Metabolic Effects of Ketogenic Diets: Exploring Whole-Body Metabolism in Connection with Adipose Tissue and Other Metabolic Organs
Open accessAbstract
The ketogenic diet (KD) is characterized by minimal carbohydrate, moderate protein, and high fat intake, leading to ketosis. It is recognized for its efficiency in weight loss, metabolic health improvement, and various therapeutic interventions. The KD enhances glucose and lipid metabolism, reducing triglycerides and total cholesterol while increasing high-density lipoprotein levels and alleviating dyslipidemia. It significantly influences adipose tissue hormones, key contributors to systemic metabolism. Brown adipose tissue, essential for thermogenesis and lipid combustion, encounters modified UCP1 levels due to dietary factors, including the KD. UCP1 generates heat by uncoupling electron transport during ATP synthesis. Browning of the white adipose tissue elevates UCP1 levels in both white and brown adipose tissues, a phenomenon encouraged by the KD. Ketone oxidation depletes intermediates in the Krebs cycle, requiring anaplerotic substances, including glucose, glycogen, or amino acids, for metabolic efficiency. Methylation is essential in adipogenesis and the body's dietary responses, with DNA methylation of several genes linked to weight loss and ketosis. The KD stimulates FGF21, influencing metabolic stability via the UCP1 pathways. The KD induces a reduction in muscle mass, potentially involving anti-lipolytic effects and attenuating proteolysis in skeletal muscles. Additionally, the KD contributes to neuroprotection, possesses anti-inflammatory properties, and alters epigenetics. This review encapsulates the metabolic effects and signaling induced by the KD in adipose tissue and major metabolic organs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ketogenic diets promote weight loss and metabolic improvements through ketosis.
“Ketogenic diets, characterized by a very low carbohydrate and high fat intake, are structured at approximately 1672 kcal/day, with macronutrient ratios of 4.8% carbohydrates, 71.1% fats, and 24.1% proteins, promoting weight loss and metabolic improvements through ketosis [164].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Adipose tissue dysfunction in obesity, diabetes, and vascular diseases
Hajer, G. R., van Haeften, T. W., & Visseren, F. L. J. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn387 · Cited by 1,410 · see citing works
Incretin hormones: Their role in health and disease
Nauck, M. A., & Meier, J. J. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13129 · Cited by 950 · see citing works
Kossoff, E. H., Zupec‐Kania, B. A., Auvin, S., Ballaban‐Gil, K. R., Christina Bergqvist, A. G., Blackford, R., Buchhalter, J. R., Caraballo, R. H., Cross, J. H., Dahlin, M. G., et al. (2018) · Epilepsia Open · doi:10.1002/epi4.12225 · Cited by 768 · see citing works
Veech, R. L. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.09.007 · Cited by 759 · see citing works
Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue
Hondares, E., Iglesias, R., Giralt, A., Gonzalez, F. J., Giralt, M., Mampel, T., & Villarroya, F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.215889 · Cited by 623 · see citing works
The cellular and functional complexity of thermogenic fat
Cohen, P., & Kajimura, S. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00350-0 · Cited by 553 · see citing works
Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics
Morigny, P., Boucher, J., Arner, P., & Langin, D. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00471-8 · Cited by 527 · see citing works
GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease
Wang, D., Day, E. A., Townsend, L. K., Djordjevic, D., Jørgensen, S. B., & Steinberg, G. R. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00529-7 · Cited by 526 · see citing works
Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?
Rada, P., González‐Rodríguez, Á., García‐Monzón, C., & Valverde, Á. M. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03003-w · Cited by 522 · see citing works
The role of adipose tissue in cardiovascular health and disease
Oikonomou, E. K., & Antoniades, C. A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0097-6 · Cited by 509 · see citing works
Ketogenic diet in the treatment of cancer – Where do we stand?
Weber, D. D., Aminzadeh-Gohari, S., Tulipan, J., Catalano, L., Feichtinger, R. G., & Kofler, B. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.06.026 · Cited by 464 · see citing works
mTOR substrate phosphorylation in growth control
Battaglioni, S., Benjamin, D., Wälchli, M., Maier, T., & Hall, M. N. (2022) · Cell · doi:10.1016/j.cell.2022.04.013 · Cited by 437 · see citing works
Dietary polyunsaturated fatty acids and regulation of gene transcription
Jump, D. Β. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200204000-00007 · Cited by 430 · see citing works
A high-fat, ketogenic diet induces a unique metabolic state in mice
Kennedy, A. R., Pissios, P., Otu, H., Xue, B., Asakura, K., Furukawa, N., Marino, F. E., Liu, F.-F., Kahn, B. B., Libermann, T. A., et al. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00717.2006 · Cited by 420 · see citing works
Zhu, H., Bi, D., Zhang, Y., Kong, C., Du, J., Wu, X., Wei, Q., & Qin, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00831-w · Cited by 412 · see citing works
β-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares
Goldberg, E. L., Asher, J. L., Molony, R. D., Shaw, A. C., Zeiss, C. J., Wang, C., Morozova-Roche, L. A., Herzog, R. I., Iwasaki, A., & Dixit, V. D. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.004 · Cited by 370 · cited 1× · see citing works
“The KD inhibits NLRP3 activation in neutrophils to prevent inflammation [149].”
BackgroundThe Ketogenic Diet: One Decade Later
Freeman, J. M., Kossoff, E. H., & Hartman, A. L. (2007) · PEDIATRICS · doi:10.1542/peds.2006-2447 · Cited by 364 · see citing works
Hotta, Y., Nakamura, H., Konishi, M., Murata, Y., Takagi, H., Matsumura, S., Inoue, K., Fushiki, T., & Itoh, N. (2009) · Endocrinology · doi:10.1210/en.2009-0119 · Cited by 352 · see citing works
Brown adipose tissue thermogenesis and obesity
Himms‐Hagen, J. (1989) · Progress in Lipid Research · doi:10.1016/0163-7827(89)90009-x · Cited by 324 · see citing works
Ketogenic diets, mitochondria, and neurological diseases
Gano, L. B., Patel, M., & Rho, J. M. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r048975 · Cited by 279 · see citing works
A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21
Kliewer, S. A., & Mangelsdorf, D. J. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.004 · Cited by 273 · see citing works
Ułamek-Kozioł, M., Czuczwar, S. J., Januszewski, S., & Pluta, R. M. (2019) · Nutrients · doi:10.3390/nu11102510 · Cited by 267 · see citing works
Argilés, J. M. A., López-Soriano, F. J., Stemmler, B., & Busquets, S. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00734-5 · Cited by 262 · see citing works
The regulation of the release of ketone bodies by the liver
Krebs, H. A. (1966) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(66)90027-6 · Cited by 259 · see citing works
Luukkonen, P. K., Dufour, S., Lyu, K., Zhang, X., Hakkarainen, A., Lehtimäki, T. E., Cline, G. W., Petersen, K. F., Shulman, G. I., & Yki‐Järvinen, H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922344117 · Cited by 253 · see citing works
Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade
Dai, X., Bu, X., Gao, Y., Guo, J., Hu, J., Jiang, C., Zhang, Z., Xu, K., Duan, J., He, S., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.03.037 · Cited by 251 · see citing works
Cameron-Smith, D., Burke, L. M., Angus, D. J., Tunstall, R. J., Cox, G. R., Bonen, A., Hawley, J. A., & Hargreaves, M. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.2.313 · Cited by 243 · see citing works
Yuan, X., Wang, J., Yang, S., Gao, M., Cao, L., Li, X., Hong, D., Tian, S., & Sun, C. (2020) · Nutrition & Diabetes · doi:10.1038/s41387-020-00142-z · Cited by 240 · see citing works
Ketogenic diets and chronic disease: weighing the benefits against the risks
Crosby, L., Davis, B., Joshi, S., Jardine, M., Paul, J., Neola, M., & Barnard, N. D. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.702802 · Cited by 229 · cited 1× · see citing works
“The KD modifies protein utilization, as many proteins are taken up by the body for the process of gluconeogenesis while the remainder contribute to tissue repair [2].”
BackgroundMetabolic drivers of non-alcoholic fatty liver disease
Bence, K. K., & Birnbaum, M. J. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101143 · Cited by 223 · see citing works
Badman, M. K., Kennedy, A. R., Adams, A. C., Pissios, P., & Maratos–Flier, E. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00357.2009 · Cited by 217 · see citing works
Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework
Solon-Biet, S. M., Cogger, V. C., Pulpitel, T., Heblinski, M., Wahl, D., McMahon, A. C., Warren, A., Durrant-Whyte, J., Walters, K. A., Krycer, J. R., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.001 · Cited by 212 · see citing works
Parimisetty, A., Dorsemans, A.-C., Awada, R., Ravanan, P., Diotel, N., & d’Hellencourt, C. L. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0530-x · Cited by 208 · see citing works
Han, J. S., Meng, Q., Shen, L., & Wu, G. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0657-0 · Cited by 207 · see citing works
Moreno, B., Crujeiras, A. B., Bellido, D., Sajoux, I., & Casanueva, F. F. (2016) · Endocrine · doi:10.1007/s12020-016-1050-2 · Cited by 204 · see citing works
Cross-talk between skeletal muscle and adipose tissue: A link with obesity?
Argilés, J. M. A., López‐Soriano, J., Almendro, V., Busquets, S., & López-Soriano, F. J. (2004) · Medicinal Research Reviews · doi:10.1002/med.20010 · Cited by 194 · see citing works
Hepatic lipid accumulation: cause and consequence of dysregulated glucoregulatory hormones
Geisler, C. E., & Renquist, B. J. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0513 · Cited by 191 · see citing works
Cardiovascular effects of leptin
Sweeney, G. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.224 · Cited by 184 · see citing works
The Management of Very Low-Calorie Ketogenic Diet in Obesity Outpatient Clinic: A Practical Guide
Muscogiuri, G., Barrea, L., Laudisio, D., Pugliese, G., Salzano, C., Savastano, S., & Colao, A. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-2104-z · Cited by 180 · see citing works
Implicating the effect of ketogenic diet as a preventive measure to obesity and diabetes mellitus
Kumar, S., Behl, T., Sachdeva, M., Sehgal, A., Kumari, S., Kumar, A., Kaur, G., Yadav, H. N., & BUNGAU, S. G. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118661 · Cited by 175 · see citing works
Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue
Goldberg, E. L., Shchukina, I., Asher, J. L., Sidorov, S., Artyomov, M. N., & Dixit, V. D. (2020) · Nature Metabolism · doi:10.1038/s42255-019-0160-6 · Cited by 162 · see citing works
Fatty Acid Transport and Signaling: Mechanisms and Physiological Implications
Samovski, D., Jácome-Sosa, M., & Abumrad, N. A. (2022) · Annual Review of Physiology · doi:10.1146/annurev-physiol-032122-030352 · Cited by 151 · see citing works
Cunha, G. M., Guzmán, G., Mello, L. L. C. D., Trein, B., Spina, L. D. C., Bussade, I., Prata, J. M., Sajoux, I., & Countinho, W. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00607 · Cited by 147 · see citing works
Adipose tissue dysfunction in cancer cachexia
Da'as, S. I., Rizeq, B. R., & Nasrallah, G. K. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26811 · Cited by 144 · see citing works
Ketogenic diet activates protective γδ T cell responses against influenza virus infection
Goldberg, E. L., Molony, R. D., Kudo, E., Sidorov, S., Kong, Y., Dixit, V. D., & Iwasaki, A. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav2026 · Cited by 143 · see citing works
GDF15, an update of the physiological and pathological roles it plays: a review
Assadi, A., Zahabi, A., & Hart, R. A. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02459-1 · Cited by 141 · see citing works
Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease
Michailidou, Z., Gomez-Salazar, M. A., & Alexaki, V. I. (2021) · Journal of Innate Immunity · doi:10.1159/000515117 · Cited by 137 · see citing works
Srivastava, S., Kashiwaya, Y., King, M. T., Baxa, U., Tam, J., Niu, G., Chen, X. S., Clarke, K., & Veech, R. L. (2012) · The FASEB Journal · doi:10.1096/fj.11-200410 · Cited by 133 · see citing works
Stress-induced FGF21 and GDF15 in obesity and obesity resistance
Keipert, S., & Ost, M. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.08.008 · Cited by 131 · see citing works
CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease
Glatz, J. F. C., Heather, L. C., & Luiken, J. J. F. P. (2023) · Physiological Reviews · doi:10.1152/physrev.00011.2023 · Cited by 130 · see citing works
Role of Epicardial Adipose Tissue in Cardiovascular Diseases: A Review
Konwerski, M., Gąsecka, A., Opolski, G., Grabowski, M., & Mazurek, T. (2022) · Biology · doi:10.3390/biology11030355 · Cited by 127 · see citing works
Siddiqui, J. A., Pothuraju, R., Jain, M., Batra, S. K., & Nasser, M. W. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188359 · Cited by 123 · see citing works
García-Rodríguez, D., & Giménez-Cassina, A. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.732120 · Cited by 123 · see citing works
Balteau, M., Steenbergen, A. V., Timmermans, A. D., Dessy, C., Behets-Wydemans, G., Tajeddine, N., Castanares‐Zapatero, D., Gilon, P., Vanoverschelde, J., Horman, S., et al. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00210.2014 · Cited by 121 · see citing works
Okamatsu‐Ogura, Y., Kuroda, M., Tsutsumi, R., Tsubota, A., Saito, M., Kimura, K., & Sakaue, H. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154396 · Cited by 117 · see citing works
Dietary Options for Rodents in the Study of Obesity
Bastías-Pérez, M., Serra, D., & Herrero, L. (2020) · Nutrients · doi:10.3390/nu12113234 · Cited by 117 · see citing works
Unraveling the Role of Leptin in Liver Function and Its Relationship with Liver Diseases
Martinez‐Uña, M., López‐Mancheño, Y., Diéguez, C., Fernandez-Rojo, M. A., & Novelle, M. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249368 · Cited by 115 · see citing works
The Low-Carbohydrate Diet: Short-Term Metabolic Efficacy Versus Longer-Term Limitations
Barber, T. M., Hanson, P., Kabisch, S., Pfeiffer, A. F. H., & Weickert, M. O. (2021) · Nutrients · doi:10.3390/nu13041187 · Cited by 110 · see citing works
Scientific evidence underlying contraindications to the ketogenic diet: An update
Watanabe, M., Tuccinardi, D., Ernesti, I., Basciani, S., Mariani, S., Genco, A., Manfrini, S., Lubrano, C., & Gnessi, L. (2020) · Obesity Reviews · doi:10.1111/obr.13053 · Cited by 108 · see citing works
Hwang, C. Y., Choe, W., Yoon, K., Ha, J., Kim, S. S., Yeo, E., & Kang, I. (2022) · Nutrients · doi:10.3390/nu14224932 · Cited by 105 · see citing works
The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol
Song, P., Zechner, C., Hernandez, G., Canovas, J. A., Xie, Y., Sondhi, V., Wagner, M., Stadlbauer, V., Horvath, A., Leber, B., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.001 · Cited by 103 · see citing works
Leptin in Atherosclerosis: Focus on Macrophages, Endothelial and Smooth Muscle Cells
Raman, P., & Khanal, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115446 · Cited by 96 · see citing works
A ketogenic diet increases brown adipose tissue mitochondrial proteins and UCP1 levels in mice
Srivastava, S., Baxa, U., Niu, G., Chen, X. S., & Veech, R. L. (2012) · IUBMB Life · doi:10.1002/iub.1102 · Cited by 94 · see citing works
Li, R., Liu, Y., Liu, H., & Li, J. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13140 · Cited by 94 · see citing works
Adipose tissue fibrosis in human cancer cachexia: the role of TGFβ pathway
Alves, M. J., Figuerêdo, R. G., Azevedo, F. F., Cavallaro, D., Neto, N. I. P., Lima, J. D. C. C., de Matos‐Neto, E. M., Radloff, K., Riccardi, D. M., Camargo, R. G., et al. (2017) · BMC Cancer · doi:10.1186/s12885-017-3178-8 · Cited by 92 · see citing works
Paoli, A., Bianco, A., Moro, T., Mota, J. F., & Coelho‐Ravagnani, C. D. F. (2023) · Nutrients · doi:10.3390/nu15143120 · Cited by 88 · see citing works
Adipose tissue lipolysis and energy metabolism in early cancer cachexia in mice
Kliewer, K., Ke, J., Tian, M., Cole, R. M., Andridge, R., & Belury, M. A. (2014) · Cancer Biology & Therapy · doi:10.4161/15384047.2014.987075 · Cited by 87 · see citing works
Adiponectin and metabolic cardiovascular diseases: Therapeutic opportunities and challenges
Lei, X., Qiu, S., Yang, G., & Wu, Q. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.10.018 · Cited by 87 · see citing works
TFEB–GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response
Kim, J., Kim, S., Kang, H., Lee, S., Park, S., Cho, Y., Lim, Y.-M., Ahn, J. W., Kim, Y.-H., Chung, S., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00368-w · Cited by 86 · see citing works
Self-citationRafiullah, M., Musambil, M., & David, S. K. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuab040 · Cited by 86 · see citing works
CD36 in Alzheimer’s Disease: An Overview of Molecular Mechanisms and Therapeutic Targeting
Dobri, A.-M., Dudău, M., Enciu, A., & Hinescu, M. E. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.003 · Cited by 82 · see citing works
Miller, V. J., LaFountain, R. A., Barnhart, E. C., Sapper, T. N., Short, J. A., Arnold, W. D., Hyde, P. N., Crabtree, C. D., Kackley, M. L., Kraemer, W. J., et al. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00305.2020 · Cited by 81 · see citing works
Monda, V., Polito, R., Lovino, A. R., Finaldi, A., Valenzano, A. A., Nigro, E., Corso, G., Sessa, F., Asmundo, A., Nunno, N. R. D., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093228 · Cited by 80 · see citing works
Asrih, M., Altirriba, J., Rohner‐Jeanrenaud, F., & Jornayvaz, F. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126364 · Cited by 75 · see citing works
Crosstalk between the Ketogenic Diet and Epilepsy: From the Perspective of Gut Microbiota
Fan, Y., Wang, H., Liu, X., Zhang, J., & Liu, G. (2019) · Mediators of Inflammation · doi:10.1155/2019/8373060 · Cited by 70 · see citing works
Effects of ketogenic diet and ketone bodies on the cardiovascular system: Concentration matters
Nasser, S., Vialichka, V., Biesiekierska, M., Balcerczyk, A., & Pirola, L. (2020) · World Journal of Diabetes · doi:10.4239/wjd.v11.i12.584 · Cited by 69 · see citing works
GDF15 is a major determinant of ketogenic diet-induced weight loss
Lu, J. F., Zhu, M., Xia, B., Zhang, N., Liu, X. P., Liu, H., Zhang, R. X., Xiao, J. Y., Yang, H., Zhang, Y. Q., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.11.003 · Cited by 64 · see citing works
Paoli, A., Mancin, L., Caprio, M., Monti, E., Narici, M. V., Cenci, L., Piccini, F., Pincella, M., Grigoletto, D., & Marcolin, G. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-021-00459-9 · Cited by 63 · see citing works
Li, S., Lin, G., Chen, J., Chen, Z., Xu, F., Zhu, F., Zhang, J., & Yuan, S. (2022) · BMC Endocrine Disorders · doi:10.1186/s12902-022-00947-2 · Cited by 63 · see citing works
Long, F., Bhatti, M. R., Kellenberger, A., Sun, W., Modica, S., Höring, M., Liebisch, G., Krieger, J.-P., Wolfrum, C., & Challa, T. D. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101675 · Cited by 62 · see citing works
Nasser, S., Solé, T., Véga, N., Thomas, T., Balcerczyk, A., Strigini, M., & Pirola, L. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101578 · Cited by 61 · see citing works
Zhang, X., Qin, J., Zhao, Y., Shi, J., Lan, R. F., Gan, Y., Ren, H., Zhu, B., Qian, M., & Du, B. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.12.002 · Cited by 58 · see citing works
Ciaffi, J., Mitselman, D., Mancarella, L., Brusi, V., Lisi, L., Ruscitti, P., Cipriani, P., Melicòni, R., Giacomelli, R., Borghi, C., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.792846 · Cited by 58 · see citing works
Metabolic Reprogramming in Adipose Tissue During Cancer Cachexia
Weber, B. Z. C., Arabacı, D. H., & Kır, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.848394 · Cited by 58 · see citing works
The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophy
Liu, Y., Wang, D., Li, T., Yang, F., Li, Z., Bai, X., & Wang, Y.-C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1035709 · Cited by 57 · see citing works
Nakao, R., Abe, T., Yamamoto, S., & Oishi, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-56166-8 · Cited by 55 · see citing works
Fgf21 Impairs Adipocyte Insulin Sensitivity in Mice Fed a Low-Carbohydrate, High-Fat Ketogenic Diet
Murata, Y., Nishio, K., Mochiyama, T., Konishi, M., Shimada, M., Ohta, H., & Itoh, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069330 · Cited by 54 · see citing works
Molecular Mechanisms Underlying the Bioactive Properties of a Ketogenic Diet
Murakami, M., & Tognini, P. (2022) · Nutrients · doi:10.3390/nu14040782 · Cited by 54 · see citing works
SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1
Sebaa, R., Johnson, J. R., Pileggi, C. A., Norgren, M., Xuan, J. Y., Sai, Y., Tong, Q., Krystkowiak, I., Bondy‐Chorney, E., Davey, N. E., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.04.008 · Cited by 53 · see citing works
Schugar, R. C., Huang, X., Moll, A. R., Brunt, E. M., & Crawford, P. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074806 · Cited by 52 · see citing works
Knocking on GDF15’s door for the treatment of type 2 diabetes mellitus
Aguilar-Recarte, D., Barroso, E., Palomer, X., Wahli, W., & Vázquez‐Carrera, M. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.08.004 · Cited by 51 · see citing works
Crujeiras, A. B., Izquierdo, A. G., Primo, D., Milagro, F. I., Sajoux, I., Jácome, M. A., Fernández‐Quintela, A., Portillo, M. P., Martínez, J. A., Olmos, M. Á. M., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.05.010 · Cited by 47 · see citing works
Jani, S., Eira, D. D., Stefanovic, M., & Ceddia, R. B. (2022) · The Journal of Physiology · doi:10.1113/jp283552 · Cited by 47 · see citing works
Nilsson, J., Ericsson, M., Joibari, M. M., Anderson, F., Carlsson, L., Nilsson, S. K., Sjödin, A., & Burén, J. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0132-8 · Cited by 45 · see citing works
Kim, E. R., Kim, S. R., Cho, W., Lee, S., Kim, S. H., Kim, J. H., Choi, E., Kim, J., Yu, J., Lee, B., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.843520 · Cited by 44 · see citing works
Effects of Ketogenic Diet on Muscle Metabolism in Health and Disease
Yakupova, E. I., Bocharnikov, A. D., & Plotnikov, E. Y. (2022) · Nutrients · doi:10.3390/nu14183842 · Cited by 44 · see citing works
Rinaldi, R., Nucci, S. D., Castellana, F., Chito, M. D., Giannuzzi, V., Shahini, E., Zupo, R., Lampignano, L., Piazzolla, G., Triggiani, V., et al. (2023) · Nutrients · doi:10.3390/nu15040825 · Cited by 44 · see citing works
Low-carbohydrate diets for the treatment of obesity and type 2 diabetes
Hall, K., & Chung, S. (2018) · Current opinion in clinical nutrition and metabolic care · doi:10.1097/mco.0000000000000470 · Cited by 43 · see citing works
Arsyad, A., Idris, I., Rasyid, A. A., Usman, R. A., Faradillah, K. R., Latif, W. O. U., Lubis, Z. I., Aminuddin, A., Yustisia, I., & Djabir, Y. Y. (2020) · Journal of Nutrition and Metabolism · doi:10.1155/2020/3642035 · Cited by 43 · see citing works
Ketone Bodies and SIRT1, Synergic Epigenetic Regulators for Metabolic Health: A Narrative Review
Tozzi, R., Cipriani, F., Masi, D., Basciani, S., Watanabe, M., Lubrano, C., Gnessi, L., & Mariani, S. (2022) · Nutrients · doi:10.3390/nu14153145 · Cited by 42 · see citing works
Cowart, K. (2020) · Annals of Pharmacotherapy · doi:10.1177/1060028019889064 · Cited by 42 · see citing works
Li, Y., Yang, X., Zhang, J., Jiang, T., Zhang, Z., Wang, Z., Gong, M., Zhao, L., & Zhang, C. (2021) · mBio · doi:10.1128/mbio.03601-20 · Cited by 42 · see citing works
Patel, S., Haider, A., Álvarez-Guaita, A., Bidault, G., Moustafa, J. S. E.-S., Guiu‐Jurado, E., Tadross, J. A., Warner, J., Harrison, J., Virtue, S., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101589 · Cited by 40 · see citing works
Douris, N., Desai, B. N., Fisher, F. M., Cisu, T., Fowler, A. J., Zarebidaki, E., Nguyen, N. L. T., Morgan, D. A., Bartness, T. J., Rahmouni, K., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.05.017 · Cited by 39 · see citing works
Ketogenic Diet and Cardiac Substrate Metabolism
Luong, T. V., Abild, C. B., Bangshaab, M., Gormsen, L. C., & Søndergaard, E. (2022) · Nutrients · doi:10.3390/nu14071322 · Cited by 38 · see citing works
Abnormal lipid metabolism in cancer-associated cachexia and potential therapy strategy
Fang, R., Yan, L., & Liao, Z. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1123567 · Cited by 37 · see citing works
Li, S., Zou, T., Chen, J., Li, J., & You, J. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.06.033 · Cited by 37 · see citing works
Resistin, an Adipokine with Non-Generalized Actions on Sympathetic Nerve Activity
Badoer, E., Kosari, S., & Stebbing, M. J. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00321 · Cited by 36 · see citing works
Bertoli, S., Neri, I., Trentani, C., Ferraris, C., Amicis, R. S. D., Battezzati, A., Veggiotti, P., GIORGIS, V. D., & Tagliabue, A. (2015) · Nutrition · doi:10.1016/j.nut.2015.02.017 · Cited by 35 · see citing works
Low carbohydrate high fat ketogenic diets on the exercise crossover point and glucose homeostasis
Noakes, T. D., Prins, P., Volek, J. S., D’Agostino, D. P., & Koutnik, A. P. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1150265 · Cited by 35 · see citing works
Desli, E., Spilioti, M. G., Evangeliou, A., Styllas, F., Magkos, F., & Dalamaga, Μ. (2022) · Current Nutrition Reports · doi:10.1007/s13668-022-00405-4 · Cited by 34 · see citing works
Skytte, M. J., Samkani, A., Astrup, A. V., Frystyk, J., Rehfeld, J. F., Holst, J. J., Madsbad, S., Burling, K., Fenger, M., Thomsen, M. N., et al. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00165.2020 · Cited by 32 · see citing works
Li, S., Du, Y. N., Meireles, C. L., Sharma, K., Qi, L., Castillo, A., & Wang, J. (2023) · Nutrition and Diabetes · doi:10.1038/s41387-023-00246-2 · Cited by 31 · see citing works
Peng, Y., Zhao, L., Li, M., Liu, Y., Shi, Y., & Zhang, J. (2024) · Biomolecules · doi:10.3390/biom14040483 · Cited by 30 · see citing works
Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue
Waldhart, A. N., Muhire, B. M., Johnson, B. K., Pettinga, D., Madaj, Z., Wolfrum, E., Dykstra, H., Wegert, V., Pospisilik, J. A., Han, X., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109488 · Cited by 29 · see citing works
Abdurrachim, D., Teo, X. Q., Woo, C. C., Ong, S. Y., Salleh, N. F., Lalic, J., Tan, R., & Lee, P. T. H. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13608 · Cited by 29 · see citing works
Liśkiewicz, D., Liśkiewicz, A., Nowacka-Chmielewska, M. M., Grabowski, M., Pondel, N., Grabowska, K., Student, S., Barski, J. J., & Małecki, A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.733607 · Cited by 29 · see citing works
Sripongpun, P., Churuangsuk, C., & Bunchorntavakul, C. (2022) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2021.00494 · Cited by 28 · see citing works
Epigenome Modulation Induced by Ketogenic Diets
Ungaro, P., Nettore, I. C., Franchini, F., Palatucci, G., Muscogiuri, G., Colao, A., & Macchia, P. E. (2022) · Nutrients · doi:10.3390/nu14153245 · Cited by 28 · see citing works
Effect of Ketogenic Diet on Obesity and Other Metabolic Disorders: Narrative Review
Baylie, T., Ayelgn, T., Tiruneh, M., & Tesfa, K. (2024) · Diabetes, Metabolic Syndrome and Obesity · doi:10.2147/dmso.s447659 · Cited by 27 · see citing works
Cunha, G. M., de Mello, L. L. C., Hasenstab, K. A., Spina, L. D. C., Bussade, I., Mesiano, J. M. P., Coutinho, W. F., Guzmán, G., & Sajoux, I. (2020) · Clinical Radiology · doi:10.1016/j.crad.2020.02.014 · Cited by 26 · see citing works
Ketotherapy as an epigenetic modifier in cancer
Bandera-Merchán, B., Boughanem, H., Crujeiras, A. B., Macías‐González, M., & Tinahones, F. J. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09567-4 · Cited by 25 · see citing works
Upregulation of hepatic autophagy under nutritional ketosis
Liśkiewicz, D., Liśkiewicz, A., Grabowski, M., Nowacka-Chmielewska, M. M., Grabowska, K., Wojakowska, A., Marczak, Ł., Barski, J. J., & Małecki, A. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108620 · Cited by 25 · see citing works
Valsdottir, T. D., Henriksen, C., Odden, N., Nellemann, B., Jeppesen, P. B., Hisdal, J., Westerberg, A. C., & Jensen, J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01499 · Cited by 24 · see citing works
Chow diet in mouse aging studies: nothing regular about it
Lee, J., Purello, C. T., Booth, S. L., Bennett, B. J., Wiley, C. D., & Korstanje, R. (2023) · GeroScience · doi:10.1007/s11357-023-00775-9 · Cited by 24 · see citing works
Role of liver FGF21-KLB signaling in ketogenic diet-induced amelioration of hepatic steatosis
Guo, W., Cao, H., Shen, Y., Li, W., Wang, W. J., Cheng, L., Cai, M., & Xu, F. L. (2024) · Nutrition and Diabetes · doi:10.1038/s41387-024-00277-3 · Cited by 24 · see citing works
Simeone, T., Matthews, S., & Simeone, K. (2017) · Epilepsia · doi:10.1111/epi.13809 · Cited by 24 · see citing works
Jayashankar, S. S., Arifin, K. T., & Nasaruddin, M. L. (2023) · Nutrients · doi:10.3390/nu15030524 · Cited by 23 · see citing works
Kalafut, K. C., Mitchell, S. J., MacArthur, M. R., & Mitchell, J. R. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.839341 · Cited by 21 · see citing works
The Role of Adipokines in the Pathologies of the Central Nervous System
Huber, K., Szerenos, E., Lewandowski, D., Toczyłowski, K., & Sulik, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914684 · Cited by 21 · see citing works
Eucaloric Very-Low-Carbohydrate Ketogenic Diet in Acromegaly Treatment
Coopmans, E. C., Berk, K. A., El-Sayed, N., Neggers, S. J. C. M. M., & van der Lely, A. J. (2020) · New England Journal of Medicine · doi:10.1056/nejmc1915808 · Cited by 21 · see citing works
Research Progress on the Role and Mechanism of GDF15 in Body Weight Regulation
Dong, X.-C., & Xu, D. (2023) · Obesity Facts · doi:10.1159/000535089 · Cited by 18 · see citing works
Weber, A. J., Medak, K. D., Townsend, L. K., & Wright, D. C. (2022) · The Journal of Physiology · doi:10.1113/jp283469 · Cited by 17 · see citing works
Sierawska, O., & Sawczuk, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417287 · Cited by 17 · see citing works
Effect of the ketogenic diet in excitable tissues
Murano, C., Binda, A., Palestini, P., Baruscotti, M., DiFrancesco, J. C., & Rivolta, I. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00458.2020 · Cited by 16 · see citing works
Drabińska, N., Juśkiewicz, J., & Wiczkowski, W. (2022) · Nutrients · doi:10.3390/nu14224805 · Cited by 16 · see citing works
Nguyen, V. T.-T., Vu, V. V., & Pham, P. V. (2023) · Adipocyte · doi:10.1080/21623945.2023.2237164 · Cited by 15 · see citing works
Zhao, M., Zhang, X.-G., Tang, Y.-P., Zhu, Y.-X., Nie, H.-Y., Bu, D., Fang, L., & Li, C. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105617 · Cited by 15 · see citing works
The molecular mechanism of macrophage-adipocyte crosstalk in maintaining energy homeostasis
Zhang, Y., Zhang, B., & Sun, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1378202 · Cited by 14 · see citing works
Ketogenic diet and adipose tissue inflammation—a simple story? Fat chance!
Stubbs, B. J., & Newman, J. C. (2020) · Nature Metabolism · doi:10.1038/s42255-019-0164-2 · Cited by 13 · see citing works
Clinical Implications for Women of a Low-Carbohydrate or Ketogenic Diet With Intermittent Fasting
Arbour, M. W., Stec, M. A., Walker, K. C., & Wika, J. C. (2021) · Nursing for Women s Health · doi:10.1016/j.nwh.2021.01.009 · Cited by 13 · see citing works
The Role of a Ketogenic Diet in the Treatment of Dementia in Type 2 Diabetes Mellitus
Bai, L., Zhou, Y., Zhang, J., & Ma, J. (2023) · Nutrients · doi:10.3390/nu15081971 · Cited by 12 · see citing works
Ravaut, G., Carneiro, A., & Mounier, C. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1290540 · Cited by 12 · see citing works
Zeng, B., Shen, Q., Wang, B., Tang, X., Jiang, J., Zheng, Y., Huang, H., Zhuo, W., Wang, W., Gao, Y., et al. (2024) · Nutrition & Metabolism · doi:10.1186/s12986-024-00790-3 · Cited by 12 · see citing works
Impact of Maternal Ketogenic Diet on NLRP3 Inflammasome Response in the Offspring Brain
Altınöz, S., Mıçılı, S. Ç., Soy, S., Engür, D., Baysal, B., & Kumral, A. (2023) · Nutrients · doi:10.3390/nu15081994 · Cited by 12 · see citing works
Ketogenic diet in cancer management
Talib, W. H., Al-Dalaeen, A. M., & Mahmod, A. I. (2023) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000944 · Cited by 11 · see citing works
Eira, D. D., Jani, S., Stefanovic, M., & Ceddia, R. B. (2022) · Nutrition · doi:10.1016/j.nut.2022.111862 · Cited by 10 · see citing works
García-Álvarez, N. C., Riezu‐Boj, J. I., Martínez, J. A., García-Calzón, S., & Milagro, F. I. (2023) · Nutrients · doi:10.3390/nu15245023 · Cited by 10 · see citing works
CDK6 inhibits de novo lipogenesis in white adipose tissues but not in the liver
Hu, A. J., Li, W., Dinh, C., Zhang, Y., Hu, J. K., Daniele, S. G., Hou, X. S., Yang, Z., Asara, J. M., Hu, G., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45294-z · Cited by 8 · see citing works
Lower fat and better quality diet therapy for children with pharmacoresistant epilepsy
Yoon, J.-R., Kim, H. D., & Kang, H. (2013) · Korean Journal of Pediatrics · doi:10.3345/kjp.2013.56.8.327 · Cited by 8 · see citing works
Lejk, A., Chrzanowski, J., Cieslak, A. M., Fendler, W. M., & Myśliwiec, M. (2022) · Nutrients · doi:10.3390/nu14214689 · Cited by 7 · see citing works
Zhang, M., Chen, Y., Sun, S., Zhang, S., Li, Y., Xu, Y., Li, X., Chen, G., Wei, X., & Liu, C. (2023) · Nutrition · doi:10.1016/j.nut.2023.112284 · Cited by 7 · see citing works
The effect of the ketogenic diet on leptin, chemerin and resistin levels in children with epilepsy.
Chyra, M., Swietochowska, E., Gorska-Flak, K., Dudzinska, M., & Oswiecimska, J. (2021) · PubMed · Cited by 6 · see citing works
Immune-Modulating Effects of Low-Carbohydrate Ketogenic Foods in Healthy Canines
Tavener, S. K., Jackson, M. I., & Panickar, K. S. (2024) · Current Developments in Nutrition · doi:10.1016/j.cdnut.2024.102128 · Cited by 5 · see citing works
High-Fat-Diet Suppressed Ketone Body Utilization for Lipogenic Pathway in Brown Adipose Tissues
Yamasaki, M., Hasegawa, S., Ozaki, S., Imai, M., Saito, D., & Takahashi, N. K. (2023) · Metabolites · doi:10.3390/metabo13040519 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [3]Masood W. Annamaraju P. Khan Suheb M.Z. Uppaluri K.R. Ketogenic Diet StatPearls StatPearlsl Treasure Island, FL, USA 2024 29763005
Cited by
Sorted by citations
Ostaiza-Cardenas, J., Tobar, A., Costa, S. C., Calero, D. S., López-Carrera, A., Bermúdez, F. G., & Orellana-Manzano, A. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1632999 · Cited by 44 · see citing works
Xie, Y., Gu, Y., Li, Z., He, B., & Zhang, L. (2024) · Nutrients · doi:10.3390/nu16173007 · Cited by 48 · see citing works
Muhammed Saeed, A. A., Noreen, S., Awlqadr, F. H., Farooq, M. I., Qadeer, M., Rai, N., Farag, H. A., & Saeed, M. N. (2025) · Journal of Health, Population and Nutrition · doi:10.1186/s41043-025-00899-y · Cited by 29 · see citing works
“Ketogenic diets, characterized by a very low carbohydrate and high fat intake, are structured at approximately 1672 kcal/day, with macronutrient ratios of 4.8% carbohydrates, 71.1% fats, and 24.1% proteins, promoting weight loss and metabolic improvements through ketosis [164].”
InfluentialSchiavo, L., Santella, B., Mingo, M., Rossetti, G., Orio, M., Cobellis, L., Maurano, A., Iannelli, A., & Pilone, V. (2025) · Nutrients · doi:10.3390/nu17071216 · Cited by 22 · see citing works
Simancas‐Racines, D., Román-Galeano, N. M., Verde, L., Annunziata, G., Marchetti, M., Matos, A., Campuzano-Donoso, M., Reytor-González, C., Muscogiuri, G., Barrea, L., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26072895 · Cited by 23 · see citing works
Barrea, L., Verde, L., Annunziata, G., Chedraui, P. A., Petraglia, F., Cucalón, G., Camajani, E., Caprio, M., Gorini, S., Iorio, G. G., et al. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00662-8 · Cited by 15 · see citing works
Idzikowska, K., Gątarek, P., Gajda, A., Safiński, P., Przysło, Ł., & Kałużna‐Czaplińska, J. (2025) · Nutrients · doi:10.3390/nu17182969 · Cited by 15 · see citing works
Șerban, M., Toader, C., & Covache-Busuioc, R.-A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26168072 · Cited by 15 · see citing works
Aremu, S. O., Akute, B., Aremu, D. O., Zando, C., Aremu, D. E., Nwachukwu, O. J., Omosebi, M. O., Akute, V. O., Oluwole, S. T., Barkhadle, A. A., et al. (2025) · Discover Public Health · doi:10.1186/s12982-025-00818-w · Cited by 17 · see citing works
Yang, W., Pang, N., & He, X. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02693-5 · Cited by 13 · see citing works
Ketogenic Metabolism in Neurodegenerative Diseases: Mechanisms of Action and Therapeutic Potential
Pawłowska, M., Kruszka, J., Porzych, M., Garbarek, J., & Nuszkiewicz, J. (2025) · Metabolites · doi:10.3390/metabo15080508 · Cited by 13 · see citing works
Ketogenic diet and microRNAs: focus on cognitive function
Abrego-Guandique, D. M., Cione, E., Caroleo, M. C., Bonilla, D. A., & Cannataro, R. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1545832 · Cited by 9 · see citing works
Khalil, R. A. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.71309 · Cited by 11 · see citing works
Beyond epilepsy management: A narrative review of the health effects of ketogenic diets
Chamma, L., Chamma, N., Mattar, L., Slaybe, M. A., Haidar, S. A., & Rizk, R. (2025) · Nutrition · doi:10.1016/j.nut.2025.112804 · Cited by 7 · see citing works
Ghaffary, E. M., Bjørklund, G., Bhat, R. S., & Mirmosayyeb, O. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103825 · Cited by 7 · see citing works
Ye, F., Huang, Y., Zeng, L., Li, N., Hao, L., Yue, J., Li, S., Deng, J., Yu, F., & Hu, X. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.09.044 · Cited by 7 · see citing works
Cardiovascular Dysfunction in Polycystic Ovary Syndrome: Mitochondrial and Inflammatory Mechanisms
Badejogbin, O. C., Agunloye, M. O., Chijioke‐Agu, O. E., Olubiyi, M. V., Olugbuyiro, S. O., Soetan, O. A., Bamgbose, O. A., & Olaleye, T. O. (2026) · BioMed Research International · doi:10.1155/bmri/1110229 · Cited by 6 · see citing works
Nutrition and longevity – diet in centenarians
Frias-Toral, E., Reytor-González, C., Annunziata, G., Verde, L., Jiménez-Flores, E., Sen, K., Galasso, M., Muscogiuri, G., Simancas‐Racines, D., Dalamaga, Μ., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07691-4 · Cited by 6 · see citing works
Citric Acid Cycle Genes and Nutrigenetics
Vesnina, A. A., Kozlova, O., Ivanova, S. A., & Prosekov, A. Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052360 · Cited by 7 · see citing works
Signals of energy availability in sleep: consequences of a fat-based metabolism
O’Hearn, L. A. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1397185 · Cited by 4 · see citing works
Anthropometric Trajectories and Dietary Compliance During a Personalized Ketogenic Program
García-Gorrita, C., Soriano, J. M., Merino-Torres, J. F., & Onofre, N. S. (2025) · Nutrients · doi:10.3390/nu17091475 · Cited by 4 · see citing works
Impacts of Diets and Food Plans in Health and Diseases—A Narrative Review
Rahman, M. M., Pandit, M., Thukral, B., & Khandoker, M. M. (2025) · Food Safety and Health · doi:10.1002/fsh3.70043 · Cited by 2 · see citing works
Reytor-González, C., Jiménez-Flores, E., Toral-Noristz, M., Campuzano-Donoso, M., Román-Galeano, N. M., & Simancas‐Racines, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211130 · Cited by 2 · see citing works
Nutritional ketosis as therapeutic regimen for metabolic disorders: Perspectives and challenges
Ul‐Haq, I., Saleem, K., Iftikhar, H., & Abdi, G. (2025) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2025.101981 · Cited by 3 · see citing works
Vélez-Bonet, E., Gumpper, K., Chasser, K. M., Hurst, Z. A., Torres-Rosado, A., Hsueh, H., Pita-Grisanti, V., Liette, A., Vulic, G., Choueiry, F., et al. (2026) · Cancer Research · doi:10.1158/0008-5472.can-25-2379 · Cited by 1 · see citing works
Wang, Y., Zhang, K. X., Kan, C., Zhang, W., Sun, X., & Li, L. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70613 · Cited by 1 · see citing works
The Effect of a Ketogenic Diet on Liver Health: A Systematic Review and Meta-Analysis
Qu, Y., Sohouli, M. H., Rohani, P., Cerqueira, H. S. C., Gomes, G. K., & Santos, H. O. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf197 · Cited by 1 · see citing works
Ahmed, Y. R., Megeed, R. M. A., Gooda, S. M., Kamel, N. N., Raoof, G. F. A., Hassan, E. E., Farghaly, A. A., El-Saied, M. A., El-Rigal, N. S., Rizk, M. Z., et al. (2025) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-025-01776-5 · Cited by 1 · see citing works
Wang, Y.-L., Lu, Q., Ma, H.-L., Huang, J., Zhang, B., Qin, Y., Feng, Z.-W., & Jin, X.-F. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1652271 · Cited by 1 · see citing works
Khaled, K., Jardaly, H., & Oh, B. (2026) · Onco · doi:10.3390/onco6010005 · Cited by 1 · see citing works
Innate lymphoid cells: unsung heroes or villains in multiple sclerosis pathogenesis?
Aliyu, M., Saboor-Yaraghi, A. A., Sahraian, M. A., Noorbakhsh, F., Adamu, A.-M. Y., Sharif, A. A., & Abdulqadir, Z. A. (2026) · Immunologic Research · doi:10.1007/s12026-025-09734-2 · Cited by 1 · see citing works
Fahmi, A. L., Fiddaroini, S., Putri, K. F. S., ‘Aisy, K. R., Fatmah, H. E., Setiawan, E. T. V., Chandra, M. S., Susianti, H., & Sabarudin, A. (2025) · Green Analytical Chemistry · doi:10.1016/j.greeac.2025.100286 · Cited by 1 · see citing works
Aliyu, M., Saboor-Yaraghi, A., Getso, M., & Zohora, F. (2025) · InflammoPharmacology · doi:10.1007/s10787-025-01804-z · Cited by 1 · see citing works
Papież, Ł. S., Dołęga, J., Zabawa, B., Krzykawski, K., Maciejczyk, T., Sieńko, A., Hudzińska, P., Sadowski, J., Mól, P., & Łabuś, M. (2024) · Quality in Sport · doi:10.12775/qs.2024.34.56223
Egba, S. I., & Chigbo, D. C. (2025) · Archives of Cancer Science and Therapy · doi:10.29328/journal.acst.1001047
Murthy, S. T. S., & Manjappara, U. V. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152262
Nagalski, A., Koziński, K., Baggio, S., Szewczyk, Ł. M., Lipiec, M. A., Mussulini, B. H. M., Gabriel, M. O., Bem, J., Meyza, K. Z., Goncerzewicz, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.14.684361
Penna‐de‐Carvalho, A., Nagagata, B. A., Guarnieri, R. S., Borges, M. M. S., Teixeira, L. G., Ferreira-Machado, S. C., & Águila, M. B. (2025) · Nutrition · doi:10.1016/j.nut.2025.113037
Clinical Impact of Ketogenic Diet
Guarnotta, V. (2026) · Nutrients · doi:10.3390/nu18020245
Shamlan, G. H. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71457
Paskaleva, I. N., Kaleva, N., Dimcheva, T., & Ivanov, I. (2026) · Children · doi:10.3390/children13030406
Frago, L. M., Gómez-Romero, A., Casado, M. E., Canelles, S., Jiménez‐Hernáiz, M., Ros, P., Cuadrillero, D. A., Argente, J., Martos‐Moreno, G. Á., & Barrios, V. (2026) · Livers · doi:10.3390/livers6020028
Gatesman, T. A., Varadharajan, S., Johnson, B. J., Duchatel, R. J., Pathak, R., Cruz, A. F., Wolfe, H. G., Halligan, K. E., Garton, L. G., Johnson, M. A., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117522
Donghia, R., Musio, B., Luca, M. D., Balestra, F., Panzetta, G., Todisco, S., Mastrorilli, P., Coletta, S., Chito, M. D., Giannelli, G., et al. (2026) · Nutrients · doi:10.3390/nu18121950
Metabolic regulation in inherited cardiovascular diseases
Wu, Y., Mao, Q., & Liang, D. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34186-1.00013-x
Ibrahim, R. A., Elwaddah, N. M., Aziz, N. M., Yousef, J. E., El‐Aleem, S. A. A., & Saber, E. A. (2026) · Journal of Molecular Histology · doi:10.1007/s10735-026-10907-y
Romano, M., Raoul, P. C., Ianiro, G., Rondinella, D., Ribaudi, E., Galli, F. S., Cintoni, M., Gasbarrini, A., Capristo, E., Mele, M. C., et al. (2026) · Nutrients · doi:10.3390/nu18182982
Górecka, K., Solé, T., Soboska, K., Chikh, K., Maarbani, A. E., Pirola, L., Strigini, M., & Balcerczyk, A. (2026) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2026.110515
Li, T., Wang, X., hao, L. U., CHEN, M., Zhang, H., ZHANG, M., & Sun, Z. (2026) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765202620251367
- Authors
- Ahmad, Y., Seo, D. S., & Jang, Y.
- Affiliations
- Changwon National University (KR)
- Corresponding author
- Jang, Younghoon
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2024-06-27
- Volume
- 25
- Issue
- 13
- Pages
- 7076
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC11241756
- OpenAlex
- W4400080612
- Cited by
- 49
- References
- 155
- Citations by year
- 2026: 17 · 2025: 28 · 2024: 4
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Korean government (Ministry of Science, ICT, and Future Planning) and the Ministry of Education (NRF2022R1A2C1003656, NRF2022R1A6A3A01085801, 2021R1A4A1029238, 2023R1A6C101B022)
- Korea Basic Science Institute (National Research Facilities and Equipment Center) (NRF2022R1A2C1003656, NRF2022R1A6A3A01085801, 2021R1A4A1029238, 2023R1A6C101B022)
- Topics
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- ketogenic diet, ketosis, adipose tissue, brown adipose tissue, UCP1, white adipose tissue browning, ketone oxidation, Krebs cycle intermediates, DNA methylation, adipogenesis, FGF21, muscle mass, lipolysis, neuroprotection, anti-inflammatory activity, epigenetics, dyslipidemia, weight loss
- MeSH terms
- Uncoupling Protein 1, Adipose Tissue, Animals, Adipose Tissue, Brown, Energy Metabolism, Humans, Thermogenesis, Lipid Metabolism, Diet, Ketogenic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review