The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Cardiovascular Protection by ApoE and ApoE-HDL Linked to Suppression of ECM Gene Expression and Arterial Stiffening
Open accessAbstract
Arterial stiffening is a risk factor for cardiovascular disease, but how arteries stay supple is unknown. Here, we show that apolipoprotein E (apoE) and apoE-containing high-density lipoprotein (apoE-HDL) maintain arterial elasticity by suppressing the expression of extracellular matrix genes. ApoE interrupts a mechanically driven feed-forward loop that increases the expression of collagen-I, fibronectin, and lysyl oxidase in response to substratum stiffening. These effects are independent of the apoE lipid-binding domain and transduced by Cox2 and miR-145. Arterial stiffness is increased in apoE null mice. This stiffening can be reduced by administration of the lysyl oxidase inhibitor BAPN, and BAPN treatment attenuates atherosclerosis despite highly elevated cholesterol. Macrophage abundance in lesions is reduced by BAPN in vivo, and monocyte/macrophage adhesion is reduced by substratum softening in vitro. We conclude that apoE and apoE-containing HDL promote healthy arterial biomechanics and that this confers protection from cardiovascular disease independent of the established apoE-HDL effect on cholesterol.
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Citations
Cites
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
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ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
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“The arrow shows the cholesterol level in wild-type mice on a western diet (Nakashima et al., 2004).”
miR-145 and miR-143 regulate smooth muscle cell fate and plasticity
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Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell
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Apolipoprotein E: Structure-Function Relationships
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Cited by
Actin Dynamics, Architecture, and Mechanics in Cell Motility
Blanchoin, L., Boujemaa-Paterski, R., Sykes, C., & Plastino, J. (2014) · Physiological Reviews · doi:10.1152/physrev.00018.2013 · Cited by 1,457
Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease
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Lampi, M. C., & Reinhart-King, C. A. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao0475 · Cited by 551
Age-related vascular stiffening: causes and consequences
Kohn, J. C., Lampi, M. C., & Reinhart-King, C. A. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00112 · Cited by 440
“Animal studies by Kothapalli et al. (2012) recently demonstrated that arterial stiffening and ECM crosslinking precede cardiovascular disease development.”
BackgroundWells, R. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.02.007 · Cited by 384
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The arterial microenvironment: the where and why of atherosclerosis
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Biophysical regulation of macrophages in health and disease
Meli, V. S., Veerasubramanian, P. K., Atcha, H., Reitz, Z., Downing, T. L., & Liu, W. F. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.mr0318-126r · Cited by 133
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Metadata
- Authors
- Kothapalli, D., Liu, S.-L., Bae, Y. H., Monslow, J., Xu, T., Hawthorne, E. A., Byfield, F. J., Castagnino, P., Rao, S., Rader, D. J., Puré, E., Phillips, M. C., Lund-Katz, S., Janmey, P. A., & Assoian, R. K.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 2
- Issue
- 5
- Pages
- 1259-1271
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2126423643
- Cited by
- 186
- References
- 6
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- gold
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