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Cited by 197Hair Growth and DisordersSkin and Cellular Biology Researchdental development and anomalies

Signaling Networks among Stem Cell Precursors, Transit-Amplifying Progenitors, and their Niche in Developing Hair Follicles

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Rezza, Amélie, Wang, Zichen, Sennett, Rachel, Qiao, Wenlian, Wang, Dongmei, Heitman, Nicholas, Mok, Ka Wai, Clavel, Carlos +4 more·2016·Cell Reports
DOI 10.1016/j.celrep.2016.02.078PMC PMC4826467
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Abstract

The hair follicle (HF) is a complex miniorgan that serves as an ideal model system to study stem cell (SC) interactions with the niche during growth and regeneration. Dermal papilla (DP) cells are required for SC activation during the adult hair cycle, but signal exchange between niche and SC precursors/transit-amplifying cell (TAC) progenitors that regulates HF morphogenetic growth is largely unknown. Here we use six transgenic reporters to isolate 14 major skin and HF cell populations. With next-generation RNA sequencing, we characterize their transcriptomes and define unique molecular signatures. SC precursors, TACs, and the DP niche express a plethora of ligands and receptors. Signaling interaction network analysis reveals a bird's-eye view of pathways implicated in epithelial-mesenchymal interactions. Using a systematic tissue-wide approach, this work provides a comprehensive platform, linked to an interactive online database, to identify and further explore the SC/TAC/niche crosstalk regulating HF growth.

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  • Atoh-1 is expressed by hair-follicle stem cells and progenitors, and by embryonic melanocytes and placode cells.

    “Atoh-1 gene was previously shown to be expressed by hair-follicle stem cells and progenitors, and by embryonic melanocytes and placode cells [2,34,35].”

    From Efficient Generation of Skin Organoids from Pluripotent Cells via Defined Extracellular Matrix Cues and Morphogen Gradients in a Spindle‐Shaped Microfluidic Device (2024) · cites this paper as [35]

    The Results passages on cell isolation and progenitor signatures identify markers for hair-follicle cells and melanocytes, but do not identify Atoh-1 as one of them. The Discussion mentions shared signature genes in placode cells without naming Atoh-1; searches for “Atoh1,” “Atoh-1,” and “atonal homolog 1” found no passage establishing the claimed expression pattern. Page numbers were not provided in our copy. (LLM, conf=0.76)

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Research works printed but not linked: 34

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Authors
Rezza, A., Wang, Z., Sennett, R., Qiao, W., Wang, D., Heitman, N., Mok, K. W., Clavel, C., Yi, R., Zandstra, P., Ma’ayan, A., & Rendl, M.
Affiliations
  • Icahn School of Medicine at Mount Sinai (US)
  • University of Toronto (CA)
  • University of Colorado Boulder (US)
Corresponding author
Rendl, Michael
ORCID
Venue
Cell Reports
Publisher
Elsevier BV
Published
2016-03
Volume
14
Issue
12
Pages
3001-3018
ISSN
2211-1247 (ISSN-L)
DOI
10.1016/j.celrep.2016.02.078
PMC
PMC4826467
OpenAlex
W2299231398
Cited by
197
References
3
Citations by year
2026: 13 · 2025: 16 · 2024: 13 · 2023: 29 · 2022: 24 · 2021: 24 · 2020: 22 · 2019: 16 · 2018: 22 · 2017: 17 · 2016: 1
FWCI
27.21
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Reports (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • CU Scholar (University of Colorado Boulder) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases
  • New York State Department of Health (NYSTEM-C029574)
  • Irma T. Hirschl Trust
  • Fondation pour la Recherche Médicale
  • National Institutes of Health (R01DK088541, R01GM098316, U54CA189201, U54HL127624)
Topics
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
Keywords
hair follicle development, dermal papilla, stem cell niche, signaling networks, epithelial-mesenchymal interactions, gene expression profiling, hair follicle morphogenesis
MeSH terms
Animals, Flow Cytometry, Microscopy, Fluorescence, Skin, Stem Cells, Signal Transduction, Sequence Analysis, RNA, Hair Follicle, Principal Component Analysis, Mice, Keratin-14, Stem Cell Niche, SOX9 Transcription Factor, Transcriptome

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