The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
The Proteomic Landscape of Triple-Negative Breast Cancer
Open accessAbstract
Triple-negative breast cancer is a heterogeneous disease characterized by poor clinical outcomes and a shortage of targeted treatment options. To discover molecular features of triple-negative breast cancer, we performed quantitative proteomics analysis of twenty human-derived breast cell lines and four primary breast tumors to a depth of more than 12,000 distinct proteins. We used this data to identify breast cancer subtypes at the protein level and demonstrate the precise quantification of biomarkers, signaling proteins, and biological pathways by mass spectrometry. We integrated proteomics data with exome sequence resources to identify genomic aberrations that affect protein expression. We performed a high-throughput drug screen to identify protein markers of drug sensitivity and understand the mechanisms of drug resistance. The genome and proteome provide complementary information that, when combined, yield a powerful engine for therapeutic discovery. This resource is available to the cancer research community to catalyze further analysis and investigation.
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Cites
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“Protein quantifications were calculated using the iBAQ approach (Schwanhäusser et al., 2011).”
MethodThe genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
METABRIC Group, Curtis, C., Shah, S. P., Chin, S.-F., Turashvili, G., Rueda, O. M., Dunning, M. J., Speed, D., Lynch, A. G., Samarajiwa, S., et al. (2012) · Nature · doi:10.1038/nature10983 · Cited by 6,097
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Cited by
The ectonucleotidases CD 39 and CD 73: Novel checkpoint inhibitor targets
Allard, B., Longhi, M. S., Robson, S. C., & Stagg, J. (2017) · Immunological Reviews · doi:10.1111/imr.12528 · Cited by 927
The adenosine pathway in immuno-oncology
Allard, B., Allard, D., Buisseret, L., & Stagg, J. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0382-2 · Cited by 586
An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes
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Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics
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Self-citationImmunosuppressive Activities of Adenosine in Cancer
Allard, B., Beavis, P. A., Darcy, P. K., & Stagg, J. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.04.001 · Cited by 292
Metadata
- Authors
- Lawrence, R. T., Perez, E. M., Hernández, D., Miller, C. P., Haas, K. M., Irie, H. Y., Lee, S.-I., Blau, C. A., & Villén, J.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 11
- Issue
- 4
- Pages
- 630-644
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W1996822667
- Cited by
- 224
- References
- 18
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lawrence, R. T., Perez, E. M., Hernández, D., Miller, C. P., Haas, K. M., Irie, H. Y., Lee, S.-I., Blau, C. A., & Villén, J. (2015). The Proteomic Landscape of Triple-Negative Breast Cancer. Cell Reports. https://doi.org/10.1016/j.celrep.2015.03.050
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