Emulating endothelial dysfunction by implementing an early atherosclerotic microenvironment within a microfluidic chip

Shin, Yujin; Lim, Seongjin; Kim, Jinwon; Jeon, Jessie S.; Yoo, Hongki; Gweon, Bomi

doi:10.1039/c9lc00352e

Cited by 26Cellular Mechanics and Interactions3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

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Emulating endothelial dysfunction by implementing an early atherosclerotic microenvironment within a microfluidic chip

Shin, Yujin, Lim, Seongjin, Kim, Jinwon, Jeon, Jessie S., Yoo, Hongki, Gweon, Bomi·2019·Lab on a Chip

DOI 10.1039/c9lc00352e

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Abstract

The pathophysiological phenotype and function of endothelial cells (ECs) in atherosclerotic lesions are replicated within a micro-channel by mimicking the microenvironment of the lesions.

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Human monocytes directly decreased extravasation of tumor cells in a noncontact-dependent manner.
“human monocytes directly decreased the extravasation of tumor cells in a noncontact‐dependent manner.”
From 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip (2023) · cites this paper as [128]
Once monocytes transmigrated through the vasculature and became macrophage-like, they had little influence on tumor cell extravasation.
“once monocytes transmigrated through the vasculature and became macrophage‐like, they had little influence on tumor cell extravasation.”
From 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip (2023) · cites this paper as [128]

Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions.
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Sorted by citations

3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip
Li, W., Zhou, Z., Zhou, X., Khoo, B. L., Gunawan, R., Chin, Y. R., Zhang, L., Yi, C., Guan, X., & Yang, M. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202202609 · Cited by 119

Authors: Shin, Y., Lim, S., Kim, J., Jeon, J. S., Yoo, H., & Gweon, B.
Affiliations: Hanyang University (KR)
Korea Advanced Institute of Science and Technology (KR)
Cardiovascular Center
Sejong University (KR)
Corresponding author: Yoo, Hongki
Gweon, Bomi
ORCID: Shin, Yujin
Lim, Seongjin
Jeon, Jessie S.
Yoo, Hongki
Gweon, Bomi
Venue: Lab on a Chip
Publisher: Royal Society of Chemistry (RSC)
Published: 2019
Volume: 19
Issue: 21
Pages: 3664-3677
ISSN: 1473-0189 (ISSN-L)
1473-0197
DOI: 10.1039/c9lc00352e
OpenAlex: W2972472006
Cited by: 26
References: 4
Citations by year: 2026: 7 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 1
FWCI: 1.32
Type: journal article
Language: en
Open access: closed
Licence: rsc.li/journals-terms-of-use (am, 618 d)
Locations: Lab on a Chip (publishedVersion)
PubMed (publishedVersion)
Funders: National Research Foundation of Korea (NRF-2014R1A6A3A04059713, NRF-2017R1D1A1B03030428, NRF-2017R1E1A1A01074822, NRF-2018R1A2B3002001, NRF-2019M3A9E2066882)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords: endothelial dysfunction, atherosclerosis, microfluidics, fibronectin, hydrogel stiffness, vascular stiffness, endothelial permeability, VE-cadherin, collagen substrate, endothelial cell alignment, fluid flow, atherosclerotic plaque
MeSH terms: Animals, Cattle, Cells, Cultured, Endothelium, Models, Cardiovascular, Cell Culture Techniques, Endothelial Cells, Atherosclerosis, Lab-On-A-Chip Devices, Cellular Microenvironment

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Emulating endothelial dysfunction by implementing an early atherosclerotic microenvironment within a microfluidic chip

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