Postnatal neurodevelopmental disorders: meeting at the synapse?
Abstract
We often think of neurodevelopmental disorders as beginning before birth, and many certainly do. A handful, however, strike many months after birth, following a period of apparently normal growth and development. Autism and Rett syndrome are two such disorders, and here I consider some of their similarities at the phenotypic and pathogenic levels. I propose that both disorders result from disruption of postnatal or experience-dependent synaptic plasticity.
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The earliest synthetic molecular model proposed that the primary area of convergence in ASD was postnatal, experience-dependent development of the synapse.
“The earliest synthetic molecular model was based on the notion that the primary area of convergence in ASD was the postnatal, experience-dependent development of the synapse [48].”
From Genetics of autism spectrum disorders (2011) · cites this paper as [48]
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- Authors
- Zoghbi, H. Y.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Zoghbi, Huda Y.
- ORCID
- Zoghbi, Huda Y.
- Venue
- Science
- Published
- 2003-10-31
- Volume
- 302
- Issue
- 5646
- Pages
- 826-830
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2065857393
- Cited by
- 691
- References
- 78
- Citations by year
- 2026: 3 · 2025: 16 · 2024: 7 · 2023: 12 · 2022: 29 · 2021: 33 · 2020: 20 · 2019: 25 · 2018: 18 · 2017: 27 · 2016: 39 · 2015: 33 · 2014: 40 · 2013: 46 · 2012: 47
- FWCI
- 13.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD40301, P01HD040301)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- autism spectrum disorder, Rett syndrome, synaptic plasticity, experience-dependent development, synapses, pathogenesis, phenotypic similarity
- MeSH terms
- Animals, Autistic Disorder, Brain, Carrier Proteins, Child, Preschool, Chromosomal Proteins, Non-Histone, Chromosome Aberrations, DNA-Binding Proteins, Female, Humans, Infant, Magnetic Resonance Imaging, Male, Membrane Proteins, Mutation, Nerve Tissue Proteins, Neuronal Plasticity, Neurons, Phenotype, Repressor Proteins, Synapses, Rett Syndrome, Cell Adhesion Molecules, Neuronal, Age of Onset, Neuregulins, Ubiquitin-Protein Ligases, Intracellular Signaling Peptides and Proteins, Methyl-CpG-Binding Protein 2
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