High-fat diet exacerbates imiquimod-induced psoriasis-like dermatitis in mice
Abstract
Psoriasis, a chronic inflammatory skin disease, is closely related to systemic metabolism. An elevated body mass index (BMI) is a risk factor for psoriasis; inflammasomes are activated by adipose tissue macrophages in obese subjects. We hypothesized that hyperlipidaemia is involved in the pathogenesis of psoriasis and examined the role of a high-fat diet (HFD) in the development of psoriasis in imiquimod (IMQ)-treated mice. The body weight and serum level of cholesterol were significantly higher in mice fed an HFD than in a regular diet (RD). HFD mice had higher psoriasis skin scores, and the number of neutrophils infiltrating into the lesional skin was elevated. IL-17A mRNA expression was significantly increased in the skin of IMQ-treated HFD mice; the expression of IL-22, IL-23 and TNF-α mRNA was not enhanced. Caspase-1 and IL-1β were activated in the skin of IMQ-treated HFD mice, and their serum level of IL-17A, TNF-α and IL-1β was significantly upregulated. Our findings strongly suggest that hyperlipidaemia is involved in the development and progression of psoriasis via systemic inflammation and inflammasome activation.
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A high-fat diet led to an increase in free fatty acid content in mice, which is an important factor that aggravates skin inflammatory psoriasis.
“A high-fat diet led to an increase in free fatty acid content in mice, which is an important factor that aggravates skin inflammatory psoriasis.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [91]
The effect of a high-fat diet is mainly to cause aging of the skin by causing skin oxidative stress to produce inflammatory damage.
“In general, the effect of a high-fat diet is mainly to cause aging of the skin by causing skin oxidative stress to produce inflammatory damage.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [91]
A high-fat diet can promote skin inflammation and cancer by enhancing expression of inflammatory factors and tumor necrosis factor in the skin by UV-B.
“Moreover, a high-fat diet can promote skin inflammation and cancer by enhancing the expression of inflammatory factors and tumor necrosis factor in the skin by UV-B [89,90,91].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [91]
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Diet and Skin Aging—From the Perspective of Food Nutrition
Cao, C., Xiao, Z., Wu, Y., & Ge, C. (2020) · Nutrients · doi:10.3390/nu12030870 · Cited by 231 · see citing works
- Authors
- Higashi, Y., Yamakuchi, M., Fukushige, T., Ibusuki, A., Hashiguchi, T., & Kanekura, T.
- Affiliations
- Kagoshima University (JP)
- Corresponding author
- Yamakuchi, Munekazu
- ORCID
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 2018-01-09
- Volume
- 27
- Issue
- 2
- Pages
- 178-184
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W2774755860
- Cited by
- 39
- References
- 53
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 3
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Naito Foundation
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Keywords
- psoriasis, high-fat diet, hyperlipidemia, imiquimod-induced dermatitis, inflammasome activation, caspase-1, IL-1β, IL-17A, TNF-α, neutrophil infiltration, obesity, systemic inflammation, adipose tissue macrophages
- MeSH terms
- Imiquimod, Animals, Body Weight, Cholesterol, Dermatitis, Disease Models, Animal, Hyperlipidemias, Inflammation, Male, Mice, Inbred C57BL, Neutrophils, Psoriasis, Skin, Cytokines, Disease Progression, Mice, Inflammasomes, Diet, High-Fat
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