Role of cAMP and phosphodiesterase signaling in liver health and disease
Open accessAbstract
Liver disease is a significant health problem worldwide with mortality reaching around 2 million deaths a year. Non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are the major causes of chronic liver disease. Pathologically, NAFLD and ALD share similar patterns of hepatic disorders ranging from simple steatosis to steatohepatitis, fibrosis and cirrhosis. It is becoming increasingly important to identify new pharmacological targets, given that there is no FDA-approved therapy yet for either NAFLD or ALD. Since the evolution of liver diseases is a multifactorial process, several mechanisms involving parenchymal and non-parenchymal hepatic cells contribute to the initiation and progression of liver pathologies. Moreover, certain protective molecular pathways become repressed during liver injury including signaling pathways such as the cyclic adenosine monophosphate (cAMP) pathway. cAMP, a key second messenger molecule, regulates various cellular functions including lipid metabolism, inflammation, cell differentiation and injury by affecting gene/protein expression and function. This review addresses the current understanding of the role of cAMP metabolism and consequent cAMP signaling pathway(s) in the context of liver health and disease. The cAMP pathway is extremely sophisticated and complex with specific cellular functions dictated by numerous factors such abundance, localization and degradation by phosphodiesterases (PDEs). Furthermore, because of the distinct yet divergent roles of both of its effector molecules, the cAMP pathway is extensively targeted in liver injury to modify its role from physiological to therapeutic, depending on the hepatic condition. This review also examines the behavior of the cAMP-dependent pathway in NAFLD, ALD and in other liver diseases and focuses on PDE inhibition as an excellent therapeutic target in these conditions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
De-differentiation of human macrophages into monocyte-like cells has been shown to be induced by bacterial toxins that elevate cAMP.
“The de-differentiation of human macrophages into monocyte-like cells has been shown to be induced by bacterial toxins that elevate cAMP”
From Single-cell atlas of human liver and blood immune cells across fatty liver disease stages reveals distinct signatures linked to liver dysfunction and fibrogenesis (2025) · cites this paper as [52]
The section on cAMP in alcoholic liver disease discusses cAMP levels and inflammatory responses in monocytes and macrophages, but not macrophage de-differentiation. Searches for macrophages becoming monocyte-like cells and for cAMP-elevating bacterial toxins found no passage addressing the claimed transformation. (LLM, conf=0.72)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290 · see citing works
Vernon, G. C., Baranova, A. V., & Younossi, Z. M. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04724.x · Cited by 3,067 · see citing works
Mechanisms of hepatic stellate cell activation
Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909 · see citing works
Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm908 · Cited by 2,712 · see citing works
Mechanisms of Hepatic Fibrogenesis
Friedman, S. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.003 · Cited by 2,640 · see citing works
Transcriptional regulation by the phosphorylation-dependent factor CREB
Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587 · see citing works
CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals
Shaywitz, A. J., & Greenberg, M. E. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.821 · Cited by 2,135 · see citing works
Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury
Friedman, S. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2247 · Cited by 2,090 · see citing works
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
de Rooij, J., Zwartkruis, F. J. T., Verheijen, M. H. G., Cool, R. H., Nijman, S. M. B., Wittinghofer, A., & Bos, J. L. (1998) · Nature · doi:10.1038/24884 · Cited by 1,970 · see citing works
Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets
Gao, B., & Bataller, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.09.002 · Cited by 1,963 · see citing works
Hepatic stellate cells as key target in liver fibrosis
Higashi, T., Friedman, S. L., & Hoshida, Y. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.05.007 · Cited by 1,485 · see citing works
An Adenosine 3′,5′-Monophosphate-dependant Protein Kinase from Rabbit Skeletal Muscle
Walsh, D. A., Perkins, J. P., & Krebs, E. G. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)34204-8 · Cited by 1,448 · see citing works
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
Herzig, S., Long, F., Jhala, U. S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., et al. (2001) · Nature · doi:10.1038/35093131 · Cited by 1,440 · see citing works
A Family of cAMP-Binding Proteins That Directly Activate Rap1
Kawasaki, H., Springett, G. M., Mochizuki, N., Toki, S., Nakaya, M., Matsuda, M., Housman, D. E., & Graybiel, A. M. (1998) · Science · doi:10.1126/science.282.5397.2275 · Cited by 1,360 · see citing works
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
Park, S. J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.017 · Cited by 1,352 · see citing works
Liver inflammation and fibrosis
Koyama, Y., & Brenner, D. A. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88881 · Cited by 1,295 · see citing works
Conti, M., & Beavo, J. A. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060305.150444 · Cited by 1,188 · see citing works
cAMP-DEPENDENT PROTEIN KINASE: FRAMEWORK FOR A DIVERSE FAMILY OF REGULATORY ENZYMES
Taylor, S. S., Buechler, J. A., & Yonemoto, W. M. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.004543 · Cited by 1,144 · see citing works
Cyclic Nucleotide-Gated Ion Channels
Kaupp, U. B., & Seifert, R. (2002) · Physiological Reviews · doi:10.1152/physrev.00008.2002 · Cited by 1,141 · see citing works
FRACTIONATION AND CHARACTERIZATION OF A CYCLIC ADENINE RIBONUCLEOTIDE FORMED BY TISSUE PARTICLES
Sutherland, E. W., & Rall, T. W. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77423-7 · Cited by 1,080 · see citing works
Boolell, M., Mj, A., Sa, B., Gepi-Attee, S., Muirhead, G. J., Naylor, A. M., Ih, O., & Gingell, C. (1996) · PubMed · Cited by 1,067 · see citing works
Knighton, D. R., Zheng, J., Eyck, L. F. T., Xuong, N., Taylor, S. S., & Sowadski, J. M. (1991) · Science · doi:10.1126/science.1862343 · Cited by 960 · see citing works
Robinson, G. A., Butcher, R. W., & Sutherland, E. W. (1968) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.37.070168.001053 · Cited by 958 · see citing works
Triggering and resolution of inflammation in NASH
Schuster, S., Cabrera, D., Arrese, M., & Feldstein, A. E. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0009-6 · Cited by 943 · see citing works
Cyclic nucleotide research — still expanding after half a century
Beavo, J. A., & Brunton, L. L. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm911 · Cited by 906 · see citing works
Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials
Calverley, P. M. A., Rabe, K. F., Goehring, U.-M., Kristiansen, S., Fabbri, L. M., & Martínez, F. J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61255-1 · Cited by 821 · see citing works
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
Enserink, J. M., Christensen, A. E., de Rooij, J., van Triest, M. H., Schwede, F., Genieser, H., Døskeland, S. O., Blank, J. L., & Bos, J. L. (2002) · Nature Cell Biology · doi:10.1038/ncb874 · Cited by 704 · see citing works
Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice
Yin, M., Wheeler, M. D., Kono, H., Bradford, B. U., Gallucci, R. M., Luster, M. I., & Thurman, R. G. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70354-9 · Cited by 699 · see citing works
Cooperation of Liver Cells in Health and Disease
Kmieć, Z. (2001) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-56553-3 · Cited by 631 · see citing works
Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease
Llopis, M., Cassard, A., Wrzosek, L., Boschat, L., Bruneau, A., Ferrere, G., Puchois, V., Martin, J., Lepage, P., Roy, T. L., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-310585 · Cited by 562 · see citing works
Ding, X., Saxena, N. K., Lin, S., Gupta, N., & Anania, F. A. (2006) · Hepatology · doi:10.1002/hep.21006 · Cited by 557 · see citing works
Khoruts, A., Stahnke, L., McClain, C. J., Logan, G., & Allen, J. I. (1991) · Hepatology · doi:10.1002/hep.1840130211 · Cited by 549 · see citing works
Self-citationKisseleva, T., & Brenner, D. A. (2008) · Experimental Biology and Medicine · doi:10.3181/0707-mr-190 · Cited by 507 · see citing works
Iimuro, Y., Gallucci, R. M., Luster, M. I., Kono, H., & Thurman, R. G. (1997) · Hepatology · doi:10.1002/hep.510260621 · Cited by 496 · see citing works
Matrix metalloproteinases in liver injury, repair and fibrosis
Duarte, S. M., Baber, J. T., Fujii, T., & Coito, A. J. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.01.004 · Cited by 481 · see citing works
Increased Plasma Tumor Necrosis Factor in Severe Alcoholic Hepatitis
Bird, G. L. A., Sheron, N., Goka, A. K. J., Alexander, G., & Williams, R. L. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-12-917 · Cited by 457 · see citing works
Petrasek, J., Iracheta‐Vellve, A., Csák, T., Satishchandran, A., Kodys, K., Kurt‐Jones, E. A., Fitzgerald, K. A., & Szabó, G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308331110 · Cited by 449 · see citing works
Barad, M., Bourtchouladze, R., Winder, D. G., Golan, H. M., & Kandel, E. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15020 · Cited by 431 · see citing works
Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
Houslay, M. D. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.09.007 · Cited by 431 · see citing works
Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes
Joshi‐Barve, S., Barve, S. S., Amancherla, K., Gobejishvili, L., Hill, D. B., Cave, M. C., Hote, P., & McClain, C. J. (2007) · Hepatology · doi:10.1002/hep.21752 · Cited by 406 · see citing works
Self-citationSvegliati‐Baroni, G., Saccomanno, S., Rychlicki, C., Agostinelli, L., De Minicis, S., Candelaresi, C., Faraci, G., Pacetti, D., Vivarelli, M., Nicolini, D., et al. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02462.x · Cited by 405 · see citing works
Rivera, L., Morón, R., Zarzuelo, A., & Galisteo, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.027 · Cited by 391 · see citing works
Jin, S.-L. C., & Conti, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122041599 · Cited by 368 · see citing works
Epac and PKA: a tale of two intracellular cAMP receptors
Cheng, X., Ji, Z., Tsalkova, T. N., & Mei, F. C. (2008) · Acta Biochimica et Biophysica Sinica · doi:10.1111/j.1745-7270.2008.00438.x · Cited by 358 · see citing works
Peripheral Artery Disease: Current Insight Into the Disease and Its Diagnosis and Management
Olin, J. W., & Sealove, B. A. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2010.0133 · Cited by 349 · see citing works
Ollivier, V., Parry, G. C., Cobb, R. R., de Prost, D., & Mackman, N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20828 · Cited by 333 · see citing works
CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-γ
Herzig, S., Hedrick, S. A., Morantte, I. G., Koo, S., Galimi, F., & Montminy, M. (2003) · Nature · doi:10.1038/nature02110 · Cited by 321 · see citing works
PKA: a portrait of protein kinase dynamics
Taylor, S. S., Yang, J., Wu, J., Haste, N. M., Radzio-Andzelm, E., & Anand, G. S. (2003) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2003.11.029 · Cited by 318 · see citing works
Ashraf, N. U., & Sheikh, T. A. (2015) · Free Radical Research · doi:10.3109/10715762.2015.1078461 · Cited by 311 · see citing works
Plasma Tumor Necrosis Factor α Predicts Decreased Long‐Term Survival in Severe Alcoholic Hepatitis
Felver, M. E., Mezey, E., McGuire, M., Mitchell, M. C., Herlong, H. F., Veech, G. A., & Veech, R. L. (1990) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1990.tb00482.x · Cited by 293 · see citing works
The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury
Hannila, S. S., & Filbin, M. T. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.06.020 · Cited by 289 · see citing works
A concise review of non-alcoholic fatty liver disease
Than, N. N., & Newsome, P. N. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.01.001 · Cited by 289 · see citing works
Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase
SHANG, J., CHEN, L.-L., XIAO, F.-X., SUN, H., DING, H.-C., & XIAO, H. (2008) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2008.00807.x · Cited by 274 · see citing works
Phosphodiesterases as Therapeutic Targets for Alzheimer's Disease
García‐Osta, A., Cuadrado‐Tejedor, M., García, C., Oyarzábal, J., & Franco, R. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn3000907 · Cited by 260 · see citing works
Specific Role of Phosphodiesterase 4B in Lipopolysaccharide-Induced Signaling in Mouse Macrophages
Jin, S.-L. C., Lan, L., Zoudilova, M., & Conti, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.3.1523 · Cited by 256 · see citing works
Non Alcoholic Fatty Liver: Epidemiology and Natural History
Masarone, M., Federico, A., Abenavoli, L., Loguercio, C., & Persico, M. (2015) · Reviews on Recent Clinical Trials · doi:10.2174/1574887109666141216111143 · Cited by 247 · see citing works
cAMP regulation of airway smooth muscle function
Billington, C. K., Ojo, O. O., Penn, R. B., & Ito, S. (2012) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2012.05.007 · Cited by 242 · see citing works
Jeon, Y. H., Heo, Y. S., Kim, C. M., Hyun, Y.-L., Lee, T. G., Ro, S., & Cho, J. M. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-4533-5 · Cited by 234 · see citing works
Peluso, M. R. (2006) · Experimental Biology and Medicine · doi:10.1177/153537020623100802 · Cited by 218 · see citing works
The Antidepressant and Antiinflammatory Effects of Rolipram in the Central Nervous System
Zhu, J., Mix, E., & Winblad, B. G. (2001) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2001.tb00206.x · Cited by 216 · see citing works
The Role of Cyclic AMP in the Control of Carbohydrate Metabolism
Sutherland, E. W., & Robison, G. A. (1969) · Diabetes · doi:10.2337/diab.18.12.797 · Cited by 215 · see citing works
Cellular mechanisms of tissue fibrosis. 5. Novel insights into liver fibrosis
Mallat, A., & Lotersztajn, S. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00230.2013 · Cited by 211 · see citing works
CYP2E1-dependent toxicity and oxidative stress in HepG2 cells,
Cederbaum, A. I. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00743-2 · Cited by 210 · see citing works
Cilostazol for intermittent claudication
Bedenis, R., Stewart, M. C. W., Cleanthis, M., et al. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003748.pub4 · Cited by 200 · see citing works
Update on the therapeutic potential of PDE4 inhibitors
Montana, J. G., & Dyke, H. J. (2002) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.11.1.1 · Cited by 197 · see citing works
Steegborn, C. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.08.012 · Cited by 196 · see citing works
Jitrapakdee, S. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.10.001 · Cited by 189 · see citing works
Lefkowitz, R. J., Pierce, K. L., & Luttrell, L. M. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.5.971 · Cited by 180 · see citing works
Phosphodiesterases and Cyclic Nucleotide Signaling in Endocrine Cells
Conti, M. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.9.0534 · Cited by 178 · see citing works
cAMP and Epac in the regulation of tissue fibrosis
Insel, P. A., Murray, F., Yokoyama, U., Romano, S., Yun, H., Brown, L., Snead, A., Lu, D., & Aroonsakool, N. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01847.x · Cited by 175 · see citing works
Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway
Zhang, Y., Chen, M., Zhou, Y., Yi, L., Gao, Y., Ran, L., Chen, S., Zhang, T., Zhou, X., Zou, D., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500016 · Cited by 170 · see citing works
Anti-fibrogenic strategies and the regression of fibrosis
Kisseleva, T., & Brenner, D. A. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2011.02.011 · Cited by 169 · see citing works
Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies
Li, J., Liao, Z., Ping, J., Xu, D., & Wang, H. (2008) · Journal of Gastroenterology · doi:10.1007/s00535-008-2180-y · Cited by 167 · see citing works
Diamond, I., WRUBEL, B., Estrin, W. J., & Gordon, A. S. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1413 · Cited by 164 · see citing works
Tian, Y., Ma, J., Wang, W., Zhang, L., Xu, J., Wang, K., & Li, D. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2807-x · Cited by 161 · see citing works
Bode, C., & Bode, J. C. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000189280.19073.28 · Cited by 158 · see citing works
Bravi, F., Tavani, A., Bosetti, C., Boffetta, P., & Vecchia, C. L. (2016) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000252 · Cited by 151 · see citing works
Louet, J., Hayhurst, G. P., Gonzalez, F. J., Girard, J. R., & Decaux, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205087200 · Cited by 150 · see citing works
Pathogenesis, Diagnosis, and Treatment of Alcoholic Liver Disease
Menon, K. V., Gores, G. J., & Shah, V. H. (2001) · Mayo Clinic Proceedings · doi:10.4065/76.10.1021 · Cited by 149 · see citing works
Kleinboelting, S., Diaz, A., Moniot, S., van den Heuvel, J., Weyand, M., Levin, L. R., Buck, J., & Steegborn, C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322778111 · Cited by 140 · see citing works
Role of the cAMP Pathway in Glucose and Lipid Metabolism
Ravnskjær, K., Madiraju, A. K., & Montminy, M. (2015) · Handbook of experimental pharmacology · doi:10.1007/164_2015_32 · Cited by 140 · see citing works
Toll-Like Receptor Signaling and Liver Fibrosis
Aoyama, T., Paik, Y., & Seki, E. (2010) · Gastroenterology Research and Practice · doi:10.1155/2010/192543 · Cited by 139 · see citing works
The Natural cAMP Elevating Compound Forskolin in Cancer Therapy: Is It Time?
Sapio, L., Gallo, M., Illiano, M., Chiosi, E., Naviglio, D., Spina, A., & Naviglio, S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25650 · Cited by 138 · see citing works
Lebrec, D., Thabut, D., Oberti, F., Perarnau, J., Condat, B., Barraud, H., Saliba, F., Carbonell, N., Renard, P., Ramond, M.-J., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.040 · Cited by 136 · see citing works
Selective Cyclic Nucleotide Phosphodiesterase Inhibitors as Potential Therapeutic Agents
Weiss, B., & Hait, W. N. (1977) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.17.040177.002301 · Cited by 135 · see citing works
Systematic review with meta‐analysis: coffee consumption and the risk of cirrhosis
Kennedy, O. J., Roderick, P. J., Buchanan, R. M., Fallowfield, J. A., Hayes, P. C., & Parkes, J. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13523 · Cited by 126 · see citing works
Giembycz, M. A., Kaur, M., Leigh, R., & Newton, R. C. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707627 · Cited by 124 · see citing works
New Dietary Supplements for Obesity: What We Currently Know
Ríos-Hoyo, A., & Gutiérrez-Salmeán, G. (2016) · Current Obesity Reports · doi:10.1007/s13679-016-0214-y · Cited by 122 · see citing works
Phosphodiesterase 4-targeted treatments for autoimmune diseases
Kumar, N., Goldminz, A. M., Kim, N., & Gottlieb, A. B. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-96 · Cited by 121 · see citing works
CO2/HCO3−- and Calcium-regulated Soluble Adenylyl Cyclase as a Physiological ATP Sensor
Zippin, J. H., Chen, Y., Straub, S. G., Hess, K. C., Diaz, A., Lee, D., Tso, P., Holz, G. G., Sharp, G. W. G., Levin, L. R., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.510073 · Cited by 116 · see citing works
Yajima, H., Komatsu, M., Schermerhorn, T., Aizawa, T., Kaneko, T., Nagai, M., Sharp, G. W. G., & Hashizume, K. (1999) · Diabetes · doi:10.2337/diabetes.48.5.1006 · Cited by 110 · see citing works
Xu, Z., Huo, J., Ding, X., Yang, M., Li, L., Dai, J., Hosoe, K., Kubo, H., Mori, M., Higuchi, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08899-7 · Cited by 108 · see citing works
Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet
Alberdi, G., Rodríguez, V. M., Macarulla, M. T., Miranda, J., Churruca, I., & Portillo, M. P. (2012) · Nutrition · doi:10.1016/j.nut.2012.09.011 · Cited by 106 · see citing works
Wouters, E. F. �., Bredenbröker, D., Teichmann, P., Brose, M., Rabe, K. F., Fabbri, L. M., & Göke, B. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2886 · Cited by 106 · see citing works
Gut microbiome and liver disease
Betrapally, N. S., Gillevet, P. M., & Bajaj, J. S. (2016) · Translational research · doi:10.1016/j.trsl.2016.07.005 · Cited by 104 · see citing works
Recent trends in the epidemiology of alcoholic liver disease
Singal, A. K., & Anand, B. S. (2013) · Clinical Liver Disease · doi:10.1002/cld.168 · Cited by 103 · see citing works
Dual PDE 3/4 and PDE 4 Inhibitors: Novel Treatments For COPD and Other Inflammatory Airway Diseases
Abbott-Banner, K., & Page, C. P. (2014) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12209 · Cited by 99 · see citing works
Arai, T., Hiromatsu, K., Kobayashi, N., Takano, M., Ishida, H., Nimura, Y., & Yoshikai, Y. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.12.5743 · Cited by 96 · see citing works
GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis
López-Sánchez, I., Dunkel, Y., Roh, Y., Mittal, Y., Minicis, S. D., Murányi, A., Singh, S., Shanmugam, K., Aroonsakool, N., Murray, F., et al. (2014) · Nature Communications · doi:10.1038/ncomms5451 · Cited by 92 · see citing works
Gobejishvili, L., Barve, S. S., Joshi‐Barve, S., et al. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00098.2006 · Cited by 88 · see citing works
Self-citationProliferation of hepatic stellate cells is inhibited by phosphorylation of CREB on serine 133.
Houglum, K., Lee, K. S., & Chojkier, M. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119291 · Cited by 84 · see citing works
Wadhawan, M., & Anand, A. C. (2016) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2016.02.003 · Cited by 83 · see citing works
Treating COPD with PDE 4 inhibitors.
Brown, W. M. (2007) · PubMed Central · Cited by 78 · see citing works
Fukui, H. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000189278.30237.e9 · Cited by 76 · see citing works
Gobejishvili, L., Barve, S. S., Joshi‐Barve, S., & McClain, C. J. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90232.2008 · Cited by 76 · see citing works
Self-citationEl-Agroudy, N. N., El‐Naga, R. N., El‐Razeq, R. A., & El‐Demerdash, E. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13611 · Cited by 76 · see citing works
β-Adrenergic induction of lipolysis in hepatocytes is inhibited by ethanol exposure
Schott, M. B., Rasineni, K., Weller, S. G., Schulze, R. J., Sletten, A. C., Casey, C. A., & McNiven, M. A. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.777748 · Cited by 76 · see citing works
MacPherson, M. R., Molina, P., Souchelnytskyi, S., Wernstedt, C., Martı́n-Pérez, J., Portillo, F., & Cano, A. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-06-0504 · Cited by 74 · see citing works
Cyclic AMP sensor EPAC proteins and energy homeostasis
Almahariq, M. F., Mei, F. C., & Cheng, X. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.10.004 · Cited by 70 · see citing works
Greuter, T., Malhi, H., Gores, G. J., & Shah, V. H. (2017) · JCI Insight · doi:10.1172/jci.insight.95354 · Cited by 67 · see citing works
Reinehr, R., & Häussinger, D. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.09.044 · Cited by 63 · see citing works
Zhou, M., Mok, M. T. S., Sun, H., Chan, A. W. H., Huang, Y., Cheng, A. S. L., & Xu, G. (2017) · Oncogene · doi:10.1038/onc.2017.38 · Cited by 62 · see citing works
Desmoulière, A., Xu, G., Monte‐Alto‐Costa, A., et al. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80192-5 · Cited by 61 · see citing works
2 PDE4 Inhibitors – A Review of the Current Field
Press, N. J., & Banner, K. H. (2009) · Progress in medicinal chemistry · doi:10.1016/s0079-6468(08)00202-6 · Cited by 60 · see citing works
cAMP inhibits bile acid-induced apoptosis by blocking caspase activation and cytochromecrelease
Webster, C. R. L., Usechak, P., & Anwer, M. S. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00410.2001 · Cited by 60 · see citing works
McClain, C. J., Barve, S. S., Joshi‐Barve, S., Song, Z., Deaciuc, I. V., Chen, T., & Hill, D. B. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000189276.34230.f5 · Cited by 57 · see citing works
Self-citationInnate immunity and cell death in alcoholic liver disease: Role of cytochrome P4502E1
Barnes, M. A., Roychowdhury, S., & Nagy, L. E. (2014) · Redox Biology · doi:10.1016/j.redox.2014.07.007 · Cited by 55 · see citing works
Chen, R., Williams, A. J., Liao, Z., et al. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.03.033 · Cited by 54 · see citing works
Ratziu, V., Bédossa, P., Francque, S., Larrey, D. G., Aithal, G. P., Serfaty, L., Voiculescu, M., Preoțescu, L., Nevens, F., de Lédinghen, V., et al. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.01.040 · Cited by 54 · see citing works
Cullen, K. A., McCool, J., Anwer, M. S., & Webster, C. R. L. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00517.2003 · Cited by 53 · see citing works
Vetrugno, M., Uva, M. G., Russo, V., et al. (2012) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2012.0021 · Cited by 52 · see citing works
pH sensing via bicarbonate-regulated “soluble” adenylyl cyclase (sAC)
Rahman, N., Buck, J., & Levin, L. R. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00343 · Cited by 51 · see citing works
Phosphodiesterase‐4 inhibition as a therapeutic strategy for metabolic disorders
Wu, C., & Rajagopalan, S. (2016) · Obesity Reviews · doi:10.1111/obr.12385 · Cited by 49 · see citing works
Avila, D. V., Barker, D. F., Zhang, J., McClain, C. J., Barve, S. S., & Gobejishvili, L. (2016) · The Journal of Pathology · doi:10.1002/path.4760 · Cited by 49 · see citing works
Self-citationHodge, A. D., Lim, S., Goh, E., Wong, O., Marsh, P. J., Knight, V., Sievert, W., & de Courten, B. V. (2017) · Nutrients · doi:10.3390/nu9010056 · Cited by 49 · see citing works
Pentoxifylline for the treatment of nonalcoholic fatty liver disease
Zeng, T., Zhang, C., Zhao, X., & Xie, K.-Q. (2014) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000068 · Cited by 48 · see citing works
Antidiabetic Sulfonylureas and cAMP Cooperatively Activate Epac2A
Takahashi, T., Shibasaki, T., Takahashi, H., Sugawara, K., Ono, A., Inoue, N., Furuya, T., & Seino, S. (2013) · Science Signaling · doi:10.1126/scisignal.2004581 · Cited by 48 · see citing works
Differential Modulation of CYP2E1 Activity by cAMP-Dependent Protein Kinase upon Ser129Replacement
Oesch‐Bartlomowicz, B., Padma, P. R., Becker, R., Richter, B., Hengstler, J. G., Freeman, J. E., Wolf, C. R., & Oesch, F. (1998) · Experimental Cell Research · doi:10.1006/excr.1998.4120 · Cited by 48 · see citing works
Möllmann, J., Kahles, F., Lebherz, C., Kappel, B. A., Baeck, C., Tacke, F., Werner, C., Federici, M., Marx, N., & Lehrke, M. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12839 · Cited by 48 · see citing works
Roflumilast reverses polymicrobial sepsis-induced liver damage by inhibiting inflammation in mice
Feng, H.-F., Chen, J., Wang, H., et al. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2017.59 · Cited by 48 · see citing works
Lu, D., Aroonsakool, N., Yokoyama, U., Patel, H. H., & Insel, P. A. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.087742 · Cited by 47 · see citing works
Wang, H., Zhao, M., Sud, N., Christian, P., Shen, J., Song, Y., Pashaj, A., Zhang, K., Carr, T. P., & Su, Q. (2016) · Scientific Reports · doi:10.1038/srep32246 · Cited by 47 · see citing works
Gobejishvili, L., Barve, S. S., Breitkopf‐Heinlein, K., Li, Y., Zhang, J., Avila, D. V., Dooley, S., & McClain, C. J. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.204933 · Cited by 46 · see citing works
Self-citationFischer, W., Schudt, C., & Wendel, A. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90219-m · Cited by 45 · see citing works
Jensterle, M., Kocjan, T., & Janež, A. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1430 · Cited by 44 · see citing works
The role of cyclic AMP in rapid and long-term regulation of gluconeogenesis and glycolysis.
Pilkis, S. J., Claus, T. H., & El‐Maghrabi, M. R. (1988) · PubMed · Cited by 43 · see citing works
Shames, B. D., McIntyre, R. C., Bensard, D. D., et al. (2001) · Journal of Surgical Research · doi:10.1006/jsre.2001.6178 · Cited by 42 · see citing works
Henquin, J.-C., & Nenquin, M. (2014) · Endocrinology · doi:10.1210/en.2014-1247 · Cited by 41 · see citing works
Iredale, J. P., Pellicoro, A., & Fallowfield, J. A. (2017) · Digestive Diseases · doi:10.1159/000456581 · Cited by 40 · see citing works
New paradigms in cAMP signalling
Antoni, F. A. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.10.034 · Cited by 39 · see citing works
Fibrogenesis in alcoholic liver disease
Fujii, H. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i25.8048 · Cited by 37 · see citing works
Ceccarelli, S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i44.16443 · Cited by 35 · see citing works
Massimi, M., Cardarelli, S., Galli, F., et al. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25798 · Cited by 35 · see citing works
Gouillon, Z. ‐. (1999) · Frontiers in bioscience · doi:10.2741/gouillon · Cited by 34 · see citing works
Kawada, N., Kuroki, T., Kobayashi, K., Inoue, M., & Kaneda, K. (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02091547 · Cited by 33 · see citing works
Epac2: a sulfonylurea receptor?
Rehmann, H. (2012) · Biochemical Society Transactions · doi:10.1042/bst20110640 · Cited by 33 · see citing works
The TLR4‐IRE1α pathway activation contributes to palmitate‐elicited lipotoxicity in hepatocytes
Shen, C., Ma, W., Ding, L., Li, S.-T., Dou, X., & Song, Z.-Y. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13636 · Cited by 33 · see citing works
Fang, C.-L., Wen, C.-J., Aljuffali, I. A., Sung, C. T., Huang, C.-L., & Fang, J. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.06.038 · Cited by 32 · see citing works
Yamashita, H., Goto, M., Matsui‐Yuasa, I., et al. (2015) · Marine Drugs · doi:10.3390/md13063877 · Cited by 31 · see citing works
Mandal, S., Nelson, V. K., Mukhopadhyay, S., Bandhopadhyay, S., Maganti, L., Ghoshal, N., Sen, G., & Biswas, T. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.05.056 · Cited by 30 · see citing works
Yang, Y., Yang, F., Wu, X., Lv, X., & Li, J. (2015) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2015-0437 · Cited by 30 · see citing works
Taguchi, I., Oka, K., Kitamura, K., et al. (1999) · Inflammation Research · doi:10.1007/s000110050475 · Cited by 28 · see citing works
Popeye domain-containing proteins and stress-mediated modulation of cardiac pacemaking
Simrick, S., Schindler, R. F. R., Poon, K., et al. (2013) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2013.02.002 · Cited by 27 · see citing works
Kawy, H. S. A. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.01.044 · Cited by 26 · see citing works
Pentoxifylline prevents pig serum‐induced rat liver fibrosis by inhibiting interleukin‐6 production
Toda, K., Kumagai, N., Kaneko, F., et al. (2009) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05749.x · Cited by 26 · see citing works
Huerta, M., Urzúa, Z., Trujillo, X., et al. (2010) · Journal of International Medical Research · doi:10.1177/147323001003800229 · Cited by 26 · see citing works
O'Donnell, P. M., & Taffet, S. M. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/10799900252982016 · Cited by 25 · see citing works
Free Fatty Acids Shift Insulin-induced Hepatocyte Proliferation towards CD95-dependent Apoptosis
Sommerfeld, A., Reinehr, R., & Häussinger, D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.617035 · Cited by 24 · see citing works
Newman, W. H., Zhang, L.-M., Lee, D. H., et al. (1998) · Journal of Surgical Research · doi:10.1006/jsre.1998.5456 · Cited by 23 · see citing works
Lent, B. A., & Kim, K.-H. (1983) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(83)90113-3 · Cited by 22 · see citing works
Chae, M. K., Park, S. G., Song, S. O., Kang, E. S., Soo, B., Lee, H. C., & Lee, B. (2012) · Experimental Diabetes Research · doi:10.1155/2012/762565 · Cited by 22 · see citing works
Johnston, A. N., Ponzetti, K. M., Anwer, M. S., & Webster, C. R. L. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00430.2010 · Cited by 22 · see citing works
Schippers, M., Beljaars, L., Post, E., Lotersztajn, S., Reker‐Smit, C., Han, B., Muñoz-LLancao, P., Schmidt, M., & Poelstra, K. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.241646 · Cited by 22 · see citing works
Inhibitors of phosphodiesterases in the treatment of cough
Mokrý, J., Urbanová, A., Kertys, M., et al. (2018) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2018.01.008 · Cited by 22 · see citing works
cAMP prevents TNF-induced apoptosis through inhibiting DISC complex formation in rat hepatocytes
Bhattacharjee, R., Xiang, W., Wang, Y., Zhang, X., & Billiar, T. R. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.05.087 · Cited by 21 · see citing works
Hernández, E., Bucio, L., Souza, V., Escobar, M., Gómez-Quiroz, L. E., Farfan, B., Kershenobich, D., & Gutiérrez‐Ruíz, M. C. (2007) · Cell Biology and Toxicology · doi:10.1007/s10565-007-9039-5 · Cited by 20 · see citing works
Toba, K., Sudoh, N., Nagano, K., et al. (1997) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.34.577 · Cited by 19 · see citing works
Aroor, A. R., Jackson, D. E., & Shukla, S. D. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.12.045 · Cited by 18 · see citing works
Movassaghi, S., Sharifi, Z. N., Mohammadzadeh, F., et al. (2013) · PubMed · Cited by 17 · see citing works
Yalçın, M., Akarsu, M., Çelik, A., Sağol, Ö., Tunalı, S., ERTENER, Ö., Bengı, G., & Akpınar, H. (2014) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2014.5121 · Cited by 17 · see citing works
Gobejishvili, L., Ghare, S. S., Khan, R., et al. (2015) · Clinical Immunology · doi:10.1016/j.clim.2015.09.008 · Cited by 16 · see citing works
Self-citationPractical Concerns and Controversies in the Management of Alcoholic Hepatitis.
Im, G. Y., & Lucey, M. R. (2016) · PubMed Central · Cited by 15 · see citing works
Regulation of Rat Alcohol-Dehydrogenase by Cyclic AMP in Primary Hepatocyte Culture
Potter, J. J., MacDougald, O. A., & Mezey, E. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1402 · Cited by 13 · see citing works
Pentoxifylline inhibits liver fibrosis via hedgehog signaling pathway
Li, H., Hua, J., Guo, C., Wang, W., Wang, B., Yang, D., Wei, P., & Lu, Y. (2016) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-016-1594-7 · Cited by 13 · see citing works
Specific type IV phosphodiesterase inhibitor ameliorates thioacetamide‐induced liver injury in rats
Matsuhashi, T., Otaka, M., Odashima, M., et al. (2004) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2004.03512.x · Cited by 12 · see citing works
Webster, C. R. L., Boria, P. A., Usechak, P., & Anwer, M. S. (2002) · PubMed · Cited by 12 · see citing works
Kelava, T., Ćavar, I., Vukojević, K., et al. (2013) · PubMed · doi:10.14670/hh-28.245 · Cited by 9 · see citing works
Pentoxifylline inhibits hepatic stellate cells proliferation via the R af/ ERK pathway
Zhang, D., Jiang, H., Wang, Y., et al. (2012) · Apmis · doi:10.1111/j.1600-0463.2011.02868.x · Cited by 8 · see citing works
Hosono, M. (1999) · Folia Pharmacologica Japonica · doi:10.1254/fpj.114.83 · Cited by 8 · see citing works
Barlas, N., Mutchnick, M. G., Grant, G., et al. (1983) · PubMed · Cited by 8 · see citing works
Rundfeldt, C., Steckel, H., Sörensen, T. C., & Właź, P. (2012) · Archives of Dermatological Research · doi:10.1007/s00403-012-1216-6 · Cited by 6 · see citing works
Miyagi, Y., Sasayama, S., Nakajima, H., et al. (1990) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199001000-00022 · Cited by 6 · see citing works
Saito, M., Ayako, N. A. S. U., Kataoka, S., et al. (1992) · Journal of Pharmacobio-Dynamics · doi:10.1248/bpb1978.15.449 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cell-cell communication: New insights and clinical implications
Su, J., Song, Y., Zhu, Z., Huang, X., Fan, J., Qiao, J., & Mao, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01888-z · Cited by 433 · see citing works
Gut-liver axis: Recent concepts in pathophysiology in alcohol-associated liver disease
Raya Tonetti, F., Eguileor, A., Mrdjen, M., Pathak, V., Travers, J., Nagy, L. E., & Llorente, C. (2024) · Hepatology · doi:10.1097/hep.0000000000000924 · Cited by 78 · see citing works
Martin, O. P., Wallace, M. S., Oetheimer, C., Patel, H. B., Butler, E. C., Wong, L. P., Huang, P., Elbaz, J., Costentin, C., Salloum, S., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02255-y · Cited by 45 · see citing works
- Authors
- Wahlang, B., McClain, C., Barve, S., & Gobejishvili, L.
- Affiliations
- University of Louisville (US)
- Corresponding author
- Gobejishvili, Leila
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 49
- Pages
- 105-115
- ISSN
- 0898-6568 (ISSN-L)
- PMC
- PMC6445381
- OpenAlex
- W2808536863
- Cited by
- 168
- References
- 183
- Citations by year
- 2026: 13 · 2025: 43 · 2024: 23 · 2023: 20 · 2022: 20 · 2021: 14 · 2020: 20 · 2019: 13 · 2018: 1 · 2017: 1
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Update notices
- erratum (2019-01-01)
- Open access
- green
- europepmc.org
- Locations
- Cellular Signalling (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (NIAAA) (R44AA021331 (LG), U01AA021901 (CM), P50AA024337 (CM))
- National Institute of General Medical Sciences (NIGMS) (P20GM113226 (CM))
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- cAMP signaling, phosphodiesterase, phosphodiesterase-4 inhibitors, non-alcoholic fatty liver disease, alcoholic liver disease, liver fibrosis, hepatic steatosis, liver inflammation, second messenger signaling
- MeSH terms
- Cyclic AMP, Animals, Humans, Liver, Liver Diseases, Alcoholic, Phosphodiesterase Inhibitors, Phosphoric Diester Hydrolases, Signal Transduction, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review