Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism
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Loss-of-function mutations in the synaptic adhesion protein Neuroligin-4 are among the most common genetic abnormalities associated with autism spectrum disorders, but little is known about the function of Neuroligin-4 and the consequences of its loss. We assessed synaptic and network characteristics in Neuroligin-4 knockout mice, focusing on the hippocampus as a model brain region with a critical role in cognition and memory, and found that Neuroligin-4 deletion causes subtle defects of the protein composition and function of GABAergic synapses in the hippocampal CA3 region. Interestingly, these subtle synaptic changes are accompanied by pronounced perturbations of γ-oscillatory network activity, which has been implicated in cognitive function and is altered in multiple psychiatric and neurodevelopmental disorders. Our data provide important insights into the mechanisms by which Neuroligin-4-dependent GABAergic synapses may contribute to autism phenotypes and indicate new strategies for therapeutic approaches.
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Nlgn4 KO mice have decreased excitatory PSD-95-immunolabeled puncta in the stratum lucidum and lower density of GABAA receptor and gephyrin-immunoreactive synapses in the stratum pyramidale of the CA3 field.
“These mice have decreased excitatory PSD-95-immunolabeled puncta in the stratum lucidum as well as lower density of GABAA receptor and gephyrin-immunoreactive synapses in the stratum pyramidale of the CA3 field [140].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [140]
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- Authors
- Hammer, M., Krueger-Burg, D., Tuffy, L. P., Cooper, B. H., Taschenberger, H., Goswami, S. P., Ehrenreich, H., Jonas, P., Varoqueaux, F., Rhee, J.-S., & Brose, N.
- Affiliations
- Max Planck Institute of Experimental Medicine (DE)
- Institute of Science and Technology Austria (AT)
- Corresponding author
- Brose, Nils
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 13
- Issue
- 3
- Pages
- 516-523
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC5862414
- OpenAlex
- W1944530972
- Cited by
- 66
- References
- 49
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 6 · 2020: 7 · 2019: 2 · 2018: 12 · 2017: 7 · 2016: 7
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, cc-by)
- MPG.PuRe (Max Planck Society) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Max Planck Digital Library (submittedVersion, other-oa)
- GRO (submittedVersion, cc-by)
- Funders
- European Commission (115300)
- Deutsche Forschungsgemeinschaft
- Max-Planck-Gesellschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- neuroligin 4, autism spectrum disorder, hippocampus, CA3, GABAergic synapses, synaptic inhibition, gamma oscillations, synaptic adhesion proteins, network oscillations, cognitive function
- MeSH terms
- Animals, Autistic Disorder, Male, Mice, Inbred C57BL, Cell Adhesion Molecules, Neuronal, Mice, Inhibitory Postsynaptic Potentials, CA3 Region, Hippocampal, GABAergic Neurons, Gamma Rhythm
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