The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Genetics of Follicular Lymphoma Transformation
Open accessAbstract
Follicular lymphoma (FL) is an indolent disease, but 30%-40% of cases undergo histologic transformation to an aggressive malignancy, typically represented by diffuse large B cell lymphoma (DLBCL). The pathogenesis of this process remains largely unknown. Using whole-exome sequencing and copy-number analysis, we show here that the dominant clone of FL and transformed FL (tFL) arise by divergent evolution from a common mutated precursor through the acquisition of distinct genetic events. Mutations in epigenetic modifiers and antiapoptotic genes are introduced early in the common precursor, whereas tFL is specifically associated with alterations deregulating cell-cycle progression and DNA damage responses (CDKN2A/B, MYC, and TP53) as well as aberrant somatic hypermutation. The genomic profile of tFL shares similarities with that of germinal center B cell-type de novo DLBCL but also displays unique combinations of altered genes with diagnostic and therapeutic implications.
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Cites
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
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Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
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Mutational heterogeneity in cancer and the search for new cancer-associated genes
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Cited by
Germinal centres and B cell lymphomagenesis
Basso, K., & Dalla-Favera, R. (2015) · Nature Reviews Immunology · doi:10.1038/nri3814 · Cited by 510
Self-citationDisruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis
Zhang, J., Dominguez-Sola, D., Hussein, S., Lee, J.-E., Holmes, A. B., Bansal, M., Vlasevska, S., Mo, T., Tang, H., Basso, K., et al. (2015) · Nature Medicine · doi:10.1038/nm.3940 · Cited by 466
Self-citationUncovering novel mutational signatures by de novo extraction with SigProfilerExtractor
Islam, S. M. A., Díaz-Gay, M., Wu, Y., Barnes, M., Vangara, R., Bergstrom, E. N., He, Y., Vella, M., Wang, J., Teague, J. W., et al. (2022) · Cell Genomics · doi:10.1016/j.xgen.2022.100179 · Cited by 365
Green, M. R., Kihira, S., Liu, C. L., Nair, R. V., Salari, R., Gentles, A. J., Irish, J., Stehr, H., Vicente-Dueñas, C., Romero-Camarero, I., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501199112 · Cited by 355
Genetics of diffuse large B-cell lymphoma
Pasqualucci, L., & Dalla-Favera, R. (2018) · Blood · doi:10.1182/blood-2017-11-764332 · Cited by 282
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Metadata
- Authors
- Pasqualucci, L., Khiabanian, H., Fangazio, M., Vasishtha, M., Messina, M., Holmes, A. B., Ouillette, P., Trifonov, V., Rossi, D., Tabbò, F., Ponzoni, M., Chadburn, A., Murty, V. V., Bhagat, G., Gaidano, G., Inghirami, G., Malek, S. N., Rabadan, R., & Dalla-Favera, R.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 6
- Issue
- 1
- Pages
- 130-140
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2132135544
- Cited by
- 573
- References
- 49
- FWCI
- 39.25
- Type
- journal article
- Language
- en
- Open access
- gold
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- Pasqualucci, L., Khiabanian, H., Fangazio, M., Vasishtha, M., Messina, M., Holmes, A. B., Ouillette, P., Trifonov, V., Rossi, D., Tabbò, F., Ponzoni, M., Chadburn, A., Murty, V. V., Bhagat, G., Gaidano, G., Inghirami, G., Malek, S. N., Rabadan, R., & Dalla-Favera, R. (2014). Genetics of Follicular Lymphoma Transformation. Cell Reports. https://doi.org/10.1016/j.celrep.2013.12.027
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