 · 2018: 17 · 2017: 16 · 2016: 30 · 2015: 31 · 2014: 22 · 2013: 26 · 2012: 31
FWCI: 7.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cellular Signalling (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Rheumatology › Heterotopic Ossification and Related Conditions
Keywords: bone morphogenetic proteins, BMP receptors, signal transduction, Smad signaling, p38 MAPK pathway, negative feedback regulation, signaling crosstalk, embryonic development
MeSH terms: Animals, Carrier Proteins, DNA-Binding Proteins, Models, Biological, Signal Transduction, Trans-Activators, Receptors, Growth Factor, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, Feedback, Physiological, p38 Mitogen-Activated Protein Kinases, Adaptor Proteins, Signal Transducing, Smad Proteins, Bone Morphogenetic Protein Receptors

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Signal transduction of bone morphogenetic protein receptors

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