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IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling
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“IL-6 trans-signaling in hypothalamic neurons was found to consistently control feeding and systemic glucose homeostasis in HFD-fed mice (Timper et al., 2017”
From Targeting Interleukin-6 Signaling in Clinic (2019) · cites this paper as Timper et al., 2017
In the citing paper
“IL-6 expression in the CNS was shown to be negatively correlated with obesity (Stenlöf et al., 2003; Timper et al., 2017”
From Targeting Interleukin-6 Signaling in Clinic (2019) · cites this paper as Timper et al., 2017
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Inflammation, stress, and diabetes
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Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo
Kim, H.-J., Higashimori, T., Park, S.-Y., Choi, H., Dong, J., Kim, Y.-J., Noh, H.-L., Cho, Y.-R., Cline, G., Kim, Y.-B., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1060 · Cited by 534
The role of interleukin-6 signaling in nervous tissue
Rothaug, M., Becker-Pauly, C., & Rose-John, S. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.03.018 · Cited by 491
Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
Matthews, V. B., Allen, T. L., Risis, S., Chan, M. H. S., Henstridge, D. C., Watson, N., Zaffino, L. A., Babb, J. R., Boon, J., Meikle, P. J., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1865-y · Cited by 334
Kraakman, M. J., Kammoun, H. L., Allen, T. L., Deswaerte, V., Henstridge, D. C., Estevez, E., Matthews, V. B., Neill, B., White, D. A., Murphy, A. J., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.02.006 · Cited by 257
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“A study showed that IL-6 improves glucose tolerance and suppresses feeding when it is applied centrally in mice, but not intraperitoneally at the same dose (119).”
BackgroundTargeting Interleukin-6 Signaling in Clinic
Kang, S., Tanaka, T., Narazaki, M., & Kishimoto, T. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.026 · Cited by 904
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Metadata
- Authors
- Timper, K., Denson, J. L., Steculorum, S. M., Heilinger, C., Engström-Ruud, L., Wunderlich, C. M., Rose-John, S., Wunderlich, F. T., & Brüning, J. C.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 19
- Issue
- 2
- Pages
- 267-280
- ISSN
- 2211-1247
- Cited by
- 233
- References
- 12
- Language
- en
- Licence
- Funders
- Universität Basel
- Seventh Framework Programme (266408)
- Deutsche Forschungsgemeinschaft (BR 1492/7-1)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Helmholtz Association
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