Regulation of Memory Formation by the Transcription Factor XBP1
Open accessAbstract
Contextual memory formation relies on the induction of new genes in the hippocampus. A polymorphism in the promoter of the transcription factor XBP1 was identified as a risk factor for Alzheimer's disease and bipolar disorders. XBP1 is a major regulator of the unfolded protein response (UPR), mediating adaptation to endoplasmic reticulum (ER) stress. Using a phenotypic screen, we uncovered an unexpected function of XBP1 in cognition and behavior. Mice lacking XBP1 in the nervous system showed specific impairment of contextual memory formation and long-term potentiation (LTP), whereas neuronal XBP1s overexpression improved performance in memory tasks. Gene expression analysis revealed that XBP1 regulates a group of memory-related genes, highlighting brain-derived neurotrophic factor (BDNF), a key component in memory consolidation. Overexpression of BDNF in the hippocampus reversed the XBP1-deficient phenotype. Our study revealed an unanticipated function of XBP1 in cognitive processes that is apparently unrelated to its role in ER stress.
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Xbp1 can bind to the promoter of Bdnf and activate its transcription to enhance learning- and memory-related gene expression independent of its ER stress activation.
“Xbp1 can bind to the promoter of Bdnf and activate its transcription to enhance learning- and memory-related gene expression independent of its ER stress activation.49”
From 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience (2023) · cites this paper as [49]
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Halliday, M., Hughes, D. T., & Mallucci, G. R. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14112 · Cited by 68 · see citing works
“recently been shown to regulate learning and memory independently of ER stress, via the activation of brain derived neurotrophic factor (Martinez et al. 2016).”
BackgroundÖzbey, N. P., Imanikia, S., Krueger, C., Hardege, I., Morud, J., Sheng, M., Schafer, W., Casanueva, M., & Taylor, R. C. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.10.024 · Cited by 55 · see citing works
Kim, S., Kim, D. K., Jeong, S., & Lee, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115894 · Cited by 67 · see citing works
The burden of trisomy 21 disrupts the proteostasis network in Down syndrome
Aivazidis, S., Coughlan, C. M., Rauniyar, A. K., Jiang, H. L., Liggett, L. A., Maclean, K. N., & Roede, J. R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176307 · Cited by 62 · see citing works
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“Of note, defects in ER transmembrane – associated proteins have severe implications for the UFP, and ER stress is a critical feature of neurodegenerative diseases (Martínez et al. 2016; Esk et al. 2020).”
Durán-Aniotz, C., Poblete, N., Rivera-Krstulović, C., Ardiles, Á. O., Díaz, M. L., Tamburini, G., Sabusap, C., Gerakis, Y., Miranda, F. C., Diaz, J., et al. (2022) · bioRxiv · doi:10.1101/2022.06.21.496869 · Cited by 49
“Electrophysiological analysis Hippocampal slices were prepared as previously reported [25, 36].”
BackgroundMethodResultInfluentialSelf-citationXBP1s activation can globally remodel N-glycan structure distribution patterns
Wong, M. Y., Chen, K., Antonopoulos, A., Kasper, B. T., Dewal, M. B., Taylor, R. J., Whittaker, C. A., Hein, P. P., Dell, A., Genereux, J. C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805425115 · Cited by 53 · see citing works
Paiva, I., Cellai, L., Mériaux, C., Poncelet, L., Nebie, O., Saliou, J.-M., Lacoste, A.-S., Papegaey, A., Drobecq, H., Gras, S. L., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci149371 · Cited by 48 · see citing works
“Accordingly, the immediate early gene Fosb and the Xbp1 gene, which is known to play an important role in memory formation (35), were significantly more activated by the learning process under caffeine treatment (Supplemental Figure 7A).”
BackgroundCommentary: XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity
Martínez, G., Durán-Aniotz, C., Cabral-Miranda, F., & Hetz, C. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00182 · Cited by 48
Self-citationWang, Z.-R., Li, Q., Kolls, B. J., Mace, B., Yu, S.-P., Li, X., Liu, W., Chaparro, E., Shen, Y.-T., Dang, L., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-04594-8 · Cited by 46
García-Huerta, P., Troncoso-Escudero, P., Jerez, C., Hetz, C. A., & Vidal, R. L. (2016) · Brain Research · doi:10.1016/j.brainres.2016.02.052 · Cited by 47 · see citing works
Self-citationThe UPRising connection between endoplasmic reticulum stress and the tumor microenvironment
Urra, H., Aravena, R., González-Johnson, L., & Hetz, C. A. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.09.011 · Cited by 48 · see citing works
Self-citationThe UPRosome – decoding novel biological outputs of IRE1α function
Urra, H., Pihán, P., & Hetz, C. A. (2020) · Journal of Cell Science · doi:10.1242/jcs.218107 · Cited by 45 · see citing works
Self-citationGene Therapy Strategies to Restore ER Proteostasis in Disease
Valenzuela, V., Jackson, K. L., Sardi, S. P., & Hetz, C. A. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.04.004 · Cited by 46 · see citing works
“memory AAV6-XBP1s hippocampus increased learning and memory Martinez et al.(61)”
BackgroundMethodInfluentialSelf-citationSaito, A., Cai, L., Matsuhisa, K., Ohtake, Y., Kaneko, M., Kanemoto, S., Asada, R., & Imaizumi, K. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14221 · Cited by 44 · see citing works
“A putative XBP1s consensus-binding site, the UPRE core, is included in the Bdnf promoter region (Acosta-Alvear et al. 2007; Martinez et al. 2016).”
BackgroundResultInfluentialGarcía-González, P. A., Cabral‐Miranda, F., Hetz, C. A., & Osorio, F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02541 · Cited by 46 · see citing works
Self-citationLoss of XBP1 accelerates age-related decline in retinal function and neurodegeneration
McLaughlin, T., Falkowski, M., Park, J. W., Keegan, S., Elliott, M. H., Wang, J. J., & Zhang, S. X. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0250-z · Cited by 56 · see citing works
“Conditional depletion of XBP1 in the nervous system results in impairment in learning and memory formation, suggesting that XBP1 may play a role in controlling neuronal function [10].”
Endoplasmic Reticulum Stress: Implications for Neuropsychiatric Disorders
Muneer, A., & Khan, R. M. S. (2019) · Chonnam medical journal · doi:10.4068/cmj.2019.55.1.8 · Cited by 39 · see citing works
“These observations point to the significance of UPR signaling in memory-related processes, and further studies are needed to elucidate the findings.(39) Amytrophic lateral sclerosis, a catastrophic disease, is”
BackgroundThe unknown face of IRE1α - Beyond ER stress.
Abdullah, A., & Ravanan, P. (2018) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2018.05.002 · Cited by 39 · see citing works
The ER proteostasis network in ALS: Determining the differential motoneuron vulnerability
Rozas, P., Bargsted, L., Martínez, F., Hetz, C. A., & Medinas, D. B. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.04.066 · Cited by 43 · see citing works
Self-citationER Stress, CREB, and Memory: A Tangled Emerging Link in Disease
Sen, N. (2018) · The Neuroscientist · doi:10.1177/1073858418816611 · Cited by 37 · see citing works
Gene therapy to target ER stress in brain diseases
Valenzuela, V., Martínez, G., Duran-Aniotz, C. A., & Hetz, C. A. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.064 · Cited by 35 · see citing works
“Using the local administration of AAV6-XBP1s into the hippocampus of wild-type animals (rats and mice), we demonstrated an improvement in the basal performance in learning and memory tasks (Martinez et al., 2016).”
BackgroundMethodInfluentialSelf-citationER Stress and Neurodegenerative Disease: A Cause or Effect Relationship?
Cabral‐Miranda, F., & Hetz, C. A. (2017) · Current topics in microbiology and immunology · doi:10.1007/82_2017_52 · Cited by 42 · see citing works
Self-citationPakarinen, E., Danilova, T., Võikar, V., Chmielarz, P., Piepponen, P., Airavaara, M., Saarma, M., & Lindahl, M. (2020) · eNeuro · doi:10.1523/eneuro.0477-19.2019 · Cited by 35 · see citing works
“Although ER stress can impair longterm memory (Ohno, 2018), hippocampal sXBP1 overexpression, instead, has been shown to improve long-term memory through elevated Bdnf levels (Martínez et al., 2016).”
BackgroundRahman, S., Ayyagari, A., Jan, A. T., & Minakshi, R. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00030 · Cited by 31 · see citing works
“IRE1/XBP1 in AD The advantageous effects of XBP1 on memory was proven in neural-specific XBP1 knockout mice featuring impaired learning and synaptic plasticity deficit, where injections of adenoassociated viruses delivered XBP1(S) resulted in establishing long-term hippocampus memory (Martínez et al., 2016).”
BackgroundCentral role of the ER proteostasis network in healthy aging
Hetz, C. A., & Dillin, A. G. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.10.003 · Cited by 34 · see citing works
Self-citationRole of the unfolded protein response in the development of central nervous system
Murao, N., & Nishitoh, H. (2017) · The Journal of Biochemistry · doi:10.1093/jb/mvx047 · Cited by 33 · see citing works
“Furthermore, XBP1 also directly regulates the expression of BDNF transcripts and several memory-related genes in the adult mouse hippocampus and contributes to learning and memory-related processes (37).”
Silva, N. M. L. E., Gonçalves, R. A., Boehnke, S. E., Forny‐Germano, L., Munoz, D. P., & Felice, F. G. D. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.03.016 · Cited by 37 · see citing works
“Synaptophysin is a protein present in the pre-synaptic vesicles, that is used as a marker of synapse density (Masliah et al., 1990; Tarsa and Goda, 2002; Wiedenmann and Franke, 1985).”
BackgroundAggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood
Dutta, D., He, Y., Saha, A., Arvanitis, M., Battle, A., & Chatterjee, N. (2021) · Nature Communications · doi:10.1038/s41467-022-31845-9 · Cited by 30 · see citing works
Trobiani, L., Favaloro, F. L., Castro, M. A. D., Mattia, M. D., Cariello, M., Miranda, E., Canterini, S., Stefano, M. E. D., Comoletti, D., Limatola, C., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.08.026 · Cited by 34 · see citing works
Yang, W., & Paschen, W. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17723783 · Cited by 28 · see citing works
Gene Therapy: A Promising Approach for Neuroprotection in Parkinson’s Disease?
Valdés, P., & Schneider, B. (2016) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2016.00123 · Cited by 30 · see citing works
“Notably, a recent study has shown a role of XBP-1s in memory formation, indicating that potent effects are to be expected in various neuronal systems (Martínez et al., 2016).”
BackgroundSelf-citationEndoplasmic Reticulum Stress Regulators: New Drug Targets for Parkinson’s Disease
Kovaleva, V., & Saarma, M. (2021) · Journal of Parkinson's Disease · doi:10.3233/jpd-212673 · Cited by 28 · see citing works
“301 sXBP1 was also shown to improve the synaptic plas302 ticity and cognition through increasing the expression 303 of brain-derived neurotrophic factor (BDNF) in vivo 304 [54].”
BackgroundLocal Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus.
Salech, F., Varela-Nallar, L., Arredondo, S. B., Bustamante, D. B., Andaur, G., Cisneros, R., Ponce, D., Ayala, P., Inestrosa, N., Valdés, J., et al. (2019) · The journals of gerontology. Series A, Biological sciences and medical sciences · doi:10.1093/gerona/glx248 · Cited by 28 · see citing works
Self-citationAutophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act
Jiménez-Moreno, N., & Lane, J. D. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8865611 · Cited by 26 · see citing works
Injury to the nervous system: A look into the ER
Valenzuela, V., Oñate, M., Hetz, C. A., & Court, F. A. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.053 · Cited by 26 · see citing works
“In mammalian cells, the removal of 26 nucleotides from an intron of XBP1 by IRE1α generates a reading frame shift, which leads to the translation of a 371 amino acids XBP1 protein (XBP1s) containing the original DNA binding domain and a strong transactivation domain in its C-terminal region.”
InfluentialSelf-citationSiwecka, N., Saramowicz, K., Galita, G., Rozpędek‐Kamińska, W., & Majsterek, I. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082051 · Cited by 31 · see citing works
Recent advances in signal integration mechanisms in the unfolded protein response
Karagöz, G., Aragón, T., & Acosta-Alvear, D. (2019) · F1000Research · doi:10.12688/f1000research.19848.1 · Cited by 25 · see citing works
Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1
Gerakis, Y., Dunys, J., Bauer, C., & Checler, F. (2016) · Scientific Reports · doi:10.1038/srep37436 · Cited by 28 · see citing works
Emerging roles of endoplasmic reticulum proteostasis in brain development
Vásquez, G. E., Medinas, D. B., Urra, H., & Hetz, C. A. (2022) · Cells and Development · doi:10.1016/j.cdev.2022.203781 · Cited by 27 · see citing works
Self-citationDíaz-Hung, M.-L., Martínez, G., & Hetz, C. A. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2020.01.004 · Cited by 28 · see citing works
Self-citationChaperone-Dependent Mechanisms as a Pharmacological Target for Neuroprotection
Воронин, М. В., Абрамова, Е. В., Verbovaya, E. R., Vakhitova, Y. V., & Середенин, С. Б. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010823 · Cited by 27 · see citing works
“to be an important element in the positive feedback loop of BDNF-dependent regulation of synaptic plasticity, learning and memory-related processes [417,420].”
BackgroundInfluentialTriclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats
Arias‐Cavieres, A., More, J., Vicente, J. M., Adasme, T., Hidalgo, J., Valdés, J. L., Humeres, A., Valdés-Undurraga, I., Sánchez, G., Hidalgo, C., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00429 · Cited by 27 · see citing works
“To evaluate hippocampal-dependent spatial memory, we used the Oasis maze task, a modified dry-land version of the Morris water maze (Kesner et al., 1991; Clark et al., 2005; Martinez et al., 2016; More et al., 2018).”
MethodSelf-citationFine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis
Medinas, D. B., González, J. V., Falcón, P., & Hetz, C. A. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00216 · Cited by 27 · see citing works
“…the abrogation of IRE1 activity in CNS may probably not be the optimal intervention since basal levels of XBP1s appear to be needed for motoneuron homeostasis (Kiskinis et al., 2014), in addition to neuronal plasticity involved in memory and learning-associated processes (Martínez et al., 2016).”
BackgroundSelf-citationThe Transcription Factor XBP1 in Memory and Cognition: implications in Alzheimer’s Disease
Cissé, M., Duplan, E., & Checler, F. (2016) · Molecular Medicine · doi:10.2119/molmed.2016.00229 · Cited by 27 · see citing works
Sarkar, S., & Patranabis, S. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01221-z · Cited by 21 · see citing works
“Additionally, MSC-derived EVs have demonstrated neuroprotective properties by defending and preventing neurons from oxidative stress and synaptic damage brought on by A β [52, 53].”
Fang, X., Han, Q., Li, S., & Luo, A. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e10326 · Cited by 23 · see citing works
“The upregulation and downregulation of CHOP expression results in the activation of proapoptotic and antiapoptotic proteins, respectively [38, 39, 40].”
BackgroundWilm’s tumor 1 promotes memory flexibility
Mariottini, C., Munari, L., Gunzel, E., Seco, J., Tzavaras, N., Hansen, J., Stern, S. A., Gao, V., Aleyasin, H., Sharma, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11781-x · Cited by 29 · see citing works
Hegde, A., & Smith, S. G. (2019) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.048769.118 · Cited by 19 · see citing works
“…al. 2005 Srf KO ↓ performance in NOR ↓ LTD magnitude ↓ Bdnf, c-Fos, and Arc expression Etkin et al. 2006 XBP1 XBP1 KO ↓ performance in CFC and memory flexibility paradigm ↓ CA1 EPSP magnitude sustained into L-LTP ↓ Bdnf expression in HC Martínez et al. 2016 XBP1 OE ↑ performance in CFC and memory…”
BackgroundKnutson, K. R., Whiteman, S. T., Alcaino, C., Mercado-Perez, A., Finholm, I. W., Serlin, H. K., Bellampalli, S., Linden, D., Farrugia, G., & Beyder, A. (2022) · Journal of Physiology · doi:10.1113/jp283383 · Cited by 18 · see citing works
Entanglement of UPRER in Aging Driven Neurodegenerative Diseases
Rahman, S., Jan, A. T., Ayyagari, A., Kim, J., Kim, J., & Minakshi, R. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00341 · Cited by 18 · see citing works
“The administration of XBP1(S) through adeno-associated virus rescued long-term hippocampus memory in XBP1 knockout mice (Martínez et al., 2016).”
BackgroundCommon molecular biomarker signatures in blood and brain of Alzheimer’s diseasePreprint
Rahman, M. R., Islam, T., Shahjaman, M., Quinn, J. M. W., Holsinger, R. M. D., & Moni, M. A. (2018) · bioRxiv · doi:10.1101/482828 · Cited by 17 · see citing works
Chuan, L., Huang, X., Fan, C.-M., Wen, S.-Y., Yang, X.-H., Wang, J., Ren, J.-Y., Ru, J., & Ding, L. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173716 · Cited by 16
Mroczek, M., Clark, C., Dayon, L., Bowman, G., & Popp, J. (2022) · Cells · doi:10.3390/cells11061030 · Cited by 15 · see citing works
“MIME and IDS have been linked to AD [45,46].”
BackgroundWang, M., Chen, X., Zheng, Z., Yu, S.-J., Zhou, B., Liu, Y., Liu, D.-H., Chen, Y.-M., & Qian, X. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03627-3 · Cited by 15 · see citing works
Promotion of Axon Growth by the Secreted End of a Transcription Factor
McCurdy, E. P., Chung, K., Benitez-Agosto, C. R., & Hengst, U. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.101 · Cited by 15
“Examples for this so-called physiological ER stress in the nervous system include regulation of memory formation (Martínez et al., 2016), dendrite morphogenesis (Wei et al.”
BackgroundZhang, Y., Chen, X.-S., Chen, L.-Q., Shao, M., Zhu, W., Xing, T., Guo, T., Jia, Q., Yang, H.-M., Yin, P., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00771-3 · Cited by 14 · see citing works
“ER stress has been linked to the synaptic pathology in AD, as the ER stress sensor XBP1 mediates hippocampal synaptic plasticity in AD mice [59, 60].”
BackgroundA decay of the adaptive capacity of the unfolded protein response exacerbates Alzheimer's disease
Gerakis, Y., & Hetz, C. A. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.012 · Cited by 16 · see citing works
“This study is in agreement with a previous report indicating that XBP1s have an alternative function in the brain by controlling basal neuronal physiology, impacting learning and memory (Martínez et al., 2016).”
ResultSelf-citationEssential roles of the unfolded protein response in intestinal physiology
Hetz, C. A., Silva-Agüero, J. F., & Ellerby, L. (2024) · eGastroenterology · doi:10.1136/egastro-2024-100129 · Cited by 15 · see citing works
“XBP1s have important roles in the nervous system beyond proteostasis, regulating synaptic activity, connectivity, morphology, 98 99 contributing to sustained brain function during ageing 100 (reviewed in Martínez et al ) 101 Whether neuronal UPR can modulate intestinal physiology through the ENS…”
Self-citationThe functions of IRE1α in neurodegenerative diseases: Beyond ER stress.
Chen, L., Bi, M.-X., Zhang, Z., Du, X.-X., Chen, X., Jiao, Q., & Jiang, H. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101774 · Cited by 13 · see citing works
Li, X., & Yang, W. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105218 · Cited by 13
- Authors
- Martínez, G., Vidal, R. L., Mardones, P., Serrano, F. G., Ardiles, A. O., Wirth, C., Valdés, P., Thielen, P., Schneider, B. L., Kerr, B., Valdés, J. L., Palacios, A. G., Inestrosa, N. C., Glimcher, L. H., & Hetz, C.
- Affiliations
- Instituto de Neurociencia Biomédica (CL)
- Neurounion Biomedical Foundation (CL)
- Pontificia Universidad Católica de Chile (CL)
- Harvard University (US)
- École Polytechnique Fédérale de Lausanne (CH)
- Centro de Estudios Científicos (CL)
- Weill Cornell Medicine (US)
- Corresponding author
- Glimcher, Laurie H.
- Hetz, Claudio
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 14
- Issue
- 6
- Pages
- 1382-1394
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2255156876
- Cited by
- 163
- References
- 57
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 13 · 2023: 17 · 2022: 18 · 2021: 9 · 2020: 23 · 2019: 16 · 2018: 17 · 2017: 23 · 2016: 13
- FWCI
- 14.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Americanae (AECID Library) (submittedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Funders
- Millennium Institute (P09-015-F)
- Office of Naval Research-Global (ONR-G) (N62909-16-1-2003)
- FONDAP (15150012)
- Frick Foundation
- ALS Therapy Alliance (2014-F-059)
- Muscular Dystrophy Association (382453)
- CONICYT (USA2013-0003, PFB12/2007)
- Michael J Fox Foundation for Parkinson's Research
- COPEC-UC Foundation
- Ecos-Conicyt (C13S02)
- FONDECYT (1140549, 3150637, 3140388, 1150608, 3130759, 1140162, 1120156)
- ALSRP Therapeutic Idea Award (AL150111)
- Swiss National Science Foundation (147660)
- Iniciativa Cientifica Milenio (ICM-P10-001-F, ICM-P09-022-F)
- NIH
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- XBP1, unfolded protein response, endoplasmic reticulum stress, contextual memory, long-term potentiation, hippocampus, brain-derived neurotrophic factor, memory consolidation, cognitive impairment, transcription factors, Alzheimer's disease risk, bipolar disorder risk
- MeSH terms
- X-Box Binding Protein 1, Animals, Endoplasmic Reticulum, Evoked Potentials, Hippocampus, Male, Memory, Neurons, Promoter Regions, Genetic, Signal Transduction, Long-Term Potentiation, Mice, Knockout, Gene Expression Regulation, Developmental, Brain-Derived Neurotrophic Factor, Gene Expression Profiling, Diacylglycerol O-Acyltransferase, Mice, Unfolded Protein Response, Molecular Sequence Annotation, Endoplasmic Reticulum Stress
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