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Cited by 359

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

Open access
Chen, Fengju, Zhang, Yiqun, Şenbabaoğlu, Yasin, Ciriello, Giovanni, Yang, Lixing, Reznik, Ed, Shuch, Brian, Micevic, Goran, De Velasco, Guillermo, Shinbrot, Eve, Noble, Michael S., Lu, Yiling, Covington, Kyle R., Xi, Liu, Drummond, Jennifer A., Muzny, Donna, Kang, Hyojin, Lee, Junehawk, Tamboli, Pheroze, Reuter, Victor, Shelley, Carl Simon, Kaipparettu, Benny A., Bottaro, Donald P., Godwin, Andrew K., Gibbs, Richard A., Getz, Gad, Kucherlapati, Raju, Park, Peter J., Sander, Chris, Henske, Elizabeth P., Zhou, Jane H., Kwiatkowski, David J., Ho, Thai H., Choueiri, Toni K., Hsieh, James J., Akbani, Rehan, Mills, Gordon B., Hakimi, A. Ari, Wheeler, David A., Creighton, Chad J.·2016·Cell Reports
DOI 10.1016/j.celrep.2016.02.024
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Abstract

On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset.

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Metadata

Authors
Chen, F., Zhang, Y., Şenbabaoğlu, Y., Ciriello, G., Yang, L., Reznik, E., Shuch, B., Micevic, G., De Velasco, G., Shinbrot, E., Noble, M. S., Lu, Y., Covington, K. R., Xi, L., Drummond, J. A., Muzny, D., Kang, H., Lee, J., Tamboli, P., Reuter, V., Shelley, C. S., Kaipparettu, B. A., Bottaro, D. P., Godwin, A. K., Gibbs, R. A., Getz, G., Kucherlapati, R., Park, P. J., Sander, C., Henske, E. P., Zhou, J. H., Kwiatkowski, D. J., Ho, T. H., Choueiri, T. K., Hsieh, J. J., Akbani, R., Mills, G. B., Hakimi, A. A., Wheeler, D. A., & Creighton, C. J.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2016-03
Volume
14
Issue
10
Pages
2476-2489
ISSN
2211-1247 (ISSN-L)
DOI
10.1016/j.celrep.2016.02.024
OpenAlex
W2288944226
Cited by
359
References
33
FWCI
36.81
Type
journal article
Language
en
Open access
gold

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