Cited by 125Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersNeuroinflammation and Neurodegeneration Mechanisms

Two Classes of Secreted Synaptic Organizers in the Central Nervous System

Yuzaki, Michisuke·2018·Annual Review of Physiology

Abstract

Research in the last two decades has identified many synaptic organizers in the central nervous system that directly regulate the assembly of pre- and/or postsynaptic molecules, such as synaptic vesicles, active zone proteins, and neurotransmitter receptors. They are classified into secreted factors and cell adhesion molecules, such as neurexins and neuroligins. Certain secreted factors are termed extracellular scaffolding proteins (ESPs) because they are components of the synaptic extracellular matrix and serve as a scaffold at the synaptic cleft. These include Lgi1, Cbln1, neuronal pentraxins, Hevin, thrombospondins, and glypicans. Diffusible secreted factors, such as Wnts, fibroblast growth factors, and semaphorins, tend to act from a distance. In contrast, ESPs remain at the synaptic cleft and often help synaptic adhesion and/or accumulation of postsynaptic receptors. Many fundamental questions remain about when, how, and why various synaptic organizers establish and modify the vast numbers of connections during development and throughout life.

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Crossref · 10.1146/annurev-physiol-021317-121322

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Authors
Yuzaki, M.
Affiliations
Keio University (JP)
Corresponding author
Yuzaki, Michisuke
Venue
Annual Review of Physiology
Published
2018-02-10
Volume
80
Issue
1
Pages
243-262
ISSN
  • 0066-4278 (ISSN-L)
  • 1545-1585
OpenAlex
W2622842747
Cited by
125
References
131
Citations by year
2026: 12 · 2025: 18 · 2024: 11 · 2023: 16 · 2022: 12 · 2021: 21 · 2020: 25 · 2019: 5 · 2018: 5
FWCI
1.18
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (15H05772)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
synaptic organizer, secreted factors, synaptic cleft, synaptic adhesion, synaptic vesicles, active zone proteins, neurexin, neuroligins, LGI1, Cbln1, hevin, thrombospondin, glypicans, Wnt, fibroblast growth factor, semaphorins, synaptic development, synaptic plasticity
MeSH terms
Pentraxins, Animals, Brain, C-Reactive Protein, Humans, Nerve Tissue Proteins, Neuronal Plasticity, Protein Precursors, Spinal Cord, Synapses, Thrombospondins, Wnt Proteins

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