Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition
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TGF-β secreted by tumor stroma induces epithelial-to-mesenchymal transition (EMT) in cancer cells, a reversible phenotype linked to cancer progression and drug resistance. However, exposure to stromal signals may also lead to heritable changes in cancer cells, which are poorly understood. We show that epithelial cells failing to undergo proliferation arrest during TGF-β-induced EMT sustain mitotic abnormalities due to failed cytokinesis, resulting in aneuploidy. This genomic instability is associated with the suppression of multiple nuclear envelope proteins implicated in mitotic regulation and is phenocopied by modulating the expression of LaminB1. While TGF-β-induced mitotic defects in proliferating cells are reversible upon its withdrawal, the acquired genomic abnormalities persist, leading to increased tumorigenic phenotypes. In metastatic breast cancer patients, increased mesenchymal marker expression within single circulating tumor cells is correlated with genomic instability. These observations identify a mechanism whereby microenvironment-derived signals trigger heritable genetic changes within cancer cells, contributing to tumor evolution.
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Exposure to TGF-β and stem-like features linked to EMT are associated with poorer repair of double-strand DNA breaks and greater genomic instability.
“Although divergent observations are reported156,157, TGF-β treatment and EMT-associated CSC properties correlate with a decreased ability of carcinoma cells to repair double-stranded DNA breaks and increased genomic instability158,159.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [158]
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Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492 · see citing works
Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907 · see citing works
Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759 · see citing works
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Yu, M., Bardia, A., Wittner, B. S., Stott, S. L., Smas, M. E., Ting, D. T., Isakoff, S. J., Ciciliano, J. C., Wells, M. N., Shah, A. M., et al. (2013) · Science · doi:10.1126/science.1228522 · Cited by 2,476 · see citing works
Self-citationCirculating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
Aceto, N., Bardia, A., Miyamoto, D. T., Collier, M. D., Wittner, B. S., Spencer, J. A., Yu, M., Pely, A., Engstrom, A., Zhu, H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.07.013 · Cited by 2,438 · see citing works
Self-citationThe advantages and disadvantages of being polyploid
Comai, L. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1711 · Cited by 2,308 · see citing works
TGF-β Signaling in Tumor Suppression and Cancer Progression
Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275 · see citing works
The causes and consequences of genetic heterogeneity in cancer evolution
Burrell, R. A., McGranahan, N., Bartek, J., & Swanton, C. (2013) · Nature · doi:10.1038/nature12625 · Cited by 2,262 · see citing works
Zheng, X., Carstens, J. L., Kim, J., Scheible, M., Kaye, J. A., Sugimoto, H., Wu, C.-C., LeBleu, V. S., & Kalluri, R. (2015) · Nature · doi:10.1038/nature16064 · Cited by 2,018 · see citing works
Absolute quantification of somatic DNA alterations in human cancer
Carter, S. L., Cibulskis, K., Helman, E., McKenna, A., Shen, H., Zack, T. I., Laird, P. W., Onofrio, R. C., Winckler, W., Weir, B. A., et al. (2012) · Nature Biotechnology · doi:10.1038/nbt.2203 · Cited by 2,003 · see citing works
The comet assay: a method to measure DNA damage in individual cells
Olive, P. L., & Banáth, J. P. (2006) · Nature Protocols · doi:10.1038/nprot.2006.5 · Cited by 1,845 · see citing works
Pan-cancer patterns of somatic copy number alteration
Zack, T. I., Schumacher, S. E., Carter, S. L., Cherniack, A. D., Saksena, G., Tabak, B., Lawrence, M. S., Zhang, C., Wala, J. A., Mermel, C. H., et al. (2013) · Nature Genetics · doi:10.1038/ng.2760 · Cited by 1,843 · see citing works
Labelle, M., Begum, S., & Hynes, R. O. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.09.009 · Cited by 1,833 · see citing works
Fischer, K. R., Durrans, A., Lee, S., Sheng, J., Li, F., Wong, S. T. C., Choi, H., El Rayes, T., Ryu, S., Troeger, J., et al. (2015) · Nature · doi:10.1038/nature15748 · Cited by 1,791 · see citing works
Soule, H. D., Maloney, T., Wolman, S. R., Peterson, W., Brenz, R., McGrath, C. M., Russo, J., Pauley, R. J., Jones, R. F., & Brooks, S. C. (1990) · PubMed · Cited by 1,527 · see citing works
A mechanism linking extra centrosomes to chromosomal instability
Ganem, N. J., Godinho, S. A., & Pellman, D. S. (2009) · Nature · doi:10.1038/nature08136 · Cited by 1,427 · see citing works
Nuclear envelope rupture and repair during cancer cell migration
Denais, C. M., Gilbert, R. M., Isermann, P., McGregor, A. L., te Lindert, M., Weigelin, B., Davidson, P. M., Friedl, P., Wolf, K., & Lammerding, J. (2016) · Science · doi:10.1126/science.aad7297 · Cited by 1,318 · see citing works
McAlister, G. C., Nusinow, D. P., Jedrychowski, M. P., Wühr, M., Huttlin, E. L., Erickson, B. K., Rad, R., Haas, W., & Gygi, S. P. (2014) · Analytical Chemistry · doi:10.1021/ac502040v · Cited by 1,263 · see citing works
Self-citationDNA breaks and chromosome pulverization from errors in mitosis
Crasta, K., Ganem, N. J., Dagher, R., Lantermann, A. B., Ivanova, E. V., Pan, Y., Nezi, L., Protopopov, A., Chowdhury, D., & Pellman, D. (2012) · Nature · doi:10.1038/nature10802 · Cited by 1,227 · see citing works
The epigenetics of epithelial-mesenchymal plasticity in cancer
Tam, W. L., & Weinberg, R. A. (2013) · Nature Medicine · doi:10.1038/nm.3336 · Cited by 1,159 · see citing works
Oncogenic roles of EMT-inducing transcription factors
Puisieux, A., Brabletz, T., & Caramel, J. (2014) · Nature Cell Biology · doi:10.1038/ncb2976 · Cited by 1,032 · see citing works
MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics
Ting, L., Rad, R., Gygi, S. P., & Haas, W. (2011) · Nature Methods · doi:10.1038/nmeth.1714 · Cited by 1,009 · see citing works
Self-citationOcaña, O. H., Córcoles, R. C., Fabra, À., Moreno‐Bueno, G., Acloque, H., Vega, S., Barrallo‐Gimeno, A., Cano, A., & Nieto, M. A. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.012 · Cited by 973 · see citing works
ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death
Raab, M., Gentili, M., Belly, H. D., Thiam, H. R., Vargas, P., Jiménez, A. J., Lautenschläger, F., Voituriez, R., Lennon‐Duménil, A., Manel, N., et al. (2016) · Science · doi:10.1126/science.aad7611 · Cited by 946 · see citing works
Catastrophic nuclear envelope collapse in cancer cell micronuclei
Hatch, E. M., Fischer, A. H., Deerinck, T. J., & Hetzer, M. W. (2013) · Cell · doi:10.1016/j.cell.2013.06.007 · Cited by 741 · see citing works
RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance
Miyamoto, D. T., Zheng, Y., Wittner, B. S., Lee, R. J., Zhu, H., Broderick, K. T., Desai, R. N., Fox, D. B., Brannigan, B. W., Trautwein, J., et al. (2015) · Science · doi:10.1126/science.aab0917 · Cited by 706 · see citing works
Self-citationDistinct EMT programs control normal mammary stem cells and tumour-initiating cells
Ye, X., Tam, W. L., Shibue, T., Kaygusuz, Y., Reinhardt, F., Eaton, E. N., & Weinberg, R. A. (2015) · Nature · doi:10.1038/nature14897 · Cited by 697 · see citing works
Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations
Janssen, A., van der Burg, M. J., Szuhai, K., Kops, G. J. P. L., & Medema, R. H. (2011) · Science · doi:10.1126/science.1210214 · Cited by 582 · see citing works
Gruenbaum, Y., & Foisner, R. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034115 · Cited by 536 · see citing works
Orchestrating nuclear envelope disassembly and reassembly during mitosis
Güttinger, S., Laurell, E., & Kutay, U. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2641 · Cited by 465 · see citing works
Dewhurst, S. M., McGranahan, N., Burrell, R. A., Rowan, A., Gronroos, E. C., Endesfelder, D., Joshi, T., Mouradov, D., Gibbs, P., Ward, R. L., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0285 · Cited by 450 · see citing works
Polyploidy can drive rapid adaptation in yeast
Selmecki, A. M., Maruvka, Y. E., Richmond, P. A., Guillet, M., Noam Shoresh, F., Sorenson, A. L., De, S., Kishony, R., Franziska Michor, A., Dowell, R. D., et al. (2015) · Nature · doi:10.1038/nature14187 · Cited by 444 · see citing works
Tribbles Coordinates Mitosis and Morphogenesis in Drosophila by Regulating String/CDC25 Proteolysis
Mata, J., Curado, S., Ephrussi, A., & Rørth, P. (2000) · Cell · doi:10.1016/s0092-8674(00)80861-2 · Cited by 355 · see citing works
Großhans, J., & Wieschaus, E. F. (2000) · Cell · doi:10.1016/s0092-8674(00)80862-4 · Cited by 344 · see citing works
Miyazono, K. (2009) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.85.314 · Cited by 338 · see citing works
A Mitotic Lamin B Matrix Induced by RanGTP Required for Spindle Assembly
Tsai, M.-Y., Wang, S., Heidinger-Pauli, J. M., Shumaker, D. K., Adam, S. A., Goldman, R. D., & Zheng, Y. (2006) · Science · doi:10.1126/science.1122771 · Cited by 290 · see citing works
Self-citationHsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy
Chen, G., Bradford, W. D., Seidel, C. W., & Li, R. (2012) · Nature · doi:10.1038/nature10795 · Cited by 274 · see citing works
Transient nuclear envelope rupturing during interphase in human cancer cells
Vargas, J. D., Hatch, E. M., Anderson, D. J., & Hetzer, M. W. (2012) · Nucleus · doi:10.4161/nucl.18954 · Cited by 263 · see citing works
Seher, T. C., & Leptin, M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00502-9 · Cited by 254 · see citing works
Kim, E., Kim, M.-S., & Moon, A. (2004) · International Journal of Oncology · doi:10.3892/ijo.25.5.1375 · Cited by 219 · see citing works
Tumor Dissemination: An EMT Affair
Thiery, J. P., & Lim, C. T. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.03.004 · Cited by 194 · see citing works
Nguyen, D. H. A., Oketch‐Rabah, H. A., Illa-Bochaca, I., Geyer, F. C., Reis-Filho, J. S., Mao, J., Ravani, S. A., Zavadil, J., Borowsky, A. D., Jerry, D. J., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.03.011 · Cited by 150 · see citing works
DNA-Damage Response during Mitosis Induces Whole-Chromosome Missegregation
Bakhoum, S. F. W., Kabeche, L., Murnane, J. P., Zaki, B. I., & Compton, D. A. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0403 · Cited by 149 · see citing works
Self-citationMechanisms and Consequences of Cancer Genome Instability: Lessons from Genome Sequencing Studies
Lee, J. J.-K., Choi, Y., Kwon, M., & Park, P. J. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012615-044446 · Cited by 132 · see citing works
Mechanical model of blebbing in nuclear lamin meshworks
Funkhouser, C. M., Sknepnek, R., Shimi, T., Goldman, A. E., Goldman, R. D., & de la Cruz, M. O. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300215110 · Cited by 98 · see citing works
Verstraeten, V. L. R. M., Peckham, L. A., Olive, M., Capell, B. C., Collins, F. S., Nabel, E. G., Young, S. G., Fong, L. G., & Lammerding, J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019532108 · Cited by 85 · see citing works
Morphogenesis during Xenopus gastrulation requires Wee1-mediated inhibition of cell proliferation
Murakami, M. S., Moody, S. A., Daar, I. O., & Morrison, D. K. (2004) · Development · doi:10.1242/dev.00971 · Cited by 69 · see citing works
Hayashi, D., Tanabe, K., Katsube, H., & Inoue, Y. H. (2016) · Biology Open · doi:10.1242/bio.017566 · Cited by 31 · see citing works
Transition loses its invasive edge
Maheswaran, S., & Haber, D. A. (2015) · Nature · doi:10.1038/nature16313 · Cited by 27 · see citing works
Self-citationMartin, C., Chen, S., & Jackson, D. A. (2010) · Chromosome Research · doi:10.1007/s10577-010-9137-8 · Cited by 15 · see citing works
Flagged first, then by citations
1 of the 51 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
TGFβ biology in cancer progression and immunotherapy
Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944 · see citing works
Dynamic EMT: a multi‐tool for tumor progression
Brabletz, S., Schuhwerk, H., Brabletz, T., & Stemmler, M. P. (2021) · The EMBO Journal · doi:10.15252/embj.2021108647 · Cited by 770 · see citing works
The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment
Bakhoum, S. F. W., & Cantley, L. C. (2018) · Cell · doi:10.1016/j.cell.2018.08.027 · Cited by 717 · see citing works
Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells
Keller, L., & Pantel, K. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0180-2 · Cited by 549 · see citing works
A conduit to metastasis: circulating tumor cell biologyPreprint
Micalizzi, D. S., Maheswaran, S., & Haber, D. A. (2017) · Genes & Development · doi:10.1101/gad.305805.117 · Cited by 446 · see citing works
Self-citationDeterminants and clinical implications of chromosomal instability in cancer
Sansregret, L., Vanhaesebroeck, B., & Swanton, C. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.198 · Cited by 396 · see citing works
EMT and MET : necessary or permissive for metastasis?
Jolly, M. K., Ware, K. E., Gilja, S., Somarelli, J. A., & Levine, H. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12083 · Cited by 371 · see citing works
Jolly, M. K., Ward, C., Eapen, M. S., Myers, S., Hällgren, O., Levine, H., & Sohal, S. S. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24541 · Cited by 252 · see citing works
A stemness-related ZEB1–MSRB3 axis governs cellular pliancy and breast cancer genome stability
Morel, A., Ginestier, C., Pommier, R. M., Cabaud, O., Ruiz, E. M., Wicinski, J., Devouassoux‐Shisheboran, M., Combaret, V., Finetti, P., Chassot, C., et al. (2017) · Nature Medicine · doi:10.1038/nm.4323 · Cited by 179 · see citing works
Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family
Katsuno, Y., & Derynck, R. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.028 · Cited by 187 · see citing works
de Vitis, M., Berardinelli, F., & Sgura, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020606 · Cited by 180 · see citing works
EMT/MET plasticity in cancer and Go-or-Grow decisions in quiescence: the two sides of the same coin?
Akhmetkaliyev, A., Alibrahim, N., Shafiee, D., & Tulchinsky, E. M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01793-z · Cited by 174 · see citing works
Nuclear Membrane Rupture and Its Consequences
Maciejowski, J., & Hatch, E. M. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-020520-120627 · Cited by 165 · see citing works
Genomic instability, inflammatory signaling and response to cancer immunotherapy
Chen, M., Linstra, R., & van Vugt, M. A. T. M. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188661 · Cited by 166 · see citing works
Chromosome Segregation Fidelity in Epithelia Requires Tissue Architecture
Knouse, K. A., Lopez, K. E., Bachofner, M., & Amon, A. (2018) · Cell · doi:10.1016/j.cell.2018.07.042 · Cited by 134 · see citing works
Guo, X., Ni, J., Liang, Z., Xue, J., Fenech, M. F., & Wang, X. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.11.001 · Cited by 125 · see citing works
Perkhofer, L., Schmitt, A., Carrasco, M. C. R., Ihle, M., Hampp, S., Ruess, D. A., Heßmann, E., Russell, R., Lechel, A., Azoitei, N., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0634 · Cited by 112 · see citing works
Dynamics of Phenotypic Heterogeneity Associated with EMT and Stemness during Cancer Progression
Jolly, M. K., & Celià-Terrassa, T. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101542 · Cited by 109 · see citing works
Galle, E., Thienpont, B., Cappuyns, S., Venken, T., Busschaert, P., Haele, M. V., Cutsem, E. V., Roskams, T., van Pelt, J. F., Verslype, C., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-0821-z · Cited by 103 · see citing works
Micalizzi, D. S., Haber, D. A., & Maheswaran, S. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12081 · Cited by 76 · see citing works
Self-citationCentrosome dysfunction: a link between senescence and tumor immunity
Wu, Q., Li, B., Liu, L., Sun, S., & Sun, S. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00214-7 · Cited by 76 · see citing works
NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer
Guo, H., Golczer, G., Wittner, B. S., Langenbucher, A., Zachariah, M. A., Dubash, T. D., Hong, X., Comaills, V., Burr, R., Ebright, R. Y., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.09.016 · Cited by 74 · see citing works
Self-citationTGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
Matsuda, S., Revandkar, A., Dubash, T. D., Ravi, A., Wittner, B. S., Lin, M., Morris, R. T., Burr, R., Guo, H., Seeger, K., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112129 · Cited by 71 · see citing works
Self-citationDrug and apoptosis resistance in cancer stem cells (CSCs): A puzzle with many pieces
Safa, A. R. (2022) · Cancer Drug Resistance · doi:10.20517/cdr.2022.20 · Cited by 71 · see citing works
Gauthier, B. R., & Comaills, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147281 · Cited by 67 · see citing works
Self-citationLi, Y., Liu, Y., Chiang, Y. J., Huang, F., Li, Y., Li, X., Ning, Y., Zhang, W., Deng, H., & Chen, Y.-G. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.045 · Cited by 61 · see citing works
Partial EMT in Squamous Cell Carcinoma: A Snapshot
Liao, C., Wang, Q., An, J., Long, Q., Wang, H., Xiang, M., Xiang, M., Zhao, Y., Liu, Y., Liu, J., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.61566 · Cited by 55 · see citing works
Role of tissue microenvironment resident adipocytes in colon cancer
Tabuso, M., Homer‐Vanniasinkam, S., Adya, R., & Arasaradnam, R. P. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i32.5829 · Cited by 50 · see citing works
It Takes Two to Tango: Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology
Hiepen, C., Mendez, P., & Knaus, P. I. (2020) · Cells · doi:10.3390/cells9091965 · Cited by 47 · see citing works
Hybrid E/M Phenotype(s) and Stemness: A Mechanistic Connection Embedded in Network Topology
Pasani, S., Sahoo, S., & Jolly, M. K. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm10010060 · Cited by 46 · see citing works
Evolutionary fingerprints of epithelial-to-mesenchymal transition
Perelli, L., Zhang, L., Mangiameli, S. M., Giannese, F., Mahadevan, K. K., Peng, F., Citron, F., Khan, H., Le, C. N., Gurreri, E., et al. (2025) · Nature · doi:10.1038/s41586-025-08671-2 · Cited by 48 · see citing works
Proactive and reactive roles of TGF-β in cancer
Kuburich, N. A., Sabapathy, T., Demestichas, B. R., Maddela, J. J., den Hollander, P., & Mani, S. A. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.08.002 · Cited by 44 · see citing works
Rivera-Rivera, Y., Marina, M. E., Jusino, S., Lee, M.-Y., Velázquez, J. J. V., Chardón-Colón, C., Vargas, G., Padmanabhan, J., Chellappan, S., & Saavedra, H. I. (2021) · Scientific Reports · doi:10.1038/s41598-021-88512-0 · Cited by 43 · see citing works
The Role of Emerin in Cancer Progression and Metastasis
Liddane, A. G., & Holaska, J. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011289 · Cited by 39 · see citing works
Chromosomal Instability in Genome Evolution: From Cancer to Macroevolution
Comaills, V., & Castellano‐Pozo, M. (2023) · Biology · doi:10.3390/biology12050671 · Cited by 40 · see citing works
Self-citationBersini, S., Miermont, A., Pavesi, A., Kamm, R. D., Thiery, J. P., Moretti, M., & Adriani, G. (2018) · Oncotarget · doi:10.18632/oncotarget.26306 · Cited by 38 · see citing works
Subbalakshmi, A. R., Sahoo, S., Manjunatha, P., Goyal, S., Kasiviswanathan, V. A., Mahesh, Y., Ramu, S., McMullen, I., Somarelli, J. A., & Jolly, M. K. (2023) · Journal of Biological Engineering · doi:10.1186/s13036-023-00333-z · Cited by 39 · see citing works
NLRP1 Overexpression Is Correlated with the Tumorigenesis and Proliferation of Human Breast Tumor
Wei, Y., Huang, H., Qiu, Z., Li, H., Tan, J., Ren, G., & Wang, X. (2017) · BioMed Research International · doi:10.1155/2017/4938473 · Cited by 37 · see citing works
Zhou, W., Rowitz, B. M., & Dailey, M. J. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370218785152 · Cited by 36 · see citing works
Transitional dynamics of cancer stem cells in invasion and metastasis
Richard, V., Kumar, T. R. S., & Pillai, R. M. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100909 · Cited by 34 · see citing works
Tian, Z., Cen, L., Feng, W., Dong, J., Huang, Y., Han, Y., Wang, Z., Deng, J., & Jiang, Y. (2025) · Oncology Letters · doi:10.3892/ol.2025.15121 · Cited by 34 · see citing works
Simi, A. K., Anlaş, A. A., Stallings‐Mann, M. L., Zhang, S., Hsia, T., Cichon, M. A., Radisky, D. C., & Nelson, C. M. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2899 · Cited by 33 · see citing works
Mechanical Control of Cell Differentiation: Insights from the Early Embryo
Nelson, C. M. (2022) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-060418-052527 · Cited by 30 · see citing works
Drainas, A. P., Lambuta, R. A., Ivanova, I., Serçin, Ö., Sarropoulos, I., Smith, M. L., Efthymiopoulos, T., Raeder, B., Stütz, A. M., Waszak, S. M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.029 · Cited by 30 · see citing works
Pastorino, G. A., Sheraj, I., Huebner, K., Ferrero, G., Kunze, P., Hartmann, A., Hampel, C., Hüsnügil, H. H., Maiuthed, A., Gebhart, F., et al. (2024) · The Journal of Pathology · doi:10.1002/path.6240 · Cited by 31 · see citing works
CHD4 mutations promote endometrial cancer stemness by activating TGF-beta signaling.
Li, Y., Liu, Q., McGrail, D. J., Dai, H., Li, K., & Lin, S. (2018) · Europe PMC (PubMed Central) · Cited by 29 · see citing works
Peyre, L., Meyer, M., Hofman, P. M., & Roux, J. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01177-w · Cited by 29 · see citing works
TGFβ Promotes Genomic Instability after Loss of RUNX3
Krishnan, V., Chong, Y. L., Tan, T. Z., Kulkarni, M., Rahmat, M. B. B., Tay, L. S., Sankar, H., Jokhun, D. S., Ganesan, A., Chuang, L. S. H., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1178 · Cited by 29 · see citing works
Corsi, F., Capradossi, F., Pelliccia, A., Briganti, S., Bruni, E., Traversa, E., Torino, F., Reichle, A., & Ghibelli, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031152 · Cited by 27 · see citing works
Li, Y., Xi, Y., Zhu, G., Jia, J., Huang, H., Liu, Y., Guo, Y., & Liu, L. (2019) · Oncology Reports · doi:10.3892/or.2019.7303 · Cited by 25 · see citing works
Rabie, E., Zhang, S. X., Dunn, C., & Nelson, C. (2021) · Molecular Biology of the Cell · doi:10.1091/mbc.e21-02-0072 · Cited by 23 · see citing works
Deep sequencing reveals a global reprogramming of lncRNA transcriptome during EMT
Liao, J.-Y., Wu, J., Wang, Y., He, J.-H., Deng, W.-X., Hu, K.-S., Zhang, Y., Zhang, Y., Yan, H., Wang, D.-L., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.06.003 · Cited by 24 · see citing works
cGAS-STING signalings potentiate tumor progression via sustaining cancer stemness
Liu, F.-R., Jiang, M., Mei, Z., Lin, C.-J., & Tian, L. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101404 · Cited by 24 · see citing works
Kuang, X., & Li, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.895961 · Cited by 22 · see citing works
Reale, A., Carmichael, I., Xu, R., Mithraprabhu, S., Khong, T. T., Chen, M., Fang, H., Savvidou, I., Ramachandran, M., Bingham, N. E., et al. (2021) · PROTEOMICS · doi:10.1002/pmic.202000119 · Cited by 20 · see citing works
Karyotype Aberrations in Action: The Evolution of Cancer Genomes and the Tumor Microenvironment
Baudoin, N. C., & Bloomfield, M. (2021) · Genes · doi:10.3390/genes12040558 · Cited by 20 · see citing works
Jain, P., Pillai, M., Duddu, A. S., Somarelli, J. A., Goyal, Y., & Jolly, M. K. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.09.007 · Cited by 22 · see citing works
The emerging role of circulating tumor cells in cancer management.
Li, X., Dong, M., Zang, X.-Y., Li, M.-Y., Zhou, J., Ma, J., & Wang, G.-Y. (2020) · PubMed Central · Cited by 20 · see citing works
Alhaddad, L., Osipov, A. N., & Leonov, S. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113577 · Cited by 21 · see citing works
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles
Perni, M., Aprile, F. A., Casford, S., Mannini, B., Sormanni, P., Dobson, C. M., & Vendruscolo, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-13755-9 · Cited by 19 · see citing works
Fritz, A. J., Gillis, N. E., Gerrard, D. L., Rodriguez, P. D., Hong, D., Rose, J. T., Ghule, P. N., Bolf, E. L., Gordon, J. A., Tye, C. E., et al. (2019) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22731 · Cited by 19 · see citing works
Fan, J. C., Chang, S.-N., Chu, C., & Chen, H. (2023) · iScience · doi:10.1016/j.isci.2023.106992 · Cited by 18 · see citing works
Xiao, J.-F., Kua, L.-F., Ding, L., Sun, Q.-Y., Myint, K. N., Chia, X.-R., Venkatachalam, N., Loh, X., Duex, J. E., Neang, V., et al. (2022) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-21-0402 · Cited by 16 · see citing works
Epithelial-Mesenchymal Plasticity in Circulating Tumor Cells, the Precursors of Metastasis
Burr, R., Gilles, C., Thompson, E. W., & Maheswaran, S. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-35805-1_2 · Cited by 16 · see citing works
Self-citationAt the nucleus of cancer: how the nuclear envelope controls tumor progression
Paganelli, F., Poli, A., Truocchio, S., Martelli, A. M., Palumbo, C., Lattanzi, G., & Chiarini, F. (2025) · MedComm · doi:10.1002/mco2.70073 · Cited by 15 · see citing works
Physical Forces and Transient Nuclear Envelope Rupture during Metastasis: The Key for Success?
Gauthier, B. R., Lorenzo, P. I., & Comaills, V. (2021) · Cancers · doi:10.3390/cancers14010083 · Cited by 15 · see citing works
Self-citationCharacteristics of Cancer Stem Cells and Their Potential Role in Endometrial Cancer
Frąszczak, K., & Barczyński, B. (2024) · Cancers · doi:10.3390/cancers16061083 · Cited by 13 · see citing works
A high-content screen reveals new regulators of nuclear membrane stability
Gunn, A., Yashchenko, A. I., Dubrulle, J., Johnson, J., & Hatch, E. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-56613-1 · Cited by 13 · see citing works
Single-cell tracking as a tool for studying EMT-phenotypes
Quinsgaard, E. M. B., Korsnes, M. S., Korsnes, R., & Moestue, S. A. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.113993 · Cited by 12 · see citing works
Jain, P., Kizhuttil, R., Nair, M. B., Bhatia, S., Thompson, E. W., George, J. T., & Jolly, M. K. (2024) · iScience · doi:10.1016/j.isci.2024.110310 · Cited by 13 · see citing works
Emerin deficiency drives MCF7 cells to an invasive phenotype
Hansen, E., Rolling, C., Wang, M., & Holaska, J. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-70752-5 · Cited by 12 · see citing works
Context-dependent effects of whole-genome duplication during mammary tumor recurrence
Newcomb, R., Dean, E., McKinney, B. J., & Alvarez, J. V. (2021) · Scientific Reports · doi:10.1038/s41598-021-94332-z · Cited by 16 · see citing works
Genomic Instability in Circulating Tumor Cells
Freitas, M. O., Gartner, J. G., Pozzo, A. R., & Mai, S. (2020) · Cancers · doi:10.3390/cancers12103001 · Cited by 12 · see citing works
Wu, J., He, J., Zhang, J., Ji, H., Wang, N., Ma, S., Yan, X., Gao, X., Du, J., Liu, Z., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.887693 · Cited by 11 · see citing works
Alabi, Y., Aksenova, V., Arnaoutov, A., Marin, H. C., Dasso, M., & Buchwalter, A. L. (2025) · Molecular Biology of the Cell · doi:10.1091/mbc.e25-02-0057 · Cited by 11 · see citing works
Vanhaesebroeck, B., Bilanges, B., Madsen, R., Dale, K. L., Lau, E., & Vladimirou, E. (2019) · Biomolecules · doi:10.3390/biom9080331 · Cited by 12 · see citing works
Claudin-4 Modulates Autophagy via SLC1A5/LAT1 as a Mechanism to Regulate Micronuclei
Villagómez, F. R., Lang, J., Rosario, F. J., Núñez-Avellaneda, D., Webb, P. G., Neville, M. C., Woodruff, E. R., & Bitler, B. G. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-24-0240 · Cited by 9 · see citing works
mRNA-1273 is placenta-permeable and immunogenic in the fetus
Chen, J., Hsu, M., Kuo, R., Wang, L., Kuo, M., Tseng, L.-Y., Chang, H., & Chiu, C. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102489 · Cited by 10 · see citing works
Ohshima, K., Nagashima, T., Fujiya, K., Hatakeyama, K., Watanabe, Y., Morimoto, K., Kamada, F., Shimoda, Y., Ohnami, S., Naruoka, A., et al. (2023) · Cancer Research Communications · doi:10.1158/2767-9764.crc-22-0364 · Cited by 9 · see citing works
Najafi, A., Jolly, M. K., & George, J. T. (2023) · iScience · doi:10.1016/j.isci.2023.106964 · Cited by 9 · see citing works
Caruso, J. A., Chen‐Tanyolac, C., & Tlsty, T. D. (2024) · Breast Cancer Research · doi:10.1186/s13058-024-01920-8 · Cited by 8 · see citing works
Fowler, E. W., van Venrooy, E. J., Witt, R. L., & Jia, X. (2022) · Scientific Reports · doi:10.1038/s41598-022-19253-x · Cited by 9 · see citing works
Minari, R., Valentini, S., Madeddu, D., Cavazzoni, A., Monica, S. L., Lagrasta, C. A. M., Bertorelli, R., Sanctis, V. D., Fassan, P., Azzoni, C., et al. (2022) · JTO Clinical and Research Reports · doi:10.1016/j.jtocrr.2022.100278 · Cited by 8 · see citing works
Epithelial-Mesenchymal Transition of Cancer Cells on Micropillar Arrays
Liu, R., Wang, H., & Ding, J. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c00343 · Cited by 7 · see citing works
Mesenchymal drift: A convergent framework for the hallmarks of aging
Lu, J. Y., Tu, W. B., Ma, S., Ma, Z., Imaz-Rosshandler, I., Weng, M., Qu, J., Esteban, C. R., Reddy, P., Liu, G.-H., et al. (2026) · Cell · doi:10.1016/j.cell.2026.04.020 · Cited by 10 · see citing works
Karmakar, D., Lahiri, P., Bedi, M., Ghosh, A., Ghosh, A., Barui, A., Varshney, S. K., Lahiri, B., & Sengupta, S. (2023) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30408 · Cited by 6 · see citing works
Epithelial-to-mesenchymal transition drives cancer genomic instability
Carstens, J. L., & Lovisa, S. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03402-x · Cited by 6 · see citing works
Phipps, S., Garry, C., Kamal, S., Johnson, J. D., Gilmer, J. F., Long, A., Kelleher, D. P., & Duggan, S. P. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.05.002 · Cited by 6 · see citing works
He, L., Fan, X.-X., Li, Y.-R., Cui, B., Shi, Z., Zhou, D.-Z., & Lin, H. (2019) · Cancer Genetics · doi:10.1016/j.cancergen.2019.04.003 · Cited by 4 · see citing works
Perinuclear assembly of vimentin intermediate filaments induces cancer cell nuclear dysmorphia
Pan, K.-W., & Chen, H. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107981 · Cited by 4 · see citing works
Hassan, S., Blick, T., Wood, J., Thompson, E. W., & Williams, E. D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.858013 · Cited by 4 · see citing works
Integrative analysis indicates the potential values of ANKRD53 in stomach adenocarcinoma
Jin, C., Lu, X., Yang, M., & Hou, S. (2024) · Discover Oncology · doi:10.1007/s12672-024-01054-5 · Cited by 3 · see citing works
Biophysical Regulation of TGFβ Signaling in the Tumor Microenvironment
Sankhe, C. S., Sacco, J. L., & Gomez, E. W. (2023) · Current cancer research · doi:10.1007/978-3-031-22802-5_6 · Cited by 3 · see citing works
Structure-Function Relationships of Nuclear LaminsPreprint
Patil, S., & Sengupta, K. (2020) · Preprints.org · doi:10.20944/preprints202009.0604.v1 · Cited by 3 · see citing works
Advances in the study of epithelial mesenchymal transition in cancer progression: Role of miRNAs
Zhang, J., Yin, R., Xue, Y., Qin, R., Wang, X., Wu, S., Zhu, J., Li, Y.-S., Zhang, C., & Yuan, W. (2025) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2025.04.001 · Cited by 2 · see citing works
The cell-of-origin dictates the genomic landscape of breast cancers
Puisieux, A., Pommier, R. M., Tissier, A., & Morel, A. (2017) · Molecular & Cellular Oncology · doi:10.1080/23723556.2017.1338931 · Cited by 2 · see citing works
Half the Chromosome It Used to Be: Identifying Cancer Treatments Targeting Aneuploid Losses
Disharoon, A., & Delaney, J. R. (2025) · Genes · doi:10.3390/genes16060708 · Cited by 1 · see citing works
Chromosomal Instability and Chromoanagenesis as Forces for Genomic Evolution
Castellano‐Pozo, M., & Comaills, V. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4750-9_36 · Cited by 1 · see citing works
Self-citationEmerin expression stratification across breast cancer subtypes
Ghiarone, T., Hansen, E., & Holaska, J. M. (2025) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2025.101037 · Cited by 1 · see citing works
- Authors
- Comaills, V., Kabeche, L., Morris, R., Buisson, R., Yu, M., Madden, M. W., LiCausi, J. A., Boukhali, M., Tajima, K., Pan, S., Aceto, N., Sil, S., Zheng, Y., Sundaresan, T., Yae, T., Jordan, N. V., Miyamoto, D. T., Ting, D. T., Ramaswamy, S., Haas, W., Zou, L., Haber, D. A., & Maheswaran, S.
- Affiliations
- Harvard University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Maheswaran, Shyamala
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 17
- Issue
- 10
- Pages
- 2632-2647
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC5320932
- OpenAlex
- W2560567639
- Cited by
- 124
- References
- 51
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 14 · 2023: 15 · 2022: 12 · 2021: 15 · 2020: 16 · 2019: 10 · 2018: 11 · 2017: 12
- FWCI
- 5.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- Human Frontier Science Program
- Susan G. Komen for the Cure (KG09042)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Breast Cancer Research Foundation
- National Foundation for Cancer Research
- National Institutes of Health (CA129933, GM076388)
- University of Massachusetts Amherst
- Philippe Foundation
- National Cancer Institute
- Howard Hughes Medical Institute
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- genomic instability, epithelial-mesenchymal transition, TGF-beta, tumor microenvironment, aneuploidy, mitotic abnormalities, nuclear envelope proteins, circulating tumor cells, metastatic breast cancer, tumor evolution, drug resistance
- MeSH terms
- Breast Neoplasms, Cell Differentiation, Female, Humans, Lamin Type B, Genomic Instability, Cell Line, Tumor, Cell Proliferation, Transforming Growth Factor beta1, Epithelial-Mesenchymal Transition
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