Human Telomerase RNA Processing and Quality Control

The RNA Component of Human Telomerase

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Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis

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A telomerase component is defective in the human disease dyskeratosis congenita

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The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

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RNA Exosome Depletion Reveals Transcription Upstream of Active Human Promoters

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Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA

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RNA-quality control by the exosome

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Secondary Structure of Vertebrate Telomerase RNA

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Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2

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A Box H/ACA Small Nucleolar RNA-Like Domain at the Human Telomerase RNA 3′ End

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Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening

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Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex

Lubas, M., Christensen, M. S., Kristiansen, M. S., Domanski, M., Falkenby, L. G., Lykke‐Andersen, S., Andersen, J., Dziembowski, A., & Jensen, T. H. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.028 · Cited by 422 · see citing works

Finding the end: recruitment of telomerase to telomeres

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Telomeres: Cancer to Human Aging

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Identification of ATPases Pontin and Reptin as Telomerase Components Essential for Holoenzyme Assembly

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Nrd1 Interacts with the Nuclear Exosome for 3′ Processing of RNA Polymerase II Transcripts

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Unravelling the means to an end: RNA polymerase II transcription termination

Kuehner, J. N., Pearson, E. L., & Moore, C. L. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3098 · Cited by 299 · see citing works

Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle

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Association between aplastic anaemia and mutations in telomerase RNA

Vulliamy, T., Marrone, A., Dokal, I. S., & Mason, P. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09087-6 · Cited by 276 · see citing works

Box H/ACA Small Ribonucleoproteins

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The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery

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The Telomerase Database

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Purification of Human Telomerase Complexes Identifies Factors Involved in Telomerase Biogenesis and Telomere Length Regulation

Fu, D., & Collins, K. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.023 · Cited by 229 · see citing works

The human cap-binding complex is functionally connected to the nuclear RNA exosome

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The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing

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The Human Nuclear Exosome Targeting Complex Is Loaded onto Newly Synthesized RNA to Direct Early Ribonucleolysis

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Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita

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Exon ligation is proofread by the DExD/H-box ATPase Prp22p

Mayas, R. M., Maita, H., & Staley, J. P. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1093 · Cited by 183 · see citing works

Distinct Biogenesis Pathways for Human Telomerase RNA and H/ACA Small Nucleolar RNAs

Fu, D., & Collins, K. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00196-5 · Cited by 182 · see citing works

Biogenesis of telomerase ribonucleoproteins

Egan, E. D., & Collins, K. (2012) · RNA · doi:10.1261/rna.034629.112 · Cited by 177 · see citing works

Both Transcriptional and Posttranscriptional Mechanisms Regulate Human Telomerase Template RNA Levels

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Biogenesis and Intranuclear Trafficking of Human Box C/D and H/ACA RNPsPreprint

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Origins and activities of the eukaryotic exosome

Lykke‐Andersen, S., Brodersen, D. E., & Jensen, T. H. (2009) · Journal of Cell Science · doi:10.1242/jcs.047399 · Cited by 169 · see citing works

Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming

Berndt, H., Harnisch, C., Rammelt, C., Stöhr, N., Zirkel, A., Dohm, J. C., Himmelbauer, H., Tavanez, J. P., Hüttelmaier, S., & Wahle, E. (2012) · RNA · doi:10.1261/rna.032292.112 · Cited by 166 · see citing works

Threading the barrel of the RNA exosome

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C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing

Schilders, G., van Dijk, E., & Pruijn, G. J. M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm082 · Cited by 132 · see citing works

Molecular Basis for Coordinating Transcription Termination with Noncoding RNA Degradation

Tudek, A., Porrúa, O., Kabzinski, T., Lidschreiber, M., Kubíček, K., Fořtová, A., Lacroute, F., Vaňáčová, Š., Cramer, P., Štefl, R., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.031 · Cited by 126 · see citing works

Heterozygous telomerase RNA mutations found in dyskeratosis congenita and aplastic anemia reduce telomerase activity via haploinsufficiency

Marrone, A., Stevens, D., Vulliamy, T., Dokal, I. S., & Mason, P. J. (2004) · Blood · doi:10.1182/blood-2004-05-1829 · Cited by 124 · see citing works

TER1, the RNA subunit of fission yeast telomerase

Leonardi, J., Box, J. A., Bunch, J. T., & Baumann, P. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1343 · Cited by 123 · see citing works

Low abundance of telomerase in yeast: Implications for telomerase haploinsufficiency

Mozdy, A. D., & Cech, T. R. (2006) · RNA · doi:10.1261/rna.134706 · Cited by 123 · see citing works

A Polyadenylation-Dependent 3′ End Maturation Pathway Is Required for the Synthesis of the Human Telomerase RNA

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SHQ1 is required prior to NAF1 for assembly of H/ACA small nucleolar and telomerase RNPs

Grozdanov, P. N., Roy, S., Kittur, N. D., & Meier, U. T. (2009) · RNA · doi:10.1261/rna.1532109 · Cited by 115 · see citing works

Identification and characterization of the Schizosaccharomyces pombe TER1 telomerase RNA

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Identification and comparative analysis of telomerase RNAs from Candida species reveal conservation of functional elements

Gunišová, S., Elboher, E., Nosek, J., Gorkovoy, V., Brown, Y., Lucier, J., Laterreur, N., Wellinger, R. J., Tzfati, Y., & Tomáška, Ľ. (2009) · RNA · doi:10.1261/rna.1194009 · Cited by 105 · see citing works

Haploinsufficiency of mTR results in defects in telomere elongation

Hathcock, K. S., Hemann, M. T., Opperman, K., Strong, M. A., Greider, C. W., & Hodes, R. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012549799 · Cited by 102 · see citing works

Spliceosomal cleavage generates the 3′ end of telomerase RNA

Box, J. A., Bunch, J. T., Tang, W., & Baumann, P. (2008) · Nature · doi:10.1038/nature07584 · Cited by 99 · see citing works

Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function

Zhu, Y., Qi, C., Cao, W., Yeldandi, A. V., Rao, M. S., & Reddy, J. K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181347498 · Cited by 99 · see citing works

Yeast Nrd1, Nab3, and Sen1 transcriptome-wide binding maps suggest multiple roles in post-transcriptional RNA processing

Jamonnak, N., Creamer, T. J., Darby, M. M., Schaughency, P., Wheelan, S. J., & Corden, J. L. (2011) · RNA · doi:10.1261/rna.2840711 · Cited by 99 · see citing works

Bone marrow failure and developmental delay caused by mutations in poly(A)-specific ribonuclease (PARN)

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Structural and Functional Characterization of Human Telomerase RNA Processing and Cajal Body Localization Signals

Theimer, C. A., Jády, B. E., Chim, N., Richard, P., Breece, K. E., Kiss, T., & Feigon, J. F. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.017 · Cited by 92 · see citing works

An Enhanced H/ACA RNP Assembly Mechanism for Human Telomerase RNA

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Air1 Zinc Knuckles 4 and 5 and a Conserved IWRXY Motif Are Critical for the Function and Integrity of the Trf4/5-Air1/2-Mtr4 Polyadenylation (TRAMP) RNA Quality Control Complex

Fasken, M. B., Leung, S. W., Banerjee, A., Kodani, M., Chavez, R., Bowman, E. A., Purohit, M. K., Rubinson, M. E., Rubinson, E. H., & Corbett, A. H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.271494 · Cited by 69 · see citing works

Inhibition of mRNA Deadenylation by the Nuclear Cap Binding Complex (CBC)

Balatsos, N. A. A., Nilsson, P., Mazza, C., Cusack, S., & Virtanen, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508590200 · Cited by 68 · see citing works

hNaf1 is required for accumulation of human box H/ACA snoRNPs, scaRNPs, and telomerase

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Quality control of assembly-defective U1 snRNAs by decapping and 5′-to-3′ exonucleolytic digestion

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Budding yeast telomerase RNA transcription termination is dictated by the Nrd1/Nab3 non-coding RNA termination pathway

Noël, J.-F., Larose, S., Elela, S. A., & Wellinger, R. J. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks200 · Cited by 49 · see citing works

The Sm Complex Is Required for the Processing of Non-Coding RNAs by the Exosome

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3′ terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing

Goldfarb, K. C., & Cech, T. R. (2013) · BMC Molecular Biology · doi:10.1186/1471-2199-14-23 · Cited by 36 · see citing works

Exosome substrate targeting: the long and short of it

Mitchell, P. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140088 · Cited by 33 · see citing works

Diverse mechanisms for spliceosome-mediated 3′ end processing of telomerase RNA

Kannan, R., Helston, R. M., Dannebaum, R. O., & Baumann, P. (2015) · Nature Communications · doi:10.1038/ncomms7104 · Cited by 26 · see citing works

Prevalent and distinct spliceosomal 3′-end processing mechanisms for fungal telomerase RNA

Qi, X., Rand, D. P., Podlevsky, J. D., Li, Y., Axel Mosig, A., Stadler, P. F., & Chen, J. J. ‐. (2015) · Nature Communications · doi:10.1038/ncomms7105 · Cited by 24 · see citing works

Identification of Telomerase RNAs from Filamentous Fungi Reveals Conservation with Vertebrates and Yeasts

Kuprys, P. V., Davis, S. M., Hauer, T., Meltser, M., Tzfati, Y., & Kirk, K. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058661 · Cited by 23 · see citing works

Intronic sequence elements impede exon ligation and trigger a discard pathway that yields functional telomerase RNA in fission yeastPreprint

Kannan, R., Hartnett, S., Voelker, R. B., Berglund, J. A., Staley, J. P., & Baumann, P. (2013) · Genes & Development · doi:10.1101/gad.212738.112 · Cited by 23 · see citing works

Polygenic basis and biomedical consequences of telomere length variation

Codd, V., Wang, Q., Allara, E., Musicha, C., Kaptoge, S. K., Stoma, S., Jiang, T., Hamby, S. E., Braund, P. S., Bountziouka, V. P., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00944-6 · Cited by 376 · see citing works

Regulation of human telomerase in homeostasis and disease

Roake, C. M., & Artandi, S. E. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0234-z · Cited by 341 · see citing works

Diverse role of survival motor neuron protein

Singh, R. N., Howell, M. D., Ottesen, E. W., & Singh, N. N. (2017) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.12.008 · Cited by 301 · see citing works

Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts

Meola, N., Domanski, M., Karadoulama, E., Chen, Y., Gentil, C., Pultz, D., Vitting-Seerup, K., Lykke-Andersen, S., Andersen, J. S., Sandelin, A., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.09.025 · Cited by 290 · see citing works

Genetics of human telomere biology disorders

Revy, P., Kannengiesser, C., & Bertuch, A. A. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00527-z · Cited by 242 · see citing works

Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactorsPreprint

Zinder, J. C., & Lima, C. D. (2017) · Genes & Development · doi:10.1101/gad.294769.116 · Cited by 234 · see citing works

Telomerase Mechanism of Telomere Synthesis

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Molecular basis of the human ribosomopathy Shwachman-Diamond syndrome

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Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex

Weick, E.-M., Puno, M. R., Januszyk, K., Zinder, J. C., DiMattia, M. A., & Lima, C. D. (2018) · Cell · doi:10.1016/j.cell.2018.05.041 · Cited by 153 · see citing works

The Function of Non-Coding RNAs in Lung Cancer Tumorigenesis

Braicu, C., Zimța, A., Haranguș, A., Iurca, I., Irimie, A., Coza, O. F., & Berindan‐Neagoe, I. (2019) · Cancers · doi:10.3390/cancers11050605 · Cited by 148 · see citing works

Pre-Ribosomal RNA Processing in Human Cells: From Mechanisms to Congenital Diseases

Aubert, M., O’Donohue, M.-F., Lebaron, S., & Gleizes, P. (2018) · Biomolecules · doi:10.3390/biom8040123 · Cited by 122 · see citing works

A Polyadenylation-Dependent 3′ End Maturation Pathway Is Required for the Synthesis of the Human Telomerase RNA

Nguyen, D., St-Sauveur, V. G., Bergeron, D., Dupuis‐Sandoval, F., Scott, M. S., & Bachand, F. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.11.003 · Cited by 121 · see citing works

Evolutionary perspectives of telomerase RNA structure and function

Podlevsky, J. D., & Chen, J. J. ‐. (2016) · RNA Biology · doi:10.1080/15476286.2016.1205768 · Cited by 121 · see citing works

ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturationPreprint

Gable, D. L., Gaysinskaya, V. A., Atik, C. C., Talbot, C. C., Kang, B., Stanley, S. E., Pugh, E., Amat-Codina, N., Schenk, K. M., Arcasoy, M. O., et al. (2019) · Genes & Development · doi:10.1101/gad.326785.119 · Cited by 121 · see citing works

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

Shukla, S., Schmidt, J. C., Goldfarb, K. C., Cech, T. R., & Parker, R. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3184 · Cited by 114 · see citing works

Predictive models of subcellular localization of long RNAs

Zuckerman, B. M., & Ulitsky, I. (2019) · RNA · doi:10.1261/rna.068288.118 · Cited by 115 · see citing works

Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells

Nagpal, N., Wang, J., Zeng, J., Lo, E., Moon, D. H., Luk, K., Braun, R. O., Burroughs, L. M., Keel, S. B., Reilly, C., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.03.016 · Cited by 105 · see citing works

Molecular mechanisms of telomere biology disorders

Grill, S., & Nandakumar, J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.014017 · Cited by 2 · see citing works

The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation

Shukla, S., Bjerke, G. A., Muhlrad, D., Yi, R., & Parker, R. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.01.010 · Cited by 91 · see citing works

Telomerase in Cancer: Function, Regulation, and Clinical Translation

Robinson, N. J., & Schiemann, W. P. (2022) · Cancers · doi:10.3390/cancers14030808 · Cited by 95 · see citing works

Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression

Garland, W., Müller, I. I., Wu, M., Schmid, M., Imamura, K., Rib, L., Sandelin, A., Helin, K., & Jensen, T. H. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.03.004 · Cited by 93 · see citing works

Transcription and splicing: A two‐way street

Tellier, M., Maudlin, I., & Murphy, S. (2020) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1593 · Cited by 82 · see citing works

The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processingPreprint

Rambout, X., & Maquat, L. E. (2020) · Genes & Development · doi:10.1101/gad.339986.120 · Cited by 85 · see citing works

Telomerase Regulation from Beginning to the End

MacNeil, D., Bensoussan, H., & Autexier, C. (2016) · Genes · doi:10.3390/genes7090064 · Cited by 82 · see citing works

Somatic reversion impacts myelodysplastic syndromes and acute myeloid leukemia evolution in the short telomere disorders

Schratz, K. E., Gaysinskaya, V. A., Cosner, Z. L., DeBoy, E. A., Xiang, Z., Kasch-Semenza, L., Florea, L., Shah, P. D., & Armanios, M. Y. (2021) · Journal of Clinical Investigation · doi:10.1172/jci147598 · Cited by 78 · see citing works

PARN and TOE1 Constitute a 3′ End Maturation Module for Nuclear Non-coding RNAs

Son, A., Park, J.-E., & Kim, V. N. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.089 · Cited by 75 · see citing works

RNA Surveillance by the Nuclear RNA Exosome: Mechanisms and Significance

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Grad‐seq in a Gram‐positive bacterium reveals exonucleolytic sRNA activation in competence control

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Protein encoded in human telomerase RNA is involved in cell protective pathways

Rubtsova, M. P., Нарайкина, Ю. В., Vasilkova, D., Meerson, M., Zvereva, M. I., Prassolov, V., Лазарев, В. Н., Manuvera, V. A., Kovalchuk, S. I., Anikanov, N. A., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky705 · Cited by 65 · see citing works

Hypo- and Hyper-Assembly Diseases of RNA–Protein Complexes

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Integrator is a key component of human telomerase RNA biogenesis

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Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease

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The RNA exosome nuclease complex regulates human embryonic stem cell differentiation

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Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation

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The H/ACA complex disrupts triplex in hTR precursor to permit processing by RRP6 and PARN

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Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita

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Genome Instability in Multiple Myeloma: Facts and Factors

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Human Telomerase RNA: Telomerase Component or More?

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Poly(A)-specific ribonuclease sculpts the 3′ ends of microRNAs

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Combined bioscaffold with stem cells and exosomes can improve traumatic brain injury

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Competition between maturation and degradation drives human snRNA 3′ end quality controlPreprint

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TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly

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PARN Modulates Y RNA Stability and Its 3′-End Formation

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Plant telomere biology: The green solution to the end-replication problem

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Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy

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Composition and Function of Telomerase—A Polymerase Associated with the Origin of Eukaryotes

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Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment

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Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis

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Targeting the nuclear RNA exosome: Poly(A) binding proteins enter the stage

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Post-transcriptional control of cellular differentiation by the RNA exosome complex

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From incomplete penetrance with normal telomere length to severe disease and telomere shortening in a family with monoallelic and biallelic PARN pathogenic variants

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Noncoding RNA Surveillance: The Ends Justify the Means

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Identification of distinct maturation steps involved in human 40S ribosomal subunit biosynthesis

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The Dihydroquinolizinone Compound RG7834 Inhibits the Polyadenylase Function of PAPD5 and PAPD7 and Accelerates the Degradation of Matured Hepatitis B Virus Surface Protein mRNA

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Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast

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SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing

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The Unforeseen Non-Coding RNAs in Head and Neck Cancer

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AGO2 promotes telomerase activity and interaction between the telomerase components TERT and TERC

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N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation

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Many Functions of Telomerase Components: Certainties, Doubts, and Inconsistencies

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Antiviral activities of 4H-chromen-4-one scaffold-containing flavonoids against SARS–CoV–2 using computational and in vitro approaches

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TERRA stability is regulated by RALY and polyadenylation in a telomere-specific manner

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The functional requirement of two structural domains within telomerase RNA emerged early in eukaryotes

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Telomere biology disorders: time for moving towards the clinic?

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TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends

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RNA-Degrading Exosome Complexes: Molecular Mechanisms and Structural Insights

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The PARN, TOE1, and USB1 RNA deadenylases and their roles in non-coding RNA regulation

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Nurturing longevity through natural compounds: Where do we stand, and where do we go?

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Telomere Maintenance Pathway Activity Analysis Enables Tissue- and Gene-Level Inferences

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Inherited Predispositions to Myeloid Neoplasms: Pathogenesis and Clinical Implications

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NHP2 downregulation counteracts hTR‐mediated activation of the DNA damage response at ALT telomeres

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Human intron-encoded AluACA RNAs and telomerase RNA share a common element promoting RNA accumulation

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Genetic divergence in the transcriptional engram of chronic alcohol abuse: A laser-capture RNA-seq study of the mouse mesocorticolimbic system

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Poly(A) tale: From A to A; RNA polyadenylation in prokaryotes and eukaryotes

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The Intrinsically Disordered C-Terminal Domain Triggers Nucleolar Localization and Function Switch of PARN in Response to DNA Damage

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Dysregulation of RNA-Exosome machinery is directly linked to major cancer hallmarks in prostate cancer: Oncogenic role of PABPN1

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Regulation of poly(a)-specific ribonuclease activity by reversible lysine acetylation

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Human Telomerase RNA Protein Encoded by Telomerase RNA is Involved in Metabolic Responses

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A putative cap binding protein and the methyl phosphate capping enzyme Bin3/MePCE function in telomerase biogenesis

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MPP6 stimulates both RRP6 and DIS3 to degrade a specified subset of MTR4-sensitive substrates in the human nucleus

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Post-Transcriptional and Post-Translational Modifications in Telomerase Biogenesis and Recruitment to Telomeres

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Dyskeratosis Congenita and the Telomere Biology Disorders

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How RNAi machinery enters the world of telomerase

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How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript

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A missense variant in the nuclear localization signal of DKC1 causes Hoyeraal-Hreidarsson syndrome

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Identification of an RNase that preferentially cleaves A/G nucleotides

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Small Molecules Restore Telomeres in Patient Stem Cells

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The H/ACA complex disrupts triplex in hTR precursor to permit processing by RRP6 and PARN

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A Polyadenylation-Dependent 3′ End Maturation Pathway Is Required for the Synthesis of the Human Telomerase RNA

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Exosome-mediated decay of unstable long extended precursors of human telomerase RNA is dependent on 5′-cap trimethylationPreprint

Samajdar, A., Amato, R., Jo, S., Cordes, E., Tai, A., Raffa, G. D., & Batista, L. F. Z. (2026) · Genes & Development · doi:10.1101/gad.353100.125 · Cited by 3 · see citing works

Integrator is a key component of human telomerase RNA biogenesis

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Role of RNA Biogenesis Factors in the Processing and Transport of Human Telomerase RNA

Pakhomova, T., Moshareva, M., Vasilkova, D., Zatsepin, T. S., Dontsova, O. А., & Rubtsova, M. P. (2022) · Biomedicines · doi:10.3390/biomedicines10061275 · Cited by 7 · see citing works