The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment
Open accessAbstract
The Hippo signalling pathway is an emerging growth control and tumour suppressor pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling and hyperactivation of its downstream effectors Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) contribute to the development of cancer, which suggests that pharmacological inhibition of YAP and TAZ activity may be an effective anticancer strategy. Conversely, YAP and TAZ can also have beneficial roles in stimulating tissue repair and regeneration following injury, so their activation may be therapeutically useful in these contexts. A complex network of intracellular and extracellular signalling pathways that modulate YAP and TAZ activities have recently been identified. Here, we review the regulation of the Hippo signalling pathway, its functions in normal homeostasis and disease, and recent progress in the identification of small-molecule pathway modulators.
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Cites
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Self-citationRegulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
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YAP1 increases organ size and expands undifferentiated progenitor cells
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Cited by
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma
The Cancer Genome Atlas Research Network (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1505917 · Cited by 1,336
YAP/TAZ upstream signals and downstream responses
Totaro, A., Panciera, T., & Piccolo, S. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0142-z · Cited by 1,086
Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine
Moya, I. M., & Halder, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0086-y · Cited by 981
Self-citationReparative inflammation takes charge of tissue regeneration
Karin, M., & Clevers, H. (2016) · Nature · doi:10.1038/nature17039 · Cited by 767
A gp130–Src–YAP module links inflammation to epithelial regeneration
Taniguchi, K., Wu, L.-W., Grivennikov, S. I., de Jong, P. R., Lian, I., Yu, F.-X., Wang, K., Ho, S. B., Boland, B. S., Chang, J. T., et al. (2015) · Nature · doi:10.1038/nature14228 · Cited by 633
Metadata
- Authors
- Johnson, R., & Halder, G.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2013-12-13
- Volume
- 13
- Issue
- 1
- Pages
- 63-79
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W1996690536
- Cited by
- 881
- References
- 19
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- green
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