The secreted protein C1ql1 and its receptor BAI3 control the synaptic connectivity of excitatory inputs converging on cerebellar purkinje cells
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Precise patterns of connectivity are established by different types of afferents on a given target neuron, leading to well-defined and non-overlapping synaptic territories. What regulates the specific characteristics of each type of synapse, in terms of number, morphology, and subcellular localization, remains to be understood. Here, we show that the signaling pathway formed by the secreted complement C1Q-related protein C1QL1 and its receptor, the adhesion-GPCR brain angiogenesis inhibitor 3 (BAI3), controls the stereotyped pattern of connectivity established by excitatory afferents on cerebellar Purkinje cells. The BAI3 receptor modulates synaptogenesis of both parallel fiber and climbing fiber afferents. The restricted and timely expression of its ligand C1QL1 in inferior olivary neurons ensures the establishment of the proper synaptic territory for climbing fibers. Given the broad expression of C1QL and BAI proteins in the developing mouse brain, our study reveals a general mechanism contributing to the formation of a functional brain.
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Both the ADGRB3 receptor (BAI3) and kainate receptors are bound postsynaptically by C1ql proteins, regulating synaptogenesis in the case of ADGRB3 binding and postsynaptic recruitment in the case of kainate receptors.
“Both the ADGRB3 receptor (BAI3) and kainate receptors are bound postsynaptically by C1ql proteins, regulating synaptogenesis in the case of ADGRB3 binding and postsynaptic recruitment in the case of kainate receptors (Sigoillot et al., 2015;Matsuda et al., 2016;Bolliger et al., 2011;Yuzaki, 2017;Martinelli et al., 2016).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Sigoillot et al., 2015
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C1ql1 is expressed in adult outer hair cells of the cochlea in a tonotopic gradient
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Complement drives circuit modulation in the adult brain
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What would a synthetic connectome look like?
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CTRP4 ablation impairs associative learning and memory
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Deletion of C1ql1 Causes Hearing Loss and Abnormal Auditory Nerve Fibers in the Mouse Cochlea
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CTRP14 inactivation alters physical activity and food intake response to fasting and refeeding
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CTRP11 contributes modestly to systemic metabolism and energy balance
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Generation and initial characterization of mice lacking full‐length BAI3 (ADGRB3) expression
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Adhesion G protein-coupled receptors
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Genome-wide association studies (GWAS) and post-GWAS analyses of impulsivity: A systematic review
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Synaptic Gα12/13 signaling establishes hippocampal PV inhibitory circuits
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Functional mosaic organization of neuroligins in neuronal circuits
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Mapping and targeting of C1ql1-expressing cells in the mouse
Moghimyfiroozabad, S., Paul, M. A., Sigoillot, S. M., & Selimi, F. (2023) · Scientific Reports · doi:10.1038/s41598-023-42924-2 · Cited by 10 · see citing works
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C1ql1 expression in oligodendrocyte progenitor cells promotes oligodendrocyte differentiation
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UNC-30/PITX coordinates neurotransmitter identity with postsynaptic GABA receptor clustering
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CTRP13 ablation improves systemic glucose and lipid metabolism
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Stepwise molecular specification of excitatory synapse diversity onto cerebellar Purkinje cells
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Essential Role of Latrophilin-1 Adhesion GPCR Nanoclusters in Inhibitory Synapses
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Structure of the complex of C1q-like 3 protein with adhesion-GPCR BAI3
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Noncanonical Regulation of cAMP-dependent Insulin Secretion and Its Implications in Type 2 Diabetes
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Loss of CTRP10 results in female obesity with preserved metabolic healthPreprint
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Noncanonical Regulation of cAMP‐Dependent Insulin Secretion and Its Implications in Type 2 Diabetes
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The spiny relationship between parallel fibers, climbing fibers, and Purkinje cells
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C1QL1/CTRP14 Is Largely Dispensable for Atherosclerosis Formation in Apolipoprotein-E-Deficient Mice
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Patient mutations in DRP1 perturb synaptic maturation of cortical neuronsPreprint
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Structural basis of calcium-dependent C1ql1/BAI3 assemblies in synaptic connectivity
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- Authors
- Sigoillot, S. M., Iyer, K., Binda, F., González-Calvo, I., Talleur, M., Vodjdani, G., Isope, P., & Selimi, F.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Corresponding author
- Selimi, Fekrije
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 10
- Issue
- 5
- Pages
- 820-832
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W1997258848
- Cited by
- 144
- References
- 39
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 16 · 2023: 11 · 2022: 16 · 2021: 18 · 2020: 9 · 2019: 9 · 2018: 11 · 2017: 11 · 2016: 13 · 2015: 4
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- univOAK (4 institutions : Université de Strasbourg, Université de Haute Alsace, INSA Strasbourg, Bibliothèque Nationale et Universitaire de Strasbourg) (submittedVersion, cc-by-nc-nd)
- Funders
- Agence Nationale de la Recherche (10-LABX-54, ANR-11-IDEX-0001, ANR11IDEX000102, ANR–10–LABX–54, ANR-11IDEX-0001-02 PSL, ANR-10-IDEX-0001, ANR-11-IDEX, ANR-13-SAMA-0010, ANR-10, IDEX-0001-02)
- Centre National de la Recherche Scientifique (ANR-11-IDEX-0001-02)
- Interreg
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- C1QL1, BAI3, Purkinje cells, synaptic connectivity, synaptogenesis, adhesion GPCRs, brain development
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