Liver inflammation and fibrosis

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works

Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice

Chen, Y., Wang, L., Kang, Q., Zhang, X., Yu, G., Wan, X., Wang, J., & Zhu, K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477308 · Cited by 10,730 · see citing works

Exploring the full spectrum of macrophage activation

Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works

A core gut microbiome in obese and lean twins

Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works

Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice

Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332 · see citing works

A metagenome-wide association study of gut microbiota in type 2 diabetes

Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works

Liver fibrosis

Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958 · see citing works

Development of Monocytes, Macrophages, and Dendritic Cells

Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049 · see citing works

Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome

Vrieze, A., Van Nood, E., Holleman, F., Salojärvi, J., Kootte, R. S., Bartelsman, J. F. W. M., Dallinga–Thie, G. M., Ackermans, M. T., Serlie, M. J., Oozeer, R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.031 · Cited by 2,913 · see citing works

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578 · see citing works

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339 · cited 2× · see citing works

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial

Neuschwander-Tetri, B. A., Loomba, R., Sanyal, A. J., Lavine, J. E., Van Natta, M. L., Abdelmalek, M. F., Chalasani, N., Dasarathy, S., Diehl, A. M., Hameed, B., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61933-4 · Cited by 2,237 · see citing works

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

Xue, J., Schmidt, S. V., Sander, J., Draffehn, A., Krebs, W., Quester, I., De Nardo, D., Gohel, T. D., Emde, M., Schmidleithner, L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.01.006 · Cited by 2,210 · see citing works

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145 · see citing works

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

Salomon, B. L., Lenschow, D. J., Rhee, L., Ashourian, N., Singh, B., Sharpe, A. H., & Bluestone, J. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80195-8 · Cited by 2,058 · see citing works

TLR4 enhances TGF-β signaling and hepatic fibrosis

Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine · doi:10.1038/nm1663 · Cited by 1,942 · see citing works

The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

Boursier, J., Mueller, O., Barret, M., Machado, M., Fizanne, L., Araujo‐Perez, F., Guy, C. D., Seed, P. C., Rawls, J. F., David, L. A., et al. (2016) · Hepatology · doi:10.1002/hep.28356 · Cited by 1,483 · see citing works

Normalization of obesity-associated insulin resistance through immunotherapy

Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2001 · Cited by 1,370 · see citing works

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

McDonald, B., Pittman, K., Menezes, G. B., Hirota, S. A., Slaba, I., Waterhouse, C. C. M., Beck, P. L., Muruve, D. A., & Kubes, P. (2010) · Science · doi:10.1126/science.1195491 · Cited by 1,210 · see citing works

Harmful molecular mechanisms in sepsis

Rittirsch, D., Flierl, M. A., & Ward, P. A. (2008) · Nature reviews. Immunology · doi:10.1038/nri2402 · Cited by 1,199 · see citing works

Immunology in the liver — from homeostasis to disease

Heymann, F., & Tacke, F. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.200 · Cited by 1,180 · see citing works

Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis

Mokdad, A. A., Lopez, A. D., Shahraz, S., Lozano, R., Mokdad, A. H., Stanaway, J., Murray, C. J., & Naghavi, M. (2014) · BMC Medicine · doi:10.1186/s12916-014-0145-y · Cited by 1,129 · see citing works

Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis

Feldstein, A. E., Canbay, A., Angulo, P., Taniai, M., Burgart, L. J., Lindor, K. D., & Gores, G. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00907-7 · Cited by 1,085 · see citing works

Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

Ratziu, V., Harrison, S. A., Francque, S., Bedossa, P., Lehert, P., Serfaty, L., Romero-Gomez, M., Boursier, J., Abdelmalek, M., Caldwell, S., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.01.038 · Cited by 1,035 · see citing works

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17–secreting T cells

Dusséaux, M., Martin, E., Serriari, N., Péguillet, I., Prémel, V., Louis, D., Milder, M., Bourhis, L. L., Soudais, C., Treiner, E., et al. (2010) · Blood · doi:10.1182/blood-2010-08-303339 · Cited by 1,031 · see citing works

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

Ramachandran, P., Pellicoro, A., Vernon, M. A., Boulter, L., Aucott, R. L., Ali, A., Hartland, S. N., Snowdon, V. K., Cappon, A., Gordon-Walker, T. T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119964109 · Cited by 1,001 · see citing works

Interactions Between the Intestinal Microbiome and Liver Diseases

Schnabl, B., & Brenner, D. A. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.020 · Cited by 971 · see citing works

Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease

Mudaliar, S., Henry, R. R., Sanyal, A. J., Morrow, L., Marschall, H., Kipnes, M., Adorini, L., Sciacca, C. I., Clopton, P., Castelloe, E., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.05.042 · Cited by 931 · see citing works

Genetic, Biochemical, and Clinical Features of Chronic Granulomatous Disease

Segal, B. H., Leto, T. L., Gallin, J. I., Malech, H. L., & Holland, S. M. (2000) · Medicine · doi:10.1097/00005792-200005000-00004 · Cited by 877 · see citing works

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

Hueber, W., Patel, D. D., Dryja, T., Wright, A. M., Koroleva, I., Bruin, G., Antoni, C., Draelos, Z., Gold, M. H., the Psoriasis Study Group, et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001107 · Cited by 860 · see citing works

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Scott, C. L., Zheng, F., De Baetselier, P., Martens, L., Saeys, Y., De Prijck, S., Lippens, S., Abels, C., Schoonooghe, S., Raes, G., et al. (2016) · Nature Communications · doi:10.1038/ncomms10321 · Cited by 860 · see citing works

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

Kisseleva, T., Cong, M., Paik, Y., Scholten, D., Jiang, C., Benner, C., Iwaisako, K., Moore-Morris, T., Scott, B., Tsukamoto, H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201840109 · Cited by 805 · see citing works

Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor

Ananthanarayanan, M., Balasubramanian, N., Makishima, M., Mangelsdorf, D. J., & Suchy, F. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011610200 · Cited by 804 · see citing works

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

Hoeffel, G., Wang, Y., Greter, M., See, P., Teo, P., Malleret, B., Leboeuf, M., Low, D., Oller, G., Almeida, F., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120340 · Cited by 786 · see citing works

Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis

Karlmark, K. R., Weiskirchen, R., Zimmermann, H. W., Gassler, N., Ginhoux, F., Weber, C., Merad, M., Luedde, T., Trautwein, C., & Tacke, F. (2009) · Hepatology · doi:10.1002/hep.22950 · Cited by 782 · see citing works

Alarmins: chemotactic activators of immune responses

Oppenheim, J. J., & Yang, D. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.06.002 · Cited by 780 · see citing works

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

Miura, K., Kodama, Y., Inokuchi, S., Schnabl, B., Aoyama, T., Ohnishi, H., Olefsky, J. M., Brenner, D. A., & Seki, E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.052 · Cited by 741 · see citing works

Silencing of TGF-β signalling by the pseudoreceptor BAMBI

Onichtchouk, D., Chen, Y., Dosch, R., Gawantka, V., Delius, H., Massagué, J., & Niehrs, C. (1999) · Nature · doi:10.1038/46794 · Cited by 727 · see citing works

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

Meng, F., Wang, K., Aoyama, T., Grivennikov, S. I., Paik, Y., Scholten, D., Cong, M., Iwaisako, K., Liu, X., Zhang, M., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.05.049 · Cited by 711 · see citing works

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

Turpin-Nolan, S. M., Nicholls, H. T., Willmes, D. M., Mourier, A., Brodesser, S., Wunderlich, C. M., Mauer, J., Xu, E., Hammerschmidt, P., Brönneke, H. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.08.002 · Cited by 693 · see citing works

Toll-Like Receptor 4 Mediates Inflammatory Signaling by Bacterial Lipopolysaccharide in Human Hepatic Stellate Cells

Paik, Y.-H., Schwabe, R. F., Bataller, R., Russo, M. P., Jobin, C., & Brenner, D. A. (2003) · Hepatology · doi:10.1053/jhep.2003.50182 · Cited by 651 · see citing works

Alternative Metabolic States in Murine Macrophages Reflected by the Nitric Oxide Synthase/Arginase Balance: Competitive Regulation by CD4+ T Cells Correlates with Th1/Th2 Phenotype

Munder, M., Eichmann, K., & Modolell, M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.11.5347 · Cited by 647 · see citing works

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

Pradere, J.-P., Kluwe, J., De Minicis, S., Jiao, J.-J., Gwak, G.-Y., Dapito, D. H., Jang, M.-K., Guenther, N. D., Mederacke, I., Friedman, R., et al. (2013) · Hepatology · doi:10.1002/hep.26429 · Cited by 613 · see citing works

TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype

Zhang, F., Wang, H., Wang, X., Jiang, G., Liu, H., Zhang, G., Wang, H., Fang, R., Bu, X., Cai, S., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10561 · Cited by 580 · see citing works

M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease

Wan, J., Benkdane, M., Teixeira-Clerc, F., Bonnafous, S., Louvet, A., Lafdil, F., Pecker, F., Tran, A., Gual, P., Mallat, A., et al. (2014) · Hepatology · doi:10.1002/hep.26607 · Cited by 558 · see citing works

A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair

Wang, J., & Kubes, P. (2016) · Cell · doi:10.1016/j.cell.2016.03.009 · Cited by 537 · see citing works

Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in the United States and the Rest of the World

Sayiner, M., Koenig, A., Henry, L., & Younossi, Z. M. (2016) · Clinics in Liver Disease · doi:10.1016/j.cld.2015.10.001 · Cited by 529 · see citing works

Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes

Hirsova, P., Ibrahim, S. H., Krishnan, A., Verma, V. K., Bronk, S. F., Werneburg, N. W., Charlton, M., Shah, V. H., Malhi, H., & Gores, G. J. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.12.037 · Cited by 510 · see citing works

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

Miura, K., Yang, L., van Rooijen, N., Ohnishi, H., & Seki, E. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00365.2011 · Cited by 503 · see citing works

Phase I study of GC1008 (fresolimumab): a human anti‐transforming growth factor‐beta (TGFβ) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma

Morris, J. C., Tan, A. R., Olencki, T. E., Shapiro, G. I., Dezube, B. J., Reiss, M., Hsu, F. J., Berzofsky, J. A., & Lawrence, D. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090353 · Cited by 487 · see citing works

Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells

Sheng, J., Ruedl, C., & Karjalainen, K. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.016 · Cited by 482 · see citing works

Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury

Zigmond, E., Samia-Grinberg, S., Pasmanik‐Chor, M., Brazowski, E., Shibolet, O., Halpern, Z., & Varol, C. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400574 · Cited by 477 · see citing works

Peroxisome proliferator-activated receptors and hepatic stellate cell activation

Miyahara, T., Schrum, L., Rippe, R., Xiong, S., Yee, H. F., Motomura, K., Anania, F. A., Willson, T. M., & Tsukamoto, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006577200 · Cited by 473 · see citing works

Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage

Blaner, W. S., O'Byrne, S. M., Wongsiriroj, N., Kluwe, J., D'Ambrosio, D. M., Jiang, H., Schwabe, R. F., Hillman, E. M. C., Piantedosi, R., & Libien, J. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.11.001 · Cited by 444 · see citing works

CCR1 and CCR5 promote hepatic fibrosis in mice

Seki, E., De Minicis, S., Gwak, G.-Y., Kluwe, J., Inokuchi, S., Bursill, C. A., Llovet, J. M., Brenner, D. A., & Schwabe, R. F. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37444 · Cited by 431 · see citing works

CCR2 promotes hepatic fibrosis in mice #

Seki, E., Minicis, S. D., Inokuchi, S., Taura, K., Miyai, K. N., van Rooijen, N., Schwabe, R. F., & Brenner, D. A. (2009) · Hepatology · doi:10.1002/hep.22952 · Cited by 415 · see citing works

Ligands of peroxisome proliferator-activated receptor γ modulate profibrogenic and proinflammatory actions in hepatic stellate cells

Marra, F., Efsen, E., Romanelli, R. G., Caligiuri, A., Pastacaldi, S., Batignani, G., Bonacchi, A., Caporale, R., Laffi, G., Pinzani, M., et al. (2000) · Gastroenterology · doi:10.1053/gast.2000.9365 · Cited by 409 · see citing works

Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients

Bertola, A., Ciucci, T., Rousseau, D., Bourlier, V., Duffaut, C., Bonnafous, S., Blin‐Wakkach, C., Anty, R., Iannelli, A., Gugenheim, J., et al. (2012) · Diabetes · doi:10.2337/db11-1274 · Cited by 403 · see citing works

The interleukin-17 pathway is involved in human alcoholic liver disease # †

Lemmers, A., Moreno, C., Gustot, T., Maréchal, R., Degré, D., Demetter, P., de Nadai, P., Geerts, A., Quertinmont, E., Vercruysse, V., et al. (2009) · Hepatology · doi:10.1002/hep.22680 · Cited by 394 · see citing works

The role of TGFβ1 in initiating hepatic stellate cell activation in vivo

Hellerbrand, C., Stefanovic, B., Giordano, F., Burchardt, E. R., & Brenner, D. A. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80010-5 · Cited by 393 · see citing works

A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature.

Wong, J., Johnston, B., Lee, S. S., Bullard, D. C., Smith, C. W., Beaudet, A. L., & Kubes, P. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119468 · Cited by 392 · see citing works

Leptin receptor–mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat

Ikejima, K., Takei, Y., Honda, H., Hirose, M., Yoshikawa, M., Zhang, Y., Lang, T., Fukuda, T., Yamashina, S., Kitamura, T., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.32995 · Cited by 385 · see citing works

Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases

Gao, B., Radaeva, S., & Park, O. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0309135 · Cited by 380 · see citing works

Plasmacytoid Dendritic Cells Mediate Oral Tolerance

Goubier, A., Dubois, B., Gheit, H., Joubert, G., Villard‐Truc, F., Asselin‐Paturel, C., Trinchieri, G., & Kaiserlian, D. (2008) · Immunity · doi:10.1016/j.immuni.2008.06.017 · Cited by 376 · see citing works

Epidemiology and Natural History of Nonalcoholic Fatty Liver Disease

Satapathy, S. K., & Sanyal, A. J. (2015) · Seminars in Liver Disease · doi:10.1055/s-0035-1562943 · Cited by 372 · see citing works

Mouse Plasmacytoid Cells

O’Keeffe, M. A., Hochrein, H., Vremec, D., Caminschi, I., Miller, J. L., Anders, E. M., Wu, L., Lahoud, M. H., Henri, S., Scott, B., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20021031 · Cited by 368 · see citing works

Quantitation, tissue distribution and proliferation kinetics of kupffer cells in normal rat liver

Bouwens, L., Baekeland, M., Zanger, R. D., & Wisse, E. (1986) · Hepatology · doi:10.1002/hep.1840060430 · Cited by 366 · see citing works

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

Huebener, P., Pradère, J., Hernandez, C., Gwak, G., Caviglia, J. M., Mu, X., Loike, J. D., Jenkins, R. E., Antoine, D. J., & Schwabe, R. F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76887 · Cited by 353 · see citing works

Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients

Rice, L. M., Padilla, C. M., McLaughlin, S. R., Mathes, A., Ziemek, J., Goummih, S., Nakerakanti, S., York, M., Farina, G., Whitfield, M. L., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77958 · Cited by 351 · see citing works

Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids

McDonald, B., McAvoy, E. F., Lam, F., Gill, V., de la Motte, C., Savani, R., & Kubes, P. (2008) · Journal of Experimental Medicine · doi:10.1084/jem.20071765 · Cited by 345 · see citing works

Inhibition of Fibrocyte Differentiation by Serum Amyloid P 1

Pilling, D., Buckley, C., Salmon, M., & Gomer, R. (2003) · Journal of Immunology · doi:10.4049/jimmunol.171.10.5537 · Cited by 331 · see citing works

The Role of Inflammation in the Pathogenesis of Idiopathic Pulmonary Fibrosis

Bringardner, B. D., Baran, C. P., Eubank, T. D., & Marsh, C. B. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1897 · Cited by 315 · see citing works

Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients

Magalhaes, I., Pingris, K., Poitou, C., Bessoles, S., Venteclef, N., Kiaf, B., Beaudoin, L., Silva, J. D., Allatif, O., Rossjohn, J., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78941 · Cited by 313 · see citing works

Functional Contribution of Elevated Circulating and Hepatic Non-Classical CD14+CD16+ Monocytes to Inflammation and Human Liver Fibrosis

Zimmermann, H. W., Seidler, S., Nattermann, J., Gaßler, N., Hellerbrand, C., Zernecke, A., Tischendorf, J. J. W., Luedde, T., Weiskirchen, R., Trautwein, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011049 · Cited by 311 · see citing works

Methionine Metabolism and Liver Disease

Mato, J. M., Martínez‐Chantar, M. L., & Lu, S. C.-L. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155438 · Cited by 311 · see citing works

Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver

Rau, M., Schilling, A.-K., Meertens, J., Hering, I., Weiss, J., Jurowich, C., Kudlich, T., Hermanns, H. M., Bantel, H., Beyersdorf, N., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501175 · Cited by 302 · see citing works

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

Huebener, P., Pradère, J., Hernandez, C., Gwak, G., Caviglia, J. M., Mu, X., Loike, J. D., Jenkins, R. E., Antoine, D. J., & Schwabe, R. F. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126975 · Cited by 301 · see citing works

Ferritin functions as a proinflammatory cytokine via iron‐independent protein kinase C zeta/nuclear factor kappaB–regulated signaling in rat hepatic stellate cells†

Ruddell, R. G., Hoang‐Le, D., Barwood, J. M., Rutherford, P. S., Piva, T. J., Watters, D. J., Santambrogio, P., Arosio, P., & Ramm, G. A. (2009) · Hepatology · doi:10.1002/hep.22716 · Cited by 298 · see citing works

Adipogenic Transcriptional Regulation of Hepatic Stellate Cells*

She, H.-Y., Xiong, S., Hazra, S., & Tsukamoto, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410078200 · Cited by 295 · see citing works

Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis

Rensen, S. S., Slaats, Y., Nijhuis, J., Jans, A., Bieghs, V., Driessen, A., Malle, E., Greve, J. W., & Buurman, W. A. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080999 · Cited by 290 · see citing works

Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease

Porez, G., Prawitt, J., Gross, B. S., & Staels, B. (2012) · Journal of Lipid Research · doi:10.1194/jlr.r024794 · Cited by 287 · see citing works

Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner

Kakazu, E., Mauer, A. S., Yin, M., & Malhi, H. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m063412 · Cited by 280 · see citing works

Alarmin(g) news about danger

Harris, H. E., & Raucci, A. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400759 · Cited by 278 · see citing works

The Fatty Acid–Bile Acid Conjugate Aramchol Reduces Liver Fat Content in Patients With Nonalcoholic Fatty Liver Disease

Safadi, R., Konikoff, F. M., Mahamid, M., Zelber‐Sagi, S., Halpern, M., Gilat, T., Oren, R., Safadi, R., Konikoff, F. M., Hershkovitz, A., et al. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.04.038 · Cited by 275 · see citing works

Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity

Murphy, E. F., Cotter, P. D., Hogan, A., O’Sullivan, Ó., Joyce, A., Fouhy, F., Clarke, S. F., Marques, T. M., O’Toole, P. W., Stanton, C., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-300705 · Cited by 273 · see citing works

Inhibition of inhibitor of κB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis

Oakley, F., Meso, M., Iredale, J. P., Green, K., Marek, C. J., Zhou, X., May, M. J., Millward‐Sadler, H., Wright, M. C., & Mann, D. A. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.10.003 · Cited by 265 · see citing works

Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice

Berres, M., Koenen, R. R., Rueland, A., Zaldivar, M. M., Heinrichs, D., Sahin, H., Schmitz, P., Streetz, K. L., Berg, T., Gaßler, N., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41732 · Cited by 264 · see citing works

Neutrophil Activation in Morbid Obesity, Chronic Activation of Acute Inflammation

Nijhuis, J., Rensen, S. S., Slaats, Y., van Dielen, F. M. H., Buurman, W. A., & Greve, J. W. M. (2009) · Obesity · doi:10.1038/oby.2009.113 · Cited by 263 · see citing works

A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis

Trachtman, H., Fervenza, F. C., Gipson, D. S., Heering, P., Jayne, D. R. W., Peters, H., Rota, S., Remuzzi, G., Rump, L. C., Sellin, L. K., et al. (2011) · Kidney International · doi:10.1038/ki.2011.33 · Cited by 263 · see citing works

Interleukin-33 overexpression is associated with liver fibrosis in mice and humans

Marvie, P., Lisbonne, M., L’Helgoualc’h, A., Rauch, M., Turlin, B., Preisser, L., Bourd‐Boittin, K., Théret, N., Gascan, H., Piquet‐Pellorce, C., et al. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00801.x · Cited by 251 · see citing works

Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice

Czochra, P., Klopcic, B. R. S., Meyer, E., Herkel, J., Garcia-Lazaro, J. F., Thieringer, F. R., Schirmacher, P., Biesterfeld, S., Galle, P. R., Lohse, A. W., et al. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.04.010 · Cited by 244 · see citing works

NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation

Xu, J., Chi, F., Guo, T., Punj, V., Lee, W. N. P., French, S. W., & Tsukamoto, H. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76468 · Cited by 241 · see citing works

Nuclear factor high-mobility group box1 mediating the activation of toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice

Li, L., Chen, L., Hu, L., Liu, Y., Sun, H., Tang, J. P., Hou, Y.-J., Chang, Y., Tu, Q., Feng, G., et al. (2011) · Hepatology · doi:10.1002/hep.24552 · Cited by 236 · see citing works

Mixed lineage kinase 3 mediates release of C‐X‐C motif ligand 10–bearing chemotactic extracellular vesicles from lipotoxic hepatocytes

Ibrahim, S. H., Hirsova, P., Tomita, K., Bronk, S. F., Werneburg, N. W., Harrison, S. A., Goodfellow, V. S., Malhi, H., & Gores, G. J. (2016) · Hepatology · doi:10.1002/hep.28252 · Cited by 232 · see citing works

Lipopolysaccharide-Induced IL-18 Secretion from Murine Kupffer Cells Independently of Myeloid Differentiation Factor 88 That Is Critically Involved in Induction of Production of IL-12 and IL-1β

Seki, E., Tsutsui, H., Nakano, H., Tsuji, N. M., Hoshino, K., Adachi, O., Adachi, K., Futatsugi‐Yumikura, S., Kuida, K., Takeuchi, O., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2651 · Cited by 231 · see citing works

Reduction of Bleomycin-Induced Pulmonary Fibrosis by Serum Amyloid P

Pilling, D., Roife, D., Wang, M., Ronkainen, S. D., Crawford, J. R., Travis, E. L., & Gomer, R. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4035 · Cited by 230 · see citing works

Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c+ Cells in Adipose Tissue and Liver

Stefanović-Račić, M., Yang, X., Turner, M. S., Mantell, B. S., Stolz, D. B., Sumpter, T. L., SIPULA, I. J., Dedousis, N. L., Scott, D. K., Morel, P. A., et al. (2012) · Diabetes · doi:10.2337/db11-1523 · Cited by 229 · see citing works

Extracellular Vesicles in Liver Pathobiology: Small Particles With Big Impact

Hirsova, P., Ibrahim, S. H., Verma, V. K., Morton, L. A., Shah, V. H., LaRusso, N. F., Gores, G. J., & Malhi, H. (2016) · Hepatology · doi:10.1002/hep.28814 · Cited by 229 · see citing works

Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis

Kakisaka, K., Cazanave, S. C., Fingas, C. D., Guicciardi, M. E., Bronk, S. F., Werneburg, N. W., Mott, J. L., & Gores, G. J. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00301.2011 · Cited by 222 · see citing works

Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles

Verma, V. K., Li, H., Wang, R., Hirsova, P., Mushref, M., Liu, Y., Cao, S., Contreras, P. C., Malhi, H., Kamath, P. S., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.11.020 · Cited by 221 · see citing works

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis

Afonso, M. B., Rodrigues, P. M., Carvalho, T., Caridade, M., Borralho, P., Cortez‐Pinto, H., Castro, R. E., & Rodrigues, C. M. P. (2015) · Clinical Science · doi:10.1042/cs20140732 · Cited by 219 · see citing works

Functional Linkage of Cirrhosis-Predictive Single Nucleotide Polymorphisms of Toll-Like Receptor 4 to Hepatic Stellate Cell Responses

Guo, J., Loke, J., Zheng, F., Hong, F., Yea, S., Fukata, M., Tarocchi, M., Abar, O. T., Huang, H., Sninsky, J. J., et al. (2009) · Hepatology · doi:10.1002/hep.22697 · Cited by 217 · see citing works

Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1

Jeffery, H. C., van Wilgenburg, B., Kurioka, A., Parekh, K., Stirling, K., Roberts, S., Dutton, E. E., Hunter, S., Geh, D., Braitch, M. K., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.12.017 · Cited by 212 · see citing works

Kupffer cells mediate leptin-induced liver fibrosis

Wang, J., Leclercq, I., Brymora, J. M., Xu, N., Ramezani–Moghadam, M., London, R. M., Brigstock, D., & George, J. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.011 · Cited by 210 · see citing works

MAIT cells: new guardians of the liver

Kurioka, A., Walker, L. J., Klenerman, P., & Willberg, C. B. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.51 · Cited by 205 · see citing works

CYTOKINE EXPRESSION IN THREE MOUSE MODELS OF EXPERIMENTAL HEPATITIS

Sass, G., Heinlein, S., Agli, A., Bang, R., Schümann, J., & Tiegs, G. (2002) · Cytokine · doi:10.1006/cyto.2002.1948 · Cited by 197 · see citing works

Efficacy and safety study of cenicriviroc for the treatment of non-alcoholic steatohepatitis in adult subjects with liver fibrosis: CENTAUR Phase 2b study design

Friedman, S. L., Sanyal, A. J., Goodman, Z. D., Lefebvre, E. A., Gottwald, M. D., Fischer, L., & Ratziu, V. (2016) · Contemporary Clinical Trials · doi:10.1016/j.cct.2016.02.012 · Cited by 197 · see citing works

The Nicotinamide Adenine Dinucleotide Phosphate Oxidase Homologues NOX1 and NOX2/gp91phox Mediate Hepatic Fibrosis in Mice

Paik, Y., Iwaisako, K., Seki, E., Inokuchi, S., Schnabl, B., Österreicher, C. H., Kisseleva, T., & Brenner, D. A. (2011) · Hepatology · doi:10.1002/hep.24281 · Cited by 195 · see citing works

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

Lan, T., Kisseleva, T., & Brenner, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129743 · Cited by 192 · see citing works

Dual Role of CCR2 in the Constitution and the Resolution of Liver Fibrosis in Mice

Mitchell, C., Couton, D., Couty, J., Anson, M., Crain‐Denoyelle, A., Bizet, V., Rénia, L., Pol, S., Mallet, V. O., & Gilgenkrantz, H. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080632 · Cited by 189 · see citing works

Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk

Wagner, N., Brandhorst, G., Czepluch, F. S., Lankeit, M., Eberle, C. S., Herzberg, S., Faustin, V., Riggert, J., Oellerich, M., Hasenfuss, G. P., et al. (2013) · Obesity · doi:10.1002/oby.20087 · Cited by 177 · see citing works

Leptin Promotes the Myofibroblastic Phenotype in Hepatic Stellate Cells by Activating the Hedgehog Pathway

Choi, S. S., Syn, W., Karaca, G., Omenetti, A., Moylan, C. A., Witek, R. P., Agboola, K. M., Jung, Y., Michelotti, G. A., & Diehl, A. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.168542 · Cited by 174 · see citing works

A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse

Moles, A., Murphy, L., Wilson, C. L., Chakraborty, J. B., Fox, C., Park, E. J., Mann, J., Oakley, F., Howarth, R., Brain, J., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.12.005 · Cited by 169 · see citing works

Hepatocyte nicotinamide adenine dinucleotide phosphate reduced oxidase 4 regulates stress signaling, fibrosis, and insulin sensitivity during development of steatohepatitis in mice

Bettaieb, A., Jiang, J. X., Sasaki, Y., Chao, T.-I., Kiss, Z., Chen, X., Tian, J., Katsuyama, M., Yabe-Nishimura, C., Xi, Y., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.009 · Cited by 167 · see citing works

Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation

Wang, L., Johnson, E. E., Shi, H. N., Walker, W. A., Wessling-Resnick, M., & Cherayil, B. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.4.2723 · Cited by 159 · see citing works

Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist

Iwaisako, K., Haimerl, M., Paik, Y.-H., Taura, K., Kodama, Y., Sirlin, C., Yu, E., Yu, R. T., Downes, M., Evans, R. M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202464109 · Cited by 157 · see citing works

Dendritic Cell Regulation of Carbon Tetrachloride–Induced Murine Liver Fibrosis Regression

Jiao, J., Sastre, D., Fiel, M. I., Lee, U. E., Ghiassi–Nejad, Z., Ginhoux, F., Vivier, E., Friedman, S. L., Merad, M., & Aloman, C. (2012) · Hepatology · doi:10.1002/hep.24621 · Cited by 154 · see citing works

Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease

Petrášek, J., Iracheta‐Vellve, A., Saha, B., Satishchandran, A., Kodys, K., Fitzgerald, K. A., Kurt‐Jones, E. A., & Szabó, G. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ab1214-590r · Cited by 153 · see citing works

Glutathione Levels Discriminate between Oxidative Stress and Transforming Growth Factor-β Signaling in Activated Rat Hepatic Stellate Cells

Bleser, P. J. D., Xu, G., Rombouts, K., Rogiers, V., & Geerts, A. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.33881 · Cited by 149 · see citing works

Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice

Wang, M., You, Q., Lor, K., Chen, F., Gao, B., & Ju, C. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.6a0114-004rr · Cited by 148 · see citing works

Cutaneous keratoacanthomas/squamous cell carcinomas associated with neutralization of transforming growth factor β by the monoclonal antibody fresolimumab (GC1008)

Lacouture, M. E., Morris, J. C., Lawrence, D. P., Tan, A. R., Olencki, T. E., Shapiro, G. I., Dezube, B. J., Berzofsky, J. A., Hsu, F. J., & Guitart, J. (2015) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-015-1653-0 · Cited by 145 · see citing works

Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease

Pacana, T., Cazanave, S. C., Verdianelli, A., Patel, V. A., Min, H., Mirshahi, F., Quinlivan, E. P., & Sanyal, A. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136822 · Cited by 140 · see citing works

Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat–cholesterol–sugar diet model in mice

Ganz, M., Bukong, T., Csák, T., Saha, B., Park, J.-K., Ambade, A. V., Kodys, K., & Szabo, G. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0552-7 · Cited by 135 · see citing works

Death Receptor 5 Signaling Promotes Hepatocyte Lipoapoptosis

Cazanave, S. C., Mott, J. L., Bronk, S. F., Werneburg, N. W., Fingas, C. D., Meng, X. W., Finnberg, N. K., El‐Deiry, W. S., Kaufmann, S. H., & Gores, G. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.280420 · Cited by 133 · see citing works

Implication of Th17 and Th1 Cells in Patients with Chronic Active Hepatitis B

Ge, J., Wang, K., Meng, Q., Qi, Z.-X., Meng, F.-L., & Fan, Y. (2009) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9328-2 · Cited by 120 · see citing works

Selective inactivation of NF-κB in the liver using NF-κB decoy suppresses CCl4-induced liver injury and fibrosis

Son, G., Iimuro, Y., Seki, E., Hirano, T., Kaneda, Y., & Fujimoto, J. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00185.2007 · Cited by 119 · see citing works

Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood

Eguchi, A., Lazaro, R. G., Wang, J., Kim, J., Povero, D., Willliams, B., Ho, S. B., Stärkel, P., Schnabl, B., Lucila Ohno-machado, A., et al. (2016) · Hepatology · doi:10.1002/hep.28838 · Cited by 115 · see citing works

Recombinant human pentraxin-2 therapy in patients with idiopathic pulmonary fibrosis: safety, pharmacokinetics and exploratory efficacy

van den Blink, B., Dillingh, M. R., Ginns, L. C., Morrison, L. D., Moerland, M., Wijsenbeek, M. S., Trehu, E., Bartholmai, B. J., & Burggraaf, J. (2016) · European Respiratory Journal · doi:10.1183/13993003.00850-2015 · Cited by 98 · see citing works

TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess

Idrissova, L., Malhi, H., Werneburg, N. W., LeBrasseur, N. K., Bronk, S. F., Fingas, C. D., Tchkonia, T., Pirtskhalava, T., White, T. A., Stout, M. B., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.11.033 · Cited by 95 · see citing works

Inhibition of type I natural killer T cells by retinoids or following sulfatide‐mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice

Maricic, I., Sheng, H., Marrero, I., Seki, E., Kisseleva, T., Chaturvedi, S., Molle, N., Mathews, S., Gao, B., & Kumar, V. (2014) · Hepatology · doi:10.1002/hep.27632 · Cited by 94 · see citing works

Development, Differentiation, and Maturation of Fetal Mouse Yolk Sac Macrophages in Cultures

Naito, M., Yamamura, F., Nishikawa, S.-L., & Takahashi, K. (1989) · Journal of Leukocyte Biology · doi:10.1002/jlb.46.1.1 · Cited by 91 · see citing works

Origin and kinetics of Kupffer cells during an acute inflammatory response.

Dulk, M. M. C. D.-D., Crofton, R. W., & van Furth, R. (1979) · PubMed · Cited by 89 · see citing works

Metabolically induced liver inflammation leads to NASH and differs from LPS- or IL-1β-induced chronic inflammation

Liang, W., Lindeman, J. H. N., Menke, A. L., Koonen, D. P. Y., Morrison, M. C., Havekes, L. M., van den Hoek, A. M., & Kleemann, R. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.11 · Cited by 83 · see citing works

The Complex Myeloid Network of the Liver with Diverse Functional Capacity at Steady State and in Inflammation

Eckert, C., Klein, N., Kornek, M., & Kornek, M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00179 · Cited by 83 · see citing works

The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-β-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms

Sancho, P., Bertrán, E., Caja, L., Carmona‐Cuenca, I., Murillo, M. M., & Fabregat, I. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.09.003 · Cited by 83 · see citing works

Transforming Growth Factor β Neutralization Ameliorates Pre-Existing Hepatic Fibrosis and Reduces Cholangiocarcinoma in Thioacetamide-Treated Rats

Ling, H., Roux, E., Hempel, D. M., Tao, J., Smith, M. M., Lonning, S. M., Zuk, A., ARBEENY, C. M., & Ledbetter, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054499 · Cited by 82 · see citing works

Oral Administration of OKT3 MAb to Patients with NASH, Promotes Regulatory T-cell Induction, and Alleviates Insulin Resistance: Results of a Phase IIa Blinded Placebo-Controlled Trial

Lalazar, G., Mizrahi, M., Turgeman, I., Adar, T., Yaʼacov, A. B., Shabat, Y., Assy, N., Hemed, N., Zolotarovya, L., Lichtenstein, Y., et al. (2015) · Journal of Clinical Immunology · doi:10.1007/s10875-015-0160-6 · Cited by 77 · see citing works

Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation

Chatzigeorgiou, A., Chung, K., García-Martín, R., Alexaki, V. I., Ameln, A. K., Phieler, J., Sprott, D., Kanczkowski, W., Tzanavari, T., Bdeir, M., et al. (2014) · Hepatology · doi:10.1002/hep.27233 · Cited by 71 · see citing works

Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells

Tokita, D., Sumpter, T. L., Raimondi, G., Zahorchak, A. F., Wang, Z., Nakao, A., Mazariegos, G. V., Abe, M., & Thomson, A. W. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.07.028 · Cited by 71 · see citing works

NKT cells are required to induce high IL‐33 expression in hepatocytes during ConA‐induced acute hepatitis

Arshad, M. I., Rauch, M., L’Helgoualc’h, A., Julia, V., Leite‐de‐Moraes, M., Lucas‐Clerc, C., Piquet‐Pellorce, C., & Samson, M. (2011) · European Journal of Immunology · doi:10.1002/eji.201041332 · Cited by 65 · see citing works

Prevention of Diet–Induced Fatty Liver in Experimental Animals by the Oral Administration of A Fatty Acid Bile Acid Conjugate (Fabac)

Gilat, T., Leikin-Frenkel, A. I., Goldiner, I., Juhel, C., Lafont, H., Gobbi, D., & Konikoff, F. M. (2003) · Hepatology · doi:10.1053/jhep.2003.50348 · Cited by 61 · see citing works

Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration

Potter, J. J., Rennie-Tankesley, L., & Mezey, E. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00414-2 · Cited by 56 · see citing works

Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet‐induced steatohepatitis

Ibrahim, S. H., Gores, G. J., Hirsova, P., Kirby, M., Miles, L., Jaeschke, A., & Kohli, R. (2013) · Liver International · doi:10.1111/liv.12353 · Cited by 54 · see citing works

Underdiagnosis of hereditary haemochromatosis: lack of presentation or penetration?

Ryan, E. M., Byrnes, V., Coughlan, B., Flanagan, A.-M., Barrett, S., O’Keane, J. C., & Crowe, S. F. (2002) · Gut · doi:10.1136/gut.51.1.108 · Cited by 47 · see citing works

Identification and Characterization of the Hepatic Stellate Cell Transferrin Receptor

Bridle, K. R., Crawford, D. H., & Ramm, G. A. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64300-3 · Cited by 46 · see citing works

Ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: a multi-centered randomized controlled trial.

Zhang, L., Xh, L., Hb, Q., Li, Z., Fu, X.-D., Chen, L., & Shao, Y. (2015) · PubMed · Cited by 43 · see citing works

Effects of oral intake of hydrogen water on liver fibrogenesis in mice

Koyama, Y., Taura, K., Hatano, E., Tanabe, K., Yamamoto, G., Nakamura, K., Yamanaka, K., Kitamura, K., Narita, M., Nagata, H., et al. (2013) · Hepatology Research · doi:10.1111/hepr.12165 · Cited by 42 · see citing works

Increased ratio of neutrophil elastase to α1‐antitrypsin is closely associated with liver inflammation in patients with nonalcoholic steatohepatitis

Zang, S., Ma, X., Zhuang, Z., Liu, J., Bian, D., Xun, Y., Zhang, Q., Zhao, F., Yang, W., Liu, J., et al. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12499 · Cited by 37 · see citing works

Dilinoleoylphosphatidylcholine Decreases Ethanol-Induced Cytochrome P4502E1

Aleynik, M. K., & Lieber, C. S. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5870 · Cited by 33 · see citing works

Serum amyloid P inhibits granulocyte adhesion

Maharjan, A., Roife, D., Brazill, D. T., & Gomer, R. H. (2013) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-6-2 · Cited by 33 · see citing works

Prednisolone plus S-adenosil-l-methionine in severe alcoholic hepatitis

Tkachenko, P., Maevskaya, M. V., Pavlov, A., Komkova, I., Pavlov, C. S., & Ivashkin, V. T. (2016) · Hepatology International · doi:10.1007/s12072-016-9751-4 · Cited by 32 · see citing works

The Spectrum of Histologic Findings in Hepatic Outflow Obstruction

González, R. S., Gilger, M. A., Huh, W. J., & Washington, M. K. (2016) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2015-0388-oa · Cited by 27 · see citing works

Neurotropin Suppresses Inflammatory Cytokine Expression and Cell Death through Suppression of NF-κB and JNK in Hepatocytes

Zhang, B., Roh, Y. S., Liang, S., Liu, C., Naiki, M., Masuda, K., & Seki, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114071 · Cited by 25 · see citing works

CD28 deletion improves obesity-induced liver steatosis but increases adiposity in mice

Poggi, M., Morin, S. O., Bastelica, D., Govers, R., Canault, M., Bernot, D., Georgelin, O., Verdier, M., Burcelin, R., Olive, D., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.26 · Cited by 18 · see citing works

Pathophysiological analysis of primary biliary cirrhosis focusing on choline/phospholipid metabolism

Kohjima, M., Enjoji, M., Yada, R., Yoshimoto, T., Nakamura, T., Fukuizumi, K., Fukushima, N., Murata, Y., Nakashima, M., Kato, M., et al. (2014) · Liver International · doi:10.1111/liv.12526 · Cited by 16 · see citing works

Clinical grading of Intrahepatic Cholestasis Pregnancy

Pradhan, M., & Shao, Y. (2013) · Journal of Nepal Medical Association · doi:10.31729/jnma.1638 · Cited by 7 · see citing works

Quantitative determination of saroglitazar, a predominantly PPAR alpha agonist, in human plasma by a LC–MS/MS method utilizing electrospray ionization in a positive mode

Ghoghari, A. M., Dash, R. P., Bhatt, C., Singh, K., Jha, A., Patel, H., Gupta, R., Kansagra, K., & Srinivas, N. R. (2016) · Biomedical Chromatography · doi:10.1002/bmc.3760 · Cited by 4 · see citing works

Inflammatory mechanisms linking obesity and metabolic disease

Saltiel, A. R., & Olefsky, J. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92035 · Cited by 2,212 · see citing works

Mechanisms and disease consequences of nonalcoholic fatty liver disease

Loomba, R., Friedman, S. L., & Shulman, G. I. (2021) · Cell · doi:10.1016/j.cell.2021.04.015 · Cited by 2,002 · see citing works

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

Parola, M., & Pinzani, M. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.09.002 · Cited by 1,183 · see citing works

Triggering and resolution of inflammation in NASH

Schuster, S., Cabrera, D., Arrese, M., & Feldstein, A. E. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0009-6 · Cited by 943 · see citing works

Western Diet and the Immune System: An Inflammatory Connection

Christ, A., Lauterbach, M., & Latz, E. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.020 · Cited by 907 · see citing works

Shared and distinct mechanisms of fibrosis

Distler, J. H. W., Györfi, A., Ramanujam, M., Whitfield, M. L., Königshoff, M., & Lafyatis, R. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0322-7 · Cited by 645 · see citing works

Recent insights into the pathogenesis of nonalcoholic fatty liver disease

Arab, J. P., Arrese, M., & Trauner, M. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-043617 · Cited by 573 · see citing works

Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

Rada, P., González‐Rodríguez, Á., García‐Monzón, C., & Valverde, Á. M. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03003-w · Cited by 522 · see citing works

Pathophysiology of obesity and its associated diseases

Jin, X., Qiu, T., Li, L., Yu, R., Chen, X., Li, C., Proud, C. G., & Jiang, T. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.01.012 · Cited by 552 · see citing works

Nonalcoholic Fatty Liver Disease: Basic Pathogenetic Mechanisms in the Progression From NAFLD to NASH

Pierantonelli, I., & Svegliati‐Baroni, G. (2018) · Transplantation · doi:10.1097/tp.0000000000002480 · Cited by 459 · see citing works

An Integrated View of Immunometabolism

Lee, Y. S., Wollam, J., & Olefsky, J. M. (2018) · Cell · doi:10.1016/j.cell.2017.12.025 · Cited by 440 · see citing works

NAFLD: Mechanisms, Treatments, and Biomarkers

Nassir, F. (2022) · Biomolecules · doi:10.3390/biom12060824 · Cited by 422 · see citing works

Lipid nanoparticle technology for therapeutic gene regulation in the liver

Witzigmann, D., Kulkarni, J. A., Leung, J., Chen, S., Cullis, P. R., & van der Meel, R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.026 · Cited by 376 · see citing works

Autophagy in liver diseases: A review

Qian, H., Chao, X., Williams, J. A. R., Fulte, S., Li, T., Yang, L., & Ding, W. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100973 · Cited by 377 · see citing works

Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets

Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371 · see citing works

Resolution of organ fibrosis

Jun, J.-I., & Lau, L. F. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93563 · Cited by 348 · see citing works

GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease

Loomba, R., Kayali, Z., Noureddin, M., Ruane, P., Lawitz, E. J., Bennett, M., Wang, L., Harting, E., Tarrant, J. M., McColgan, B. J., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.07.027 · Cited by 340 · see citing works

Chronic tissue inflammation and metabolic diseasePreprint

Lee, Y. S., & Olefsky, J. M. (2021) · Genes & Development · doi:10.1101/gad.346312.120 · Cited by 342 · see citing works

Liver Macrophages: Old Dogmas and New Insights

Guillot, A., & Tacke, F. (2019) · Hepatology Communications · doi:10.1002/hep4.1356 · Cited by 309 · see citing works

T Cells in Fibrosis and Fibrotic Diseases

Zhang, M., & Zhang, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01142 · Cited by 333 · see citing works

Toxicity of carbon tetrachloride, free radicals and role of antioxidants

Ünsal, V., Çiçek, M., & Sabancılar, İ. (2020) · Reviews on Environmental Health · doi:10.1515/reveh-2020-0048 · Cited by 336 · see citing works

The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease

Fujii, H., Kawada, N., & Japan Study Group of NAFLD (JSG-NAFLD) (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113863 · Cited by 300 · see citing works

Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis

Widjaja, A. A., Singh, B. K., Adami, E., Viswanathan, S., Dong, J., D’Agostino, G. A., Ng, B., Lim, W., Tan, J., Paleja, B. S., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.05.002 · Cited by 276 · see citing works

Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation

Ibrahim, S. H., Hirsova, P., & Gores, G. J. (2018) · Gut · doi:10.1136/gutjnl-2017-315691 · Cited by 278 · see citing works

Targeting ferroptosis alleviates methionine‐choline deficient (MCD)‐diet induced NASH by suppressing liver lipotoxicity

Li, X., Wang, T., Huang, X., Li, Y., Sun, T., Zang, S., Guan, K., Xiong, Y., Liu, J., & Yuan, H. (2020) · Liver International · doi:10.1111/liv.14428 · Cited by 279 · see citing works

Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression

Caligiuri, A., Gentilini, A., Pastore, M., Gitto, S., & Marra, F. (2021) · Cells · doi:10.3390/cells10102759 · Cited by 273 · see citing works

Novel insights into the genetically obese (ob/ob) and diabetic (db/db) mice: two sides of the same coin

Suriano, F., Vieira‐Silva, S., Falony, G., Roumain, M., Paquot, A., Pelicaen, R., Régnier, M., Delzenne, N. M., Raes, J., Muccioli, G. G., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01097-8 · Cited by 276 · see citing works

Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223

Calvente, C. J., Tameda, M., Johnson, C. D., del Pilar, H., Lin, Y. C., Adronikou, N., De Mollerat Du Jeu, X., Llorente, C., Boyer, J., & Feldstein, A. E. (2019) · Journal of Clinical Investigation · doi:10.1172/jci122258 · Cited by 268 · see citing works

Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease

Svegliati‐Baroni, G., Pierantonelli, I., Torquato, P., Marinelli, R., Ferreri, C., Chatgilialoglu, C., Bartolini, D., & Galli, F. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.05.029 · Cited by 250 · see citing works

Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver

Hegde, P., Weiss, E., Paradis, V., Wan, J., Mabire, M., Sukriti, S., Rautou, P.-E., Albuquerque, M., Picq, O., Gupta, A. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04450-y · Cited by 232 · see citing works

FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2

Rao, J., Wang, H., Ni, M., Wang, Z., Wang, Z., Wei, S., Liu, M., Wang, P., Qiu, J., Zhang, L., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-325150 · Cited by 241 · see citing works

Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis

Gao, H., Jin, Z., Bandyopadhyay, G., Wang, G., Zhang, D., Rocha, K. C. E., Liu, X., Zhao, H., Kisseleva, T., Brenner, D. A., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.07.006 · Cited by 224 · see citing works

Liver fibrosis in NAFLD/NASH: from pathophysiology towards diagnostic and therapeutic strategies

Parola, M., & Pinzani, M. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2023.101231 · Cited by 226 · see citing works

Ceria‐Based Therapeutic Antioxidants for Biomedical Applications

Kim, Y. G., Lee, Y., Lee, N., Soh, M., Kim, D., & Hyeon, T. (2023) · Advanced Materials · doi:10.1002/adma.202210819 · Cited by 216 · see citing works

FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases

Tillman, E. J., & Rolph, T. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.601290 · Cited by 209 · see citing works

Nonalcoholic steatohepatitis is associated with liver-related outcomes and all-cause mortality in chronic hepatitis B

Choi, H. S. J., Brouwer, W. P., Zanjir, W. M. R., de Man, R. A., Feld, J. J., Hansen, B. E., Janssen, H. L. A., & Patel, K. (2020) · Hepatology · doi:10.1002/hep.30857 · Cited by 211 · see citing works

Myeloid‐Cell–Specific IL‐6 Signaling Promotes MicroRNA‐223‐Enriched Exosome Production to Attenuate NAFLD‐Associated Fibrosis

Hou, X., Yin, S., Ren, R., Liu, S., Yong, L., Liu, Y., Li, Y., Zheng, M., Kunos, G., Gao, B., et al. (2021) · Hepatology · doi:10.1002/hep.31658 · Cited by 223 · see citing works

Carcinogenesis: Failure of resolution of inflammation?

Fishbein, A., Hammock, B. D., Serhan, C. N., & Panigrahy, D. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107670 · Cited by 207 · see citing works

Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis

Sun, X., Seidman, J. S., Zhao, P., Troutman, T. D., Spann, N. J., Que, X., Zhou, F., Liao, Z., Pasillas, M. P., Yang, X., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.10.014 · Cited by 205 · see citing works

Necroptosis contributes to chronic inflammation and fibrosis in aging liver

Mohammed, S., Thadathil, N., Selvarani, R., Nicklas, E. H., Wang, D., Miller, B. F., Richardson, A., & Deepa, S. S. (2021) · Aging Cell · doi:10.1111/acel.13512 · Cited by 192 · see citing works

Hepatic Stellate Cell-Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis

Matsuda, M., & Seki, E. (2020) · Seminars in Liver Disease · doi:10.1055/s-0040-1708876 · Cited by 189 · see citing works

Metaflammation in obesity and its therapeutic targeting

Schleh, M. W., Caslin, H. L., Garcia, J. N., Mashayekhi, M., Srivastava, G., Bradley, A. B., & Hasty, A. H. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adf9382 · Cited by 191 · see citing works

Neutrophils in liver diseases: pathogenesis and therapeutic targets

Liu, K., Wang, F., & Xu, R. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00560-0 · Cited by 177 · see citing works

Extracellular Matrix Remodeling in Chronic Liver Disease

Ortiz, C., Schierwagen, R., Schaefer, L., Klein, S., Trepat, X., & Trebicka, J. (2021) · Current Tissue Microenvironment Reports · doi:10.1007/s43152-021-00030-3 · Cited by 183 · see citing works

Targeted Therapy for Inflammatory Diseases with Mesenchymal Stem Cells and Their Derived Exosomes: From Basic to Clinics

Wang, S., Lei, B., Zhang, E., Gong, P., Gu, J., He, L., Han, L., & Yuan, Z. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s355366 · Cited by 180 · see citing works

Human hepatic 3D spheroids as a model for steatosis and insulin resistance

Kozyra, M., Johansson, I., Nordling, Å., Ullah, S., Lauschke, V. M., & Ingelman‐Sundberg, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-32722-6 · Cited by 173 · see citing works

Gut microbiota exaggerates triclosan-induced liver injury via gut-liver axis

Zhang, P., Zheng, L., Duan, Y., Gao, Y., Gao, H., Mao, D., & Luo, Y. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.126707 · Cited by 174 · see citing works

Role of cAMP and phosphodiesterase signaling in liver health and disease

Wahlang, B., McClain, C., Barve, S., & Gobejishvili, L. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.06.005 · Cited by 168 · see citing works

Neutrophil-Hepatic Stellate Cell Interactions Promote Fibrosis in Experimental Steatohepatitis

Zhou, Z., Xu, M.-J., Cai, Y., Wang, W., Jiang, J. X., Varga, Z. V., Feng, D., Pacher, P., Kunos, G., Torok, N. J., et al. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.01.003 · Cited by 164 · see citing works

Hepatocyte-specific deletion of IL1-RI attenuates liver injury by blocking IL-1 driven autoinflammation

Gehrke, N., Hövelmeyer, N., Waisman, A., Straub, B. K., Weinmann‐Menke, J., Wörns, M., Galle, P. R., & Schattenberg, J. M. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.01.008 · Cited by 162 · see citing works

Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling

Chen, C., Chen, J., Wang, Y., Fang, L., Guo, C., Sang, T., Peng, H., Zhao, Q., Chen, S., Lin, X., et al. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154626 · Cited by 161 · see citing works

Reversal of liver fibrosis: From fiction to reality

Zoubek, M. E., Trautwein, C., & Strnad, P. (2017) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2017.04.005 · Cited by 157 · see citing works

Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver

Su, Q., Kim, S. Y., Adewale, F., Zhou, Y., Aldler, C., Ni, M., Wei, Y., Burczynski, M. E., Atwal, G. S., Sleeman, M. W., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103233 · Cited by 154 · see citing works

SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis

Zhou, J., Cui, S., He, Q., Guo, Y., Pan, X., Zhang, P., Huang, N., Ge, C., Wang, G., Gonzalez, F. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14138-6 · Cited by 154 · see citing works

Friend or foe? The elusive role of hepatic stellate cells in liver cancer

Cogliati, B., Yashaswini, C. N., Wang, S., Sia, D., & Friedman, S. L. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00821-z · Cited by 157 · see citing works

Fibrosis imaging: Current concepts and future directions

Baues, M., Dasgupta, A., Ehling, J., Prakash, J., Boor, P., Tacke, F., Kiessling, F. M., & Lammers, T. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.10.013 · Cited by 151 · see citing works

AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis

Xu, H., Zhao, Q., Song, N., Yan, Z., Lin, R., Wu, S., Jiang, L., Hong, S., Xie, J., Zhou, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19668-y · Cited by 151 · see citing works

Hepatocyte-Macrophage Acetoacetate Shuttle Protects Against Tissue Fibrosis

Puchalska, P., Martin, S. E., Huang, X., Lengfeld, J. E., Daniel, B., Graham, M. J., Han, X., Nagy, L., Patti, G. J., & Crawford, P. A. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.015 · Cited by 138 · see citing works

Heterogeneity of HSCs in a Mouse Model of NASH

Rosenthal, S. B., Liu, X., Ganguly, S., Dhar, D., Pasillas, M. P., Ricciardelli, E., Li, R. Z., Troutman, T. D., Kisseleva, T., Glass, C. K., et al. (2021) · Hepatology · doi:10.1002/hep.31743 · Cited by 145 · see citing works

Immunomodulatory Role of the Extracellular Matrix Within the Liver Disease Microenvironment

McQuitty, C. E., Williams, R., Chokshi, S., & Urbani, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.574276 · Cited by 146 · see citing works

Pharmacokinetics of obese adults: Not only an increase in weight

Gouju, J., & Legeay, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115281 · Cited by 146 · see citing works

Immunopathobiology and therapeutic targets related to cytokines in liver diseases

He, Y., Hwang, S., Ahmed, Y. A., Feng, D., Li, N., Ribeiro, M. D. C., Lafdil, F., Kisseleva, T., Szabó, G., & Gao, B. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00580-w · Cited by 136 · see citing works

Pathogenesis of NASH: the Impact of Multiple Pathways

Noureddin, M., & Sanyal, A. J. (2018) · Current Hepatology Reports · doi:10.1007/s11901-018-0425-7 · Cited by 135 · see citing works

Pathophysiology and Treatment Options for Hepatic Fibrosis: Can It Be Completely Cured?

Khanam, A., Saleeb, P. G., & Kottilil, S. (2021) · Cells · doi:10.3390/cells10051097 · Cited by 132 · see citing works

Role of mitochondria in liver metabolic health and diseases

Morio, B., Panthu, B., Bassot, A., & Rieusset, J. (2020) · Cell Calcium · doi:10.1016/j.ceca.2020.102336 · Cited by 130 · see citing works

Multi-omic profiling of primary mouse neutrophils predicts a pattern of sex- and age-related functional regulation

Lu, R. J., Taylor, S., Contrepois, K., Kim, M., Bravo, J. I., Ellenberger, M., Sampathkumar, N. K., & Benayoun, B. A. (2021) · Nature Aging · doi:10.1038/s43587-021-00086-8 · Cited by 128 · see citing works

Wnt/β-Catenin Signaling as a Potential Target for the Treatment of Liver Cirrhosis Using Antifibrotic Drugs

Nishikawa, K., Osawa, Y., & Kimura, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103103 · Cited by 126 · see citing works

The Role of Sinusoidal Endothelial Cells in the Axis of Inflammation and Cancer Within the Liver

Wilkinson, A. L., Qurashi, M., & Shetty, S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00990 · Cited by 121 · see citing works

PPARs in liver physiology

Berthier, A., Johanns, M., Zummo, F. P., Lefebvre, P., & Staels, B. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166097 · Cited by 125 · see citing works

Macrophages in organ fibrosis: from pathogenesis to therapeutic targets

Jiang, Y., Cai, R., Huang, Y., Zhu, L., Xiao, L., Wang, C., & Wang, L. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02247-1 · Cited by 126 · see citing works

Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway

Liu, X.-X., Mi, X.-J., Wang, Z., Zhang, M., Hou, J., Jiang, S., Wang, Y., Chen, C., & Li, W. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2597-7 · Cited by 124 · see citing works

The Emerging Role of B Cells in the Pathogenesis of NAFLD

Barrow, F., Khan, S., Wang, H., & Revelo, X. S. (2021) · Hepatology · doi:10.1002/hep.31889 · Cited by 126 · see citing works

Cirrhosis: A Questioned Risk Factor for Hepatocellular Carcinoma

Garrido, A., & Djouder, N. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.08.005 · Cited by 122 · see citing works

The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation

Beyer, D., Hoff, J., Sommerfeld, O., Zipprich, A., Gaßler, N., & Press, A. T. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00510-8 · Cited by 122 · see citing works

The role of cGAS-STING signalling in liver diseases

Chen, R., Du, J., Zhu, H., & Ling, Q. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100324 · Cited by 124 · see citing works

Sarcopenia in chronic liver disease: mechanisms and countermeasures

Allen, S., Quinlan, J. I., Dhaliwal, A., Armstrong, M. J., Elsharkawy, A. M., Greig, C. A., Lord, J. M., Lavery, G. G., & Breen, L. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00373.2020 · Cited by 124 · see citing works

Systemic immune-inflammation index is associated with hepatic steatosis: Evidence from NHANES 2015-2018

Song, Y., Guo, W., Li, Z., Guo, D. L., Zhao, L., & Li, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1058779 · Cited by 118 · see citing works

Crocin: A fighter against inflammation and pain

Hashemzaei, M., Mamoulakis, C., Tsarouhas, K., Georgiadis, G., Lazopoulos, G., Tsatsakis, A. M., Asrami, E. S., & Rezaee, R. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111521 · Cited by 117 · see citing works

Historical Perspectives and Advances in Mesenchymal Stem Cell Research for the Treatment of Liver Diseases

Lee, C., Chen, Y.-F., Wu, H.-H., & Lee, O. K. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.09.049 · Cited by 115 · see citing works

Non-alcoholic Fatty Liver Disease as a Canonical Example of Metabolic Inflammatory-Based Liver Disease Showing a Sex-Specific Prevalence: Relevance of Estrogen Signaling

Torre, S. D. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.572490 · Cited by 118 · see citing works

Hepatocellular Carcinoma Mechanisms Associated with Chronic HCV Infection and the Impact of Direct-Acting Antiviral Treatment

Dash, S., Aydın, Y., Widmer, K., & Nayak, L. (2020) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s221187 · Cited by 127 · see citing works

Crosstalk Between Liver Macrophages and Surrounding Cells in Nonalcoholic Steatohepatitis

Li, H., Zhou, Y., Wang, H., Zhang, M., Qiu, P., Zhang, M., Zhang, R., Zhao, Q., & Liu, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01169 · Cited by 114 · see citing works

Targeting CSF-1R represents an effective strategy in modulating inflammatory diseases

Xiang, C., Li, H., & Tang, W. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106566 · Cited by 114 · see citing works

MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization

Zhang, J., Liu, Y., Chen, H., Yuan, Q., Wang, J., Niu, M., Hou, L., Gu, J., & Zhang, J. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04802-z · Cited by 112 · see citing works

Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin

Qin, L., Liu, N., Bao, C.-L.-M., Yang, D.-Z., Ma, G.-X., Yi, W.-H., Xiao, G.-Z., & Cao, H.-L. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00952-0 · Cited by 114 · see citing works

ERK Pathway in Activated, Myofibroblast-Like, Hepatic Stellate Cells: A Critical Signaling Crossroad Sustaining Liver Fibrosis

Foglia, B., Cannito, S., Bocca, C., Parola, M., & Novo, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112700 · Cited by 110 · see citing works

Organ and brain crosstalk: The liver-brain axis in gastrointestinal, liver, and pancreatic diseases

Matsubara, Y., Kiyohara, H., Teratani, T., Mikami, Y., & Kanai∥, T. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108915 · Cited by 114 · see citing works

ROS/RNS as molecular signatures of chronic liver diseases

Che, Z., Zhou, Z., Li, S.-Q., Gao, L., Xiao, J., & Wong, N.-K. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.08.001 · Cited by 110 · see citing works

Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress

Mohammed, S., Nicklas, E. H., Thadathil, N., Selvarani, R., Royce, G. H., Kinter, M. T., Richardson, A. G., & Deepa, S. S. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.449 · Cited by 108 · see citing works

Macrophage in liver Fibrosis: Identities and mechanisms

Wang, Z., Du, K., Jin, N., Tang, B., & Zhang, W. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110357 · Cited by 114 · see citing works

Kupffer-derived matrix metalloproteinase-9 contributes to liver fibrosis resolution

Feng, M., Ding, J., Wang, M., Zhang, J., Zhu, X., & Guan, W. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.25589 · Cited by 107 · see citing works

Silencing lncRNA Lfar1 alleviates the classical activation and pyoptosis of macrophage in hepatic fibrosis

Zhang, K., Shi, Z., Zhang, M., Dong, X., Zheng, L., Li, G., Han, X., Yao, Z., Han, T., & Wei, H. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2323-5 · Cited by 106 · see citing works

Hepatic stellate cells: balancing homeostasis, hepatoprotection and fibrogenesis in health and disease

Schwabe, R. F., & Brenner, D. A. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01068-6 · Cited by 112 · see citing works

Aflatoxin B1 enhances pyroptosis of hepatocytes and activation of Kupffer cells to promote liver inflammatory injury via dephosphorylation of cyclooxygenase-2: an in vitro, ex vivo and in vivo study

Zhang, L., Zhan, D.-L., Chen, Y., Wang, W., He, C., Lin, Y., Lin, Z., & Lin, Z. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02572-w · Cited by 106 · see citing works

Metabolic Dysfunction‐Associated Steatotic Liver Disease ( MASLD ): Mechanisms, Clinical Implications and Therapeutic Advances

Miller, D. M., McCauley, K. F., & Dunham‐Snary, K. J. (2025) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.70132 · Cited by 125 · see citing works

Metabolic inflammation as an instigator of fibrosis during non-alcoholic fatty liver disease

Katsarou, A., Moustakas, I. I., Pyrina, I., Lembessis, P., Koutsilieris, M., & Chatzigeorgiou, A. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i17.1993 · Cited by 101 · see citing works

Animal and Organoid Models of Liver Fibrosis

Bao, Y., Wang, L., Pan, H., Zhang, T.-R., Chen, Y., Xu, S.-J., Mao, X., & Li, S.-W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.666138 · Cited by 101 · see citing works

Endothelial p300 Promotes Portal Hypertension and Hepatic Fibrosis Through C‐C Motif Chemokine Ligand 2–Mediated Angiocrine Signaling

Gao, J., Wei, B., Liu, M., Hirsova, P., Sehrawat, T. S., Cao, S., Hu, X., Xue, F., Yaqoob, U., Kang, N., et al. (2021) · Hepatology · doi:10.1002/hep.31617 · Cited by 100 · see citing works

Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease

Dong, J., Chen, L., Ye, F., Tang, J., Liu, B., Lin, J., Zhou, P., Lü, B., Wu, M., Lu, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44057-6 · Cited by 99 · see citing works

From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases

Zhao, P., & Saltiel, A. R. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.011356 · Cited by 101 · see citing works

Hepatic inflammation and fibrosis: Functional links and key pathways

Seki, E., & Schwabe, R. F. (2015) · Hepatology · doi:10.1002/hep.27332 · Cited by 972 · see citing works

Liver fibrosis: from basic science towards clinical progress, focusing on the central role of hepatic stellate cells

Akkız, H., Gieseler, R. K., & Canbay, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147873 · Cited by 191 · see citing works

Cellular Interplay as a Consequence of Inflammatory Signals Leading to Liver Fibrosis Development

Ignat, S.-R., Dinescu, S., Hermenean, A. O., & Costache, M. (2020) · Cells · doi:10.3390/cells9020461 · Cited by 72 · see citing works

Chronic inflammation as a molecular basis of nonalcoholic steatohepatitis: role of macrophages and fibroblasts in the liver.

Itoh, M., Ogawa, Y., & Suganami, T. (2020) · Europe PMC (PubMed Central) · doi:10.18999/nagjms.82.3.391 · Cited by 5 · see citing works

Pleiotropic effects of CD5L in hepatic inflammation and fibrosis

Zhou, T., & Glaser, S. S. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.05.039 · Cited by 2 · see citing works